Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri.

Authors: Malych, Ronald¹, Folgosa, Filipe², Pilátová, Jana^3,4,5, Mikeš, Libor⁶, Dohnálek, Vít¹, Mach, Jan¹, Matějková, Magdaléna¹, Kopecký, Vladimír³, Doležal, Pavel¹, Sutak, Robert¹, sutak@natur.cuni.cz

Source: PLoS Pathogens; 3/17/2025, Vol. 21 Issue 3, p1-29, 29p

The protist cultural renaissance

Authors: del Campo, Javier, Carlos-Oliveira, Maria, Čepička, Ivan, Hehenberger, Elisabeth, Horák, Aleš, Karnkowska, Anna, Kolisko, Martin, Lara, Enrique, Lukeš, Julius, Pánek, Tomáš, Piwosz, Kasia, Richter, Daniel J., Škaloud, Pavel, Sutak, Robert, Tachezy, Jan, Hampl, Vladimír

Source: In Trends in Microbiology February 2024 32(2):128-131

Copper in parasitic protists – a hitherto neglected virulence factor

Authors: Grechnikova, Maria, Füssy, Zoltán, Sutak, Robert

Source: In Trends in Parasitology January 2024 40(1):5-9

Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate Amphidinium carterae

Authors: Malych, Ronald, Stopka, Pavel, Mach, Jan, Kotabová, Eva, Prášil, Ondřej, Sutak, Robert

Source: Computational and Structural Biotechnology Journal. 20:287-295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190063583.0x000001&indx=1&recIds=ETOCvdc_100190063583.0x000001

Elucidation of iron homeostasis in Acanthamoeba castellanii

Authors: Grechnikova, Maria, Arbon, Dominik, Ženíšková, Kateřina, Malych, Ronald, Mach, Jan, Krejbichová, Lucie, Šimáčková, Aneta, Sutak, Robert

Source: International journal for parasitology. 52(8):497-508

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166667278.0x000001&indx=1&recIds=ETOCvdc_100166667278.0x000001

Molecular Mechanisms of Acanthamoeba castellanii Response to Different Sources of Oxidative Stress.

Authors: Ženíšková, Kateřina, Stopka, Pavel, Martín-Pérez, Tania, Chevreux, Guillaume, Grechnikova, Maria, Drncová, Eliška, Malych, Ronald, Mach, Jan, Walochnik, Julia, Camadro, Jean-Michel, Sutak, Robert

Source: Journal of Proteome Research; 2/7/2025, Vol. 24 Issue 2, p449-458, 10p

A cytosolic ferredoxin-independent hydrogenase possibly mediates hydrogen uptake in Trichomonas vaginalis

Authors: Smutná, Tamara, Dohnálková, Alena, Sutak, Róbert, Narayanasamy, Ravi Kumar, Tachezy, Jan, Hrdý, Ivan

Source: In Current Biology 10 January 2022 32(1):124-135

Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system

Authors: Grechnikova, Maria, Ženíšková, Kateřina, Malych, Ronald, Mach, Jan, Sutak, Robert

Source: In International Journal for Parasitology: Drugs and Drug Resistance December 2020 14:126-135

Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone

Authors: Bae, Dong-Hun, Lane, Darius J.R., Siafakas, Aritee R., Sutak, Robert, Paluncic, Jasmina, Huang, Michael L.H., Jansson, Patric J., Rahmanto, Yohan Suryo, Richardson, Des R.

Source: In BBA - Molecular Basis of Disease 1 October 2020 1866(10)

Iron in parasitic protists – from uptake to storage and where we can interfereElectronic supplementary information (ESI) available: The result of bioinformatic search for selected groups of proteins important in the iron metabolism pathway. The HMM search146 was performed using MyHMMER script kindly provided by Vojtěch Žárský (Department of Parasitology, Faculty of Science, Charles University in Prague) using alignments of known homologs present in Pfam database in 2019.147 See DOI: 10.1039/d0mt00125b

Authors: Mach, Jan, Sutak, Robert

Source: Metallomics. 12(9):1335-1347

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110477179.0x000001&indx=1&recIds=ETOCvdc_100110477179.0x000001

Staurosporine as a Potential Treatment for Acanthamoeba Keratitis Using Mouse Cornea as an Ex Vivo Model.

Authors: Rodríguez-Expósito, Rubén L., Sifaoui, Ines, Salazar-Villatoro, Lizbeth, Bethencourt-Estrella, Carlos J., Fernández, José J., Díaz-Marrero, Ana R., Sutak, Robert, Omaña-Molina, Maritza, Piñero, José E., Lorenzo-Morales, Jacob

Source: Marine Drugs; Sep2024, Vol. 22 Issue 9, p423, 12p

Iron economy in Naegleria gruberi reflects its metabolic flexibility

Authors: Mach, Jan, Bíla, Jarmila, Ženíšková, Kateřina, Arbon, Dominik, Malych, Ronald, Glavanakovová, Marie, Nývltová, Eva, Sutak, Robert

Source: In International Journal for Parasitology August 2018 48(9-10):719-727

Giardia Mitosomes and Trichomonad Hydrogenosomes Share a Common Mode of Protein Targeting

Authors: Dolezal, Pavel, Smid, Ondrej, Rada, Petr, Zubácová, Zuzana, Bursać, Dejan, Suták, Robert, Nebesárová, Jana, Lithgow, Trevor, Tachezy, Jan, Palmer, Jeffrey D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 01. 102(31), 10924-10929.

Access URL: https://www.jstor.org/stable/3376193

Copper and iron metabolism in Ostreococcus tauri – the role of phytotransferrin, plastocyanin and a chloroplast copper-transporting ATPaseElectronic supplementary information (ESI) available. See DOI: 10.1039/c9mt00078j

Authors: Scheiber, Ivo Florin, Pilátová, Jana, Malych, Ronald, Kotabova, Eva, Krijt, Matyáš, Vyoral, Daniel, Mach, Jan, Léger, Thibaut, Camadro, Jean-Michel, Prášil, Ondřej, Lesuisse, Emmanuel, Sutak, Robert

Source: Metallomics. 11(10):1657-1666

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090956186.0x000001&indx=1&recIds=ETOCvdc_100090956186.0x000001

In vivo localization of iron starvation induced proteins under variable iron supplementation regimes in Phaeodactylum tricornutum

Authors: Kazamia, Elena, Mach, Jan, McQuaid, Jeffrey B., Gao, Xia, Coale, Tyler H., Malych, Ronald, Camadro, Jean‐Michel, Lesuisse, Emmanuel, Allen, Andrew E., Bowler, Chris, Sutak, Robert

Source: Plant direct. 6(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169073690.0x000001&indx=1&recIds=ETOCvdc_100169073690.0x000001

Mitochondrial-Type Assembly of FeS Centers in the Hydrogenosomes of the Amitochondriate Eukaryote Trichomonas vaginalis

Authors: Sutak, Robert, Dolezal, Pavel, Fiumera, Heather L., Hrdy, Ivan, Dancis, Andrew, Delgadillo-Correa, Maria, Johnson, Patricia J., Müller, Miklós, Tachezy, Jan, Trager, William

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Jul . 101(28), 10368-10373.

Access URL: https://www.jstor.org/stable/3372898

Amoebicidal Effect of COVID Box Molecules against Acanthamoeba : A Study of Cell Death.

Authors: Sifaoui, Ines, Rodríguez-Expósito, Rubén L., Reyes-Batlle, María, Sutak, Robert, Piñero, José E., Lorenzo-Morales, Jacob

Source: Pharmaceuticals (14248247); Jun2024, Vol. 17 Issue 6, p808, 17p

Subject Terms: ACANTHAMOEBA, CELL death, ACANTHAMOEBA castellanii, APOPTOSIS, COVID-19

Chelation of Mitochondrial Iron as an Antiparasitic Strategy.

Authors: Arbon, Dominik, Mach, Jan, Čadková, Aneta, Sipkova, Anna, Stursa, Jan, Klanicová, Kristýna, Machado, Marta, Ganter, Markus, Levytska, Viktoriya, Sojka, Daniel, Truksa, Jaroslav, Werner, Lukáš, Sutak, Robert

Source: ACS Infectious Diseases; 2/9/2024, Vol. 10 Issue 2, p676-687, 12p

Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton

Authors: Botebol, Hugo, Lesuisse, Emmanuel, Šuták, Robert, Six, Christophe, Lozano, Jean-Claude, Schatt, Philippe, Vergé, Valérie, Kirilovsky, Amos, Morrissey, Joe, Léger, Thibaut, Camadro, Jean-Michel, Gueneugues, Audrey, Bowler, Chris, Blain, Stéphane, Bouget, François-Yves

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Nov . 112(47), 14652-14657.

Access URL: https://www.jstor.org/stable/26465873

Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline.

Authors: Rodríguez-Expósito, Rubén L., Sifaoui, Ines, Reyes-Batlle, María, Fuchs, Frieder, Scheid, Patrick L., Piñero, José E., Sutak, Robert, Lorenzo-Morales, Jacob

Source: Antioxidants; Dec2023, Vol. 12 Issue 12, p2081, 18p

Subject Terms: APOPTOSIS, ACANTHAMOEBA, CELL permeability, AUTOPHAGY, PROTEIN overexpression