TREM-1 and TREM-2 as therapeutic targets: clinical challenges and perspectives

Authors: Alexander B. Sigalov

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: TREM-1, TREM-2, inflammation, clinical trial failure, multiligand receptors, antagonists & inhibitors, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498993/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e1d9d4d27298465d978adc180c472249

HBCOC attenuates cerebral ischemia-reperfusion injury in mice by inhibiting the inflammatory response and autophagy via TREM-1/ERK/NF-κB

Authors: Li, Rongyuan ^{a, 1}, Li, Qin ^{b, 1}, Yang, Congmin ^a, Liu, Hanlin ^c, Xiao, Yijun ^a, Yang, Pengyu ^d, Gong, Gu ^a, Wu, Wei ^{a, ⁎}

Source: In Journal of Stroke and Cerebrovascular Diseases May 2025 34(5)

Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Authors: Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

Source: European Journal of Histochemistry, Vol 68, Iss 3 (2024)

Subject Terms: Subarachnoid hemorrhage, propofol, miR-140-5p, TREM-1, microglia, M1 polarization, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ejh.it/ejh/article/view/4034; https://doaj.org/toc/1121-760X; https://doaj.org/toc/2038-8306

Access URL: https://doaj.org/article/6ce804938f6744ee9a84ffb615251720

Inhibition of triggering receptor expressed on myeloid cells-1(TREM-1) attenuates chronic intermittent hypoxia-induced atherosclerosis in mouse models

Authors: YU Hanqiao, LI Chao, YU Yubin, FENG Lina, SHENG Xiaosheng, YE Xiaoxia, WANG Linyan

Source: Jichu yixue yu linchuang, Vol 44, Iss 3, Pp 368-373 (2024)

Subject Terms: triggering receptor expressed on myeloid cells-1(trem-1), chronic intermittent hypoxia, atherosclerosis, lipids in serum, macrophage, Medicine

File Description: electronic resource

Relation: http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-3-368.pdf; https://doaj.org/toc/1001-6325

Access URL: https://doaj.org/article/5feab79b97ee48efbd4c837a0f5b1000

TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils

Authors: Tong Shen, Guiyun Cui, Hao Chen, Long Huang, Wei Song, Jie Zu, Wei Zhang, Chuanying Xu, Liguo Dong, Yongmei Zhang

Source: Neural Regeneration Research, Vol 19, Iss 6, Pp 1375-1384 (2024)

Subject Terms: 1-methyl-4-phenylpyridiniumion, dopaminergic neurons, infiltration, 1-methyl-4-phenyl-1, 6-tetrahydropyridine, microglia, neutrophils, neuroinflammation, parkinson’s disease, syk, trem-1, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1375;epage=1384;aulast=Shen; https://doaj.org/toc/1673-5374

Access URL: https://doaj.org/article/c704e74950144ab5afdebf640db5d4c7

The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization

Authors: Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Mike Telemaco Contreras Colmenares, Geraldo Rodrigues Sartori, Marcelle Silva-Sales, João Herminio Martins Da Silva, Bruno Junior Neves, Carolina Horta Andrade, Helioswilton Sales-Campos

Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2579-2590 (2023)

Subject Terms: TREM-1, Binding domain, CDR3, TREM-1 ligands, Pattern recognition receptor, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023001617; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/5d1fcfbcc45e47249cd2614e828de236

Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients

Authors: Sébastien Gibot, Thomas Lafon, Laurent Jacquin, Benjamin Lefevre, Antoine Kimmoun, Anne Guillaumot, Marie-Reine Losser, Marion Douplat, Laurent Argaud, Guillaume De Ciancio, Lucie Jolly, Nina Touly, Marc Derive, Catherine Malaplate, Amandine Luc, Cédric Baumann, Bruno François

Source: Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-11 (2023)

Subject Terms: COVID-19, ARDS, TREM-1, Prognostication, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

File Description: electronic resource

Relation: https://doaj.org/toc/2197-425X

Access URL: https://doaj.org/article/c0019eedc40e4a83b8e6e09b127cab0b

TREM-1 as a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma

Authors: Yaling Pu, Danyang Cai, Lingling Jin, Fenfen Xu, Enru Ye, Lina Wu, Licai Mo, Suzhi Liu, Qunyi Guo, Gang Wu

Source: World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-15 (2023)

Subject Terms: Immune-related signature, Clear cell renal cell carcinoma, The Cancer Genome Atlas, Tumor immune microenvironment, TREM-1, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1477-7819

Access URL: https://doaj.org/article/9b08b3a7600449299b6b49e531f034b9

TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury

Authors: Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You, Yong Zhou

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)

Subject Terms: Acute lung injury, TREM-1, Macrophages, Necroptosis, Mitochondrial fission, mTOR, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/5c3849e23fbb44e4ae3551fa4fe54735

TREM-1, TREM-2 and their association with disease severity in patients with COVID-19

Authors: Ruyue Fan, Zuowang Cheng, Zhisheng Huang, Ying Yang, Na Sun, Bin Hu, Peibin Hou, Bo Liu, Chuanjun Huang, Shuai Liu

Source: Annals of Medicine, Vol 55, Iss 2 (2023)

Subject Terms: TREM-1, TREM-2, disease severity, COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

Access URL: https://doaj.org/article/fd86dd9793834a1dad19bb04dad393cc

The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases

Authors: Chunyan Zhang, Xugang Kan, Baole Zhang, Haibo Ni, Jianfeng Shao

Source: Molecular Brain, Vol 15, Iss 1, Pp 1-15 (2022)

Subject Terms: TREM-1, Inflammatory response, Central nervous system, Disease, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/18e03819b98d4256b11f95c6781c0a1d

Soluble TREM-1 plasma levels are associated with acute kidney injury, acute atrial fibrillation and prolonged ICU stay after cardiac surgery- a proof-concept study

Authors: Marie Vandestienne, Rayan Braik, Jean-Rémi Lavillegrand, Geoffroy Hariri, Zoe Demailly, Nadine Ben Hamouda, Fabienne Tamion, Thomas Clavier, Hafid Ait-Oufella

Source: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

Subject Terms: cardiopulmonary bypass, cytokine, TREM-1, inflammation, outcome, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2023.1098914/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/06fd94eae5314b8db2c72a0a15ba044e

Expression of Inflammation Depending on the Stage of Cervical Cancer

Authors: Agne Vitkauskaite, Daiva Urboniene, Joana Celiesiute, Kristina Jariene, Saulius Paskauskas, Daiva Vaitkiene, Astra Vitkauskiene

Source: Medicina, Vol 60, Iss 3, p 349 (2024)

Subject Terms: cervical cancer, inflammatory markers, interleukin-6, lipocalin-2, stages of cervical cancer, TREM-1, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/1648-9144/60/3/349; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144

Access URL: https://doaj.org/article/b6ef6209ebce4de2b40fbab4a50ade11

sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

Authors: Márcio Bezerra-Santos, Lays G. Santos Bomfim, Camilla N. Oliveira Santos, Maria Wiliane N. Cunha, Eduardo J. Rocha de Moraes, Rodrigo A. Cazzaniga, Martha D. L. Tenório, Jonnia M. Sherlock Araujo, Lucas Menezes-Silva, Lucas Sousa Magalhães, Aline S. Barreto, Steven G. Reed, Malcolm S. Duthie, Michael W. Lipscomb, Roque Pacheco de Almeida, Tatiana Rodrigues de Moura, Amélia Ribeiro de Jesus

Source: Frontiers in Medicine, Vol 10 (2023)

Subject Terms: leprosy, soluble TREM-1, inflammatory cytokine, immune markers, leprosy complications, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2023.1177375/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/5ebd7568f2d9442681357e834d4c7180

Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice

Authors: Satoshi Yamaga, Atsushi Murao, Gaifeng Ma, Max Brenner, Monowar Aziz, Ping Wang

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: TREM-1, macrophage, ionizing radiation, eCIRP, DAMP, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151250/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/84742775f26d4f0b89e9f4366f9c78d5

Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity

Authors: Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sébastien Gibot

Source: Frontiers in Endocrinology, Vol 13 (2023)

Subject Terms: Obesity, TREM-1, adipocyte, inflammation, insulin resistance, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.983827/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/b6ff6e41d9164abb9b813d9d309d6dd9

Keratinocytes and Activation of TREM-1 Pathway in Cutaneous Leishmaniasis Lesions

Authors: Sara Nunes, Mariana Rosa Ampuero, Ícaro Bonyek-Silva, Reinan Lima, Filipe Rocha Lima, Sérgio Marcos Arruda, Ricardo Khouri, Pablo Rafael Silveira Oliveira, Aldina Barral, Viviane Sampaio Boaventura, Cláudia Ida Brodskyn, Natalia Machado Tavares

Source: Microbiology Research, Vol 12, Iss 4, Pp 765-778 (2021)

Subject Terms: Leishmania, inflammation, TREM-1, keratinocytes, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2036-7481/12/4/56; https://doaj.org/toc/2036-7481

Access URL: https://doaj.org/article/c3d91b01911249728e8cbb247a83ceb4

Soluble Triggering Receptors Expressed on Myeloid Cells-1 as a Neonatal Ventilator-Associated Pneumonia Biomarker

Authors: Yang ZQ, Mai JY, Zhu ML, Xiao XM, He XX, Chen SQ, Lin ZL, Feng X

Source: International Journal of General Medicine, Vol Volume 14, Pp 4529-4534 (2021)

Subject Terms: pneumonia, neonatal ventilator-associated pneumonia, soluble trem-1, neonate, c-reactive protein, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/soluble-triggering-receptors-expressed-on-myeloid-cells-1-as-a-neonata-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074

Access URL: https://doaj.org/article/015782b82dbc4ea29ccc52c1c04d521f

Periodontitis

Contributors: Johansson, Anders

Subject Terms: apical periodontitis, adaptive immunity, saliva, serum, antibody, Aggregatibacter actinomycetemcomitans, invasiveness, leukotoxin, cytolethal distending toxin, serum resistance, outer membrane vesicles, oral microbiome, nitric oxide, nitrate, nitrite, periodontal disease, alveolar bone loss, gingiva, bacteria, biofilm, immunity, inflammation, smoking, Rheumatoid arthritis, Porphyromonas gingivalis, periodontitis, citrullination, peptidylarginine deiminase, ACPA, anti-CCP, host response, infection, oral microbiota, virulence factors, metabolites, TREM-1, intervention, LP17, IL-17, RANKL, OPG, cardiovascular diseases, rheumatoid arthritis, inflammatory response, Medicine and Nursing

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/69297
https://mdpi.com/books/pdfview/book/3087

Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker

Authors: Cabral, João Victor, Silveira, Maria Mariana Barros Melo da, Xavier, Amanda Tavares, Assunção, Norma de, Sobral Filho, Dário Celestino, Oliveira, Dinaldo Cavalcanti de

Source: Revista da Associação Médica Brasileira. March 2021 67(3)

Subject Terms: TREM-1 Protein, Sepsis, Child

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000400449