MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

Authors: Wang, Xiaohai ^*, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.

Source: In The Journal of Pharmacology and Experimental Therapeutics August 2020 374(2):252-263

Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET

Authors: Shuping, Joanna L., Matthews, Dawn C., Adamczuk, Katarzyna, Scott, David, Rowe, Christopher C., Kreisl, William C., Johnson, Sterling C., Lukic, Ana S., Johnson, Keith A., Rosa‐Neto, Pedro, Andrews, Randolph D., Van Laere, Koen, Cordes, Lindsay, Ward, Larry, Wilde, Claire L., Barakos, Jerome, Purcell, Derk D., Devanand, Davangere P., Stern, Yaakov, Luchsinger, Jose A., Sur, Cyrille, Price, Julie C., Brickman, Adam M., Klunk, William E., Boxer, Adam L., Mathotaarachchi, Sulantha S., Lao, Patrick J., Evelhoch, Jeffrey L.

Source: Alzheimer's & dementia.Translational research & clinical interventions. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182260568.0x000001&indx=1&recIds=ETOCvdc_100182260568.0x000001

Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles

Authors: Koole, Michel, Lohith, Talakad G., Valentine, John L., Bennacef, Idriss, Declercq, Ruben, Reynders, Tom, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Ferry-Martin, Sandrine, Laroque, Philippe, Walji, Abbas, Hostetler, Eric D., Briscoe, Richard J., de Hoon, Jan, Sur, Cyrille, Van Laere, Koen, Struyk, Arie

Source: Molecular imaging and biology. 22(1):173-180

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161928832.0x000001&indx=1&recIds=ETOCvdc_100161928832.0x000001

N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity

Authors: Sur, Cyrille, Mallorga, Pierre J., Wittmann, Marion, Jacobson, Marlene A., Pascarella, Danette, Williams, Jacinta B., Brandish, Philip E., Pettibone, Douglas J., Scolnick, Edward M., Conn, P. Jeffrey

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Nov 01. 100(23), 13674-13679.

Access URL: https://www.jstor.org/stable/3148198

A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging

Authors: Mo, Yi, Stromswold, Julie, Wilson, Kimberly, Holder, Daniel, Sur, Cyrille, Laterza, Omar, Savage, Mary J., Struyk, Arie, Scheltens, Philip, Teunissen, Charlotte E., Burke, James, Macaulay, S. Lance, Bråthen, Geir, Sando, Sigrid Botne, White, Linda R., Weiss, Christy, Cowes, Arturo, Bush, Michele M., DeSilva, Ganga, Darby, David G., Rainey-Smith, Stephanie R., Surls, Jackie, Sagini, Eileen, Tanen, Michael, Altman, Amy, Luthman, Johan, Egan, Michael F.

Source: In Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017 6:201-209

A Single Serine Residue Controls the Cation Dependence of Substrate Transport by the Rat Serotonin Transporter

Authors: Sur, Cyrille, Betz, Heinrich, Schloss, Patrick

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Jul 01. 94(14), 7639-7644.

Access URL: https://www.jstor.org/stable/42732

The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI‐3 updates and global perspectives

Authors: Weber, Christopher J., Carrillo, Maria C., Jagust, William, Jack, Clifford R., Shaw, Leslie M., Trojanowski, John Q., Saykin, Andrew J., Beckett, Laurel A., Sur, Cyrille, Rao, Naren P., Mendez, Patricio Chrem, Black, Sandra E., Li, Kuncheng, Iwatsubo, Takeshi, Chang, Chiung‐Chih, Sosa, Ana Luisa, Rowe, Christopher C., Perrin, Richard J., Morris, John C., Healan, Amanda M.B., Hall, Stephen E., Weiner, Michael W.

Source: Alzheimer's & dementia.Translational research & clinical interventions. 7(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140148415.0x000001&indx=1&recIds=ETOCvdc_100140148415.0x000001

Longitudinal investigation for enhancing Down Syndrome Research (LIFE‐DSR) Study: Tau PET and CSF sub‐studies

Authors: Hendrix, James A., Britton, Angela, Christian, Bradley T., Ledesma, Duvia Lara, Egan, Michael F., Feldman, Howard, Hendrix, Suzanne B., Herring, W. Joseph, Kennedy, Matthew E., Nicodemus‐Johnson, Jessie, Revta, Carolyn, Struyk, Arie, Sur, Cyrille, Mobley, William C.

Source: Alzheimer's & dementia. 17(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138849474.0x000001&indx=1&recIds=ETOCvdc_100138849474.0x000001

In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

Authors: Hostetler, Eric D. ^*, Joshi, Aniket D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Purcell, Mona, Gantert, Liza, Riffel, Kerry, Williams, Mangay, O’Malley, Stacey, Miller, Patricia, Selnick, Harold G., Gallicchio, Steven N., Bell, Ian M., Salvatore, Christopher A., Kane, Stefanie A., Li, Chi-Chung, Hargreaves, Richard J., de Groot, Tjibbe, Bormans, Guy, Van Hecken, Anne, Derdelinckx, Inge, de Hoon, Jan, Reynders, Tom, Declercq, Ruben, De Lepeleire, Inge, Kennedy, W.P., Blanchard, Rebecca, Marcantonio, Eugene E., Sur, Cyrille, Cook, Jacquelynn J., Van Laere, Koen, Evelhoch, Jeffrey L.

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2013 347(2):478-486

Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

Authors: Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Gantert, Liza, Williams, Mangay, Miller, Patricia, O'Malley, Stacey, Kameda, Minoru, Ando, Makoto, Sato, Nagaaki, Ozaki, Satoshi, Tokita, Shigeru, Ohta, Hisashi, Williams, David, Sur, Cyrille, Cook, Jacquelynn J., Burns, H. Donald, Hargreaves, Richard

Source: In NeuroImage 14 February 2011 54(4):2635-2642

[ 18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey

Authors: Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Gammage, Linda, Miller, Patricia, O'Malley, Stacey, Connolly, Brett, Mulhearn, James, Harrison, Scott T., Wolkenberg, Scott E., Barrow, James C., Williams, David L., Jr., Hargreaves, Richard J., Sur, Cyrille, Cook, Jacquelynn J.

Source: In Nuclear Medicine and Biology 2011 38(8):1193-1203

The M1 Muscarinic Receptor Allosteric Agonists AC-42 and 1-[1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one Bind to a Unique Site Distinct from the Acetylcholine Orthosteric Site

Authors: Jacobson, Marlene A. ^*, Kreatsoulas, Constantine, Pascarella, Danette M., O’Brien, Julie A., Sur, Cyrille

Source: In Molecular Pharmacology October 2010 78(4):648-657

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

Authors: Salvatore, Christopher A. ^*, Moore, Eric L., Calamari, Amy, Cook, Jacquelynn J., Michener, Maria S., O'Malley, Stacey, Miller, Patricia J., Sur, Cyrille, Williams, David L., Jr., Zeng, Zhizhen, Danziger, Andrew, Lynch, Joseph J., Regan, Christopher P., Fay, John F., Tang, Yui S., Li, Chi-Chung, Pudvah, Nicole T., White, Rebecca B., Bell, Ian M., Gallicchio, Steven N., Graham, Samuel L., Selnick, Harold G., Vacca, Joseph P., Kane, Stefanie A.

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2010 333(1):152-160

Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose

Authors: Uslaner, Jason M., Drott, Jason T., Sharik, Steven S., Theberge, Cory R., Sur, Cyrille, Zeng, Zhizhen, Williams, David L., Hutson, Pete H.

Source: In Behavioural Brain Research 2010 207(1):37-43

A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models

Authors: Haines, Brian B., Bettano, Kimberly A., Chenard, Melissa, Sevilla, Raquel S., Ware, Christopher, Angagaw, Minilik H., Winkelmann, Christopher T., Tong, Christopher, Reilly, John F., Sur, Cyrille, Zhang, Weisheng

Source: In Neoplasia January 2009 11(1):39-47

A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies

Authors: Zeng, Zhizhen, O'Brien, Julie A., Lemaire, Wei, O'Malley, Stacey S., Miller, Patricia J., Zhao, Zhijian, Wallace, Michael A., Raab, Conrad, Lindsley, Craig W., Sur, Cyrille, Williams, David L., Jr.

Source: In Nuclear Medicine and Biology 2008 35(3):315-325

Evaluation of ¹⁸F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer's disease.

Authors: Sur, Cyrille¹ cyrille_sur@merck.com, Adamczuk, Katarzyna², Scott, David², Kost, James¹, Sampat, Mehul², Buckley, Christopher³, Farrar, Gill³, Newton, Ben³, Suhy, Joyce², Bennacef, Idriss¹, Egan, Michael F.¹

Source: Molecular Imaging & Biology. Dec2022, Vol. 24 Issue 6, p862-873. 12p.

Subject Terms: *ALZHEIMER'S disease diagnosis, *BRAIN physiology, *POSITRON emission tomography, *DATA analysis, *CLINICAL trials

Substituted azabenzoxazoles

Optical Imaging of Tumor Cells in Hollow Fibers: Evaluation of the Antitumor Activities of Anticancer Drugs, Target Validation

Authors: Zhang, Guo-Jun, Chen, Tsing-Bau, Bednar, Bohumil, Connolly, Brett M., Hargreaves, Richard, Sur, Cyrille, Williams, David L., Jr.

Source: In Neoplasia August 2007 9(8):652-661

NOVEL SUBSTITUTED AZABENZOXAZOLES