Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence

Authors: Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

Source: Microbiology Spectrum, Vol 13, Iss 2 (2025)

Subject Terms: Acanthamoeba castellanii, Candida auris, interactions, virulence, resistance, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/bdf45f8c2702497f890842ebedcb0763

Comprehensive characterization of extracellular vesicles produced by environmental (Neff) and clinical (T4) strains of Acanthamoeba castellanii

Authors: Elisa Gonçalves Medeiros, Michele Ramos Valente, Leandro Honorato, Marina da Silva Ferreira, Susana Ruiz Mendoza, Diego de Souza Gonçalves, Lucas Martins Alcântara, Kamilla Xavier Gomes, Marcia Ribeiro Pinto, Ernesto S. Nakayasu, Geremy Clair, Isadora Filipaki Munhoz da Rocha, Flavia C. G. dos Reis, Marcio L. Rodrigues, Lysangela R. Alves, Leonardo Nimrichter, Arturo Casadevall, Allan Jefferson Guimarães

Source: mSystems, Vol 9, Iss 6 (2024)

Subject Terms: Acanthamoeba castellanii, extracelular vesicles, mPLEX, Neff, T4, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/6d88a4b62eab476089b31eb9bf95d733

The Psychological Science Accelerator’s COVID-19 rapid-response dataset

Authors: Erin M. Buchanan, Savannah C. Lewis, Bastien Paris, Patrick S. Forscher, Jeffrey M. Pavlacic, Julie E. Beshears, Shira Meir Drexler, Amélie Gourdon-Kanhukamwe, Peter R Mallik, Miguel Alejandro A. Silan, Jeremy K. Miller, Hans IJzerman, Hannah Moshontz, Jennifer L. Beaudry, Jordan W. Suchow, Christopher R. Chartier, Nicholas A. Coles, MohammadHasan Sharifian, Anna Louise Todsen, Carmel A. Levitan, Flávio Azevedo, Nicole Legate, Blake Heller, Alexander J. Rothman, Charles A. Dorison, Brian P. Gill, Ke Wang, Vaughan W. Rees, Nancy Gibbs, Amit Goldenberg, Thuy-vy Thi Nguyen, James J. Gross, Gwenaêl Kaminski, Claudia C. von Bastian, Mariola Paruzel-Czachura, Farnaz Mosannenzadeh, Soufian Azouaghe, Alexandre Bran, Susana Ruiz-Fernandez, Anabela Caetano Santos, Niv Reggev, Janis H. Zickfeld, Handan Akkas, Myrto Pantazi, Ivan Ropovik, Max Korbmacher, Patrícia Arriaga, Biljana Gjoneska, Lara Warmelink, Sara G. Alves, Gabriel Lins de Holanda Coelho, Stefan Stieger, Vidar Schei, Paul H. P. Hanel, Barnabas Szaszi, Maksim Fedotov, Jan Antfolk, Gabriela-Mariana Marcu, Jana Schrötter, Jonas R. Kunst, Sandra J. Geiger, Adeyemi Adetula, Halil Emre Kocalar, Julita Kielińska, Pavol Kačmár, Ahmed Bokkour, Oscar J. Galindo-Caballero, Ikhlas Djamai, Sara Johanna Pöntinen, Bamikole Emmanuel AGESIN, Teodor Jernsäther, Anum Urooj, Nikolay R. Rachev, Maria Koptjevskaja-Tamm, Murathan Kurfalı, Ilse L. Pit, Ranran Li, Sami Çoksan, Dmitrii Dubrov, Tamar Elise Paltrow, Gabriel Baník, Tatiana Korobova, Anna Studzinska, Xiaoming Jiang, John Jamir Benzon R. Aruta, Jáchym Vintr, Faith Chiu, Lada Kaliska, Jana B. Berkessel, Murat Tümer, Sara Morales-Izquierdo, Hu Chuan-Peng, Kevin Vezirian, Anna Dalla Rosa, Olga Bialobrzeska, Martin R. Vasilev, Julia Beitner, Ondřej Kácha, Barbara Žuro, Minja Westerlund, Mina Nedelcheva-Datsova, Andrej Findor, Dajana Krupić, Marta Kowal, Adrian Dahl Askelund, Razieh Pourafshari, Jasna Milošević Đorđević, Nadya-Daniela Schmidt, Ekaterina Baklanova, Anna Szala, Ilya Zakharov, Marek A. Vranka, Keiko Ihaya, Caterina Grano, Nicola Cellini, Michał Białek, Lisa Anton-Boicuk, Ilker Dalgar, Arca Adıgüzel, Jeroen P. H. Verharen, Princess Lovella G. Maturan, Angelos P. Kassianos, Raquel Oliveira, Martin Čadek, Vera Cubela Adoric, Asil Ali Özdoğru, Therese E. Sverdrup, Balazs Aczel, Danilo Zambrano, Afroja Ahmed, Christian K. Tamnes, Yuki Yamada, Leonhard Volz, Naoyuki Sunami, Lilian Suter, Luc Vieira, Agata Groyecka-Bernard, Julia Arhondis Kamburidis, Ulf-Dietrich Reips, Mikayel Harutyunyan, Gabriel Agboola Adetula, Tara Bulut Allred, Krystian Barzykowski, Benedict G Antazo, Andras N. Zsido, Dušana Dušan Šakan, Wilson Cyrus-Lai, Lina Pernilla Ahlgren, Matej Hruška, Diego Vega, Efisio Manunta, Aviv Mokady, Mariagrazia Capizzi, Marcel Martončik, Nicolas Say, Katarzyna Filip, Roosevelt Vilar, Karolina Staniaszek, Milica Vdovic, Matus Adamkovic, Niklas Johannes, Nandor Hajdu, Noga Cohen, Clara Overkott, Dino Krupić, Barbora Hubena, Gustav Nilsonne, Giovanna Mioni, Claudio Singh Solorzano, Tatsunori Ishii, Zhang Chen, Elizaveta Kushnir, Cemre Karaarslan, Rafael R. Ribeiro, Ahmed Khaoudi, Małgorzata Kossowska, Jozef Bavolar, Karlijn Hoyer, Marta Roczniewska, Alper Karababa, Maja Becker, Renan P. Monteiro, Yoshihiko Kunisato, Irem Metin-Orta, Sylwia Adamus, Luca Kozma, Gabriela Czarnek, Artur Domurat, Eva Štrukelj, Daniela Serrato Alvarez, Michal Parzuchowski, Sébastien Massoni, Johanna Czamanski-Cohen, Ekaterina Pronizius, Fany Muchembled, Kevin van Schie, Aslı Saçaklı, Evgeniya Hristova, Anna O. Kuzminska, Abdelilah Charyate, Gijsbert Bijlstra, Reza Afhami, Nadyanna M. Majeed, Erica D. Musser, Miroslav Sirota, Robert M. Ross, Siu Kit Yeung, Marietta Papadatou-Pastou, Francesco Foroni, Inês A. T. Almeida, Dmitry Grigoryev, David M. G. Lewis, Dawn L. Holford, Steve M. J. Janssen, Srinivasan Tatachari, Carlota Batres, Jonas K. Olofsson, Shimrit Daches, Anabel Belaus, Gerit Pfuhl, Nadia Sarai Corral-Frias, Daniela Sousa, Jan Philipp Röer, Peder Mortvedt Isager, Hendrik Godbersen, Radoslaw B. Walczak, Natalia Van Doren, Dongning Ren, Tripat Gill, Martin Voracek, Lisa M. DeBruine, Michele Anne, Sanja Batić Očovaj, Andrew G. Thomas, Alexios Arvanitis, Thomas Ostermann, Kelly Wolfe, Nwadiogo Chisom Arinze, Carsten Bundt, Claus Lamm, Robert J Calin-Jageman, William E. Davis, Maria Karekla, Saša Zorjan, Lisa M. Jaremka, Jim Uttley, Monika Hricova, Monica A Koehn, Natalia Kiselnikova, Hui Bai, Anthony J. Krafnick, Busra Bahar Balci, Tonia Ballantyne, Samuel Lins, Zahir Vally, Celia Esteban-Serna, Kathleen Schmidt, Paulo Manuel L. Macapagal, Paulina Szwed, Przemysław Marcin Zdybek, David Moreau, W. Matthew Collins, Jennifer A. Joy-Gaba, Iris Vilares, Ulrich S. Tran, Jordane Boudesseul, Nihan Albayrak-Aydemir, Barnaby James Wyld Dixson, Jennifer T Perillo, Ana Ferreira, Erin C. Westgate, Christopher L. Aberson, Azuka Ikechukwu Arinze, Bastian Jaeger, Muhammad Mussaffa Butt, Jaime R. Silva, Daniel Shafik Storage, Allison P Janak, William Jiménez-Leal, Jose A. Soto, Agnieszka Sorokowska, Randy McCarthy, Alexa M Tullett, Martha Frias-Armenta, Matheus Fernando Felix Ribeiro, Andree Hartanto, Paul A. G. Forbes, Megan L. Willis, María del Carmen Tejada R, Adriana Julieth Olaya Torres, Ian D Stephen, David C. Vaidis, Anabel de la Rosa-Gómez, Karen Yu, Clare A. M. Sutherland, Mathi Manavalan, Behzad Behzadnia, Jan Urban, Ernest Baskin, Joseph P. McFall, Chisom Esther Ogbonnaya, Cynthia H. Y. Fu, Rima-Maria Rahal, Izuchukwu L. G. Ndukaihe, Thomas J. Hostler, Heather Barry Kappes, Piotr Sorokowski, Meetu Khosla, Ljiljana B. Lazarevic, Luis Eudave, Johannes K. Vilsmeier, Elkin O. Luis, Rafał Muda, Elena Agadullina, Rodrigo A. Cárcamo, Crystal Reeck, Gulnaz Anjum, Mónica Camila Toro Venegas, Michal Misiak, Richard M. Ryan, Nora L. Nock, Giovanni A. Travaglino, Michael C. Mensink, Gilad Feldman, Aaron L. Wichman, Weilun Chou, Ignazio Ziano, Martin Seehuus, William J. Chopik, Franki Y. H. Kung, Joelle Carpentier, Leigh Ann Vaughn, Hongfei Du, Qinyu Xiao, Tiago J. S. Lima, Chris Noone, Sandersan Onie, Frederick Verbruggen, Theda Radtke, Maximilian A. Primbs

Source: Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/23c1e613ab7f4eed9fa8bdb95f15e697

Aplicaciones terapéuticas del eculizumab

Authors: Natalia Campos-González, Susana Ruiz-Jiménez, Johanna Rodríguez-Jiménez, Luz Chacón-Jiménez

Source: Universidad y Salud, Vol 24, Iss 2, Pp 184-196 (2022)

Subject Terms: eculizumab, activación de complemento, inmunoglobulinas, enfermedades raras, Medicine (General), R5-920, Social history and conditions. Social problems. Social reform, HN1-995

File Description: electronic resource

Relation: https://revistas.udenar.edu.co/index.php/usalud/article/view/6487; https://doaj.org/toc/0124-7107; https://doaj.org/toc/2389-7066

Access URL: https://doaj.org/article/60971ec1e3c74faeb2855c287cb9d1e2

Endometrial whole metabolome profile at the receptive phase: influence of Mediterranean Diet and infertility

Authors: Nerea M. Molina, Lucas Jurado-Fasoli, Alberto Sola-Leyva, Raquel Sevilla-Lorente, Analuce Canha-Gouveia, Susana Ruiz-Durán, Juan Fontes, Concepción M. Aguilera, Signe Altmäe

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: endometriosis, endometrium, folic acid, lifestyle, metabolomics, Mediterranean diet, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1120988/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/e290ce966fe8486a9a23c80997a2ebf2

Influence of mental health medication on microbiota in the elderly population in the Valencian region

Authors: Nicole Pesantes, Ana Barberá, Benjamí Pérez-Rocher, Alejandro Artacho, Sergio Luís Vargas, Andrés Moya, Susana Ruiz-Ruiz

Source: Frontiers in Microbiology, Vol 14 (2023)

Subject Terms: aging, microbiota, gut-brain axis, mental health disorders, 16S rRNA gene sequencing, metagenomics, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1094071/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/792077e0f5ab43ac9d6978435f5df48b

Exploring the universal healthy human gut microbiota around the World

Authors: Samuel Piquer-Esteban, Susana Ruiz-Ruiz, Vicente Arnau, Wladimiro Diaz, Andrés Moya

Source: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 421-433 (2022)

Subject Terms: Human gut microbiota, Core microbiota, Enrichment strategies, Metagenomics, Genome databases, Western bias, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021005444; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/9ee87db420b54b4896adc7ce3bafd534

IDA (INFLORESCENCE DEFICIENT IN ABSCISSION)-like peptides and HAE (HAESA)-like receptors regulate corolla abscission in Nicotiana benthamiana flowers

Authors: Daniel Ventimilla, Karelia Velázquez, Susana Ruiz-Ruiz, Javier Terol, Miguel A. Pérez-Amador, Mª. Carmen Vives, José Guerri, Manuel Talon, Francisco R. Tadeo

Source: BMC Plant Biology, Vol 21, Iss 1, Pp 1-14 (2021)

Subject Terms: Abscission zone, Abscission signaling module, Cell separation, Gene silencing and overexpression, Hormone peptide, LRR-RLKs, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2229

Access URL: https://doaj.org/article/6bbb73c6ed8946d5a4067deb28ff2d7d

Metagenomic analysis of formalin-fixed paraffin-embedded tumor and normal mucosa reveals differences in the microbiome of colorectal cancer patients

Authors: Gabriela Debesa-Tur, Vicente Pérez-Brocal, Susana Ruiz-Ruiz, Adela Castillejo, Amparo Latorre, José Luis Soto, Andrés Moya

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/48a2fdc003d6491cbad65c71967336a6

Contenido de materia orgánica en suelos de sistemas silvopastoriles establecidos en el Chaco Central paraguayo

Authors: Maura Isabel Díaz Lezcano, Cynthia Carolina Gamarra Lezcano, Susana Ruiz Diaz, Mirtha Vera de Ortiz

Source: Revista de la Sociedad Científica del Paraguay, Vol 25, Iss 2, Pp 131-143 (2020)

Subject Terms: producción, algarrobo, suelos, Engineering (General). Civil engineering (General), TA1-2040, Science (General), Q1-390

File Description: electronic resource

Relation: http://sociedadcientifica.org.py/ojs/index.php/rscpy/article/view/114; https://doaj.org/toc/0379-9123; https://doaj.org/toc/2617-4731

Access URL: https://doaj.org/article/4d90b3b4007e4d0aa9e3b1d47754f747

Vulnerabilidad jurídica-laboral de la figura del asistente personal

Authors: Mercedes López Pérez, Susana Ruiz Seisdedos

Source: Revista Española de Discapacidad, Vol 10, Iss 1 (2022)

Subject Terms: Asistente personal, personas con discapacidad, vida independiente, condiciones laborales, Social Sciences, Social sciences (General), H1-99

File Description: electronic resource

Relation: https://www.cedid.es/redis/index.php/redis/article/view/806; https://doaj.org/toc/2340-5104

Access URL: https://doaj.org/article/3219d605d8d548f89e5b28ca1658ee17

Recognition of Cell Wall Mannosylated Components as a Conserved Feature for Fungal Entrance, Adaptation and Survival Within Trophozoites of Acanthamoeba castellanii and Murine Macrophages

Authors: Marina da Silva Ferreira, Susana Ruiz Mendoza, Diego de Souza Gonçalves, Claudia Rodríguez-de la Noval, Leandro Honorato, Leonardo Nimrichter, Luís Felipe Costa Ramos, Fábio C. S. Nogueira, Gilberto B. Domont, José Mauro Peralta, Allan J. Guimarães

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: Acanthamoeba, macrophages, interaction, pathogenic fungi, mannose receptor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.858979/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/fc90fefe2867417da58b89a51da65d52

A Real-Time PCR Assay for Detection of Low Pneumocystis jirovecii Levels

Authors: Susana Ruiz-Ruiz, Carolina A. Ponce, Nicole Pesantes, Rebeca Bustamante, Gianna Gatti, Viviana San Martin, Mireya Gutierrez, Pamela Bórquez, Sergio L. Vargas, Fabien Magne, Enrique J. Calderón, Vicente Pérez-Brocal, Andrés Moya

Source: Frontiers in Microbiology, Vol 12 (2022)

Subject Terms: real-time PCR, low P. jirovecii loads, major surface glycoproteins, mitochondrial large subunit rRNA, simultaneous detection, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.787554/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/c4b648de7d304f56a755b93afcba4997

IDEST: International Database of Emotional Short Texts.

Authors: Johanna K Kaakinen, Egon Werlen, Yvonne Kammerer, Cengiz Acartürk, Xavier Aparicio, Thierry Baccino, Ugo Ballenghein, Per Bergamin, Núria Castells, Armanda Costa, Isabel Falé, Olga Mégalakaki, Susana Ruiz Fernández

Source: PLoS ONE, Vol 17, Iss 10, p e0274480 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b399fc1ffd874c7d92c346d0d7625efd

Contextual factors predicting compliance behavior during the COVID-19 pandemic: A machine learning analysis on survey data from 16 countries

Authors: Nandor Hajdu, Kathleen Schmidt, Gergely Acs, Jan P. Röer, Alberto Mirisola, Isabella Giammusso, Patrícia Arriaga, Rafael Ribeiro, Dmitrii Dubrov, Dmitry Grigoryev, Nwadiogo C. Arinze, Martin Voracek, Stefan Stieger, Matus Adamkovic, Mahmoud Elsherif, Bettina M. J. Kern, Krystian Barzykowski, Ewa Ilczuk, Marcel Martončik, Ivan Ropovik, Susana Ruiz-Fernandez, Gabriel Baník, José Luis Ulloa, Balazs Aczel, Barnabas Szaszi

Source: PLoS ONE, Vol 17, Iss 11 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704675/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b6bd9469173541e3a1bd658488ab6e40

Influence of Resilience and Optimism on Distress and Intention to Self-Isolate: Contrasting Lower and Higher COVID-19 Illness Risk Samples From an Extended Health Belief Model

Authors: Sergio Cervera-Torres, Susana Ruiz-Fernández, Hendrik Godbersen, Lena Massó, David Martínez-Rubio, Sheila Pintado-Cucarella, Rosa M. Baños

Source: Frontiers in Psychology, Vol 12 (2021)

Subject Terms: COVID-19, resilience (psychological), dispositional optimism, distress, intention to self-isolate, health belief model, Psychology, BF1-990

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyg.2021.662395/full; https://doaj.org/toc/1664-1078

Access URL: https://doaj.org/article/9ab964daf645450e9b839dbdad001dbd

Mining of Gram-Negative Surface-Active Enzybiotic Candidates by Sequence-Based Calculation of Physicochemical Properties

Authors: Roberto Vázquez, Sofía Blanco-Gañán, Susana Ruiz, Pedro García

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: lysins, Gram-negative bacteria, bioinformatic analysis, enzybiotics, antimicrobials, enzyme mining, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.660403/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/a3afe1e194c746bcab98cadd77c88840

Improvement of the Antibacterial Activity of Phage Lysin-Derived Peptide P87 through Maximization of Physicochemical Properties and Assessment of Its Therapeutic Potential

Authors: Roberto Vázquez, Antonio Doménech-Sánchez, Susana Ruiz, Julio Sempere, Jose Yuste, Sebastián Albertí, Pedro García

Source: Antibiotics, Vol 11, Iss 10, p 1448 (2022)

Subject Terms: phage lysins, antimicrobial peptides, Pseudomonas aeruginosa, synergy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2079-6382/11/10/1448; https://doaj.org/toc/2079-6382

Access URL: https://doaj.org/article/34f943607225459d8724aec883f766d9

Tracking the effect of temperature in marine demersal fish communities

Authors: Antonio Punzón, Lucía López-López, José Manuel González-Irusta, Izaskun Preciado, Manuel Hidalgo, Alberto Serrano, Elena Tel, Raquel Somavilla, Julia Polo, Marian Blanco, Susana Ruiz-Pico, Olaya Fernández-Zapico, Francisco Velasco, Enric Massuti

Source: Ecological Indicators, Vol 121, Iss , Pp 107142- (2021)

Subject Terms: Community Weighted Mean Temperature, Temperature, Climate change, Demersal fish community, Temperate ecosystem, Thermal niche, Ecology, QH540-549.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1470160X20310815; https://doaj.org/toc/1470-160X

Access URL: https://doaj.org/article/d3cf96db1ef7477fa41d73b0783f0aa1

Designing Visual-Arts Education Programs for Transfer Effects: Development and Experimental Evaluation of (Digital) Drawing Courses in the Art Museum Designed to Promote Adolescents’ Socio-Emotional Skills

Authors: Lydia Kastner, Nora Umbach, Aiste Jusyte, Sergio Cervera-Torres, Susana Ruiz Fernández, Sven Nommensen, Peter Gerjets

Source: Frontiers in Psychology, Vol 11 (2021)

Subject Terms: arts education, visual arts, art museum, transfer effect, socio-emotional skills, empathy, Psychology, BF1-990

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.603984/full; https://doaj.org/toc/1664-1078

Access URL: https://doaj.org/article/a586705ace7545edbbf0abb908cdb799