hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF‐κB/MAPK Signaling Pathway via TGR5

Authors: Zetian Wang, Wei Luo, Qing Wang, Chunzheng Liu, Yanshan Gong, Baitian Li, Xuejiao Zeng, Jiaqi Lin, Zehua Su, Xin Li, Yongze Yu, Zhongmin Liu, Ling Gao, Lijun Liao

Source: Food Frontiers, Vol 6, Iss 1, Pp 575-589 (2025)

Subject Terms: HDCA, heart failure, hUCMSCs, intestinal injury, TGR5, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://doaj.org/toc/2643-8429

Access URL: https://doaj.org/article/4d0e0865d414465692c1811161fac8a2

Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation

Authors: Zi-yi Zhang, Xiu-liu Guo, Jing-tian-yi Liu, Yi-jie Gu, Xing-wei Ji, Shu Zhu, Jin-yan Xie, Feng Guo

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)

Subject Terms: Acute pancreatitis, Bile acid, TGR5, NLRP3 inflammasome, TCDCA, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1c5c7cd30c984c91a3852dc7817326f5

Takeda G protein–coupled receptor 5 (TGR5): an attractive therapeutic target for aging-related cardiovascular diseases

Authors: Yufeng He, Siqi Liu, Yali Zhang, Yumei Zuo, Keming Huang, Li Deng, Bin Liao, Yi Zhong, Jian Feng

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: aging, cardiovascular disease, TGR5, heart failure, myocardial infarction, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1493662/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/09ba5a5d03124ce3a8ebe4f81e2353a5

Bile acid signaling in skeletal muscle homeostasis: from molecular mechanisms to clinical applications

Authors: Feng Jia, Xiangliang Liu, Yahui Liu

Source: Frontiers in Endocrinology, Vol 16 (2025)

Subject Terms: bile acids, skeletal muscle, FXR, tgr5, sarcopenia, biomarkers, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2025.1551100/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/9959666e1bcb427ab2fc7e483dca2046

Decoding TGR5: A comprehensive review of its impact on cerebral diseases

Authors: Zehan Zhang, Yifei Zhang, Hongye Peng, Qingqian Yu, Xiangdong Kang, Ying Liu, Yuxiao Zheng, Fafeng Cheng, Xueqian Wang, Feng Li

Source: Pharmacological Research, Vol 213, Iss , Pp 107671- (2025)

Subject Terms: TGR5, Cerebral diseases, Biological process, Therapeutic target, Agonist, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661825000969; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/eb890cebe93e4628868c01537e8c84bb

Phillygenin ameliorates tight junction proteins reduction, fibrosis, and apoptosis in mice with chronic colitis via TGR5-mediated PERK-eIF2α-Ca2+ pathway

Authors: Huanhuan Xue, Peijie Li, Jing Guo, Tinggui Chen, Shifei Li, Liwei Zhang

Source: Journal of Pharmaceutical Analysis, Vol 15, Iss 1, Pp 101042- (2025)

Subject Terms: Ulcerative colitis, Phillygenin, TGR5, Intestinal fibrosis, PERK-eIF2α-Ca2+ pathway, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2095177924001394; https://doaj.org/toc/2095-1779

Access URL: https://doaj.org/article/b88de7fdd4f448c7b87f1258dc01c24f

Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment

Authors: Ojochenemi A. Enejoh, Chinelo H. Okonkwo, Hector Nortey, Olalekan A. Kemiki, Ainembabazi Moses, Florence N. Mbaoji, Abdulrazak S. Yusuf, Olaitan I. Awe

Source: Frontiers in Chemistry, Vol 12 (2025)

Subject Terms: TGR5, type 2 diabetes, machine learning, molecular docking, molecular dynamics simulation, COCONUT database, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1503593/full; https://doaj.org/toc/2296-2646

Access URL: https://doaj.org/article/266733a85c5e44b0b6155bddb8fa0afc

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Authors: Arief Gunawan Darmanto, Ting-Lin Yen, Jing-Shiun Jan, Tran Thanh Duy Linh, Rajeev Taliyan, Chih-Hao Yang, Joen-Rong Sheu

Source: Pharmacological Research, Vol 211, Iss , Pp 107564- (2025)

Subject Terms: Bile Acids, TGR5 Receptor, Psychiatric Disorders, Gut-Brain Axis, Pharmacological Interventions, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824005097; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/cbb100f271984e2392889bf7e7f880ca

TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis

Authors: Philippe Zizzari, Ashley Castellanos-Jankiewicz, Selma Yagoub, Vincent Simon, Samantha Clark, Marlene Maître, Nathalie Dupuy, Thierry Leste-Lasserre, Delphine Gonzales, Kristina Schoonjans, Valérie S. Fénelon, Daniela Cota

Source: Molecular Metabolism, Vol 91, Iss , Pp 102071- (2025)

Subject Terms: Bile acids, TGR5 receptor, SF1 neurons, Food intake, Glucose metabolism, Insulin sensitivity, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824002023; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/9935fd1039a444b58b8c864701f33d28

Immunobiology of bile and cholangiocytes

Authors: Li, Yang ^a, Leung, Patrick SC. ^b, Zhang, Weici ^b, Zhang, Shucheng ^c, Liu, Zhenning ^a, Kurth, Mark ^d, Patterson, Andrew D. ^e, Gershwin, M. Eric ^b, Song, Junmin ^{f, ⁎}

Source: In Journal of Autoimmunity February 2025 151

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

Authors: B. Reilly-O’Donnell, E. Ferraro, R. Tikhomirov, R. Nunez-Toldra, A. Shchendrygina, L. Patel, Y. Wu, A. L. Mitchell, A. Endo, L. Adorini, R. A. Chowdhury, P. K. Srivastava, F. S. Ng, C. Terracciano, C. Williamson, J. Gorelik

Source: Frontiers in Cardiovascular Medicine, Vol 11 (2024)

Subject Terms: cardiac fibrosis, antifibrotic, TGR5, ursodeoxycholic acid, dilated cardiomyopathy, Interleukin-11, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1430772/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/8c20f039b50c4792893e250d610b77f3

The bile acid receptor TGR5 inhibits platelet activation and thrombus formation

Authors: Friedrich Reusswig, Maria Reich, Leonard Wienands, Diran Herebian, Verena Keitel-Anselmino, Margitta Elvers

Source: Platelets, Vol 35, Iss 1 (2024)

Subject Terms: Bile acid, platelets, TGR5 receptor, thrombus formation, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/bd0012fe927e40debefd73b999196fd8

The potential mechanism of action of gut flora and bile acids through the TGR5/TRPV1 signaling pathway in diabetic peripheral neuropathic pain

Authors: Peng Chen, Xian Jiang, Jia Fu, Cehua Ou, Yao Li, Jing Jia, Changli Liao

Source: Frontiers in Endocrinology, Vol 15 (2024)

Subject Terms: diabetic peripheral neuropathic pain, gut flora, bile acids, TGR5, TRPV1, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1419160/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/d3e649cff04948cbbda79921a7efca2b

Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway

Authors: Liu, Zhineng ^{a, 1}, Qin, Xinyun ^{a, 1}, Zhang, Bin ^{a, 1}, Nong, Keyi ^{a, 1}, Chen, Wanyan ^a, Yang, Zheng ^a, Lang, Wen ^a, Liu, Xiande ^{b, ⁎}, Li, Lianbin ^a, Wang, Xuemei ^a, Shi, Huiyu ^a, Zhang, Haiwen ^{a, ⁎}

Source: In International Journal of Biological Macromolecules May 2025 307 Part 1

Oleanolic acid inhibits appetite through the TGR5/cAMP signaling pathway

Authors: Liu, Shuang, Chen, Xiaoling, Chen, Daiwen, Yu, Bing, Zheng, Ping, Luo, Yuheng, He, Jun, Huang, Zhiqing ^⁎

Source: In The Journal of Nutritional Biochemistry April 2025 138

TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney

Authors: Xu, Long ^{a, b, 1}, Wu, Xinyan ^{a, c, 1}, Long, Luosha ^{a, b}, Li, Suchun ^{d, e}, Huang, Meiying ^{a, c}, Li, Meng ^{a, b}, Feng, Pinning ^f, Levi, Moshe ^g, Chen, Wei ^{d, e}, Wang, Lei ^{h, ⁎}, Li, Chunling ^{a, b, ⁎⁎}, Wang, Weidong ^{a, c, ⁎⁎⁎}

Source: In Metabolism April 2025 165

Targeting TGR5 to mitigate liver fibrosis: Inhibition of hepatic stellate cell activation through modulation of mitochondrial fission

Authors: Sun, Li ^{a, 1}, Shao, Yuancheng ^{a, 1}, Zhuang, Zehao ^{a, b, 1}, Liu, Zhixin ^a, Liu, Mingjun ^{a, c}, Qu, Chang ^a, Yang, Haojun ^{a, ⁎}

Source: In International Immunopharmacology 25 October 2024 140

Tomato juice regulates bile acid-TGR5 signaling and reverses cognitive deficit and neuroinflammation in high-fat high-cholesterol diet-induced mice

Authors: Song, Xunyu, Zhang, Lujia, Sun, Jun, Zhang, Xinbing, Li, Daotong, Hu, Xiaosong, Chen, Fang ^⁎

Source: In Food Bioscience October 2024 61

Activation of TGR5 Increases Urine Concentration by Inducing AQP2 and AQP3 Expression in Renal Medullary Collecting Ducts

Authors: Yanlin Guo, Rongfang Qiao, Guixiang Xie, Yao Yao, Chunxiu Du, Yunxia Shao, Youfei Guan, Xiaoyan Zhang

Source: Kidney Diseases, Pp 1-12 (2024)

Subject Terms: tgr5, bile acid, aquaporin, collecting duct, urine concentration, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://beta.karger.com/Article/FullText/538107; https://doaj.org/toc/2296-9357

Access URL: https://doaj.org/article/9742a8d4bd4949298d3932dd080e02cf

Mechanism of action of the bile acid receptor TGR5 in obesity

Authors: Weijun Lun, Qihao Yan, Xinghua Guo, Minchuan Zhou, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 468-491 (2024)

Subject Terms: Obesity, TGR5, Bile acids, Ligand, Appetite, Metabolism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523004343; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/2bca73c040104794b9f24d1ce9a76fae