Visible-Light-Mediated Aerobic α-Oxygenation of Tetrahydroisoquinolines and Isoindolines Without External Photocatalysts.

Authors: Ye, Taiqiang¹ (AUTHOR), Li, Yuzheng¹ (AUTHOR) lifengsnu@ytu.edu.cn, Zhao, Feng¹ (AUTHOR) yetaiqiang@s.ytu.edu.cn, Song, Aorou¹ (AUTHOR), Zhong, Zhaoxia¹ (AUTHOR), Tan, Shenpeng¹ (AUTHOR), Li, Feng¹ (AUTHOR) zhaofeng@ytu.edu.cn

Source: Molecules. Feb2025, Vol. 30 Issue 3, p743. 12p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *VISIBLE spectra, *PHOTOCATALYSTS, *BIOCHEMICAL substrates, *OXYGEN in the blood

Transition Metal‐Catalyzed Synthesis of 1,2,3,4‐Tetrasubstituted 1,3‐Dienes from Propargylic Esters.

Authors: Dai, Mengfu¹ (AUTHOR), Kabandula, Lucy Felicity¹ (AUTHOR), Tai, Lanzhu¹ (AUTHOR), Wu, Boxue¹ (AUTHOR), Song, Liangliang² (AUTHOR) liangliangsong@njfu.edu.cn, Chen, Liang‐An¹ (AUTHOR) lachen@njnu.edu.cn

Source: ChemCatChem. 7/22/2024, Vol. 16 Issue 14, p1-6. 6p.

Subject Terms: *ESTERS, *TETRAHYDROISOQUINOLINES, *ORGANIC synthesis, *STEREOISOMERS

In Vitro Synergistic Activity of Combinations of Tetrahydroisoquinolines and Treatment Antibiotics against Multidrug-Resistant Salmonella.

Authors: Ndip, Rita Ayuk¹ (AUTHOR), Hanna, Joelle Ngo² (AUTHOR), Mbah, James Ajeck³ (AUTHOR), Ghogomu, Stephen Mbigha¹ (AUTHOR), Ngemenya, Moses Njutain^1,4 (AUTHOR)

Source: Advances in Pharmacological & Pharmaceutical Sciences. 12/13/2023, p1-8. 8p.

Subject Terms: *SALMONELLA diseases, *TETRAHYDROISOQUINOLINES, *ANTIBIOTICS, *SALMONELLA typhi, *CIPROFLOXACIN, *CHLORAMPHENICOL, *SALMONELLA

Synthesis and bioactivity of 1-substituted tetrahydroisoquinolines derived from phenolic aldehydes.

Authors: Dizdar, Muamer¹ muamer.dizdar@pmf.unsa.ba, Maksimović, Milka¹, Topčagić, Anela¹, Avdić, Monia², Vidic, Danijela¹

Source: Organic Communications. Oct-Dec2023, Vol. 16 Issue 4, p197-203. 7p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *ALDEHYDE derivatives, *ALDEHYDES, *STRUCTURE-activity relationships, *REACTIVE oxygen species, *PHENOLIC acids

Analysis of tetrahydroisoquinolines formed after simultaneous consumption of ethanol and amphetamine or its derivatives by LC–MS/MS in human blood, brain, and liver tissue.

Authors: Sonnenberg, Marianne¹ (AUTHOR), Czekelius, Constantin² (AUTHOR), Temme, Oliver¹ (AUTHOR), Pawlik, Evelyn¹ (AUTHOR), Daldrup, Thomas¹ (AUTHOR) fortoxi@uni-duesseldorf.de

Source: Analytical & Bioanalytical Chemistry. Nov2024, Vol. 416 Issue 28, p6497-6516. 20p.

Subject Terms: *MATRIX effect, *TETRAHYDROISOQUINOLINES, *BLOOD testing, *AMPHETAMINES, *BIOCHEMICAL substrates, *ACETALDEHYDE

Decarboxylative Aminomethylation of Ferulic Acids via Visible‐Light‐Promoted Flavin Photocatalysis and its Application in the Synthesis of Anti‐Inflammatory Lead Compounds.

Authors: Wang, Lin^1,2 (AUTHOR), Lv, Xinye^1,3 (AUTHOR), Huang, Lei^1,3 (AUTHOR), Yang, Yingxue^1,3 (AUTHOR), Ge, Xiaomei^1,3 (AUTHOR), Zeng, Jianguo^1,3 (AUTHOR) zengjianguo@hunau.edu.cn, Cheng, Pi^1,3 (AUTHOR) picheng55@126.com

Source: Advanced Synthesis & Catalysis. Nov2024, Vol. 366 Issue 22, p4702-4708. 7p.

Subject Terms: *NATURAL products, *TETRAHYDROISOQUINOLINES, *VITAMIN B2, *PHOTOCATALYSIS

Diastereoselective dearomative bifunctionalization of isoquinolinium salts to access bridged tetrahydroisoquinolines.

Authors: Pei, Jiaqi¹ (AUTHOR), Tang, Tiantian¹ (AUTHOR), Zhang, Jianing¹ (AUTHOR), Qin, Yunlong¹ (AUTHOR), Cheng, Pengfei¹ (AUTHOR) feipengcheng@henu.edu.cn, Wang, Qilin¹ (AUTHOR) wangqilin@henu.edu.cn

Source: New Journal of Chemistry. 10/7/2024, Vol. 48 Issue 37, p16151-16154. 4p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *AMINES, *SALTS, *SPECIES

Diastereoselective Synthesis of (–)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic Acid via Morpholinone Derivatives.

Authors: Chrzanowska, Maria¹ (AUTHOR) marylch@amu.edu.pl, Grajewska, Agnieszka¹ (AUTHOR) marylch@amu.edu.pl, Rozwadowska, Maria D.¹ (AUTHOR)

Source: Molecules. Apr2023, Vol. 28 Issue 7, p3200. 14p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *RING formation (Chemistry), *BORONIC acids, *ACIDS

The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines.

Authors: Cárdenas‐Fernández, Max^1,2 (AUTHOR) m.cardenas-fernandez@kent.ac.uk, Roddan, Rebecca³ (AUTHOR), Carter, Eve M.³ (AUTHOR), Hailes, Helen C.³ (AUTHOR), Ward, John M.¹ (AUTHOR) j.ward@ucl.ac.uk

Source: ChemCatChem. 2/8/2023, Vol. 15 Issue 3, p1-8. 8p.

Subject Terms: *REDUCTASES, *TETRAHYDROISOQUINOLINES, *NICOTINAMIDE adenine dinucleotide phosphate, *AMINATION, *GLUCOSE-6-phosphate dehydrogenase, *TERTIARY amines, *KETONES

Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds.

Authors: Kandinska, Meglena I.¹ (AUTHOR), Burdzhiev, Nikola T.¹ (AUTHOR) nburdzhiev@chem.uni-sofia.bg, Cheshmedzhieva, Diana V.¹ (AUTHOR), Ilieva, Sonia V.¹ (AUTHOR), Grozdanov, Peter P.² (AUTHOR), Vilhelmova-Ilieva, Neli² (AUTHOR), Nikolova, Nadya² (AUTHOR), Lozanova, Vesela V.³ (AUTHOR), Nikolova, Ivanka² (AUTHOR) nburdzhiev@chem.uni-sofia.bg

Source: Molecules. Feb2023, Vol. 28 Issue 3, p1495. 23p.

Subject Terms: *MOIETIES (Chemistry), *TETRAHYDROISOQUINOLINES, *PIPERIDONES, *COMPARATIVE studies, *IMINES

Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico.

Authors: Azamatov, Azizbek A.¹ (AUTHOR), Zhurakulov, Sherzod N.^1,2 (AUTHOR), Vinogradova, Valentina I.¹ (AUTHOR), Tursunkhodzhaeva, Firuza¹ (AUTHOR), Khinkar, Roaa M.³ (AUTHOR), Malatani, Rania T.³ (AUTHOR), Aldurdunji, Mohammed M.⁴ (AUTHOR), Tiezzi, Antonio⁵ (AUTHOR), Mamadalieva, Nilufar Z.¹ (AUTHOR) nmamadalieva@yahoo.com

Source: Molecules. Jan2023, Vol. 28 Issue 2, p477. 17p.

Subject Terms: *LOCAL anesthetics, *TETRAHYDROISOQUINOLINES, *ISOQUINOLINE alkaloids, *PICTET-Spengler reaction, *ALKALOIDS, *NUCLEAR magnetic resonance

Three-Component Synthesis of Tetrahydroisoquinolines via SNVin Reaction.

Authors: Dyachenko, I. V.¹ (AUTHOR), Dyachenko, V. D.¹ (AUTHOR), Dorovatovskii, P. V.² (AUTHOR), Khrustalev, V. N.^3,4 (AUTHOR), Nenajdenko, V. G.⁵ (AUTHOR) nenajdenko@gmail.com

Source: Russian Journal of Organic Chemistry. Sep2024, Vol. 60 Issue 9, p1619-1629. 11p.

Subject Terms: *SUBSTITUTION reactions, *TETRAHYDROISOQUINOLINES, *ELECTROPHILES, *ALKYLATION, *KETONES

Evaluation of Phenyldiazenyl as a Protective/Activating Group in Lithiation–Substitution Reactions of Tetrahydroisoquinolines.

Authors: Kaur, Babaldeep^1,2 (AUTHOR), Kaur, Manjot³ (AUTHOR), Singh, Pushpinder⁴ (AUTHOR), Sharma, Esha⁵ (AUTHOR), Batra, Aanchal³ (AUTHOR), Kaur, Amarjit¹ (AUTHOR), Singh, Kamal Nain¹ (AUTHOR) kns@pu.ac.in

Source: Synlett. Aug2024, Vol. 35 Issue 13, p1577-1583. 7p.

Subject Terms: *HALOALKANES, *TETRAHYDROISOQUINOLINES, *CARBANIONS, *ELECTROPHILES, *ISOCYANATES

Synthesis, Structural, Spectral Studies and Activity Studies of 6-Methyl-4-(3-Nitro-Phenyl)-2-Oxo-1,2,3,4 Tetrahydropyrimidine-5-Carboxylic Acid Ethyl Ester Catalyzed Using BF3-OEt2.

Authors: Priya Matharasi, D.¹ (AUTHOR), Jayaprakash, P.² (AUTHOR) jayajp85@gmail.com

Source: Polycyclic Aromatic Compounds. 2024, Vol. 44 Issue 6, p4137-4156. 20p.

Subject Terms: *ETHYL esters, *TETRAHYDROISOQUINOLINES, *PROTON magnetic resonance, *MASS spectrometry, *NUCLEAR magnetic resonance, *CALCIUM antagonists, *MOLECULAR docking

Synthesis of N¹-(2,3,4-trimethoxybenzyl)-N²-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine Organic Salts and their Cardiotropic Activity.

Authors: Mokrov, G. V.¹ (AUTHOR) g.mokrov@gmail.com, Bobrovskii, S. I.¹ (AUTHOR), Barchukov, V. V.¹ (AUTHOR), Kryzhanovskii, S. A.¹ (AUTHOR), Tsorin, I. B.¹ (AUTHOR), Vititnova, M. B.¹ (AUTHOR), Rebeko, A. G.¹ (AUTHOR), Gudasheva, T. A.¹ (AUTHOR)

Source: Pharmaceutical Chemistry Journal. Nov2022, Vol. 56 Issue 8, p1049-1053. 5p.

Subject Terms: *SALTS, *TETRAHYDROISOQUINOLINES, *CITRATES

Endogenous Synthesis of Tetrahydroisoquinoline Derivatives from Dietary Factors: Neurotoxicity Assessment on a 3D Neurosphere Culture.

Authors: Aro, Rania¹ (AUTHOR), Nachtergael, Amandine¹ (AUTHOR), Palmieri, Claudio¹ (AUTHOR), Ris, Laurence² (AUTHOR), Duez, Pierre¹ (AUTHOR) pierre.duez@umons.ac.be

Source: Molecules. Nov2022, Vol. 27 Issue 21, p7443. 25p.

Subject Terms: *DOPAMINE, *TETRAHYDROISOQUINOLINES, *MAILLARD reaction, *ESSENTIAL tremor, *DOPAMINE receptors, *NEUROTOXICOLOGY, *CENTRAL nervous system

Synthesis and Some Transformations of Ethyl 6,7-Dimethoxy-2',3',5',6'-tetrahydro-3H-spiro[isoquinoline-4,4'-pyran]-1-carboxylate.

Authors: Aghekyan, A. A.¹ (AUTHOR) aaghekyan@mail.ru, Panosyan, H. A.¹ (AUTHOR)

Source: Russian Journal of Organic Chemistry. Nov2022, Vol. 58 Issue 11, p1581-1588. 8p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *OXALATES, *RING formation (Chemistry), *AMINES, *CARBOXAMIDES, *PHOSPHORUS

Synthesis and Anti-Monoamine Oxidase Activity of 2-Substituted 4,4-Dimethyl-1,2,3,4-tetrahydroisoquinoline Derivatives.

Authors: Aghekyan, A. A.¹ (AUTHOR) aaghekyan@mail.ru, Arustamyan, Zh. S.¹ (AUTHOR), Margaryan, R. E.¹ (AUTHOR), Panosyan, H. A.¹ (AUTHOR), Grigoryan, A. S.¹ (AUTHOR), Gasparyan, H. V.¹ (AUTHOR)

Source: Russian Journal of Organic Chemistry. Oct2022, Vol. 58 Issue 10, p1409-1415. 7p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *ACID derivatives, *ACYL chlorides, *SULFURIC acid, *PROPIONIC acid, *CARBOXYLIC acids, *DOUBLE bonds, *PHOSPHORIC acid

New Synthesis of Tetrahydroisoquinolines.

Authors: Dyachenko, I. V.¹ (AUTHOR), Dyachenko, V. D.¹ (AUTHOR), Dorovatovskii, P. V.² (AUTHOR), Khrustalev, V. N.^3,4 (AUTHOR), Nenajdenko, V. G.⁵ (AUTHOR) nenajdenko@gmail.com

Source: Russian Journal of Organic Chemistry. May2022, Vol. 58 Issue 5, p657-662. 6p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *ETHANES, *BENZENE, *SOLVENTS

One-pot C(sp³)–H difluoroalkylation of tetrahydroisoquinolines and isochromans via electrochemical oxidation and organozinc alkylation.

Authors: Kamata, Kazuya¹ (AUTHOR), Kuriyama, Masami¹ (AUTHOR), Tahara, Hironobu² (AUTHOR), Nishikawa, Akira¹ (AUTHOR), Yamamoto, Kosuke¹ (AUTHOR), Demizu, Yosuke³ (AUTHOR), Onomura, Osamu¹ (AUTHOR) onomura@nagasaki-u.ac.jp

Source: Chemical Communications. 6/25/2024, Vol. 60 Issue 50, p6395-6398. 4p.

Subject Terms: *TETRAHYDROISOQUINOLINES, *AMINES, *SCALABILITY, *ETHERS, *ALKYLATION