Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Authors: Smith, Cameron J. ^{1, ‡}, Eavis, Heledd ^{1, ‡}, Briggs, Carla ¹, Henrici, Ryan ², Karpiyevich, Maryia ¹, Ansbro, Megan R. ³, Hoshizaki, Johanna ³, van der Heden van Noort, Gerbrand J. ⁴, Ascher, David B. ⁵, Sutherland, Colin J. ², Lee, Marcus C.S. ^{3, 6}, Artavanis-Tsakonas, Katerina ^{1, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

The spread of molecular markers of artemisinin partial resistance and diagnostic evasion in Eritrea: a retrospective molecular epidemiology study

Authors: Mihreteab, Selam ^a, Anderson, Karen ^{b, c}, Fuente, Irene Molina de la ^{d, e}, Sutherland, Colin J. ^f, Smith, David ^{b, c}, Cunningham, Jane ^g, Beshir, Khalid B. ^{f, ∗∗}, Cheng, Qin ^{b, c, ∗}

Source: In The Lancet Microbe February 2025 6(2)

Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study

Authors: Beshir, Khalid B, Muwanguzi, Julian, Nader, Johanna, Mansukhani, Raoul, Traore, Aliou, Gamougam, Kadidja, Ceesay, Sainey, Bazie, Thomas, Kolie, Fassou, Lamine, Mahaman M, Cairns, Matt, Snell, Paul, Scott, Susana, Diallo, Abdoulaye, Merle, Corinne S, NDiaye, Jean Louis, Razafindralambo, Lanto, Moroso, Diego, Ouedraogo, Jean-Bosco, Zongo, Issaka, Kessely, Hamit, Doumagoum, Daugla, Bojang, Kalifa, Ceesay, Serign, Loua, Kovana, Maiga, Hamma, Dicko, Alassane, Sagara, Issaka, Laminou, Ibrahim M, Ogboi, Sonny Johnbull, Eloike, Tony, Milligan, Paul, Sutherland, Colin J

Source: Lancet infectious diseases. 23(3):361-370

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183940178.0x000001&indx=1&recIds=ETOCvdc_100183940178.0x000001

Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America

Authors: Ibrahim, Amy, Manko, Emilia, Dombrowski, Jamille G., Campos, Mónica, Benavente, Ernest Diez, Nolder, Debbie, Sutherland, Colin J., Nosten, Francois, Fernandez, Diana, Vélez-Tobón, Gabriel, Castaño, Alberto Tobón, Aguiar, Anna Caroline C., Pereira, Dhelio Batista, da Silva Santos, Simone, Suarez-Mutis, Martha, Di Santi, Silvia Maria, Regina de Souza Baptista, Andrea, Dantas Machado, Ricardo Luiz, Marinho, Claudio R.F., Clark, Taane G., Campino, Susana

Source: In The Lancet Regional Health - Americas February 2023 18

Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species

Authors: van Schalkwyk, Donelly A., Moon, Robert W., Duffey, Maëlle, Leroy, Didier, Sutherland, Colin J.

Source: In International Journal for Parasitology: Drugs and Drug Resistance December 2021 17:5-11

Subpatent Plasmodium with mutant pfmdr1, pfcrt, and pvmdr1 alleles from endemic provinces in Mindanao, the Philippines: implications for local malaria elimination

Authors: Dacuma, Mary Grace B., Dimalibot, Judeline C., Baril, Joselito A., Allian, Fatima, Bahidjan, Dayang Karna, Mori, Virgilio, Asri, Sukarno, Yadao, Federico, Notario, Walter, Bona, Ernesto, Jr., Jose Barroquillo, Oguike, Mary, Drakeley, Chris, Hallett, Rachel, Sutherland, Colin J.

Source: In International Journal of Infectious Diseases September 2021 110:45-53

Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.

Authors: Ibrahim, Amy, Mohring, Franziska, Manko, Emilia, van Schalkwyk, Donelly A., Phelan, Jody E., Nolder, Debbie, Borrmann, Steffen, Adegnika, Ayola A., Di Santi, Silvia Maria, Alam, Mohammad Shafiul, Mondal, Dinesh, Nosten, Francois, Sutherland, Colin J., Moon, Robert W., Clark, Taane G., Campino, Susana

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-12, 12p

Subject Terms: MEDICAL sciences, MEDICAL genetics, LIFE sciences, MEDICAL microbiology, NUCLEOTIDE sequencing

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Authors: Ngwana-Joseph, Gabrielle C., Phelan, Jody E., Manko, Emilia, Dombrowski, Jamille G., da Silva Santos, Simone, Suarez-Mutis, Martha, Vélez-Tobón, Gabriel, Tobón Castaño, Alberto, Machado, Ricardo Luiz Dantas, Marinho, Claudio R. F., Nolder, Debbie, Nosten, François, Sutherland, Colin J., Campino, Susana, Clark, Taane G.

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: GENOMICS, LIFE sciences, GENETIC regulation, GENETIC transcription regulation, ATP-binding cassette transporters, PLASMODIUM vivax

Population genomics of Plasmodium ovale species in sub-Saharan Africa.

Authors: Carey-Ewend, Kelly, Popkin-Hall, Zachary R., Simkin, Alfred, Muller, Meredith, Hennelly, Chris, He, Wenqiao, Moser, Kara A., Gaither, Claudia, Niaré, Karamoko, Aghakanian, Farhang, Feleke, Sindew, Brhane, Bokretsion G., Phanzu, Fernandine, Kashamuka, Melchior Mwandagalirwa, Aydemir, Ozkan, Sutherland, Colin J., Ishengoma, Deus S., Ali, Innocent M., Ngasala, Billy, Kalonji, Albert

Source: Nature Communications; 11/27/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: WHOLE genome sequencing, TETRAHYDROFOLATE dehydrogenase, GENOMICS, MALARIA prevention, PLASMODIUM

A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

Authors: Grignard, Lynn, Nolder, Debbie, Sepúlveda, Nuno, Berhane, Araia, Mihreteab, Selam, Kaaya, Robert, Phelan, Jody, Moser, Kara, van Schalkwyk, Donelly A., Campino, Susana, Parr, Jonathan B., Juliano, Jonathan J., Chiodini, Peter, Cunningham, Jane, Sutherland, Colin J., Drakeley, Chris, Beshir, Khalid B.

Source: In eBioMedicine May 2020 55

Prevalence of Plasmodium falciparum gametocytaemia in asymptomatic school children before and after treatment with dihydroartemisinin-piperaquine (DP)

Authors: Dinko, Bismarck, Awuah, Dennis, Boampong, Kwadwo, Larbi, John A., Bousema, Teun, Sutherland, Colin J.

Source: Parasite epidemiology and control. 21

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190196893.0x000001&indx=1&recIds=ETOCvdc_100190196893.0x000001

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum

Authors: van Schalkwyk, Donelly A., Blasco, Benjamin, Davina Nuñez, Rocio, Liew, Jonathan W.K., Amir, Amirah, Lau, Yee L., Leroy, Didier, Moon, Robert W., Sutherland, Colin J.

Source: In International Journal for Parasitology: Drugs and Drug Resistance April 2019 9:93-99

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

Authors: Henrici, Ryan C., Sutherland, Colin J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec 01. 115(50), 12556-12558.

Access URL: https://www.jstor.org/stable/26580124

Plasmodium -associated changes in human odor attract mosquitoes

Authors: Robinson, Ailie, Busula, Annette O., Voets, Mirjam A., Beshir, Khalid B., Caulfield, John C., Powers, Stephen J., Verhulst, Niels O., Winskill, Peter, Muwanguzi, Julian, Birkett, Michael A., Smallegange, Renate C., Masiga, Daniel K., Mukabana, W. Richard, Sauerwein, Robert W., Sutherland, Colin J., Bousema, Teun, Pickett, John A., Takken, Willem, Logan, James G., de Boer, Jetske G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 May 01. 115(18), E4209-E4218.

Access URL: https://www.jstor.org/stable/26508769

Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

Authors: Sagara, Issaka, Beavogui, Abdoul Habib, Zongo, Issaka, Soulama, Issiaka, Borghini-Fuhrer, Isabelle, Fofana, Bakary, Traore, Aliou, Diallo, Nouhoum, Diakite, Hamadoun, Togo, Amadou H, Koumare, Sekou, Keita, Mohamed, Camara, Daouda, Somé, Anyirékun F, Coulibaly, Aboubacar S, Traore, Oumar B, Dama, Souleymane, Goita, Siaka, Djimde, Moussa, Bamadio, Amadou, Dara, Niawanlou, Maiga, Hamma, Sidibe, Bouran, Dao, Francois, Coulibaly, Moctar, Alhousseini, Mohamed Lamine, Niangaly, Hamidou, Sangare, Boubou, Diarra, Modibo, Coumare, Samba, Kabore, Moïse J T, Ouattara, San Maurice, Barry, Aissata, Kargougou, Désiré, Diarra, Amidou, Henry, Noelie, Soré, Harouna, Bougouma, Edith C, Thera, Ismaila, Compaore, Yves D, Sutherland, Colin J, Sylla, Malick Minkael, Nikiema, Frederic, Diallo, Mamadou Saliou, Dicko, Alassane, Picot, Stephane, Borrmann, Steffen, Duparc, Stephan, Miller, Robert M, Doumbo, Ogobara K, Shin, Jangsik, Gil, Jose Pedro, Björkman, Anders, Ouedraogo, Jean-Bosco, Sirima, Sodiomon B, Djimde, Abdoulaye A

Source: In The Lancet 7-13 April 2018 391(10128):1378-1390

Transient temperature fluctuations severely decrease P. falciparum susceptibility to artemisinin in vitro

Authors: Henrici, Ryan C., van Schalkwyk, Donelly A., Sutherland, Colin J.

Source: International journal for parasitology.Drugs and drug resistance. 9:23-26

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078637658.0x000001&indx=1&recIds=ETOCvdc_100078637658.0x000001

Parasite clearance dynamics in children hospitalised with severe malaria in the Ho Teaching Hospital, Volta Region, Ghana

Authors: Paris, Laura, Tackie, Richmond G., Beshir, Khalid B., Tampuori, John, Awandare, Gordon A., Binka, Fred N., Urban, Britta C., Dinko, Bismarck, Sutherland, Colin J.

Source: Parasite epidemiology and control. 19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177483265.0x000001&indx=1&recIds=ETOCvdc_100177483265.0x000001

Contribution of Plasmodium knowlesi to Multispecies Human Malaria Infections in North Sumatera, Indonesia

Authors: Lubis, Inke N. D., Wijaya, Hendri, Lubis, Munar, Lubis, Chairuddin P., Divis, Paul C. S., Beshir, Khalid B., Sutherland, Colin J.

Source: The Journal of Infectious Diseases, 2017 Apr 01. 215(7), 1148-1155.

Access URL: http://www.jstor.org/stable/26166982

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Authors: Ashton, Trent D., Calic, Petar P. S., Dans, Madeline G., Ooi, Zi Kang, Zhou, Qingmiao, Palandri, Josephine, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Maity, Bikash Chandra, De, Nirupam, Giannangelo, Carlo, MacRaild, Christopher A., Creek, Darren J., Mao, Emma Y., Gancheva, Maria R., Wilson, Danny W., Chowdury, Mrittika, de Koning-Ward, Tania F., Famodimu, Mufuliat T., Delves, Michael J., Pollard, Harry, Sutherland, Colin J., Baud, Delphine, Brand, Stephen, Jackson, Paul F., Cowman, Alan F., Sleebs, Brad E.

Source: Journal of Medicinal Chemistry; August 2024, Vol. 67 Issue: 16 p14493-14523, 31p

Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology.

Authors: Mousa, Andria, Cuomo-Dannenburg, Gina, Thompson, Hayley A., Chico, R. Matthew, Beshir, Khalid B., Sutherland, Colin J., Schellenberg, David, Gosling, Roly, Alifrangis, Michael, Hocke, Emma Filtenborg, Hansson, Helle, Chopo-Pizarro, Ana, Mbacham, Wilfred F., Ali, Innocent M., Chaponda, Mike, Roper, Cally, Okell, Lucy C.

Source: PLoS Medicine; 5/9/2024, Vol. 21 Issue 5, p1-18, 18p

Subject Terms: CHEMOPREVENTION, DRUG resistance, MARKOV chain Monte Carlo, MALARIA

Company/Entity: WORLD Health Organization