Unlocking the potential of chimeric antigen receptor T cell engineering immunotherapy: Long road to achieve precise targeted therapy for hepatobiliary pancreatic cancers

Authors: Gao, Hongli ^{a, 1}, Qu, Lianyue ^{b, 1}, Li, Mu ^{c, 1}, Guan, Xin ^d, Zhang, Shuang ^c, Deng, Xin ^{c, ⁎}, Wang, Jin ^{e, ⁎}, Xing, Fei ^{a, ⁎}

Source: In International Journal of Biological Macromolecules March 2025 297

Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma

Authors: Jun Ren, Congcong Li, Dazhao Xu, Kun Wan, Chuxiong Zeng, Lina Hu, Xianzhi Guo, Feifei Huo, Xiumei Rong, Xinna Zhou, Tiecheng Wu, Xiaoli Wang, Bo Sun, JingJing Lou, Amy Hobeika, Michael A. Morse, Herbert Kim Lyerly

Source: International Journal of Hyperthermia, Vol 41, Iss 1 (2024)

Subject Terms: Adoptive T-cell immunotherapy, hyperthermia, immune checkpoint inhibitor, molecular target therapy, renal cell carcinoma, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157

Access URL: https://doaj.org/article/bc311b8df66144a488149fa33a320674

CRISPR in Targeted Therapy and Adoptive T Cell Immunotherapy for Hepatocellular Carcinoma

Authors: Palaz F, Ozsoz M, Zarrinpar A, Sahin I

Source: Journal of Hepatocellular Carcinoma, Vol Volume 11, Pp 975-995 (2024)

Subject Terms: crispr, hepatocellular carcinoma (hcc), targeted cancer therapy, adoptive t cell immunotherapy, car t cell therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.dovepress.com/crispr-in-targeted-therapy-and-adoptive-t-cell-immunotherapy-for-hepat-peer-reviewed-fulltext-article-JHC; https://doaj.org/toc/2253-5969

Access URL: https://doaj.org/article/99a10f975b51442b8d879afdeda046fe

EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

Authors: Isshiki, Yusuke ¹, Chen, Xi ^{1, 10}, Teater, Matt ^{1, 2, 10}, Karagiannidis, Ioannis ¹, Nam, Henna ¹, Cai, Winson ³, Meydan, Cem ^{2, 4}, Xia, Min ¹, Shen, Hao ¹, Gutierrez, Johana ¹, Easwar Kumar, Vigneshwari ¹, Carrasco, Sebastián E. ^{5, 6}, Ouseph, Madhu M. ⁵, Yamshon, Samuel ¹, Martin, Peter ¹, Griess, Ofir ⁷, Shema, Efrat ⁷, Porazzi, Patrizia ⁸, Ruella, Marco ⁸, Brentjens, Renier J. ^{3, 9}, Inghirami, Giorgio ⁵, Zappasodi, Roberta ¹, Chadburn, Amy ⁵, Melnick, Ari M. ¹, Béguelin, Wendy ^{1, 11, ∗}

Source: In Cancer Cell 13 January 2025 43(1):49-68

Case report: Bridging radiation therapy before chimeric antigen receptor T-cell therapy induces sustained remission in patients with relapsed/refractory double-expressor diffuse large B-cell lymphoma with localized compressive symptoms

Authors: Liying Yang, Mengdi Wu, Hao Yang, Xiaorong Sun, Lijie Xing, Dan Liu, Ligang Xing, Jinming Yu

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: lymphoma, double-expressor diffuse large B-cell lymphoma, chimeric antigen receptor T-cell immunotherapy, radiotherapy, bridging therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1441404/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f361748b4c4a46c0a963f0350bb8c9e8

Efficacy and Safety of Dual-targeted Chimeric Antigen Receptor-T Cell Therapy in Patients with Refractory-relapsed Multiple Myeloma: a Meta-analysis

Authors: YU Haibo, ZHANG Tianyu, LI Xin, ZHANG Jiajia, SHEN Man, ZHAN Xiaokai, TANG Ran, FAN Sibin, ZHAO Fengyi, HUANG Zhongxia

Source: Zhongguo quanke yixue, Vol 27, Iss 08, Pp 985-994 (2024)

Subject Terms: multiple myeloma, refractory-relapsed multiple myelomachimeric, antigen receptor t-cell immunotherapy, meta-analysis, Medicine

File Description: electronic resource

Relation: https://www.chinagp.net/fileup/1007-9572/PDF/20230454.pdf; https://doaj.org/toc/1007-9572

Access URL: https://doaj.org/article/6fa5885c5f6e4628aa9263abe7165eaa

B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis

Authors: Dai-Shi Tian, Chuan Qin, Ming-Hao Dong, Michael Heming, Luo-Qi Zhou, Wen Wang, Song-Bai Cai, Yun-Fan You, Ke Shang, Jun Xiao, Di Wang, Chun-Rui Li, Min Zhang, Bi-Tao Bu, Gerd Meyer zu Hörste, Wei Wang

Source: EMBO Molecular Medicine, Vol 16, Iss 4, Pp 966-987 (2024)

Subject Terms: Chimeric Antigen Receptor (CAR) T-cell Immunotherapy, Refractory Myasthenia Gravis, B Cell Maturation Antigen, Single-Cell RNA Sequencing, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/bbc6bbd3f3864e94abcc50e72aa7cf93

The application, safety, and future of ex vivo immune cell therapies and prognosis in different malignancies

Authors: Katelyn R. Einloth, Scott Gayfield, Thomas McMaster, Alexander Didier, Lance Dworkin, Justin Fortune Creeden

Source: BioImpacts, Vol 13, Iss 6, Pp 439-455 (2023)

Subject Terms: ex vivo expansion, cancer immunotherapy, adoptive cell therapy, dc vaccination, t cell immunotherapy, circulating tumor cells, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bi.tbzmed.ac.ir/PDF/bi-13-439.pdf; https://doaj.org/toc/2228-5660; https://doaj.org/toc/2228-5652

Access URL: https://doaj.org/article/108cbecef2d7450cb6830151afab2483

Inflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically

Authors: Kirstin O. Lowe, Constantin E. Tanase, Susan Maghami, Leanne E. Fisher, Amir M. Ghaemmaghami

Source: Immuno, Vol 3, Iss 4, Pp 375-408 (2023)

Subject Terms: liver, immunity, fibrosis, immune modulation, T cell immunotherapy, regulatory T cells, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2673-5601/3/4/23; https://doaj.org/toc/2673-5601

Access URL: https://doaj.org/article/da3172be06424989b6783965f8acafad

PHE1-based IgG-like antibody platform provides a novel strategy for enhanced T-cell immunotherapy

Authors: Lingbin Wang, Haojie Jiang, Xuying Yin, Tingting Liang, Guoming Li, Chen Ding, Mina Yang, Lin Zhang, Junling Liu, Yanyan Xu

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: bispecific antibody, T-cell engaging bsAb, T-cell immunotherapy, B cell mature antigen, PHE1-based bsAb, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1415834/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/339e70f57f50486d99304ae66a6b61ff

Targeting metabolism of breast cancer and its implications in T cell immunotherapy

Authors: Jialuo Zou, Cunjun Mai, Zhiqin Lin, Jian Zhou, Guie Lai

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: breast cancer, T cell immunotherapy, metabolic reprogramming, immune escape, glucose, amino acid, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381970/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/1b9b5d044a214d948b9d1593f754ba3a

TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells

Authors: Beatrice Claudia Cianciotti, Zulma Irene Magnani, Alessia Ugolini, Barbara Camisa, Ivan Merelli, Valentina Vavassori, Alessia Potenza, Antonio Imparato, Francesco Manfredi, Danilo Abbati, Laura Perani, Antonello Spinelli, Eric Shifrut, Fabio Ciceri, Luca Vago, Raffaella Di Micco, Luigi Naldini, Pietro Genovese, Eliana Ruggiero, Chiara Bonini

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: TCR - T cell receptor, adoptive T cell immunotherapy, inhibitory receptor, genome editing, CRISPR/Cas9, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1315283/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0c75a1d1ee5c498d8c626e70eae69c03

CAR-T cell therapy for hematological malignancies: History, status and promise

Authors: Wang, Chao, Wang, Jianpeng, Che, Shusheng, Zhao, Hai ^∗

Source: In Heliyon November 2023 9(11)

Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system

Authors: Chris P. Miller, Megan Fung, Carla A. Jaeger-Ruckstuhl, Yuexin Xu, Edus H. Warren, Shreeram Akilesh, Scott S. Tykodi

Source: Neoplasia: An International Journal for Oncology Research, Vol 46, Iss , Pp 100948- (2023)

Subject Terms: Tumor-on-a-chip, Microphysiological system, 3D cell culture, Collective cell migration, T cells, T-cell immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558623000726; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/9a6a0ba591d64c2b98c9db933ac8344f

Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay

Authors: Kiriakos Koukoulias, Penelope G. Papayanni, Julia Jones, Manik Kuvalekar, Ayumi Watanabe, Yovana Velazquez, Sarah Gilmore, Anastasia Papadopoulou, Ann M. Leen, Spyridoula Vasileiou

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: viral infection, adoptive T cell immunotherapy, virus specific T cells (VSTs), potency assays, T cell cytotoxicity, chromium release assay, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1299512/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/05d14051cbc94363a2c29ed3b40a0427

The DC–T cell axis is an effective target for the treatment of non‐small cell lung cancer

Authors: Shuangcui Wang, Guan Zhang, Qian Cui, Yanjie Yang, Dong Wang, Aqing Liu, Ying Xia, Wentao Li, Yunhe Liu, Jianchun Yu

Source: Immunity, Inflammation and Disease, Vol 11, Iss 11, Pp n/a-n/a (2023)

Subject Terms: artificial DCs, chimeric antigen receptor T cell immunotherapy, DCs, NSCLC, T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-4527

Access URL: https://doaj.org/article/5624a61947484442a923cb9f3256c539

TITAN Project: Microfluidic and Sensing Tools for Immunotherapy

Authors: Maria Serena Chiriacò, Elisabetta Primiceri, Antonio Turco, Valeria Garzarelli, Giulia Siciliano, Alessia Foscarini, Ahmed Alsadig, Annunziata Carbonara, Benedetta Stampone, Gianluca Trotta, Marco Cereda, Marco de Tullio, Giuseppe Gigli, Francesco Ferrara

Source: Proceedings, Vol 97, Iss 1, p 214 (2024)

Subject Terms: CAR-T cell immunotherapy, on-chip quality control, microfluidic and sensing platform, General Works

File Description: electronic resource

Relation: https://www.mdpi.com/2504-3900/97/1/214; https://doaj.org/toc/2504-3900

Access URL: https://doaj.org/article/505b7b83344643e9b7e6d4a950c5a3b2

Characterizing piggyBat—a transposase for genetic modification of T cells

Authors: Gaurav Sutrave, Ning Xu, Tiffany C.Y. Tang, Alla Dolnikov, Brian Gloss, David J. Gottlieb, Kenneth P. Micklethwaite, Kavitha Gowrishankar

Source: Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 250-263 (2022)

Subject Terms: chimeric antigen receptor, CAR, transposons, non-viral vector, piggybat, T cell immunotherapy, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050122000420; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/3c81a532e7eb410fa741a50dda3035f5

Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure

Authors: Sabine Tischer-Zimmermann, Elisabeth Salzer, Tamires Bitencourt, Nelli Frank, Christine Hoffmann-Freimüller, Julia Stemberger, Britta Maecker-Kolhoff, Rainer Blasczyk, Volker Witt, Gerhard Fritsch, Wolfgang Paster, Thomas Lion, Britta Eiz-Vesper, René Geyeregger

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: HSCT, Aspergillus infections, T-cell immunotherapy, Aspergillus-specific T cells, T-cell expansion, cytokine secretion, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.988947/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e7579928abb04b849c28a29c88411a08

Management of neuropsychiatric adverse events in a prostate cancer patient undergoing chimeric antigen receptor T-cell immunotherapy (a phase I clinical trial): A case report

Authors: Ruijin Tang, Qiong Wang, Jing Han, Ming Shi

Source: Asia-Pacific Journal of Oncology Nursing, Vol 10, Iss 4, Pp 100211- (2023)

Subject Terms: CAR T-cell immunotherapy, Side effects, Anxiety, Psychological support, Cancer care, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Nursing, RT1-120

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S234756252300029X; https://doaj.org/toc/2347-5625

Access URL: https://doaj.org/article/caaa92ef6cc148c2ad0139fc84d26927