Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo

Authors: Shining Ma, Michelle So, Aazam Ghelani, Rohith Srivas, Anupama Sahoo, Robyn Hall, Wenjun Liu, Hao Wu, Sherman Yu, Shiping Lu, Elly Song, Taryn Cariaga, Marcus Soto, Hong Zhou, Chi-Ming Li, Ashutosh Chaudhry, Xin Luo, Sue J. Sohn

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: regulatory T cell (Treg), interleukin-2 (IL-2), IL-2 therapy, cytokine, T cell receptor (TCR), in vivo, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257652/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4b2f7fa5bd9b408db48f01f99aa68ebe

Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy

Authors: Cody D. Moorman, Sue J. Sohn, Hyewon Phee

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: tolerogenic vaccine, autoimmune disease, CAR-Tregs, IL-2 mutein, low-dose IL-2 therapy, antigen-specific tolerance, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.657768/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a65e245ba47d461e88ca5ba05fd54e1a

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins

Authors: Aazam Ghelani, Darren Bates, Kip Conner, Min-Zu Wu, Jiamiao Lu, Yi-Ling Hu, Chi-Ming Li, Ashutosh Chaudhry, Sue J. Sohn

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: IL-2, mutein, regulatory T, Treg, tolerance, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01106/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/67075f173bb14b53b0843c3dd8d5b2db

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Authors: Svetlana Pidasheva, Sara Trifari, Anne Phillips, Jason A Hackney, Yan Ma, Ashley Smith, Sue J Sohn, Hergen Spits, Randall D Little, Timothy W Behrens, Lee Honigberg, Nico Ghilardi, Hilary F Clark

Source: PLoS ONE, Vol 6, Iss 10, p e25038 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3192060?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3ee599140d13470ebc2200332b8af4f1