Brexpiprazole: A new option in treating agitation in Alzheimer's dementia—Insights from transgenic mouse models

Authors: Naoki Amada, Shinji Sato, Dai Ishikawa, Mai Nakamura, Mikio Suzuki, Takashi Futamura, Kenji Maeda

Source: Neuropsychopharmacology Reports, Vol 44, Iss 3, Pp 557-568 (2024)

Subject Terms: aggression, agitation, Alzheimer's disease, behavioral and psychological symptoms associated with dementia (BPSD), brexpiprazole, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/fa6df26c491e472990256ede52dec2c8

Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice

Authors: Naoki Amada, Tsuyoshi Hirose, Mikio Suzuki, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda, Tetsuro Kikuchi

Source: Neuropsychopharmacology Reports, Vol 43, Iss 1, Pp 132-136 (2023)

Subject Terms: Brexpiprazole, forced swimming test, major depressive disorder, psychiatric disorder, selective serotonin reuptake inhibitor, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/539a2a2ea0d34f5d8379ae7d122281e2

Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy

Authors: Naoki Amada, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda

Source: Neuropsychopharmacology Reports, Vol 42, Iss 3, Pp 263-271 (2022)

Subject Terms: autism, depression, folate, methotrexate, psychiatric disorders, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/37482cd7e51441629de23efff9144573

Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice

Authors: Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/567ebe43dd94438ba727a55d27ace8dc

Discovery research and development history of the dopamine D2 receptor partial agonists, aripiprazole and brexpiprazole

Authors: Tetsuro Kikuchi, Kenji Maeda, Mikio Suzuki, Tsuyoshi Hirose, Takashi Futamura, Robert D. McQuade

Source: Neuropsychopharmacology Reports, Vol 41, Iss 2, Pp 134-143 (2021)

Subject Terms: aripiprazole, brexpiprazole, dopamine D2 receptor partial agonist, dopamine‐system stabilizer, serotonin‐dopamine activity modulator, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/52c7780e7f80417e97c13f70502cc28d

Brexpiprazole has a low risk of dopamine D2 receptor sensitization and inhibits rebound phenomena related to D2 and serotonin 5‐HT2A receptors in rats

Authors: Naoki Amada, Hitomi Akazawa, Yuta Ohgi, Kenji Maeda, Haruhiko Sugino, Nobuyuki Kurahashi, Tetsuro Kikuchi, Takashi Futamura

Source: Neuropsychopharmacology Reports, Vol 39, Iss 4, Pp 279-288 (2019)

Subject Terms: antipsychotic drug, brexpiprazole, D2 receptor partial agonist, rebound symptoms, receptor sensitization, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2574-173X

Access URL: https://doaj.org/article/66b91c71c5e2434aa05a0dc090222e04

DEVELOPMENT OF AN AUTOMATION SYSTEM OF CULTURE AND LONGITUDINAL EVALUATION OF PATIENT IPS CELL-DERIVED ORGANOIDS (ASCLEPIOS).

Authors: Atsushi Shiraishi, Takahito Inoue, Junji Takaba, Takashi Futamura

Source: International Journal of Neuropsychopharmacology; 2025 Supplement, Vol. 28, p1372-1372, 1/3p

Subject Terms: INDUCED pluripotent stem cells, DRUG discovery, SINGLE nucleotide polymorphisms, RNA-binding proteins, CENTRAL nervous system

CONTRIBUTION OF 5-HT2AR TO THE ANTIANHEDONIC AND NEUROPLASTICITY EFFECTS OF PSYCHEDELICS.

Authors: Ichiro Horinokita, Hiroyuki Koike, Mikio Suzuki, Takashi Futamura

Source: International Journal of Neuropsychopharmacology; 2025 Supplement, Vol. 28, pi152-i152, 1/2p

Subject Terms: TREATMENT effectiveness, STATISTICAL significance, NEURAL circuitry, HALLUCINOGENIC drugs, LABORATORY mice

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Palladium-Catalyzed Regioselective Hydroalkylation of 2-Fluoroallyl Acetates: Synthesis of Vinylmalonic Acid Ester Derivatives.

Authors: Shihori Kuki¹, Takashi Futamura¹, Ryo Suzuki¹, Mitsuaki Yamamoto¹, Maki Minakawa¹, Motoi Kawatsura¹ kawatsur@chs.nihon-u.ac.jp

Source: Synlett. 2015, Vol. 26 Issue 12, p1715-1719. 5p.

Subject Terms: *PALLADIUM catalysts, *ALLYL compounds, *ACETATES, *ESTER derivatives, *FLUORINE compounds

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