N-glycosylation signature and its relevance in cardiovascular immunometabolism

Authors: Svecla, Monika ^a, Li-Gao, Ruifang ^b, Falck, David ^c, Bonacina, Fabrizia ^{d, ⁎}

Source: In Vascular Pharmacology June 2025 159

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE^-/- mice.

Authors: Svecla, Monika¹ (AUTHOR), Moregola, Annalisa¹ (AUTHOR), Dalt, Lorenzo Da¹ (AUTHOR), Nour, Jasmine¹ (AUTHOR), Baragetti, Andrea¹ (AUTHOR), Uboldi, Patrizia¹ (AUTHOR), Idini, Alessandra¹ (AUTHOR), Wuhrer, Manfred² (AUTHOR), Beretta, Giangiacomo³ (AUTHOR), Falck, David² (AUTHOR), Bonacina, Fabrizia¹ (AUTHOR), Norata, Giuseppe Danilo¹ (AUTHOR) danilo.norata@unimi.it

Source: Cardiovascular Diabetology. 11/30/2024, Vol. 23 Issue 1, p1-14. 14p.

Subject Terms: *WESTERN diet, *BLOOD lipids, *LIPID metabolism, *ATHEROSCLEROTIC plaque, *CHOLESTEROL metabolism, *GALACTOSE, *XENOBIOTICS

Neutrophil aging exacerbates high fat diet induced metabolic alterations

Authors: Baragetti, Andrea, Da Dalt, Lorenzo, Moregola, Annalisa, Svecla, Monika, Terenghi, Ottavia, Mattavelli, Elisa, De Gaetano, Lucia Nicolini, Uboldi, Patrizia, Catapano, Alberico Luigi, Norata, Giuseppe Danilo

Source: In Metabolism July 2023 144

ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.

Authors: Svecla, Monika¹ (AUTHOR), Da Dalt, Lorenzo¹ (AUTHOR), Moregola, Annalisa¹ (AUTHOR), Nour, Jasmine¹ (AUTHOR), Baragetti, Andrea¹ (AUTHOR), Uboldi, Patrizia¹ (AUTHOR), Donetti, Elena² (AUTHOR), Arnaboldi, Lorenzo¹ (AUTHOR), Beretta, Giangiacomo³ (AUTHOR), Bonacina, Fabrizia¹ (AUTHOR), Norata, Giuseppe Danilo¹ (AUTHOR) danilo.norata@unimi.it

Source: Cardiovascular Diabetology. 1/28/2024, Vol. 23 Issue 1, p1-17. 17p.

Subject Terms: *ADIPOSE tissues, *BLOOD lipids, *LIPIDS, *ADIPOSE tissue diseases, *OBESITY, *LIVER

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

Authors: Da Dalt, Lorenzo, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, Norata, Giuseppe Danilo

Source: European heart journal. 42(32):3078-3090

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128948337.0x000001&indx=1&recIds=ETOCvdc_100128948337.0x000001

Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression

Authors: Bonacina, Fabrizia, Martini, Elisa, Svecla, Monika, Nour, Jasmine, Cremonesi, Marco, Beretta, Giangiacomo, Moregola, Annalisa, Pellegatta, Fabio, Zampoleri, Veronica, Catapano, Alberico Luigi, Kallikourdis, Marinos, Norata, Giuseppe Danilo

Source: Cardiovascular research. 117(9):2069-2082

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144900904.0x000001&indx=1&recIds=ETOCvdc_100144900904.0x000001

Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis

Authors: Pirillo, Angela, Svecla, Monika, Catapano, Alberico Luigi, Holleboom, Adriaan G, Norata, Giuseppe Danilo

Source: Cardiovascular research. 117(4):1033-1045

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130286908.0x000001&indx=1&recIds=ETOCvdc_100130286908.0x000001

Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model.

Authors: Amor, Melina, Diaz, Malena, Bianco, Valentina, Svecla, Monika, Schwarz, Birgit, Rainer, Silvia, Pirchheim, Anita, Schooltink, Laszlo, Mukherjee, Suravi, Grabner, Gernot F., Beretta, Giangiacomo, Lamina, Claudia, Norata, Giuseppe Danilo, Hackl, Hubert, Kratky, Dagmar

Source: Cardiovascular Diabetology; 8/14/2024, Vol. 23 Issue 1, p1-17, 17p

Subject Terms: BROWN adipose tissue, ADIPOSE tissue diseases, HEART metabolism disorders, TRANSCRIPTION factors, ENERGY metabolism, HIGH cholesterol diet, WESTERN diet

Single cell RNA sequencing and spatial transcriptomic to profile Kupffer cells during NASH and liver cirrhosis

Authors: Vingiani, Giovanni, Svecla, Monika, Fantini, Francesca, Da Dalt, Lorenzo, Norata, Danilo

Source: In Atherosclerosis August 2024 395 Supplement 1

Modulation of mitochondrial dynamism in Kupffer cells impacts systemic metabolism

Authors: Fantini, Francesca, Da Dalt, Lorenzo, Moregola, Annalisa, Vingiani, Giovanni, Svecla, Monika, Terenghi, Ottavia, Nour, Jasmine, Bellini, Rossella, Bonacina, Fabrizia, Norata, Danilo

Source: In Atherosclerosis August 2024 395 Supplement 1

The involvement of neutrophils in the cardio-metabolic and inflammatory consequences of high fat diet depends on their aging status

Authors: Baragetti, Andrea, Da Dalt, Lorenzo, Moregola, Annalisa, Parolini, Anna, Terenghi, Ottavia, Mattavelli, Elisa, Svecla, Monika, Uboldi, Patrizia, Catapano, Alberico, Norata, Danilo

Source: In Atherosclerosis August 2024 395 Supplement 1

Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase.

Authors: Bianco, Valentina, Svecla, Monika, Vingiani, Giovanni Battista, Kolb, Dagmar, Schwarz, Birgit, Buerger, Martin, Beretta, Giangiacomo, Norata, Giuseppe Danilo, Kratky, Dagmar

Source: Journal of Proteome Research; 4/5/2024, Vol. 23 Issue 4, p1506-1518, 13p

DDASSQ: An open‐source, multiple peptide sequencing strategy for label free quantification based on an OpenMS pipeline in the KNIME analytics platform

Authors: Svecla, Monika, Garrone, Giulia, Faré, Fiorenza, Aletti, Giacomo, Norata, Giuseppe Danilo, Beretta, Giangiacomo

Source: Proteomics. 21(16)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128630508.0x000001&indx=1&recIds=ETOCvdc_100128630508.0x000001

The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation.

Authors: Dalt, Lorenzo Da, Moregola, Annalisa, Svecla, Monika, Pedretti, Silvia, Fantini, Francesca, Ronzio, Mirko, Uboldi, Patrizia, Dolfini, Diletta, Donetti, Elena, Baragetti, Andrea, Mitro, Nico, Scorrano, Luca, Norata, Giuseppe Danilo

Source: Cardiovascular Research; Dec2023, Vol. 119 Issue 18, p2917-2929, 13p

Subject Terms: FATTY liver, BILE acids, NON-alcoholic fatty liver disease, LIVER cells, HIGH-fat diet, CHYLOMICRONS

Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice.

Authors: Amor, Melina, Bianco, Valentina, Buerger, Martin, Lechleitner, Margarete, Vujić, Nemanja, Dobrijević, Anja, Akhmetshina, Alena, Pirchheim, Anita, Schwarz, Birgit, Pessentheiner, Ariane R., Baumgartner, Franziska, Rampitsch, Katharina, Schauer, Silvia, Klobučar, Iva, Degoricija, Vesna, Pregartner, Gudrun, Kummer, Daniel, Svecla, Monika, Sommer, Gerhard, Kolb, Dagmar

Source: Cardiovascular Diabetology; 11/28/2023, Vol. 22 Issue 1, p1-18, 18p

Subject Terms: WESTERN diet, ATHEROSCLEROTIC plaque, MATRIX metalloproteinases, INSULIN sensitivity, HEART metabolism disorders, WHITE adipose tissue, LIPOPROTEIN receptors

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans.

Authors: Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

Source: Nature Communications; 8/25/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: LIPID metabolism, HDL cholesterol, HIGH density lipoproteins, MICE, BLOOD lipids, METABOLISM, LIPIDS

The low-density lipoprotein receptor-mTORC1 axis coordinates CD8^+ T cell activation

Authors: Bonacina, Fabrizia, Moregola, Annalisa, Svecla, Monika, Coe, David, Uboldi, Patrizia, Fraire, Sara, Beretta, Simona, Beretta, Giangiacomo, Pellegatta, Fabio, Catapano, Alberico Luigi

Source: Journal of cell biology. 221(11):e202202011-e202202011

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630584837&indx=1&recIds=ETOCRN630584837

Mannose Receptor Deficiency Impacts Bone Marrow and Circulating Immune Cells during High Fat Diet Induced Obesity.

Authors: Nour, Jasmine, Moregola, Annalisa, Svecla, Monika, Da Dalt, Lorenzo, Bellini, Rossella, Neyrolles, Olivier, Fadini, Gian Paolo, Rombouts, Yoann, Albiero, Mattia, Bonacina, Fabrizia, Norata, Giuseppe Danilo

Source: Metabolites (2218-1989); Dec2022, Vol. 12 Issue 12, p1205, 14p

Subject Terms: HIGH-fat diet, BONE marrow, WEIGHT gain, BONE marrow cells, MANNOSE, PROGENITOR cells

The low-density lipoprotein receptor-mTORC1 axis coordinates CD8⁺ T cell activation.

Authors: Bonacina, Fabrizia¹, Moregola, Annalisa¹, Svecla, Monika¹, Coe, David^2,3, Uboldi, Patrizia¹, Fraire, Sara¹, Beretta, Simona¹, Beretta, Giangiacomo⁴, Pellegatta, Fabio⁵, Catapano, Alberico Luigi^1,5, Marelli-Berg, Federica M.^2,3, Norata, Giuseppe Danilo^1,6, danilo.norata@unimi.it

Source: Journal of Cell Biology; 11/7/2022, Vol. 221 Issue 11, p1-18, 26p

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction.

Authors: Dalt, Lorenzo Da, Castiglioni, Laura, Baragetti, Andrea, Audano, Matteo, Svecla, Monika, Bonacina, Fabrizia, Pedretti, Silvia, Uboldi, Patrizia, Benzoni, Patrizia, Giannetti, Federica, Barbuti, Andrea, Pellegatta, Fabio, Indino, Serena, Donetti, Elena, Sironi, Luigi, Mitro, Nico, Catapano, Alberico Luigi, Norata, Giuseppe Danilo

Source: European Heart Journal; 8/21/2021, Vol. 42 Issue 32, p3078-3090, 13p

Subject Terms: LOW density lipoproteins, BLOOD lipoproteins, HEART metabolism, HEART failure, HEART diseases