Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

Authors: Smith, Cameron J. ^{1, ‡}, Eavis, Heledd ^{1, ‡}, Briggs, Carla ¹, Henrici, Ryan ², Karpiyevich, Maryia ¹, Ansbro, Megan R. ³, Hoshizaki, Johanna ³, van der Heden van Noort, Gerbrand J. ⁴, Ascher, David B. ⁵, Sutherland, Colin J. ², Lee, Marcus C.S. ^{3, 6}, Artavanis-Tsakonas, Katerina ^{1, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

The spread of molecular markers of artemisinin partial resistance and diagnostic evasion in Eritrea: a retrospective molecular epidemiology study

Authors: Mihreteab, Selam ^a, Anderson, Karen ^{b, c}, Fuente, Irene Molina de la ^{d, e}, Sutherland, Colin J. ^f, Smith, David ^{b, c}, Cunningham, Jane ^g, Beshir, Khalid B. ^{f, ∗∗}, Cheng, Qin ^{b, c, ∗}

Source: In The Lancet Microbe February 2025 6(2)

Prevalence of Plasmodium falciparum haplotypes associated with resistance to sulfadoxine–pyrimethamine and amodiaquine before and after upscaling of seasonal malaria chemoprevention in seven African countries: a genomic surveillance study

Authors: Beshir, Khalid B, Muwanguzi, Julian, Nader, Johanna, Mansukhani, Raoul, Traore, Aliou, Gamougam, Kadidja, Ceesay, Sainey, Bazie, Thomas, Kolie, Fassou, Lamine, Mahaman M, Cairns, Matt, Snell, Paul, Scott, Susana, Diallo, Abdoulaye, Merle, Corinne S, NDiaye, Jean Louis, Razafindralambo, Lanto, Moroso, Diego, Ouedraogo, Jean-Bosco, Zongo, Issaka, Kessely, Hamit, Doumagoum, Daugla, Bojang, Kalifa, Ceesay, Serign, Loua, Kovana, Maiga, Hamma, Dicko, Alassane, Sagara, Issaka, Laminou, Ibrahim M, Ogboi, Sonny Johnbull, Eloike, Tony, Milligan, Paul, Sutherland, Colin J

Source: Lancet infectious diseases. 23(3):361-370

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183940178.0x000001&indx=1&recIds=ETOCvdc_100183940178.0x000001

Creating and Validating Ligase Primers to Detect Single Nucleotide Polymorphisms Associated with Atovaquone Resistance in Plasmodium falciparum

Authors: Alruwaili, Muharib, Elahi, Rubayet, van Schalkwyk, Donelly, Sutherland, Colin, Shapiro, Theresa, Prigge, Sean, Sullivan, David

Source: American journal of tropical medicine and hygiene. 108(4):777-782

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631915669&indx=1&recIds=ETOCRN631915669

Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America

Authors: Ibrahim, Amy, Manko, Emilia, Dombrowski, Jamille G., Campos, Mónica, Benavente, Ernest Diez, Nolder, Debbie, Sutherland, Colin J., Nosten, Francois, Fernandez, Diana, Vélez-Tobón, Gabriel, Castaño, Alberto Tobón, Aguiar, Anna Caroline C., Pereira, Dhelio Batista, da Silva Santos, Simone, Suarez-Mutis, Martha, Di Santi, Silvia Maria, Regina de Souza Baptista, Andrea, Dantas Machado, Ricardo Luiz, Marinho, Claudio R.F., Clark, Taane G., Campino, Susana

Source: In The Lancet Regional Health - Americas February 2023 18

Generation of Plasmodium falciparum Gametocytes In Vitro with Specific Considerations for Field Isolates

Authors: Dinko, Bismarck, Tackie, Richmond, Henriques, Gisela, Stewart, Lindsay, Sutherland, Colin

Source: Methods in molecular biology. 2470:121-132

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629841993&indx=1&recIds=ETOCRN629841993

Towards an augmented ultrasound guided spinal needle insertion system

Authors: Sutherland, Colin, Hashtrudi-Zaad, Keyvan, Abolmaesumi, Purang, Mousavi, Parvin

Source: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. :3459-3462 Aug, 2011

Relation: 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Ex vivo susceptibility to new antimalarial agents differs among human-infecting Plasmodium species

Authors: van Schalkwyk, Donelly A., Moon, Robert W., Duffey, Maëlle, Leroy, Didier, Sutherland, Colin J.

Source: In International Journal for Parasitology: Drugs and Drug Resistance December 2021 17:5-11

Subpatent Plasmodium with mutant pfmdr1, pfcrt, and pvmdr1 alleles from endemic provinces in Mindanao, the Philippines: implications for local malaria elimination

Authors: Dacuma, Mary Grace B., Dimalibot, Judeline C., Baril, Joselito A., Allian, Fatima, Bahidjan, Dayang Karna, Mori, Virgilio, Asri, Sukarno, Yadao, Federico, Notario, Walter, Bona, Ernesto, Jr., Jose Barroquillo, Oguike, Mary, Drakeley, Chris, Hallett, Rachel, Sutherland, Colin J.

Source: In International Journal of Infectious Diseases September 2021 110:45-53

Failure of rapid diagnostic tests in Plasmodium falciparum malaria cases among travelers to the UK and Ireland: Identification and characterisation of the parasites

Authors: Nolder, Debbie, Stewart, Lindsay, Tucker, Julie, Ibrahim, Amy, Gray, Adam, Corrah, Tumena, Gallagher, Carmel, John, Laurence, O’Brien, Edel, Aggarwal, Dinesh, Benavente, Ernest Diez, van Schalkwyk, Donelly, Henriques, Gisela, Sepúlveda, Nuno, Campino, Susana, Chiodini, Peter, Sutherland, Colin, Beshir, Khalid B.

Source: In International Journal of Infectious Diseases July 2021 108:137-144

Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.

Authors: Ibrahim, Amy, Mohring, Franziska, Manko, Emilia, van Schalkwyk, Donelly A., Phelan, Jody E., Nolder, Debbie, Borrmann, Steffen, Adegnika, Ayola A., Di Santi, Silvia Maria, Alam, Mohammad Shafiul, Mondal, Dinesh, Nosten, Francois, Sutherland, Colin J., Moon, Robert W., Clark, Taane G., Campino, Susana

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-12, 12p

Subject Terms: MEDICAL sciences, MEDICAL genetics, LIFE sciences, MEDICAL microbiology, NUCLEOTIDE sequencing

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Authors: Ngwana-Joseph, Gabrielle C., Phelan, Jody E., Manko, Emilia, Dombrowski, Jamille G., da Silva Santos, Simone, Suarez-Mutis, Martha, Vélez-Tobón, Gabriel, Tobón Castaño, Alberto, Machado, Ricardo Luiz Dantas, Marinho, Claudio R. F., Nolder, Debbie, Nosten, François, Sutherland, Colin J., Campino, Susana, Clark, Taane G.

Source: Nature Communications; 12/30/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: GENOMICS, LIFE sciences, GENETIC regulation, GENETIC transcription regulation, ATP-binding cassette transporters, PLASMODIUM vivax

Population genomics of Plasmodium ovale species in sub-Saharan Africa.

Authors: Carey-Ewend, Kelly, Popkin-Hall, Zachary R., Simkin, Alfred, Muller, Meredith, Hennelly, Chris, He, Wenqiao, Moser, Kara A., Gaither, Claudia, Niaré, Karamoko, Aghakanian, Farhang, Feleke, Sindew, Brhane, Bokretsion G., Phanzu, Fernandine, Kashamuka, Melchior Mwandagalirwa, Aydemir, Ozkan, Sutherland, Colin J., Ishengoma, Deus S., Ali, Innocent M., Ngasala, Billy, Kalonji, Albert

Source: Nature Communications; 11/27/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: WHOLE genome sequencing, TETRAHYDROFOLATE dehydrogenase, GENOMICS, MALARIA prevention, PLASMODIUM

Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study

Authors: Baba, Ebenezer, Hamade, Prudence, Kivumbi, Harriet, Marasciulo, Maddy, Maxwell, Kolawole, Moroso, Diego, Roca-Feltrer, Arantxa, Sanogo, Adama, Stenstrom Johansson, Joanna, Tibenderana, James, Abdoulaye, Rahila, Coulibaly, Patrice, Hubbard, Eric, Jah, Huja, Lama, Eugene Kaman, Razafindralambo, Lantorina, Van Hulle, Suzanne, Jagoe, George, Tchouatieu, André-Marie, Collins, David, Gilmartin, Colin, Tetteh, Gladys, Djibo, Yacine, Ndiaye, Fara, Kalleh, Momodou, Kandeh, Balla, Audu, Bala, Ntadom, Godwin, Kiba, Alice, Savodogo, Yacouba, Boulotigam, Kodbesse, Sougoudi, Djiddi Ali, Guilavogui, Timothee, Keita, Moussa, Kone, Diakalidia, Jackou, Hadiza, Ouba, Ibrahim, Ouedraogo, Emile, Messan, Halimatou Alassana, Jah, Fatou, Kaira, Markieu Janneh, Sano, Mariama Sire, Traore, Mamadou Chérif, Ngarnaye, Nadine, Elagbaje, Aishatu Yinusa Cassandra, Halleux, Christine, Merle, Corinne, Iessa, Noha, Pal, Shanthi, Sefiani, Houda, Souleymani, Rachida, Laminou, Ibrahim, Doumagoum, Daugla, Kesseley, Hamit, Coldiron, Matt, Grais, Rebecca, Kana, Musa, Ouedraogo, Jean Bosco, Zongo, Issaka, Eloike, Tony, Ogboi, Sonny Johnbull, Achan, Jane, Bojang, Kalifa, Ceesay, Serign, Dicko, Alassane, Djimde, Abdoulaye, Sagara, Issaka, Diallo, Abdoulaye, NdDiaye, Jean Louis, Loua, Kovana Marcel, Beshir, Khalid, Cairns, Matt, Fernandez, Yolanda, Lal, Sham, Mansukhani, Raoul, Muwanguzi, Julian, Scott, Susana, Snell, Paul, Sutherland, Colin, Tuta, Rhosyn, Milligan, Paul

Source: In The Lancet 5-11 December 2020 396(10265):1829-1840

A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

Authors: Grignard, Lynn, Nolder, Debbie, Sepúlveda, Nuno, Berhane, Araia, Mihreteab, Selam, Kaaya, Robert, Phelan, Jody, Moser, Kara, van Schalkwyk, Donelly A., Campino, Susana, Parr, Jonathan B., Juliano, Jonathan J., Chiodini, Peter, Cunningham, Jane, Sutherland, Colin J., Drakeley, Chris, Beshir, Khalid B.

Source: In eBioMedicine May 2020 55

Prevalence of Plasmodium falciparum gametocytaemia in asymptomatic school children before and after treatment with dihydroartemisinin-piperaquine (DP)

Authors: Dinko, Bismarck, Awuah, Dennis, Boampong, Kwadwo, Larbi, John A., Bousema, Teun, Sutherland, Colin J.

Source: Parasite epidemiology and control. 21

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190196893.0x000001&indx=1&recIds=ETOCvdc_100190196893.0x000001

Plasmodium knowlesi exhibits distinct in vitro drug susceptibility profiles from those of Plasmodium falciparum

Authors: van Schalkwyk, Donelly A., Blasco, Benjamin, Davina Nuñez, Rocio, Liew, Jonathan W.K., Amir, Amirah, Lau, Yee L., Leroy, Didier, Moon, Robert W., Sutherland, Colin J.

Source: In International Journal for Parasitology: Drugs and Drug Resistance April 2019 9:93-99

Parasite clearance and protection from Plasmodium falciparum infection (PCPI): a three-arm, parallel, double-blinded, placebo-controlled, randomised trial of presumptive sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine plus amodiaquine versus artesunate monotherapy among asymptomatic children 3–5 years of age in Cameroon

Authors: Martinez-Vega, Rosario, Mbacham, Wilfred Fon, Ali, Innocent, Nji, Akindeh, Mousa, Andria, Beshir, Khalid B., Chopo-Pizarro, Ana, Kaur, Harparkash, Okell, Lucy, Hansson, Helle, Hocke, Emma Filtenborg, Alifrangis, Michael, Gosling, Roland, Roper, Cally, Sutherland, Colin, Chico, R. Matthew

Source: BMC Infectious Diseases; 9/26/2024, Vol. 24 Issue 1, p1-12, 12p

Subject Terms: POLYMERASE chain reaction, MALARIA, PLASMODIUM falciparum, CHEMOPREVENTION, RESEARCH protocols

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

Authors: Henrici, Ryan C., Sutherland, Colin J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Dec 01. 115(50), 12556-12558.

Access URL: https://www.jstor.org/stable/26580124

Plasmodium -associated changes in human odor attract mosquitoes

Authors: Robinson, Ailie, Busula, Annette O., Voets, Mirjam A., Beshir, Khalid B., Caulfield, John C., Powers, Stephen J., Verhulst, Niels O., Winskill, Peter, Muwanguzi, Julian, Birkett, Michael A., Smallegange, Renate C., Masiga, Daniel K., Mukabana, W. Richard, Sauerwein, Robert W., Sutherland, Colin J., Bousema, Teun, Pickett, John A., Takken, Willem, Logan, James G., de Boer, Jetske G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 May 01. 115(18), E4209-E4218.

Access URL: https://www.jstor.org/stable/26508769