iDOMO: identification of drug combinations via multi-set operations for treating diseases.

Authors: Zhou, Xianxiao^1,2,3 (AUTHOR), Wu, Ling⁴ (AUTHOR), Wang, Minghui^1,2,3 (AUTHOR), Wu, Guojun⁴ (AUTHOR), Zhang, Bin^1,2,3,5 (AUTHOR)

Source: Briefings in Bioinformatics. Jan2025, Vol. 26 Issue 1, p1-13. 13p.

Subject Terms: Triple-negative breast cancer, Drug synergism, Drug repositioning, Rank correlation (Statistics), Cell growth

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.

Authors: Höfer, Stefanie¹ (AUTHOR), Frasch, Larissa¹ (AUTHOR), Brajkovic, Sarah¹ (AUTHOR), Putzker, Kerstin² (AUTHOR), Lewis, Joe² (AUTHOR), Schürmann, Hendrik^3,4,5 (AUTHOR), Leone, Valentina⁶ (AUTHOR), Sakhteman, Amirhossein¹ (AUTHOR), The, Matthew¹ (AUTHOR), Bayer, Florian P¹ (AUTHOR), Müller, Julian¹ (AUTHOR), Hamood, Firas¹ (AUTHOR), Siveke, Jens T^3,4 (AUTHOR), Reichert, Maximilian^6,7 (AUTHOR), Kuster, Bernhard^1,7 (AUTHOR) kuster@tum.de

Source: Molecular Systems Biology. Mar2025, Vol. 21 Issue 3, p231-253. 23p.

Subject Terms: *DRUG synergism, *PANCREATIC cancer, *KINASE inhibitors, *DNA damage, *CHECKPOINT kinase 1, *DNA repair

Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures.

Authors: Nunes, Mariana^1,2 (AUTHOR) mnunes@i3s.up.pt, Ricardo, Sara^1,3,4,5 (AUTHOR) sara.ricardo@iucs.cespu.pt

Source: Pharmaceuticals (14248247). Jan2025, Vol. 18 Issue 1, p14. 17p.

Subject Terms: *DRUG synergism, *DRUG repositioning, *DRUG interactions, *IVERMECTIN, *CELL lines, *PACLITAXEL, *CARBOPLATIN, *CELL culture

Fluoroquinolones and Biofilm: A Narrative Review.

Authors: Geremia, Nicholas^1,2 (AUTHOR) nicholas.geremia@aulss3.veneto.it, Giovagnorio, Federico³ (AUTHOR) federico.giovagnorio@studenti.unipd.it, Colpani, Agnese⁴ (AUTHOR) colpaniagnese@gmail.com, De Vito, Andrea⁴ (AUTHOR) andreadevitoaho@gmail.com, Botan, Alexandru⁵ (AUTHOR) botan.alexandru@elearn.umfcluj.ro, Stroffolini, Giacomo⁶ (AUTHOR) giacomo.stroffolini@gmail.com, Toc, Dan-Alexandru⁷ (AUTHOR) toc.dan.alexandru@elearn.umfcluj.ro, Zerbato, Verena⁸ (AUTHOR) verena.zerbato@gmail.com, Principe, Luigi⁹ (AUTHOR) luigi.principe@ospedalerc.it, Madeddu, Giordano⁴ (AUTHOR) giordano@uniss.it, Luzzati, Roberto¹⁰ (AUTHOR) roberto.luzzati@asugi.sanita.fvg.it, Parisi, Saverio Giuseppe³ (AUTHOR) saverio.parisi@unipd.it, Di Bella, Stefano¹⁰ (AUTHOR) stefano932@gmail.com

Source: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1673. 31p.

Subject Terms: *DRUG synergism, *MEDICAL equipment, *ANTI-infective agents, *ONLINE databases, *FLUOROQUINOLONES, *RIFAMPIN

Potential Drug Synergy Through the ERBB2 Pathway in HER2+ Breast Tumors.

Authors: Rojas-Salazar, Yareli¹ (AUTHOR) yarojas177662@gmail.com, Gómez-Montañez, Emiliano¹ (AUTHOR) emgomez177566@gmail.com, Rojas-Salazar, Jorge¹ (AUTHOR) rojas19111@gmail.com, de Anda-Jáuregui, Guillermo^1,2,3 (AUTHOR) gdeanda@inmegen.edu.mx, Hernández-Lemus, Enrique^1,2 (AUTHOR) gdeanda@inmegen.edu.mx

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12840. 19p.

Subject Terms: *HER2 positive breast cancer, *DRUG synergism, *PROTEIN-tyrosine kinase inhibitors, *ERLOTINIB, *ANTINEOPLASTIC agents

Impact of Nordihydroguaiaretic Acid on Proliferation, Energy Metabolism, and Chemosensitization in Non-Small-Cell Lung Cancer (NSCLC) Cell Lines.

Authors: Chipón, Carina^1,2 (AUTHOR) cchipon21@outlook.com, Riffo, Paula¹ (AUTHOR) paula.riffo@alumnos.uach.cl, Ojeda, Loreto¹ (AUTHOR) ojedatampeloreto@gmail.com, Salas, Mónica¹ (AUTHOR) monicasalas@uach.cl, Burgos, Rafael A.^2,3 (AUTHOR) ingridehrenfeld@uach.cl, Ehrenfeld, Pamela^3,4 (AUTHOR), López-Muñoz, Rodrigo^2,3 (AUTHOR) rodrigo.lopez@uach.cl, Zambrano, Angara^1,3 (AUTHOR) rodrigo.lopez@uach.cl

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11601. 20p.

Subject Terms: *NON-small-cell lung carcinoma, *DRUG synergism, *LUNG cancer, *THERAPEUTICS, *CELL lines

Utility of prostaglandin analogues and phosphodiesterase inhibitors as promising last resorts for the treatment of vitiligo: A systematic review, from mechanisms of action to mono‐, combination and comparative therapies.

Authors: Pourriyahi, Homa¹ (AUTHOR), Hosseini, Nastaran‐Sadat² (AUTHOR), Nooshabadi, Mohammadreza Padooiy¹ (AUTHOR), Pourriahi, Homayoun¹ (AUTHOR), Baradaran, Hamid Reza^3,4 (AUTHOR), Abtahi‐Naeini, Bahareh^5,6 (AUTHOR), Goodarzi, Azadeh⁷ (AUTHOR) azadeh_goodarzi1984@yahoo.com

Source: Journal of Cosmetic Dermatology. Nov2024, Vol. 23 Issue 11, p3466-3487. 22p.

Subject Terms: *DRUG synergism, *PHOSPHODIESTERASE inhibitors, *CARBON dioxide lasers, *OPHTHALMIC drugs, *CHILD patients

A multi-task graph deep learning model to predict drugs combination of synergy and sensitivity scores.

Authors: Monem, Samar^1,2 (AUTHOR) samarmahmoud@science.bsu.edu.eg, Hassanien, Aboul Ella^2,3 (AUTHOR), Abdel-Hamid, Alaa H.¹ (AUTHOR) hamid_alh@science.bsu.edu.eg

Source: BMC Bioinformatics. 10/10/2024, Vol. 25 Issue 1, p1-23. 23p.

Subject Terms: *DRUG synergism, *DEEP learning, *CROSS-stitch, *CELL lines, *CANCER cells

A multi-view feature representation for predicting drugs combination synergy based on ensemble and multi-task attention models.

Authors: Monem, Samar¹ (AUTHOR) samarmahmoud@science.bsu.edu.eg, Hassanien, Aboul Ella² (AUTHOR), Abdel-Hamid, Alaa H.¹ (AUTHOR)

Source: Journal of Cheminformatics. 9/27/2024, Vol. 16 Issue 1, p1-15. 15p.

Subject Terms: *STANDARD deviations, *DRUG synergism, *DRUG labeling, *MOLECULAR graphs, *DEEP learning

BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures.

Authors: Verploegh, Iris S. C.^1,2 (AUTHOR) i.verploegh@erasmusmc.nl, Conidi, Andrea^2,3 (AUTHOR), El Hassnaoui, Hoesna¹ (AUTHOR), Verhoeven, Floor A. M.¹ (AUTHOR), Korporaal, Anne L.² (AUTHOR), Ntafoulis, Ioannis¹ (AUTHOR), van den Hout, Mirjam C. G. N.^2,4 (AUTHOR), Brouwer, Rutger W. W.^2,4 (AUTHOR), Lamfers, Martine L. M.¹ (AUTHOR), van IJcken, Wilfred F. J.^2,4 (AUTHOR), Huylebroeck, Danny² (AUTHOR), Leenstra, Sieger¹ (AUTHOR) s.leenstra@erasmusmc.nl

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10176. 14p.

Subject Terms: *BONE morphogenetic proteins, *DRUG synergism, *MEDICAL research, *INHIBITION of cellular proliferation, *TEMOZOLOMIDE, *CANCER stem cells

Ferroptosis-inducing nanomedicine and targeted short peptide for synergistic treatment of hepatocellular carcinoma.

Authors: Wang, Luyang^1,2,3,4 (AUTHOR), Tong, Le^1,5,6 (AUTHOR), Xiong, Zecheng⁷ (AUTHOR), Chen, Yi² (AUTHOR), Zhang, Ping² (AUTHOR), Gao, Yan² (AUTHOR), Liu, Jing² (AUTHOR), Yang, Lei² (AUTHOR), Huang, Chunqi⁴ (AUTHOR), Ye, Gaoqi² (AUTHOR), Du, Jing² (AUTHOR) dujing1@hmc.edu.cn, Liu, Huibiao⁷ (AUTHOR) liuhb@iccas.ac.cn, Yang, Wei² (AUTHOR) yang623621810@163.com, Wang, Ying^1,2,5 (AUTHOR) nancywangying@163.com

Source: Journal of Nanobiotechnology. 9/3/2024, Vol. 22 Issue 1, p1-18. 18p.

Subject Terms: *DRUG synergism, *PEPTIDES, *CANCER prognosis, *IRON ions, *GENE expression

Exploring the Antibiofilm Effect of Sertraline in Synergy with Cinnamomum verum Essential Oil to Counteract Candida Species.

Authors: Barbarossa, Alexia¹ (AUTHOR) alexia.barbarossa@uniba.it, Rosato, Antonio¹ (AUTHOR) antonio.carrieri@uniba.it, Carrieri, Antonio¹ (AUTHOR) roberta.tardugno@uniba.it, Fumarola, Luciana² (AUTHOR) luciana.fumarola@uniba.it, Tardugno, Roberta¹ (AUTHOR) filomena.corbo@uniba.it, Corbo, Filomena¹ (AUTHOR) giuseppe.fracchiolla@uniba.it, Fracchiolla, Giuseppe¹ (AUTHOR), Carocci, Alessia¹ (AUTHOR) alexia.barbarossa@uniba.it

Source: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1109. 15p.

Subject Terms: *SEROTONIN uptake inhibitors, *DRUG synergism, *CINNAMON tree, *DRUG repositioning, *ESSENTIAL oils

Non-Negative Matrix Tri-Factorization for Representation Learning in Multi-Omics Datasets with Applications to Drug Repurposing and Selection.

Authors: Messa, Letizia¹ (AUTHOR), Testa, Carolina¹ (AUTHOR), Carelli, Stephana^2,3 (AUTHOR), Rey, Federica³ (AUTHOR), Jacchetti, Emanuela⁴ (AUTHOR), Cereda, Cristina² (AUTHOR), Raimondi, Manuela Teresa⁴ (AUTHOR), Ceri, Stefano¹ (AUTHOR), Pinoli, Pietro¹ (AUTHOR) pietro.pinoli@polimi.it

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9576. 23p.

Subject Terms: *ARTIFICIAL intelligence, *DRUG synergism, *DRUG repositioning, *NONNEGATIVE matrices, *DRUG design

Understanding the Cytomegalovirus Cyclin-Dependent Kinase Ortholog pUL97 as a Multifaceted Regulator and an Antiviral Drug Target.

Authors: Marschall, Manfred¹ (AUTHOR) manfred.marschall@fau.de, Schütz, Martin¹ (AUTHOR) markus-wild@mail.de, Wild, Markus¹ (AUTHOR) christina.wangen@uk-erlangen.de, Socher, Eileen² (AUTHOR) eileen.socher@fau.de, Wangen, Christina¹ (AUTHOR) kishore.dhotre@uk-erlangen.de, Dhotre, Kishore¹ (AUTHOR), Rawlinson, William D.³ (AUTHOR) w.rawlinson@unsw.edu.au, Sticht, Heinrich⁴ (AUTHOR) heinrich.sticht@fau.de

Source: Cells (2073-4409). Aug2024, Vol. 13 Issue 16, p1338. 32p.

Subject Terms: *DRUG synergism, *PROTEIN kinases, *TARGETED drug delivery, *VIRAL replication, *HUMAN cytomegalovirus

Harnessing Porphyrin Accumulation in Liver Cancer: Combining Genomic Data and Drug Targeting.

Authors: Adapa, Swamy R.^1,2 (AUTHOR) pravinsdeesha@gmail.com, Meshram, Pravin² (AUTHOR), Sami, Abdus³ (AUTHOR) abdussami@usf.edu, Jiang, Rays H. Y.^1,2 (AUTHOR) jiang2@usf.edu

Source: Biomolecules (2218-273X). Aug2024, Vol. 14 Issue 8, p959. 19p.

Subject Terms: *ORGANS (Anatomy), *DRUG synergism, *CYTOCHROME P-450, *DRUG metabolism, *LIVER cancer

PermuteDDS: a permutable feature fusion network for drug-drug synergy prediction.

Authors: Zhao, Xinwei¹ (AUTHOR), Xu, Junqing² (AUTHOR), Shui, Youyuan¹ (AUTHOR), Xu, Mengdie¹ (AUTHOR), Hu, Jie^1,3 (AUTHOR), Liu, Xiaoyan⁴ (AUTHOR), Che, Kai^5,6 (AUTHOR), Wang, Junjie^1,3 (AUTHOR) junjie2021@njmu.edu.cn, Liu, Yun^1,3,7 (AUTHOR) liuyun@njmu.edu.cn

Source: Journal of Cheminformatics. 4/15/2024, Vol. 16 Issue 1, p1-14. 14p.

Subject Terms: *DRUG synergism, *COMBINATION drug therapy, *CELL lines, *HIGH throughput screening (Drug development), *DRUG interactions, *DRUG delivery devices

MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction.

Authors: Dong, Yunyun¹ (AUTHOR) dongyunyun@tyut.edu.cn, Chang, Yunqing¹ (AUTHOR), Wang, Yuxiang¹ (AUTHOR), Han, Qixuan¹ (AUTHOR), Wen, Xiaoyuan¹ (AUTHOR), Yang, Ziting¹ (AUTHOR), Zhang, Yan¹ (AUTHOR), Qiang, Yan² (AUTHOR) qiangyan@tyut.edu.cn, Wu, Kun³ (AUTHOR), Fan, Xiaole⁴ (AUTHOR), Ren, Xiaoqiang⁴ (AUTHOR)

Source: BMC Bioinformatics. 4/1/2024, Vol. 25 Issue 1, p1-24. 24p.

Subject Terms: *DRUG synergism, *INTERACTIVE learning, *COLLABORATIVE learning, *COMBINATION drug therapy, *ANTINEOPLASTIC agents

SynergyX: a multi-modality mutual attention network for interpretable drug synergy prediction.

Authors: Guo, Yue¹ (AUTHOR), Hu, Haitao^1,2 (AUTHOR), Chen, Wenbo^1,2 (AUTHOR), Yin, Hao^1,2 (AUTHOR), Wu, Jian³ (AUTHOR) wujian2000@zju.edu.cn, Hsieh, Chang-Yu^4,5 (AUTHOR) wujian2000@zju.edu.cn, He, Qiaojun^1,4,6,7,8 (AUTHOR) wujian2000@zju.edu.cn, Cao, Ji^1,4,6,7,8 (AUTHOR) wujian2000@zju.edu.cn

Source: Briefings in Bioinformatics. Mar2024, Vol. 25 Issue 2, p1-15. 15p.

Subject Terms: Drug synergism, Biological networks, Drug interactions, Antineoplastic agents, Lung cancer, Medical screening

Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential.

Authors: Miranda, Maria Rosaria^1,2 (AUTHOR) mmiranda@unisa.it, Vestuto, Vincenzo¹ (AUTHOR) gipepe@unisa.it, Amodio, Giuseppina³ (AUTHOR) gamodio@unisa.it, Manfra, Michele⁴ (AUTHOR) michele.manfra@unibas.it, Pepe, Giacomo^1,5 (AUTHOR) pcampiglia@unisa.it, Campiglia, Pietro^1,4 (AUTHOR)

Source: Life (2075-1729). Mar2024, Vol. 14 Issue 3, p420. 24p.

Subject Terms: *DRUG synergism, *FRUIT, *BREAST cancer, *FREE radicals, *BERRIES, *ANTINEOPLASTIC agents

Interpreting drug synergy in breast cancer with deep learning using target-protein inhibition profiles.

Authors: Srithanyarat, Thanyawee^1,2 (AUTHOR), Taoma, Kittisak^1,2 (AUTHOR), Sutthibutpong, Thana^3,4 (AUTHOR), Ruengjitchatchawalya, Marasri^1,5 (AUTHOR), Liangruksa, Monrudee⁶ (AUTHOR) monrudee@nanotec.or.th, Laomettachit, Teeraphan^1,4 (AUTHOR) teeraphan.lao@kmutt.ac.th

Source: BioData Mining. 2/29/2024, Vol. 17 Issue 1, p1-17. 17p.

Subject Terms: *ARTIFICIAL neural networks, *DRUG synergism, *DEEP learning, *BREAST cancer, *PEARSON correlation (Statistics), *CHEMICAL fingerprinting