Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Authors: Tomczak, Piotr, Choueiri, Toni, Park, Se Hoon, Venugopal, Balaji, Ferguson, Thomas R., Hajek, Jaroslav, Lin, Tzu-Ping, Symeonides, Stefan N., Lee, Jae Lyun, Sawrycki, Piotr, Haas, Naomi B., Gurney, Howard P., Mahave, Mauricio, Sarwar, Naveed, Thiery-Vuillemin, Antoine, Gross-Goupil, Marine, Chevreau, Christine, Burke, John M., Doshi, Gurjyot, Melichar, Bohuslav, Topart, Delphine, Oudard, Stephane, Kopyltsov, Evgeniy, Hammers, Hans-Joerg, Quinn, David I., Alva, Ajjai, Menezes, Juliana de Janoski, Silva, Adriano Goncalves e, Winquist, Eric W., Hamzaj, Alketa, Procopio, Giuseppe, Karaszewska, Boguslawa, Nowakowska-Zajdel, Ewa M., Alekseev, Boris Y., Gafanov, Rustem A., Izmailov, Adel, Semenov, Andrey, Afanasyev, Sergey G., Lipatov, Oleg N., Powles, Thomas B., Srinivas, Sandy, McDermott, David, Kochuparambil, Samith T., Davis, Ian D., Peltola, Katriina, Sabbatini, Roberto, Chung, Jinsoo, Shkolnik, Michail I., Matveev, Vsevolod B., Gajate Borau, Pablo, McCune, Steven, Hutson, Thomas E., Dri, Alejandro, Sales, Silvio Correia, Yeung, Carrie, Alcala Castro, Carmen Marcela, Bostrom, Peter, Laguerre, Brigitte, Buttigliero, Consuelo, de Giorgi, Ugo, Fomin, Eugeniy A., Zakharia, Yousef, Hwang, Clara, Singer, Eric A., Yorio, Jeffrey T., Waterhouse, David, Kowalyszyn, Ruben Dario, Alfie, Margarita Sonia, Yanez Ruiz, Eduardo, Buchler, Tomas, Kankaanranta, Krista, Ferretti, Gianluigi, Kimura, Go, Nishimura, Kazuo, Masumori, Naoya, Tamada, Satoshi, Kato, Haruaki, Kitamura, Hiroshi, Danielewicz, Iwona, Wojcik-Tomaszewska, Joanna, Sala Gonzalez, Nuria, Chiu, Kun-Yuan, Atkins, Michael B., Heath, Elisabeth, Rojas-Uribe, Gustavo Adolfo, Gonzalez Fernandez, Manuel Enrique, Feyerabend, Susan, Pignata, Sandro, Numakura, Kazuyuki, Cybulska Stopa, Bozena, Zukov, Ruslan, Climent Duran, Miguel Angel, Maroto Rey, Pablo Jose, Montesa Pino, Alvaro, Chang, Chao-Hsiang, Vengalil, Salil, Waddell, Tom S., Cobb, Patrick W., Hauke, Ralph, Anderson, Daniel M., Sarantopoulos, John, Gourdin, Theodore, Zhang, Tian, Jayram, Gautam, Fein, Luis Enrique, Harris, Carole, Beato, Patricia Medeiros Milhomem, Flores, Francisco, Estay, Angela, Rubiano, Juan Andres, Bedke, Jens, Hauser, Stefan, Neisius, Andreas, Busch, Jonas, Anai, Satoshi, Tsunemori, Hiroyuki, Sawka, Dariusz, Sikora-Kupis, Bozena, Arranz, Jose Angel, Delgado, Ignacio, Chen, Chung-Hsin, Gunderson, Elizabeth, Tykodi, Scott, Koletsky, Alan, Chen, Kevin, Agrawal, Manish, Kaen, Diego Lucas, Sade, Juan Pablo, Tatangelo, Marcelo Daniel, Parnis, Francis, Barbosa, Fernando Maciel, Faucher, Genevieve, Iqbal, Nayyer, Marceau, Daniele, Paradis, Jean-Benoit, Hanna, Nawar, Acevedo, Alejandro, Ibanez, Carolina, Villanueva, Luis, Galaz, Pedro Pablo, Durango, Isabel Cristina, Manneh, Ray, Kral, Zdenek, Holeckova, Petra, Hakkarainen, Heikki, Ronkainen, Hanna, Abadie-Lacourtoisie, Sophie, Tartas, Sophie, Goebell, Peter J., Grimm, Marc-Oliver, Hoefner, Thomas, Wirth, Manfred, Panic, Andrej, Schultze-Seemann, Wolfgang, Yokomizo, Akira, Mizuno, Ryuichi, Uemura, Hirotsugu, Eto, Masatoshi, Tsujihata, Masao, Matsukawa, Yoshihisa, Murakami, Yoji, Kim, Miso, Hamberg, Paul, Marczewska-Skrodzka, Malgorzata, Szczylik, Cezary, Humphreys, Alison C., Jiang, Peter, Kumar, Birendra, Lu, Gary, Desai, Arpita, Karam, Jose Antonio, Keogh, George, Fleming, Mark, Zarba, Juan Jose, Leiva, Viviana E., Mendez, Guillermo Ariel, Harris, Samuel J., Brown, Stephen J., Antonio Junior, Joao Neif, Costamilan, Rita de Cassia, Rocha, Roberto Odebrecht, Muniz, David, Brust, Leandro, Lalani, Aly-Khan, Graham, Jeffrey, Levesque, Michael, Orlandi, Francisco, Kotasek, Rostislav, Deville, Jean L., Borchiellini, Delphine, Merseburger, Axel, Rink, Michael, Roos, Frederik, McDermott, Ray, Oyama, Masafumi, Yamamoto, Yoshiaki, Tomita, Yoshihiko, Miura, Yuji, Ioritani, Naomasa, Westgeest, Hans, Kubiatowski, Tomasz, Bal, Wieslaw, Girones Sarrio, Regina, Rowe, Julie, Prow, Debra M., Senecal, Francis, Hashemi-Sadraei, Neda, Cole, Scott W., Kendall, Stephan D., Richards, Donald A., Schnadig, Ian D., Gupta, Mukul, Powles, Thomas ^*, Ferguson, Thomas, Symeonides, Stefan N, Gurney, Howard, Chang, Yen-Hwa, Haas, Naomi B, Burgents, Joseph E, Xu, Lei, Imai, Kentaro, Quinn, David I, Choueiri, Toni K

Source: In The Lancet Oncology September 2022 23(9):1133-1144

A phase 1 dose escalation/expansion study of GSK5764227 (GSK'227), a B7-homolog 3 (B7-H3) protein targeted antibody-drug conjugate (ADC), in patients with advanced solid tumors, including gastrointestinal (GI) cancers.

Authors: Saif, Wasif M., Cassier, Philippe Alexandre, Curigliano, Giuseppe, Daniele, Gennaro, Hilton, John Frederick, Koganemaru, Shigehiro, Kowalyszyn, Ruben, LoRusso, Patricia, Moreno, Victor, Olmedo Garcia, Maria Eugenia, Perroud, Herman Andres, Symeonides, Stefan N., Yamamoto, Noboru, Aziez, Amine, Anjum, Rana, LaMacchia, John, Sembhi, Harjeet, Ratia, Nirav, Italiano, Antoine

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, pTPS847-TPS847, 47p

The integrin adhesome and control of anti-tumour immunity.

Authors: Webb, Emily R., Black, Annabel, Barth, Nicole D., Symeonides, Stefan N., Brunton, Valerie G.

Source: Biochemical Society Transactions; Dec2024, Vol. 52 Issue 6, p2455-2468, 14p

Subject Terms: FOCAL adhesion kinase, FOCAL adhesions, TUMOR microenvironment, EXTRACELLULAR matrix, OVERALL survival

Overall survival results from the phase 3 KEYNOTE-564 study of adjuvant pembrolizumab versus placebo for the treatment of clear cell renal cell carcinoma (ccRCC).

Authors: Choueiri, Toni K., Tomczak, Piotr, Park, Se Hoon, Venugopal, Balaji, Ferguson, Thomas, Symeonides, Stefan N., Hajek, Jaroslav, Chang, Yen-Hwa, Lee, Jae-Lyun, Sarwar, Naveed, Gurney, Howard, Gross-Goupil, Marine, Mahave, Mauricio, Haas, Naomi B., Sawrycki, Piotr, Zhang, Tian, Cornell, Jerry, Elfiky, Aymen, Burgents, Joseph E., Powles, Thomas

Source: Journal of Clinical Oncology; 2024 Supplement 4, Vol. 42, pLBA359-LBA359, 6p

A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer.

Authors: Kristeleit, Rebecca, Plummer, Ruth, Jones, Robert, Carter, Louise, Blagden, Sarah, Sarker, Debashis, Arkenau, Tobias, Evans, Thomas R. Jeffry, Danson, Sarah, Symeonides, Stefan N., Veal, Gareth J., Klencke, Barbara J., Kowalski, Mark M., Banerji, Udai

Source: British Journal of Cancer; Jul2023, Vol. 129 Issue 1, p38-45, 8p

Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study.

Authors: Oswald, Ailsa J., Symeonides, Stefan N., Wheatley, Duncan, Chan, Stephen, Brunt, Adrian Murray, McAdam, Karen, Schmid, Peter, Waters, Simon, Poole, Christopher, Twelves, Chris, Perren, Timothy, Bartlett, John, Piper, Tammy, Chisholm, Eve Macdonald, Welsh, Michelle, Hill, Robert, Hopcroft, Lisa E. M., Barrett-Lee, Peter, Cameron, David A.

Source: Breast Cancer Research & Treatment; May2023, Vol. 199 Issue 1, p35-46, 12p

ADJUVANT PEMBROLIZUMAB FOR RENAL CELL CARCINOMA (KEYNOTE-564): EXPLORATORY ANALYSIS ACROSS UCLA INTEGRATED STAGING SYSTEM RISK GROUPS AND DISEASE STAGE

Authors: Zhang, Tian, Choueiri, Toni K., Tomczak, Piotr, Park, Se Hoon, Venugopal, Balaji, Ferguson, Tom, Symeonides, Stefan N., Hajek, Jaroslav, Chang, Yen-Hwa, Lee, Jae-Lyun, Sarwar, Naveed, Thiery-Vuillemin, Antoine, Gross-Goupil, Marine, Mahave, Mauricio, Haas, Naomi B., Sawrycki, Piotr, Xu, Lei, Imai, Kentaro, Poehlein, Christian, Powles, Thomas

Source: In Urologic Oncology: Seminars and Original Investigations March 2024 42 Supplement:S7-S8

Initial active surveillance for patients with metastatic renal cell carcinoma: 10 years' experience at a regional cancer Centre.

Authors: Stares, Mark, Chauhan, Vishwani, Moudgil‐Joshi, Jigi, Kong, Qiu G., Malik, Jahangeer, Sundaramurthy, Aravindhan, Elliott, Tony, Mains, Edward, Leung, Steve, Laird, Alexander, Symeonides, Stefan N.

Source: Cancer Medicine; Mar2023, Vol. 12 Issue 5, p5255-5264, 10p

Subject Terms: RENAL cell carcinoma, WATCHFUL waiting, DISEASE risk factors, C-reactive protein, METASTASIS, OVERALL survival

High-level production in Pichia pastoris of an anti-p185 HER-2 single-chain antibody fragment using an alternative secretion expression vector.

Authors: Gurkan, Cemal, Symeonides, Stefan N., Ellar, David J.

Source: Biotechnology & Applied Biochemistry; February 2004, Vol. 39 Issue 1, p115-122, 8p

Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data.

Authors: James, Gareth D.^1,2, Symeonides, Stefan N.^2,3, Marshall, Jayne², Young, Julia², Clack, Glen² glen.clack@astrazeneca.com

Source: BMC Cancer. 8/31/2016, Vol. 16, p1-12. 12p. 3 Charts, 8 Graphs.

Subject Terms: *ANDROGEN receptors, *ONCOLOGY, *DRUG dosage, *DRUG toxicity, *CLINICAL trials, *COMPARATIVE studies, *ALGORITHMS, *ANTIANDROGENS, *ANTINEOPLASTIC agents, *COMPUTER simulation, *DOSE-effect relationship in pharmacology, *HETEROCYCLIC compounds, *MATHEMATICAL models, *RESEARCH methodology, *MEDICAL cooperation, *PROBABILITY theory, *PROSTATE tumors, *RESEARCH, *THEORY, *EVALUATION research

Development of a LC–MS/MS method for the quantification of toxic payload DM1 cleaved from BT1718 in a Phase I study.

Authors: Gowland, Catherine, Berry, Philip, Errington, Julie, Jeffrey, Phillip, Bennett, Gavin, Godfrey, Lisa, Pittman, Marc, Niewiarowski, Andrew, Symeonides, Stefan N, Veal, Gareth J

Source: Bioanalysis; Jan2021, Vol. 13 Issue 2, p101-113, 13p

Treatment Strategies in Metastatic Renal Cancer: Dose Titration in Clear Cell Renal Cell Carcinoma

Authors: Brown, Janet E., Symeonides, Stefan N.

Source: In European Urology September 2022 82(3):293-294

Modi-1, anti-citrullinated neoepitope vaccine, alone and combined with checkpoint inhibitors in patients with head and neck, breast, renal, and ovarian cancers: ModiFy phase I/II basket clinical trial—Report after completion of monotherapy...

Authors: Ottensmeier, Christian H.H, Pinato, David J. James, Armstrong, Anne C., Symeonides, Stefan N., Patel, Poulam M., Danson, Sarah, Korolewicz, James, Cameron, David, Miller, Robert M., Master, Fayaz, Paston, Samantha, Durrant, Lindy G.

Source: Journal of Clinical Oncology; 2023 Supplement 16, Vol. 41, p2566-2566, 1p

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Predictive value of C reactive protein (CRP) in patients with metastatic renal cell carcinoma (mRCC) treated with pembrolizumab (pembro) and axitinib (axi).

Authors: Qaisar, Aitzaz, Venugopal, Balaji, Ansel, Sonam, Jones, Robert J., Slater, Sarah, Symeonides, Stefan N., Malik, Jahangeer, Sundaramurthy, Aravindhan, Elliott, Tony, Devasar, Abeera, Stares, Mark, Randhawa, Manreet

Source: Journal of Clinical Oncology; 2/21/2023 Supplement, Vol. 41, p716-716, 1p

Adjuvant pembrolizumab (pembro) for renal cell carcinoma (RCC) across UCLA Integrated Staging System (UISS) risk groups and disease stage: Subgroup analyses from the KEYNOTE-564 study.

Authors: Choueiri, Toni K., Tomczak, Piotr, Park, Se Hoon, Venugopal, Balaji, Ferguson, Tom, Symeonides, Stefan N., Hajek, Jaroslav, Chang, Yen-Hwa, Lee, Jae-Lyun, Sarwar, Naveed, Thiery-Vuillemin, Antoine, Gross-Goupil, Marine, Mahave, Mauricio, Haas, Naomi B., Sawrycki, Piotr, Zhang, Tian, Xu, Lei, Imai, Kentaro, Poehlein, Christian Heinrich, Powles, Thomas

Source: Journal of Clinical Oncology; 2/21/2023 Supplement, Vol. 41, p679-679, 1p

Real-world survival outcomes of patients (pts) treated with 6-weekly pembrolizumab 400mg (pem6w) plus axitinib (axi) for advanced renal cell carcinoma (aRCC).

Authors: Ansel, Sonam, Stares, Mark, Jones, Robert J., Symeonides, Stefan N., Manson, Laura, Ray-Chaudhuri, Anirban, Randhawa, Manreet, Slater, Sarah, Devasar, Abeera, Malik, Jahangeer, Sundaramurthy, Aravindhan, Elliott, Tony, Venugopal, Balaji

Source: Journal of Clinical Oncology; 2/21/2023 Supplement, Vol. 41, p645-645, 1p

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Leptin regulation of expression of Neuropeptide Y and its receptor

Authors: Symeonides, Stefan N., Morris, Margaret. J., Bournat, Juan-Carlos, Allen, Janet M.

Source: Biochemical Society Transactions; August 1998, Vol. 26 Issue: 3 pS203-S203, 1p