CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation

Authors: Tatsunori Ito, Tomohiro Ichikawa, Mitsuhiro Yamada, Yuichiro Hashimoto, Naoya Fujino, Tadahisa Numakura, Yusaku Sasaki, Ayumi Suzuki, Katsuya Takita, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Akira Koarai, Tsutomu Tamada, Hisatoshi Sugiura

Source: Allergology International, Vol 73, Iss 1, Pp 151-163 (2024)

Subject Terms: Asthma, CYP27A1, Eosinophils, Oxysterols, 27-Hydroxycholesterol, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1323893023000813; https://doaj.org/toc/1323-8930

Access URL: https://doaj.org/article/82c3640da9044697a018e9257ae32e5a

Supersulphides provide airway protection in viral and chronic lung diseases

Authors: Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike

Source: Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1a6db92f44634602affb96764e95005a

Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma

Authors: Koji Itakura, Naoya Fujino, Yosuke Kamide, Ikuo Saito, Mitsuhiro Yamada, Koji Okutomo, Yoko Tsukita, Takuya Saito, Tomohiro Ichikawa, Tadahisa Numakura, Yorihiko Kyogoku, Hiroyuki Aizawa, Yoshinao Ono, Shuichiro Matsumoto, Tracy Hussell, Masami Taniguchi, Masakazu Ichinose, Hisatoshi Sugiura

Source: Allergology International, Vol 71, Iss 3, Pp 383-394 (2022)

Subject Terms: Airway, Asthma, Axl receptor tyrosine kinase, Eosinophilic inflammation, Granulocyte-macrophage colony-stimulating factor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S132389302200034X; https://doaj.org/toc/1323-8930

Access URL: https://doaj.org/article/940d6e3cedc14ea78ab7602d71eff235

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator

Authors: Mitsuhiro Yamada, Ikuko N. Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N. Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto

Source: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/309a84e839cb4d95a792a8865914587f

Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation

Authors: Ayumi Mitsune, Mitsuhiro Yamada, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Suzuki, Shuichiro Matsumoto, Yoshiya Mitsuhashi, Koji Itakura, Tomonori Makiguchi, Akira Koarai, Tsutomu Tamada, Shota Endo, Toshiyuki Takai, Yoshinori Okada, Satoshi Suzuki, Masakazu Ichinose, Hisatoshi Sugiura

Source: Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)

Subject Terms: Pulmonary macrophage, Matrix metalloproteinase 12, Pulmonary emphysema, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/5d6df3c0d4c34c4e9f5808a0a6b3bb64

PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite

Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura

Source: Respiratory Research, Vol 22, Iss 1, Pp 1-16 (2021)

Subject Terms: Asthma, Airway barrier dysfunction, PGC-1α, House dust mite, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/1c6805845dce4a2c89d800dedaf961f4

A case of localized tracheobronchial relapsing polychondritis with positive matrilin-1 staining

Authors: Tomonori Makiguchi, Akira Koarai, Chihiro Inoue, Yayoi Aoyama, Taizo Hirano, Takashi Ohe, Tomohiro Ichikawa, Yutaka Shishikura, Hanae Komuro, Yoko Tsukita, Naoki Tode, Tadahisa Numakura, Tsutomu Saito, Teruyuki Sato, Yoshiya Mitsuhashi, Tsutomu Tamada, Hisatoshi Sugiura, Masakazu Ichinose

Source: BMC Rheumatology, Vol 4, Iss 1, Pp 1-6 (2020)

Subject Terms: Relapsing polychondritis, Tracheobronchial, Matrilin-1, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2520-1026

Access URL: https://doaj.org/article/95daa19c872048b48a4b6d052f320521

The first case of multiple pulmonary granulomas with amyloid deposition in a dental technician; a rare manifestation as an occupational lung disease

Authors: Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura, Masakazu Ichinose

Source: BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-5 (2018)

Subject Terms: Dental technician, Amyloid deposition, Pulmonary granulomas, Silica, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12890-018-0654-0; https://doaj.org/toc/1471-2466

Access URL: https://doaj.org/article/4f5aea79f1c94e2ea7a9c894f9f42c1b

Oxidative stress enhances the expression of IL-33 in human airway epithelial cells

Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose

Source: Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)

Subject Terms: COPD, Exacerbation, IL-33, Oxidative stress, Viral infection, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12931-018-0752-9; https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/22e130c82d2543998c8d2a045b551b94

Correction to: PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite

Authors: Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura

Source: Respiratory Research, Vol 22, Iss 1, Pp 1-1 (2021)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/7973662e963848eca6989b0352109e4e

Correction to: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells

Authors: Hiroyuki Aizawa, Akira Koarai, Yutaka Shishikura, Satoru Yanagisawa, Mutsuo Yamaya, Hisatoshi Sugiura, Tadahisa Numakura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Masafumi Noda, Yoshinori Okada, Masakazu Ichinose

Source: Respiratory Research, Vol 19, Iss 1, Pp 1-2 (2018)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12931-018-0817-9; https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/6d258dafe4a24fdfbcc8c36891630619

Hermansky-Pudlak Syndrome with an Improvement in the Respiratory Symptoms after the Administration of Pirfenidone.

Authors: Yoshinao Ono, Naoki Tode, Yuri Yamamoto, Chikashi Iwasaki, Shuichi Konno, Hatsumi Sugiyama, Takuto Endo, Shunichi Takeda, Shuichiro Matsumoto, Tadahisa Numakura, Tomohiro Ichikawa, Tsutomu Tamada, Hisatoshi Sugiura

Source: Internal Medicine; 2024, Vol. 63 Issue 24, p3353-3358, 6p

Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease.

Authors: Takuya Saito, Naoya Fujino, Yorihiko Kyogoku, Mitsuhiro Yamada, Koji Okutomo, Yoshinao Ono, Shuichi Konno, Takuto Endo, Koji Itakura, Shuichiro Matsumoto, Hirohito Sano, Hiroyuki Aizawa, Tadahisa Numakura, Katsuhiro Onodera, Yoshinori Okada, Hussell, Tracy, Masakazu Ichinose, Hisatoshi Sugiura

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jun2024, Vol. 326 Issue 6, pL672-L686, 15p

Subject Terms: CHRONIC obstructive pulmonary disease, ALVEOLAR macrophages, PHENOTYPES

A Novel Development of Sarcoidosis Following COVID-19 Vaccination and a Literature Review.

Authors: Tadahisa Numakura, Koji Murakami, Tsutomu Tamada, Chiaki Yamaguchi, Chihiro Inoue, Shinya Ohkouchi, Naoki Tode, Hirohito Sano, Hiroyuki Aizawa, Kei Sato, Ayumi Mitsune, Hajime Kurosawa, Toru Nakazawa, Hisatoshi Sugiura

Source: Internal Medicine; 10/15/2022, Vol. 61 Issue 20, p3101-3106, 6p

Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis.

Authors: Shinya Ohkouchi, Masahiko Kanehira, Daisuke Saigusa, Manabu Ono, Ryushi Tazawa, Hideya Terunuma, Taizou Hirano, Tadahisa Numakura, Hirotsugu Notsuda, Chihiro Inoue, Ryoko Saito-Koyama, Masao Tabata, Toshiya Irokawa, Hiromasa Ogawa, Hajime Kurosawa, Yoshinori Okada

Source: American Journal of Respiratory Cell & Molecular Biology; Sep2022, Vol. 67 Issue 3, p320-333, 14p

Subject Terms: PULMONARY fibrosis, METABOLIC regulation, LUNGS, IDIOPATHIC pulmonary fibrosis, TIME-of-flight mass spectrometry, UNCOUPLING proteins, METHYLATION, HISTONE methylation

Production of reactive persulfide species in chronic obstructive pulmonary disease.

Authors: Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Source: Thorax; Dec2017, Vol. 72 Issue 12, p1074-1083, 10p

Subject Terms: PERSULFATES, POLYSULFIDES, BIOSYNTHESIS, OBSTRUCTIVE lung diseases, ANTIOXIDANTS, CYSTEINE metabolism, REACTIVE oxygen species, CELL culture, CHEMOKINES, CYTOKINES, GLUTATHIONE, INFLAMMATORY mediators, LUNGS, RESPIRATORY measurements, SMOKING, SPUTUM, SULFIDES, SULFUR compounds, OXIDATIVE stress, VITAL capacity (Respiration), CYSTEINE

Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.

Authors: Katsuhiro Onodera, Hisatoshi Sugiura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Rie Tanaka, Tadahisa Numakura, Shinsaku Togo, Kei Sato, Yorihiko Kyogoku, Yuichiro Hashimoto, Tatsuma Okazaki, Tsutomu Tamada, Seiichi Kobayashi, Masaru Yanai, Motohiko Miura, Yasushi Hoshikawa, Yoshinori Okada, Satoshi Suzuki

Source: Thorax; Oct2017, Vol. 72 Issue 10, p893-904, 12p, 1 Diagram, 3 Charts, 8 Graphs

Subject Terms: OBSTRUCTIVE lung diseases, AGING, GROWTH factors, CIGARETTE smoke, MESSENGER RNA, EPITHELIAL cells, RNA metabolism, ANIMALS, BIOLOGICAL models, BLOOD plasma, BONE morphogenetic proteins, CELLULAR aging, IMMUNOHISTOCHEMISTRY, MICE, POLYMERASE chain reaction, PULMONARY function tests, SMOKE, WESTERN immunoblotting, REVERSE transcriptase polymerase chain reaction

Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium.

Authors: Yutaka Shishikura, Akira Koarai, Hiroyuki Aizawa, Mutsuo Yamaya, Hisatoshi Sugiura, Mika Watanabe, Yuichiro Hashimoto, Tadahisa Numakura, Tomonori Makiguti, Kyoko Abe, Mituhiro Yamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Source: Respiratory Research; 9/27/2016, Vol. 17, p1-14, 14p, 1 Diagram, 1 Chart, 7 Graphs

Subject Terms: DOUBLE-stranded RNA, ADENOSINE triphosphatase, EXTRACELLULAR enzymes, EPITHELIUM, RHINOVIRUSES

27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells.

Authors: Yuichiro Hashimoto, Hisatoshi Sugiura, Shinsaku Togo, Akira Koarai, Kyoko Abe, Mitsuhiro Yamada, Tomohiro Ichikawa, Takashi Kikuchi, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jun2016, Vol. 310 Issue 11, pL1028-L1041, 14p

Subject Terms: HYDROXYCHOLESTEROLS, CHOLESTEROL, ISOPENTENOIDS, AGING, OLD age

Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy.

Authors: Tadahisa Numakura, Tsutomu Tamada, Masayuki Nara, Soshi Muramatsu, Koji Murakami, Toshiaki Kikuchi, Makoto Kobayashi, Miho Muroi, Tatsuma Okazaki, Sho Takagi, Yoshinobu Eishi, Masakazu Ichinose, Numakura, Tadahisa, Tamada, Tsutomu, Nara, Masayuki, Muramatsu, Soshi, Murakami, Koji, Kikuchi, Toshiaki, Kobayashi, Makoto, Muroi, Miho

Source: BMC Pulmonary Medicine; 2/11/2016, Vol. 16, p1-5, 5p, 1 Color Photograph, 1 Diagram

Subject Terms: ANTIRHEUMATIC agents, BIOPSY, CROHN'S disease, LUNGS, SARCOIDOSIS, SKIN, VASCULITIS, DISEASE complications