Efferocytosis in liver disease

Authors: Shi, Hongxue, Moore, Mary P., Wang, Xiaobo, Tabas, Ira

Source: In JHEP Reports January 2024 6(1)

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

Authors: Wang, Xiaobo, Moore, Mary P., Shi, Hongxue, Miyata, Yoshinari, Donnelly, Sara K., Radiloff, Daniel R., Tabas, Ira

Source: In Molecular Therapy - Methods & Clinical Development 14 December 2023 31

A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23

Authors: Saito, Yoshinobu, Yin, Dingzi, Kubota, Naoto, Wang, Xiaobo, Filliol, Aveline, Remotti, Helen, Nair, Ajay, Fazlollahi, Ladan, Hoshida, Yujin, Tabas, Ira, Wangensteen, Kirk J., Schwabe, Robert F.

Source: In Gastroenterology June 2023 164(7):1279-1292

TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis

Authors: Wang, Xiaobo, Zeldin, Sharon, Shi, Hongxue, Zhu, Changyu, Saito, Yoshinobu, Corey, Kathleen E., Osganian, Stephanie A., Remotti, Helen E., Verna, Elizabeth C., Pajvani, Utpal B., Schwabe, Robert F., Tabas, Ira

Source: Journal of hepatology. 76(4):910-920

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175954450.0x000001&indx=1&recIds=ETOCvdc_100175954450.0x000001

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Authors: Gerlach, Brennan D., Ampomah, Patrick B., Yurdagul, Arif, Jr., Liu, Chuang, Lauring, Max C., Wang, Xiaobo, Kasikara, Canan, Kong, Na, Shi, Jinjun, Tao, Wei, Tabas, Ira

Source: In Cell Metabolism 7 December 2021 33(12):2445-2463

ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution

Authors: Yurdagul, Arif, Kong, Na, Gerlach, Brennan D., Wang, Xiaobo, Ampomah, Patrick, Kuriakose, George, Tao, Wei, Shi, Jinjun, Tabas, Ira

Source: Arteriosclerosis, thrombosis, and vascular biology. 41(3):e144-e159

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180891304.0x000001&indx=1&recIds=ETOCvdc_100180891304.0x000001

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Authors: Wang, Xiaobo, Cai, Bishuang, Yang, Xiaoming, Sonubi, Oluwatoni O., Zheng, Ze, Ramakrishnan, Rajasekhar, Shi, Hongxue, Valenti, Luca, Pajvani, Utpal B., Sandhu, Jaspreet, Infante, Rodney E., Radhakrishnan, Arun, Covey, Douglas F., Guan, Kun-Liang, Buck, Jochen, Levin, Lonny R., Tontonoz, Peter, Schwabe, Robert F., Tabas, Ira

Source: In Cell Metabolism 5 May 2020 31(5):969-986

Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

Authors: Schwabe, Robert F., Tabas, Ira, Pajvani, Utpal B.

Source: In Gastroenterology May 2020 158(7):1913-1928

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

Authors: Liu, Tianye, Xiang, Alec, Peng, Travis, Doran, Amanda C., Tracey, Kevin J., Barnes, Betsy J., Tabas, Ira, Son, Myoungsun, Diamond, Betty

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Nov 01. 116(46), 23254-23263.

Access URL: https://www.jstor.org/stable/26861416

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Authors: Yurdagul, Arif, Jr., Subramanian, Manikandan, Wang, Xiaobo, Crown, Scott B., Ilkayeva, Olga R., Darville, Lancia, Kolluru, Gopi K., Rymond, Christina C., Gerlach, Brennan D., Zheng, Ze, Kuriakose, George, Kevil, Christopher G., Koomen, John M., Cleveland, John L., Muoio, Deborah M., Tabas, Ira

Source: In Cell Metabolism 3 March 2020 31(3):518-533

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Authors: Cai, Bishuang, Dongiovanni, Paola, Corey, Kathleen E., Wang, Xiaobo, Shmarakov, Igor O., Zheng, Ze, Kasikara, Canan, Davra, Viralkumar, Meroni, Marica, Chung, Raymond T., Rothlin, Carla V., Schwabe, Robert F., Blaner, William S., Birge, Raymond B., Valenti, Luca, Tabas, Ira

Source: In Cell Metabolism 4 February 2020 31(2):406-421

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

Authors: Tabas, Ira, Bornfeldt, Karin E.

Source: Circulation research. 126(9):1209-1227

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190131794.0x000001&indx=1&recIds=ETOCvdc_100190131794.0x000001

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

Authors: Zheng, Ze ^*, Nayak, Lalitha, Wang, Wei, Yurdagul, Arif, Jr, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Pestell, Richard G., Jain, Mukesh K., Tabas, Ira

Source: In Blood 14 February 2019 133(7):743-753

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool

Authors: Jiao, Xuanmao, Li, Zhiping, Wang, Min, Katiyar, Sanjay, Di Sante, Gabriele, Farshchian, Mehdi, South, Andrew P., Cocola, Cinzia, Colombo, Daniele, Reinbold, Rolland, Zucchi, Ileana, Wu, Kongming, Tabas, Ira, Spike, Benjamin T., Pestell, Richard G.

Source: In Stem Cell Reports 8 January 2019 12(1):135-151

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

Authors: Thomas, David G., Doran, Amanda C., Fotakis, Panagiotis, Westerterp, Marit, Antonson, Per, Jiang, Hui, Jiang, Xian-Cheng, Gustafsson, Jan-Åke, Tabas, Ira, Tall, Alan R.

Source: In Cell Reports 26 December 2018 25(13):3774-3785

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

Authors: Proto, Jonathan D., Doran, Amanda C., Gusarova, Galina, Yurdagul, Arif, Jr., Sozen, Erdi, Subramanian, Manikandan, Islam, Mohammad N., Rymond, Christina C., Du, Jasper, Hook, Jaime, Kuriakose, George, Bhattacharya, Jahar, Tabas, Ira

Source: In Immunity 16 October 2018 49(4):666-677

Cholesterol-Induced Macrophage Apoptosis Requires ER Stress Pathways and Engagement of the Type A Scavenger Receptor

Authors: DeVries-Seimon, Tracie, Li, Yankun, Yao, Pin Mei, Stone, Elizabeth, Wang, Yibin, Davis, Roger J., Flavell, Richard, Tabas, Ira

Source: The Journal of Cell Biology, 2005 Oct 01. 171(1), 61-73.

Access URL: https://www.jstor.org/stable/3658449

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice

Authors: Wang, Xiaobo, Sommerfeld, Mark R., Jahn‐Hofmann, Kerstin, Cai, Bishuang, Filliol, Aveline, Remotti, Helen E., Schwabe, Robert F., Kannt, Aimo, Tabas, Ira

Source: Hepatology research. 3(9):1221-1234

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093622577.0x000001&indx=1&recIds=ETOCvdc_100093622577.0x000001

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Authors: Bäck, Magnus, Yurdagul, Arif, Tabas, Ira, Öörni, Katariina, Kovanen, Petri

Source: Nature reviews.Cardiology. 16(7):389-406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181192531.0x000001&indx=1&recIds=ETOCvdc_100181192531.0x000001

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Authors: Ozcan, Lale, Ghorpade, Devram S., Zheng, Ze, Cristina de Souza, Jane, Chen, Ke, Bessler, Marc, Bagloo, Melissa, Schrope, Beth, Pestell, Richard, Tabas, Ira

Source: Cell reports. 39(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173916061.0x000001&indx=1&recIds=ETOCvdc_100173916061.0x000001