Atomic Description of an Enzyme Reaction Dominated by Proton Tunneling

Authors: Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O., Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E., Mulholland, Adrian J., Sutcliffe, Michael J., Scrutton, Nigel S., Leys, David

Source: Science, 2006 Apr . 312(5771), 237-241.

Access URL: https://www.jstor.org/stable/3846037

Enzymology Takes a Quantum Leap Forward

Authors: Sutcliffe, Michael J., Scrutton, Nigel S.

Source: Philosophical Transactions: Mathematical, Physical and Engineering Sciences, 2000 Jan 01. 358(1766), 367-386.

Access URL: https://www.jstor.org/stable/2666859

To What Extent Is Capital Expenditure in UK Higher Education Meeting the Pedagogical Needs of Staff and Students?

Authors: Jones, Steven, Sutcliffe, Michael J., Bragg, Joanna, Harris, Diane

Source: Journal of Higher Education Policy and Management. 2016 38(4):477-489.

Peer Reviewed: Y

Page Count: 13

Descriptors: Foreign Countries, Higher Education, Expenditures, Resource Allocation, Building Design, Interviews, Teacher Attitudes, Student Attitudes, Interaction, College Environment, Learning Experience, Teacher Student Relationship, Outcomes of Education, Learner Engagement, Sense of Community, Transitional Programs, Alignment (Education), Online Surveys, Focus Groups

Geographic Terms: United Kingdom

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

Authors: Stevenson, Bradley J., Bibby, Jaclyn, Pignatelli, Patricia, Muangnoicharoen, Sant, O’Neill, Paul M., Lian, Lu-Yun, Müller, Pie, Nikou, Dimitra, Steven, Andrew, Hemingway, Janet, Sutcliffe, Michael J., Paine, Mark J.I.

Source: In Insect Biochemistry and Molecular Biology July 2011 41(7):492-502

Promoting Motions in Enzyme Catalysis Probed by Pressure Studies of Kinetic Isotope Effects

Authors: Hay, Sam, Sutcliffe, Michael J., Scrutton, Nigel S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Jan 01. 104(2), 507-512.

Access URL: https://www.jstor.org/stable/25426132

Hydrogen Tunnelling in Enzyme-Catalysed H-Transfer Reactions: Flavoprotein and Quinoprotein Systems

Authors: Sutcliffe, Michael J., Masgrau, Laura, Roujeinikova, Anna, Johannissen, Linus O., Hothi, Parvinder, Basran, Jaswir, Ranaghan, Kara E., Mulholland, Adrian J., Leys, David, Scrutton, Nigel S.

Source: Philosophical Transactions: Biological Sciences, 2006 Aug . 361(1472), 1375-1386.

Access URL: https://www.jstor.org/stable/20209733

Barrier Compression and Its Contribution to Both Classical and Quantum Mechanical Aspects of Enzyme Catalysis

Authors: Hay, Sam, Johannissen, Linus O., Sutcliffe, Michael J., Scrutton, Nigel S.

Source: In Biophysical Journal 2010 98(1):121-128

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Authors: Kapelyukh, Yury ¹, Paine, Mark J.I. ², Maréchal, Jean-Didier ³, Sutcliffe, Michael J. ⁴, Wolf, C. Roland, Roberts, Gordon C.K. ^*

Source: In Drug Metabolism and Disposition October 2008 36(10):2136-2144

Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X2 and P2X4 Receptors Support a Core Common Mode of ATP Action at P2X Receptors

Authors: Roberts, Jonathan A., Digby, Helen R., Kara, Madina, Ajouz, Sam El, Sutcliffe, Michael J., Evans, Richard J.

Source: In Journal of Biological Chemistry 18 July 2008 283(29):20126-20136

Activation Gating of hERG Potassium Channels: S6 GLYCINES ARE NOT REQUIRED AS GATING HINGES

Authors: Hardman, Rachael M., Stansfeld, Phillip J., Dalibalta, Sarah, Sutcliffe, Michael J., Mitcheson, John S.

Source: In Journal of Biological Chemistry 2 November 2007 282(44):31972-31981

New Insights into the Reductive Half-reaction Mechanism of Aromatic Amine Dehydrogenase Revealed by Reaction with Carbinolamine Substrates

Authors: Roujeinikova, Anna, Hothi, Parvinder, Masgrau, Laura, Sutcliffe, Michael J., Scrutton, Nigel S., Leys, David

Source: In Journal of Biological Chemistry 17 August 2007 282(33):23766-23777

IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE

Authors: Yu, Jinglei ¹, Paine, Mark J.I. ¹, Maréchal, Jean-Didier, Kemp, Carol A., Ward, Clive J., Brown, Simon, Sutcliffe, Michael J., Roberts, Gordon C.K., Rankin, Elaine M., Wolf, C. Roland ^*

Source: In Drug Metabolism and Disposition August 2006 34(8):1386-1392

IN SILICO AND IN VITRO SCREENING FOR INHIBITION OF CYTOCHROME P450 CYP3A4 BY COMEDICATIONS COMMONLY USED BY PATIENTS WITH CANCER

Authors: Marechal, Jean-Didier, Yu, Jinglei, Brown, Simon, Kapelioukh, Iouri, Rankin, Elaine M., Wolf, C. Roland, Roberts, Gordon C.K., Paine, Mark. J.I., Sutcliffe, Michael J. ^*

Source: In Drug Metabolism and Disposition April 2006 34(4):534-538

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Authors: Perry, Matthew, Stansfeld, Phillip J., Leaney, Joanne, Wood, Claire, de Groot, Marcel J., Leishman, Derek, Sutcliffe, Michael J., Mitcheson, John S. ^*

Source: In Molecular Pharmacology February 2006 69(2):509-519

The preponderance of P450s in the Mycobacterium tuberculosis genome

Authors: McLean, Kirsty J., Clift, Daniel, Lewis, D. Geraint, Sabri, Muna, Balding, Philip R., Sutcliffe, Michael J., Leys, David, Munro, Andrew W.

Source: In Trends in Microbiology 2006 14(5):220-228

Direct Analysis of Donor-Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions.

Authors: Pudney, Christopher R., Johannissen, Linus O., Sutcliffe, Michael J.

Source: Journal of the American Chemical Society; August 18 2010, Vol. 132 Issue 32, p11329-11335, 7p

Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?: THE ROLE OF KEY ACTIVE-SITE RESIDUES IN QUINIDINE BINDING

Authors: McLaughlin, Lesley A. ^{‡, 1}, Paine, Mark J.I. ^{‡, 1}, Kemp, Carol A. ^§, Maréchal, Jean-Didier ^{§, ¶}, Flanagan, Jack U. ^‡, Ward, Clive J. ^‡, Sutcliffe, Michael J. ^{§, ¶}, Roberts, Gordon C.K. ^{§, 2}, Wolf, C. Roland ^{‡, 3}

Source: In Journal of Biological Chemistry 18 November 2005 280(46):38617-38624

Role of Active Site Residues and Solvent in Proton Transfer and the Modulation of Flavin Reduction Potential in Bacterial Morphinone Reductase

Authors: Messiha, Hanan L. ^‡, Bruce, Neil C. ^§, Sattelle, Benedict M. ^‡, Sutcliffe, Michael J. ^‡, Munro, Andrew W., Scrutton, Nigel S.

Source: In Journal of Biological Chemistry 22 July 2005 280(29):27103-27110

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models.

Authors: Pudney, Christopher R., Hay, Sam, Sutcliffe, Michael J.

Source: Journal of the American Chemical Society; November 1 2006, Vol. 128 Issue 43, p14053-14058, 6p

Progress in cytochrome P450 active site modeling

Authors: Kemp, Carol A., Maréchal, Jean-Didier, Sutcliffe, Michael J. ^*

Source: In Archives of Biochemistry and Biophysics 2005 433(2):361-368