Modeling unveils sex differences of signaling networks in mouse embryonic stem cells.

Authors: Sultana, Zeba¹ (AUTHOR), Dorel, Mathurin² (AUTHOR), Klinger, Bertram² (AUTHOR), Sieber, Anja² (AUTHOR), Dunkel, Ilona¹ (AUTHOR), Blüthgen, Nils² (AUTHOR) nils.bluethgen@charite.de, Schulz, Edda G¹ (AUTHOR) edda.schulz@molgen.mpg.de

Source: Molecular Systems Biology. 11/9/2023, Vol. 19 Issue 11, p1-17. 17p.

Subject Terms: *EMBRYONIC stem cells, *X chromosome, *MAMMALIAN embryos, *PI3K/AKT pathway, *CELL communication

Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis.

Authors: Engesser, Jonas, Khatri, Robin, Schaub, Darius P., Zhao, Yu, Paust, Hans-Joachim, Sultana, Zeba, Asada, Nariaki, Riedel, Jan-Hendrik, Sivayoganathan, Varshi, Peters, Anett, Kaffke, Anna, Jauch-Speer, Saskia-Larissa, Goldbeck-Strieder, Thiago, Puelles, Victor G., Wenzel, Ulrich O., Steinmetz, Oliver M., Hoxha, Elion, Turner, Jan-Eric, Mittrücker, Hans-Willi, Wiech, Thorsten

Source: Nature Communications; 9/19/2024, Vol. 15 Issue 1, p1-12, 12p

Subject Terms: ANTINEUTROPHIL cytoplasmic antibodies, KIDNEY failure, KIDNEY physiology, DISEASE relapse, IMMUNOSUPPRESSIVE agents, T cells

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening.

Authors: Enk, Leon U. B., Hellmig, Malte, Riecken, Kristoffer, Kilian, Christoph, Datlinger, Paul, Jauch-Speer, Saskia L., Neben, Tobias, Sultana, Zeba, Sivayoganathan, Varshi, Borchers, Alina, Paust, Hans-Joachim, Zhao, Yu, Asada, Nariaki, Liu, Shuya, Agalioti, Theodora, Pelczar, Penelope, Wiech, Thorsten, Bock, Christoph, Huber, Tobias B., Huber, Samuel

Source: Science Immunology; 2024, Vol. 9 Issue 96, p1-15, 15p

Subject Terms: T cells, REGULATORY T cells, MEDICAL screening, ANTINEUTROPHIL cytoplasmic antibodies, T cell receptors

Insights into the effects of α-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data

Authors: Vali, Shireen, Chinta, Shankar J., Peng, Jun, Sultana, Zeba, Singh, Neetu, Sharma, Purushottam, Sharada, S., Andersen, Julie K., Bharath, M.M. Srinivas

Source: In Free Radical Biology and Medicine 2008 45(9):1290-1301

T Cell Egress from the Kidney to the Renal Lymph Node Is Regulated by Their Activation State and Controls Tissue Inflammation

Authors: Engesser, Jonas, Riedel, Jan-Hendrik, Asada, Nariaki, Paust, Hans-Joachim, Khatri, Robin, Sultana, Zeba, Meyer-Schwesinger, Catherine, Wiech, Thorsten, Puelles, Victor G., Bonn, Stefan, Krebs, Christian F., Panzer, Ulf

Source: Journal of the American Society of Nephrology; October 2024, Vol. 35 Issue: 10, Number 10 Supplement 10

Single-Cell Spatial Atlas of Immune and Kidney Cell States in Human Rapidly Progressive Glomerulonephritis

Authors: Sultana, Zeba, Khatri, Robin, Yousefi, Behnam, Shaikh, Nikhat, Jauch-Speer, Saskia-L., Sivayoganathan, Varshi, Paust, Hans-Joachim, Wiech, Thorsten, Huber, Tobias B., Panzer, Ulf, Bonn, Stefan, Krebs, Christian F.

Source: Journal of the American Society of Nephrology; October 2024, Vol. 35 Issue: 10, Number 10 Supplement 10

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Therapy Personalization Using Predictive Simulation Approach with Ex-Vivo Clinical Validations

Authors: Doudican, Nicole A ^*, Vij, Ravi, Fiala, Mark A ^*, King, Justin ^*, Vali, Shireen ^*, Basu, Kabya ^*, Kumar, Ansu ^*, Singh, Neeraj Kumar ^*, Sultana, Zeba ^*, Abbasi, Taher ^*, Mazumder, Amitabha

Source: In Blood 6 December 2014 124(21):2232-2232

PI3 KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance.

Authors: Azab, Feda, Vali, Shireen, Abraham, Joseph, Potter, Nicholas, Muz, Barbara, Puente, Pilar, Fiala, Mark, Paasch, Jacob, Sultana, Zeba, Tyagi, Anuj, Abbasi, Taher, Vij, Ravi, Azab, Abdel Kareem

Source: British Journal of Haematology; Apr2014, Vol. 165 Issue 1, p89-101, 13p

Subject Terms: PHOSPHATIDYLINOSITOL 3-kinases, MULTIPLE myeloma, ENZYME inhibitors, CANCER cell proliferation, DRUG synergism, DRUG resistance in cancer cells

Ex Vivo Patient-Specific Validation Of Personalized Therapeutic Designed For Multiple Myeloma

Authors: Doudican, Nicole A ^*, Vali, Shireen ^*, Kapoor, Shweta ^*, Talawdekar, Anay ^*, Sultana, Zeba ^*, Alam, Aftab ^*, Kumar, Ansu ^*, Singh, Neeraj Kumar ^*, Tyagi, Anuj ^*, Abbasi, Taher ^*, Mazumder, Amitabha

Source: In Blood 15 November 2013 122(21):4219-4219

Predictive Simulation Based Design and Validation Of Repurposed Novel Therapeutics With Multi-Target Mechanisms For Multiple Myeloma

Authors: Doudican, Nicole A ^*, Vali, Shireen ^*, Kapoor, Shweta ^*, Talawdekar, Anay ^*, Sultana, Zeba ^*, Alam, Aftab ^*, Abbasi, Taher ^*, Mazumder, Amitabha

Source: In Blood 15 November 2013 122(21):3859-3859

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Ex VivoPatient-Specific Validation Of Personalized Therapeutic Designed For Multiple Myeloma

Authors: Doudican, Nicole A, Vali, Shireen, Kapoor, Shweta, Talawdekar, Anay, Sultana, Zeba, Alam, Aftab, Kumar, Ansu, Singh, Neeraj Kumar, Tyagi, Anuj, Abbasi, Taher, Mazumder, Amitabha

Source: Blood; November 2013, Vol. 122 Issue: 21 p4219-4219, 1p