Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway

Authors: Tadashi Shiohama, Hideki Uchikawa, Nobuhiro Nitta, Tomozumi Takatani, Shingo Matsuda, Alpen Ortug, Emi Takahashi, Daisuke Sawada, Eiji Shimizu, Katsunori Fujii, Ichio Aoki, Hiromichi Hamada

Source: Frontiers in Neuroscience, Vol 18 (2024)

Subject Terms: hedgehog signaling, Ptch, Gorlin syndrome, brain magnetic resonance imaging, laterality, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2024.1449673/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/3f6094d326054064a78690b38cd63dd2

Brain morphometric changes in children born as small for gestational age without catch up growth

Authors: Tomozumi Takatani, Tadashi Shiohama, Rieko Takatani, Shinya Hattori, Hajime Yokota, Hiromichi Hamada

Source: Frontiers in Neuroscience, Vol 18 (2024)

Subject Terms: idiopathic short stature, short for gestational age, voxel-based morphometry, surface-based morphometry, brain magnetic resonance imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2024.1441563/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/952c6be49e044052834228f571c86b03

The Development of Methods of BLOTCHIP®-MS for Peptidome: Small Samples in Tuberous Sclerosis

Authors: Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

Source: Current Issues in Molecular Biology, Vol 47, Iss 1, p 34 (2025)

Subject Terms: tuberous sclerosis, autism spectrum disorders, pathophysiology, TSC2, glutathione, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/47/1/34; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/42abf0974f584c2297f0adb4c980eaa0

Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate

Authors: Mami Uegami, Hiroaki Ito, Tadashi Shiohama

Source: Diagnostics, Vol 15, Iss 2, p 205 (2025)

Subject Terms: gingival overgrowth, sodium valproate, paroxysmal sympathetic hyperactivity, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/15/2/205; https://doaj.org/toc/2075-4418

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Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms

Authors: Kunio Yui, George Imataka, Tadashi Shiohama

Source: Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9149-9164 (2023)

Subject Terms: lipid peroxidation, ferroptosis, malondialdehyde-modified low-density lipoprotein, autistic behavior, do cosahexaenoic acid, arachidonic acid, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/45/11/574; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

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Generation of human induced pluripotent stem cell lines derived from four Rett syndrome patients with MECP2 mutations

Authors: Miyu Mori, Shoko Yoshii, Michiya Noguchi, Daigo Takagi, Tomoya Shimizu, Hidenori Ito, Mami Matsuo-Takasaki, Yukio Nakamura, Satoru Takahashi, Hiromichi Hamada, Kiyoshi Ohnuma, Tadashi Shiohama, Yohei Hayashi

Source: Stem Cell Research, Vol 77, Iss , Pp 103432- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506124001302; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/6962a75bf8ac4d788cddea596e42be9a

Comprehensive High-Depth Proteomic Analysis of Plasma Extracellular Vesicles Containing Preparations in Rett Syndrome

Authors: Sho Hagiwara, Tadashi Shiohama, Satoru Takahashi, Masaki Ishikawa, Yusuke Kawashima, Hironori Sato, Daisuke Sawada, Tomoko Uchida, Hideki Uchikawa, Hironobu Kobayashi, Megumi Shiota, Shin Nabatame, Keita Tsujimura, Hiromichi Hamada, Keiichiro Suzuki

Source: Biomedicines, Vol 12, Iss 10, p 2172 (2024)

Subject Terms: Rett syndrome, extracellular vesicles containing preparations, high-depth proteome analysis, PI3K/AKT/mTOR signaling pathway, UBE3B, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/10/2172; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b85688b676e941a1bfce11dbfee50f4d

A case report of a child with pulmonary hypertension associated with SARS-CoV-2 infection

Authors: Kentaro Okunushi, Hironobu Kobayashi, Yuri Yoh, Masaya Kunimatsu, Tadashi Shiohama, Tomozumi Takatani, Hiromichi Hamada

Source: Frontiers in Pediatrics, Vol 12 (2024)

Subject Terms: SARS-CoV-2, pulmonary hypertension, children, panhypopituitarism, growth hormone, portal hypertension, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2024.1336589/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/58dbaad2c4ce48a68b5492e4c92987e0

Structural Magnetic Resonance Imaging-Based Surface Morphometry Analysis of Pediatric Down Syndrome

Authors: Jacob Levman, Bernadette McCann, Nicole Baumer, Melanie Y. Lam, Tadashi Shiohama, Liam Cogger, Allissa MacDonald, Emi Takahashi

Source: Biology, Vol 13, Iss 8, p 575 (2024)

Subject Terms: down syndrome, surface morphometry, magnetic resonance imaging, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/13/8/575; https://doaj.org/toc/2079-7737

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Case report: Progressive pulmonary artery hypertension in a case of megalencephaly-capillary malformation syndrome

Authors: Yuri Yoh, Tadashi Shiohama, Tomoko Uchida, Ryota Ebata, Hironobu Kobayashi, Kentaro Okunushi, Mitsuhiro Kato, Kazuki Watanabe, Mitsuko Nakashima, Hirotomo Saitsu, Hiromichi Hamada

Source: Frontiers in Genetics, Vol 14 (2023)

Subject Terms: megalencephaly-capillary malformation syndrome, overgrowth syndrome, pulmonary arterial hypertension, PIK3CA, PI3K/Akt/mTOR pathway, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2023.1221745/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/76d7c2d39b6c49a0b670eaf6c4b45ba8

Brain structure alterations in girls with central precocious puberty

Authors: Shoko Yoshii, Tomozumi Takatani, Tadashi Shiohama, Rieko Takatani, Yutaka Konda, Shinya Hattori, Hajime Yokota, Hiromichi Hamada

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: central precocious puberty, precuneus cortex, voxel-based morphometry, surface-based morphometry, brain magnetic resonance imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1215492/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/a078c4a7ba874a42be6aa26962e5d777

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Authors: Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi

Source: Brain Sciences, Vol 13, Iss 12, p 1655 (2023)

Subject Terms: lissencephaly, MRI, DTI, LIS1, tractography, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/13/12/1655; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/9bc5e57630de4b3a89130bd25e974c51

Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

Authors: Tadashi Shiohama, Aya Hisada, Midori Yamamoto, Kenichi Sakurai, Rieko Takatani, Katsunori Fujii, Naoki Shimojo, Chisato Mori, the Japan Environment Children’s Study (JECS) Group

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/a95c057c956a425eb64f2749f33bdd58

A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents

Authors: Tadashi Shiohama, Norihide Maikusa, Masahiro Kawaguchi, Jun Natsume, Yoshiyuki Hirano, Keito Saito, Jun-ichi Takanashi, Jacob Levman, Emi Takahashi, Koji Matsumoto, Hajime Yokota, Shinya Hattori, Keita Tsujimura, Daisuke Sawada, Tomoko Uchida, Tomozumi Takatani, Katsunori Fujii, Shinji Naganawa, Noriko Sato, Hiromichi Hamada

Source: Diagnostics, Vol 13, Iss 17, p 2774 (2023)

Subject Terms: ComBat-GAM, structural brain MRI, voxel-based morphometry, CIVET, normal reference values, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/13/17/2774; https://doaj.org/toc/2075-4418

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Comprehensive Volumetric Analysis of Mecp2-Null Mouse Model for Rett Syndrome by T2-Weighted 3D Magnetic Resonance Imaging

Authors: Yuichi Akaba, Tadashi Shiohama, Yuji Komaki, Fumiko Seki, Alpen Ortug, Daisuke Sawada, Wataru Uchida, Koji Kamagata, Keigo Shimoji, Shigeki Aoki, Satoru Takahashi, Takeshi Suzuki, Jun Natsume, Emi Takahashi, Keita Tsujimura

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: Rett syndrome, methyl-CpG-binding protein 2, magnetic resonance imaging, brain structure, volumetric analysis, neurodevelopmental disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.885335/full; https://doaj.org/toc/1662-453X

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Quantitative Structural Brain Magnetic Resonance Imaging Analyses: Methodological Overview and Application to Rett Syndrome

Authors: Tadashi Shiohama, Keita Tsujimura

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: quantitative analysis, voxel based morphometry, surface based morphometry, diffusion-weighted MRI tractography, rett syndrome (RTT), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.835964/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/cc85730f05e74559bea1585b0571f9a0

microRNA Biology on Brain Development and Neuroimaging Approach

Authors: Keita Tsujimura, Tadashi Shiohama, Emi Takahashi

Source: Brain Sciences, Vol 12, Iss 10, p 1366 (2022)

Subject Terms: miRNAs, gene expression, brain development, migration, neuronal development, neurodevelopmental disorder, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/12/10/1366; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/2d149db34ba84ef49238ab813d38eb63

Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in down syndrome: Newborns to young adults

Authors: Bernadette McCann, Jacob Levman, Nicole Baumer, Melanie Y. Lam, Tadashi Shiohama, Liam Cogger, Allissa MacDonald, Prahar Ijner, Emi Takahashi

Source: NeuroImage: Clinical, Vol 32, Iss , Pp 102815- (2021)

Subject Terms: Magnetic resonance imaging, Down syndrome, Entorhinal, Perirhinal, Volumetrics, Clinical, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221315822100259X; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/9d2cc63d20d3401ab8528ec6b4bae1ce

Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly

Authors: Lana Vasung, Arthur Rezayev, Hyuk Jin Yun, Jae W. Song, Andre van der Kouwe, Natalie Stewart, Arthi Palani, Tadashi Shiohama, Francois Chouinard-Decorte, Jacob Levman, Emi Takahashi

Source: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

Subject Terms: lissencephaly, gyrification, LIS1, DCX mutation, MRI, DTI, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2019.00124/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/34edc8f8f3474648991e7f1986d0859c

Quantitative brain morphological analysis in CHARGE syndrome

Authors: Tadashi Shiohama, Jeremy McDavid, Jacob Levman, Emi Takahashi

Source: NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158219302165; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/ebbc206c65384d34995076eb232074a8