Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.

Authors: Voineagu, Irina¹, Surka, Christine F², Shishkin, Alexander A², Krasilnikova, Maria M³, Mirkin, Sergei M²

Source: Nature Structural & Molecular Biology. Feb2009, Vol. 16 Issue 2, p226-228. 3p. 1 Diagram, 2 Graphs.

Subject Terms: *G proteins, *CHROMOSOME abnormalities, *SACCHAROMYCES cerevisiae, *PROTEINS, *YEAST, *FRAGILE X syndrome, *DNA replication

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.

Authors: McHugh, Colleen A., Chen, Chun-Kan, Chow, Amy, Surka, Christine F., Tran, Christina, McDonel, Patrick, Pandya-Jones, Amy, Blanco, Mario, Burghard, Christina, Moradian, Annie, Sweredoski, Michael J., Shishkin, Alexander A., Su, Julia, Lander, Eric S., Hess, Sonja, Plath, Kathrin, Guttman, Mitchell

Source: Nature. 5/14/2015, Vol. 521 Issue 7551, p232-236. 5p. 2 Color Photographs, 12 Graphs.

Subjects: NON-coding RNA, PROTEIN analysis, MASS spectrometry, GENE silencing, PROTEIN-protein interactions