Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3

Authors: Zihan Chen, Jingyu Wang, Baochun Lu, Heyu Li, Chuanli Liu, Huijuan Zeng, Jinping Chen, Shizhe Liu, Qifeng Jiang, Kun Jia

Source: BMC Veterinary Research, Vol 21, Iss 1, Pp 1-10 (2025)

Subject Terms: LSDV, ORF142, IRF3, TBK1, Immune evasion, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1746-6148

Access URL: https://doaj.org/article/158c77299ecb490991b5570ac3c94add

Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation

Authors: Shuang-shuang Zhao, Qisheng Qian, Yao Wang, Songlin Qiao, Rui Li

Source: Veterinary Research, Vol 55, Iss 1, Pp 1-15 (2024)

Subject Terms: PRRSV, Nsp2, TBK1, IFN-I, CMA, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1297-9716

Access URL: https://doaj.org/article/c697a7962f2d4831be10d9b1c7d54f55

cGAS, an innate dsDNA sensor with multifaceted functions

Authors: Yutong Liu, Pinglong Xu

Source: Cell Insight, Vol 4, Iss 3, Pp 100249- (2025)

Subject Terms: cGAS-STING, Pattern recognition receptors, Innate immunity, Nucleic acid sensing, dsDNA, TBK1, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772892725000239; https://doaj.org/toc/2772-8927

Access URL: https://doaj.org/article/b30aeef1c920448bb61d4853f8ed93fb

Development of a TBK1 and ALK dual inhibitor for alleviating depressive behavior via anti-inflammatory effects

Authors: Wi, Ji Hun ^{a, b, 1}, Lee, Hyelim ^{a, c, 1}, Park, Ji Min ^{d, 2}, Heo, Yeonju ^d, Jo, Seongman ^{d, e}, Lee, Jeehee ^{a, f}, Kim, Yeseul ^{a, j}, Jung, Cheulhee ^b, Kim, Nam-Jung ^{c, g}, Song, Gyu Yong ^e, Kim, Pilho ^{d, h, ⁎}, Kim, Hyejin ^{d, h, i, ⁎}, Lee, Sanghee ^{a, g, ⁎⁎}

Source: In Biomedicine & Pharmacotherapy May 2025 186

Hollow MnO2@PDLIM2 nanoplatform inhibits hepatocellular carcinoma immune evasion and progression by regulating TBK1

Authors: Liu, Zhiyi ^{a, b, c, 1}, Hu, Qinghe ^{b, c, 1}, Wang, Jin ^a, Zhu, Xu ^a, Sun, Jun ^{b, c}, Zhang, Guowei ^{b, c}, Fang, Ruqiao ^{b, c}, Wang, Renhao ^{b, c}, Zhang, Bin ^{b, c, ⁎}, Shi, Hengliang ^{b, c, d, ⁎⁎}, Gao, Fenglei ^{a, b, ⁎⁎⁎}

Source: In Chemical Engineering Journal 15 April 2025 510

Frk positively regulates innate antiviral immunity by phosphorylating TBK1

Authors: Xiaomei Zhang, Ying You, Tingrong Xiong, Xiaokai Zhang, Haibo Wang, Jinxia Geng, Miao Wang, Yanyan Xu, Shanshan Gao, Xiaoyan Wu, Yue Zheng, Xianhua Wen, Haoyu Yang, Yu Wang, Xiaohua Wen, Congcong Zhao

Source: Frontiers in Microbiology, Vol 16 (2025)

Subject Terms: macrophages, Frk, TBK1, phosphorylation, IFN-I, Microbiology, QR1-502

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Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2025.1525648/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/e9a37e3b59654542a9c5616ca8e965d7

NLRC3 regulates RIP2, STING, TBK1, and TRAF6 mediated type I IFN signaling and inflammatory response in large yellow croaker Larimichthys crocea

Authors: Xu, Yu Qing ^{a, 1}, Li, Ying ^{b, 1}, Han, Kun Huang ^c, Zhang, Jia Xi ^a, Li, Kai Qing ^d, Jiang, Jing ^a, Sun, Zhao Han ^e, Wang, Yi Lei ^a, Jiang, Yong Hua ^a, Zou, Peng Fei ^{a, ⁎}

Source: In Fish and Shellfish Immunology July 2025 162

Transcription factor BACH1 promotes epithelial-mesenchymal transition by repressing iron metabolism-related genes

Authors: Hayashi, Shuichiro ^{a, b}, Matsumoto, Mitsuyo ^{a, c, ⁎}, Liu, Liang ^{a, d}, Tanaka, Miho ^a, Unno, Michiaki ^b, Igarashi, Kazuhiko ^{a, ⁎⁎}

Source: In Biochemical and Biophysical Research Communications 30 June 2025 767

Singapore grouper iridovirus VP018 abrogates the interferon response by targeting STING-TBK1-IRF3 axis

Authors: Wang, Wenji ^{a, b}, Zhi, Linyong ^{a, b}, Liu, Shanxing ^{a, b}, Zhao, Yin ^{a, b}, Zhang, Ya ^{a, b}, Qin, Qiwei ^{a, b, c}, Huang, Xiaohong ^{a, b, ⁎}, Huang, Youhua ^{a, b, ⁎}

Source: In International Journal of Biological Macromolecules June 2025 311 Part 3

STRAP upregulates antiviral innate immunity against PRV by targeting TBK1

Authors: Wenfeng He, Hongtao Chang, Chen Li, Chenlong Wang, Longxi Li, Guoqing Yang, Jing Chen, Huimin Liu

Source: Virology Journal, Vol 21, Iss 1, Pp 1-17 (2024)

Subject Terms: STRAP, TBK1, Pseudorabies virus, Antiviral immunity, Type I interferon, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/0c9f80c5a4bf4a5fbf61616e629fd137

TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes

Authors: Rui Lu, Yunkun Qu, Zhenggang Wang, Zhiyi He, Shimeng Xu, Peng Cheng, Zhengtao Lv, Hongbo You, Fengjing Guo, Anmin Chen, Jiaming Zhang, Shuang Liang

Source: Journal of Orthopaedic Translation, Vol 47, Iss , Pp 207-222 (2024)

Subject Terms: BX795, Chondrocyte, Inflammation, Osteoarthritis, Senescence, TBK1, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214031X24000494; https://doaj.org/toc/2214-031X

Access URL: https://doaj.org/article/fede2b11d8404b65a820a8cbf5153851

Targeting TANK-binding kinase 1 attenuates painful diabetic neuropathy via inhibiting microglia pyroptosis

Authors: Qinming Liao, Yimei Yang, Yilu Li, Jun Zhang, Keke Fan, Yihao Guo, Jun Chen, Yinhao Chen, Pian Zhu, Lijin Huang, Zhongjie Liu

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: Painful diabetic neuropathy, TBK1, Pyroptosis, Microglia, Amlexanox, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/ae09029f49884c339c0e6b9223b9ec17

MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1

Authors: Xiao Li, Kai Cheng, Meng-Di Shang, Yong Yang, Bin Hu, Xi Wang, Xiao-Dan Wei, Yan-Chun Han, Xiao-Gang Zhang, Meng-Hua Dong, Zhen-Lin Yang, Jiu-Qiang Wang

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)

Subject Terms: MARCH1, STING, TBK1, mTOR, Growth factors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/c13acb335ac04ab9ae46c41fd07f1121

Research on NS1 Proteins of Group 2 Tembusu Virus Inhibiting the Production of Duck Type Ⅰ IFN

Authors: Yunzhen HUANG, Junqin ZHANG, Linlin LI, Jiawen DONG, Yong XIANG, Ming LIAO, Minhua SUN

Source: Guangdong nongye kexue, Vol 51, Iss 7, Pp 151-160 (2024)

Subject Terms: tembusu virus, non-structural protein, rig-ⅰ signaling pathway, type ⅰ interferon, tbk1 phosphorylation, Agriculture

File Description: electronic resource

Relation: http://gdnykx.cnjournals.org/gdnykx/ch/reader/view_abstract.aspx?file_no=202407014; https://doaj.org/toc/1004-874X

Access URL: https://doaj.org/article/d606c75e1f364346a76b617122c9f746

Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations

Authors: Haitian Nan, Yeon-Jeong Kim, Min Chu, Dan Li, Jieying Li, Deming Jiang, Yiming Wu, Toshihisa Ohtsuka, Liyong Wu

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-24 (2024)

Subject Terms: Frontotemporal dementia, Genetic spectrum, TBK1, OPTN, Autophagy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/90adb931fafc4c478550548d8c52986b

Molecular Identification and Expression Analysis of NOD1/2 and TBK1 in Response to Viral or Bacterial Infection in the Spotted Knifejaw (Oplegnathus punctatus)

Authors: Yu Song, Lei Wang, Kaimin Li, Mengqian Zhang, Songlin Chen

Source: Animals, Vol 15, Iss 7, p 1006 (2025)

Subject Terms: Oplegnathus punctatus, NOD1, NOD2, TBK1, immunity, infection, Veterinary medicine, SF600-1100, Zoology, QL1-991

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2615/15/7/1006; https://doaj.org/toc/2076-2615

Access URL: https://doaj.org/article/24c9028b6701472ead083e0a2d8171e5

The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2

Authors: Jin, Leiming ^{a, b, 1}, Cui, Yaqian ^{b, 1}, Zhang, Qianhui ^b, Xiong, Yongqiang ^{b, c}, Zheng, Xiangsheng ^{b, c}, Ye, Jiaxi ^b, Zhang, Anqi ^d, Xiao, Zhongxiang ^f, Zhuang, Zaishou ^b, Liang, Guang ^{b, e}, Hu, Xiang ^{c, ⁎}, Luo, Wu ^{b, c, e, ⁎}, Zhu, Weiwei ^{a, b, ⁎}

Source: In International Immunopharmacology 20 February 2025 148

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

Authors: Zhang, Xuedi ^{1, 2, 3, 4, 6}, Ling, Chunxiu ^{1, 2, 6}, Xiong, Ziying ^{1, 2}, Gong, Ting ^{3, 4}, Luo, Shuhua ^{1, 2}, Liu, Xiaolei ^{1, 2}, Zhang, Lina ^{1, 2}, Liao, Chaoxiong ^{1, 2}, Lu, Yue ^{1, 2}, Huang, Xiao ^{1, 2}, Zhou, Wending ^{1, 2}, Zhou, Shuangnan ^{5, ∗}, Liu, Youtan ^{3, 4, ∗∗}, Tang, Jing ^{1, 2, 7, ∗∗∗}

Source: In Cell Reports 24 December 2024 43(12)

Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

Authors: Hamamoto, Kouta ^{1, 5}, Liang, Xinwen ^{1, 5}, Ito, Ayako ², Lanza, Matthew ³, Bui, Van ¹, Zhang, Jiawen ¹, Opozda, David M. ¹, Hattori, Tatsuya ¹, Chen, Longgui ¹, Haddock, David ⁴, Imamura, Fumiaki ², Wang, Hong-Gang ^{1, 2, ∗}, Takahashi, Yoshinori ^{1, 6, ∗∗}

Source: In Cell Reports 24 December 2024 43(12)

TBK1 is paradoxical in tumor development: a focus on the pathway mediating IFN-I expression

Authors: Banglu Wang, Fan Zhang, Xiaoyu Wu, Mei Ji

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: TBK1, IFN-I, immunotherapy, TBK1 inhibitor, innate immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1433321/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e06587c56e054021b2127fe5b3b9e97f