Correction: LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Authors: Jui-Hung Weng, Phillip C Aoto, Robin Lorenz, Jian Wu, Sven H Schmidt, Jascha T Manschwetus, Pallavi Kaila-Sharma, Steve Silletti, Constanza Torres-Paris, Sebastian Mathea, Deep Chatterjee, Stefan Knapp, Friedrich W Herberg, Susan S Taylor

Source: PLoS Biology, Vol 23, Iss 2, p e3003017 (2025)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Role of the αC-β4 loop in protein kinase structure and dynamics

Authors: Jian Wu, Nisha A Jonniya, Sophia P Hirakis, Cristina Olivieri, Gianluigi Veglia, Alexandr P Kornev, Susan S Taylor

Source: eLife, Vol 12 (2024)

Subject Terms: αC-β4 loop, protein kinase A, local spatial pattern, F100A mutant, molecular dynamics simulations, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/91980; https://doaj.org/toc/2050-084X

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The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

Authors: Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Michele Vendruscolo, Susan S Taylor, Gianluigi Veglia

Source: eLife, Vol 12 (2024)

Subject Terms: protein kinases, cAMP-dependent kinase A, allosteric mutations, binding cooperativity, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/91506; https://doaj.org/toc/2050-084X

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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Authors: Jui-Hung Weng, Phillip C Aoto, Robin Lorenz, Jian Wu, Sven H Schmidt, Jascha T Manschwetus, Pallavi Kaila-Sharma, Steve Silletti, Sebastian Mathea, Deep Chatterjee, Stefan Knapp, Friedrich W Herberg, Susan S Taylor

Source: PLoS Biology, Vol 20, Iss 2, p e3001427 (2022)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.

Authors: Tsan-Wen Lu, Phillip C Aoto, Jui-Hung Weng, Cole Nielsen, Jennifer N Cash, James Hall, Ping Zhang, Sanford M Simon, Michael A Cianfrocco, Susan S Taylor

Source: PLoS Biology, Vol 18, Iss 12, p e3001018 (2020)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Authors: Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia

Source: eLife, Vol 9 (2020)

Subject Terms: recombinant dna, protein expression, isotopic labeling, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/55607; https://doaj.org/toc/2050-084X

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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

Authors: Jenna L Jewell, Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor, Kun-Liang Guan

Source: eLife, Vol 8 (2019)

Subject Terms: mouse, cells, cancer cells, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/43038; https://doaj.org/toc/2050-084X

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Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

Authors: Ronit Ilouz, Varda Lev-Ram, Eric A Bushong, Travis L Stiles, Dinorah Friedmann-Morvinski, Christopher Douglas, Jeffrey L Goldberg, Mark H Ellisman, Susan S Taylor

Source: eLife, Vol 6 (2017)

Subject Terms: protein kinases, cellular and subcellular localization, Immunohistochemical mouse brain images, correlated light and electron microscopy, High resolution large scale images, PKA regulatory subunits, Medicine, Science, Biology (General), QH301-705.5

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Relation: https://elifesciences.org/articles/17681; https://doaj.org/toc/2050-084X

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Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.

Authors: Hiruy S Meharena, Xiaorui Fan, Lalima G Ahuja, Malik M Keshwani, Christopher L McClendon, Angela M Chen, Joseph A Adams, Susan S Taylor

Source: PLoS Biology, Vol 14, Iss 11, p e2000127 (2016)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://europepmc.org/articles/PMC5130182?pdf=render; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Authors: Ping Zhang, Matthias J Knape, Lalima G Ahuja, Malik M Keshwani, Charles C King, Mira Sastri, Friedrich W Herberg, Susan S Taylor

Source: PLoS Biology, Vol 13, Iss 7, p e1002192 (2015)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.

Authors: Madoka Akimoto, Eric Tyler McNicholl, Avinash Ramkissoon, Kody Moleschi, Susan S Taylor, Giuseppe Melacini

Source: PLoS Biology, Vol 13, Iss 11, p e1002305 (2015)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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Deciphering the structural basis of eukaryotic protein kinase regulation.

Authors: Hiruy S Meharena, Philip Chang, Malik M Keshwani, Krishnadev Oruganty, Aishwarya K Nene, Natarajan Kannan, Susan S Taylor, Alexandr P Kornev

Source: PLoS Biology, Vol 11, Iss 10, p e1001680 (2013)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://europepmc.org/articles/PMC3797032?pdf=render; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1.

Authors: Charles C King, Mira Sastri, Philip Chang, Juniper Pennypacker, Susan S Taylor

Source: PLoS ONE, Vol 6, Iss 4, p e18713 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3083391?pdf=render; https://doaj.org/toc/1932-6203

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Identifying critical non-catalytic residues that modulate protein kinase A activity.

Authors: Eileen J Kennedy, Jie Yang, Lorraine Pillus, Susan S Taylor, Gourisankar Ghosh

Source: PLoS ONE, Vol 4, Iss 3, p e4746 (2009)

Subject Terms: Medicine, Science

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Relation: http://europepmc.org/articles/PMC2650257?pdf=render; https://doaj.org/toc/1932-6203

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A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.

Authors: Alexandr P Kornev, Susan S Taylor, Lynn F Ten Eyck

Source: PLoS Computational Biology, Vol 4, Iss 4, p e1000056 (2008)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://europepmc.org/articles/PMC2275311?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

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Structural and functional diversity of the microbial kinome.

Authors: Natarajan Kannan, Susan S Taylor, Yufeng Zhai, J Craig Venter, Gerard Manning

Source: PLoS Biology, Vol 5, Iss 3, p e17 (2007)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

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The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families.

Authors: Shibu Yooseph, Granger Sutton, Douglas B Rusch, Aaron L Halpern, Shannon J Williamson, Karin Remington, Jonathan A Eisen, Karla B Heidelberg, Gerard Manning, Weizhong Li, Lukasz Jaroszewski, Piotr Cieplak, Christopher S Miller, Huiying Li, Susan T Mashiyama, Marcin P Joachimiak, Christopher van Belle, John-Marc Chandonia, David A Soergel, Yufeng Zhai, Kannan Natarajan, Shaun Lee, Benjamin J Raphael, Vineet Bafna, Robert Friedman, Steven E Brenner, Adam Godzik, David Eisenberg, Jack E Dixon, Susan S Taylor, Robert L Strausberg, Marvin Frazier, J Craig Venter

Source: PLoS Biology, Vol 5, Iss 3, p e16 (2007)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/d3c8becc5a9947e1bccad4901b6de6ec

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Phosphorylation Reaction in cAPK Protein Kinase-Free Energy Quantum Mechanical/Molecular Mechanics Simulations.

Authors: Marat Valiev¹, Jie Yang¹, Joseph A. Adams¹, Susan S. Taylor¹, John H. Weare¹

Source: Journal of Physical Chemistry B; Nov2007, Vol. 111 Issue 47, p13455-13464, 10p

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