Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Authors: Vivien R. Sutton, Sally V. Watt, Hedieh Akhlaghi, David C. Cipolla, Kuan-Ju Chen, Daniel LaSala, Patrick P. McDonald, Paul A. Beavis, Isabelle Munoz, Adrian W. Hodel, Tahereh Noori, Ilia Voskoboinik, Joseph A. Trapani

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: DPP1, granzyme, apoptosis, serine protease, T cell, lysosome, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1396710/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/637ceae3f9ef4a27add5a0ac7f8e1bc1

ALFA-PRF: a novel approach to detect murine perforin release from CTLs into the immune synapse

Authors: Jesse A. Rudd-Schmidt, Romain F. Laine, Tahereh Noori, Amelia J. Brennan, Ilia Voskoboinik

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: cytotoxic lymphocyte, granzyme, immunological synapse, cytotoxic granules, trafficking, microscopy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.931820/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/72534967b2074930a658cb5e8e398437

NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation

Authors: Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: NKG7, cytotoxic T lymphocytes, immune synapse, tumor necrosis factor, immunotherapy, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.931630/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c8e517cb608a45a58a1cfaec14b8b317

Lipid order and charge protect killer T cells from accidental death

Authors: Jesse A. Rudd-Schmidt, Adrian W. Hodel, Tahereh Noori, Jamie A. Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A. Trapani, Bart W. Hoogenboom, Ilia Voskoboinik

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b570a4b9b4f425cbf44500be5992740

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Authors: Thijs W.H. Flinsenberg, Charnelle C. Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin Y.T. Thia, Tahereh Noori, Xiaomin Song, Han X. Aw Yeang, Daniela G. Tantalo, Sasanka Handunnetti, John F. Seymour, Andrew W. Roberts, David Ritchie, Rachel Koldej, Paul J. Neeson, Lai Wang, Joseph A. Trapani, Constantine S. Tam, Ilia Voskoboinik

Source: Haematologica, Vol 105, Iss 2 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9545; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/558c9b1e21f44feb8a3a2bbe8e5ce1a0

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Authors: Jamie A. Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S. Hildebrand, Hedieh Akhlaghi, Phillip K. Darcy, Michael H. Kershaw, Natasha J. Brown, Andrew Grigg, Joseph A. Trapani, Ilia Voskoboinik

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: familial haemophagocytic lymphohistiocytosis, cytotoxic lymphocytes, immunodeficiency, apoptosis, natural killer cells, cytotoxic T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00529/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7b7c9fbb0a424695a61c0ec7c5f47808