Applying HDACis to increase SSTR2 expression and radiolabeled DOTA-TATE uptake: from cells to mice

Authors: Klomp, Maria J., van den Brink, Lilian, van Koetsveld, Peter M., de Ridder, Corrina M.A., Stuurman, Debra C., Löwik, Clemens W.G.M., Hofland, Leo J., Dalm, Simone U.

Source: In Life Sciences 1 December 2023 334

Continued androgen signalling inhibition improves cabazitaxel efficacy in prostate cancer

Authors: Mout, Lisanne, van Royen, Martin E., de Ridder, Corrina, Stuurman, Debra, van de Geer, Wesley S., Marques, Rute, Buck, Stefan A.J., French, Pim J., van de Werken, Harmen J.G., Mathijssen, Ron H.J., de Wit, Ronald, Lolkema, Martijn P., van Weerden, Wytske M.

Source: In EBioMedicine November 2021 73

eSOMA-DM1, a Maytansinoid-Based Theranostic Small-Molecule Drug Conjugate for Neuroendocrine Tumors.

Authors: Chapeau, Dylan, Beekman, Savanne, Piet, Amber, Li, Le, de Ridder, Corrina, Stuurman, Debra, Seimbille, Yann

Source: Bioconjugate Chemistry; 11/20/2024, Vol. 35 Issue 11, p1823-1834, 12p

In Vivo Evaluation of Indium-111–Labeled 800CW as a Necrosis-Avid Contrast Agent

Authors: Stroet, Marcus C. M., de Blois, Erik, Stuurman, Debra C., de Ridder, Corrina M. A., Haeck, Joost, Seimbille, Yann, Mezzanotte, Laura, de Jong, Marion, Löwik, Clemens W. G. M., Panth, Kranthi M.

Source: Molecular imaging and biology. 22(5):1333-1341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171781699.0x000001&indx=1&recIds=ETOCvdc_100171781699.0x000001

Rapid Assessment of Bio-distribution and Antitumor Activity of the Photosensitizer Bremachlorin in a Murine PDAC Model: Detection of PDT-induced Tumor Necrosis by IRDye® 800CW Carboxylate, Using Whole-Body Fluorescent Imaging.

Authors: McMorrow, Roisin, de Bruijn, Henriette S., Que, Ivo, Stuurman, Debra C., de Ridder, Corrina M.A., Doukas, Michail, Robinson, Dominic J., Mezzanotte, Laura, Lowik, Clemens W.G.M.

Source: Molecular Imaging & Biology; Aug2024, Vol. 26 Issue 4, p616-627, 12p

Subject Terms: PHOTOSENSITIZERS, ANTINEOPLASTIC agents, PHOTODYNAMIC therapy, CYANINES, PANCREATIC duct, CELL death, NECROSIS

In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions.

Authors: van der Heide, Circe D., Ma, Hanyue, Hoorens, Mark W.H., Campeiro, Joana D., Stuurman, Debra C., de Ridder, Corrina M.A., Seimbille, Yann, Dalm, Simone U.

Source: EJNMMI Radiopharmacy & Chemistry; 7/29/2024, Vol. 9 Issue 1, p1-17, 17p

Subject Terms: RADIONUCLIDE imaging, SMALL molecules, CONFOCAL microscopy, PHARMACOPHORE, COMPANION diagnostics

Darolutamide does not interfere with OATP‐mediated uptake of docetaxel.

Authors: Buck, Stefan A. J., Talebi, Zahra, Drabison, Thomas, Jin, Yan, Gibson, Alice A., Hu, Peng, de Bruijn, Peter, de Ridder, Corrina M. A., Stuurman, Debra, Hu, Shuiying, van Weerden, Wytske M., Koolen, Stijn L. W., de Wit, Ronald, Sparreboom, Alex, Mathijssen, Ron H. J., Eisenmann, Eric D.

Source: International Journal of Cancer; Jul2024, Vol. 155 Issue 2, p314-323, 10p

Subject Terms: DOCETAXEL, ANDROGEN receptors, PROSTATE cancer patients, DRUG interactions

eTFC-01: a dual-labeled chelate-bridged tracer for SSTR2-positive tumors.

Authors: Chapeau, Dylan, Beekman, Savanne, Handula, Maryana, Murce, Erika, de Ridder, Corrina, Stuurman, Debra, Seimbille, Yann

Source: EJNMMI Radiopharmacy & Chemistry; 5/22/2024, Vol. 9 Issue 1, p1-20, 20p

Subject Terms: RADIOCHEMICAL purification, STERIC hindrance, CLICK chemistry, SOLID-phase synthesis, COPPER, BLOOD circulation, FLUORESCENT dyes

O-76 - Preclinical evaluation of ePSMA-DM1: a PSMA-targeting theranostic small molecule drug conjugate

Authors: Seimbille, Yann, Murce, Erika, Spaan, Evelien, Beekman, Savanne, Handula, Maryana, de Ridder, Corrina, Stuurman, Debra

Source: In Nuclear Medicine and Biology November-December 2023 126-127 Supplement

High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models

Authors: Marques, Rute B., Aghai, Ashraf, de Ridder, Corrina M.A., Stuurman, Debra, Hoeben, Sander, Boer, Agnes, Ellston, Rebecca P., Barry, Simon T., Davies, Barry R., Trapman, Jan, van Weerden, Wytske M.

Source: European urology. 67(6):1177-1185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069996537.0x000001&indx=1&recIds=ETOCvdc_100069996537.0x000001

Synthesis and Evaluation of ePSMA-DM1: A New Theranostic Small-Molecule Drug Conjugate (T-SMDC) for Prostate Cancer.

Authors: Murce, Erika, Spaan, Evelien, Beekman, Savanne, van den Brink, Lilian, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Dalm, Simone U., Seimbille, Yann

Source: Pharmaceuticals (14248247); Aug2023, Vol. 16 Issue 8, p1072, 19p

Subject Terms: PROSTATE cancer, COMPUTED tomography, RADIOCHEMICAL purification, ANDROGEN receptors, DRUGS, DIAGNOSTIC imaging, ANDROGENS

[ 212 Pb]Pb-eSOMA-01: A Promising Radioligand for Targeted Alpha Therapy of Neuroendocrine Tumors.

Authors: Chapeau, Dylan, Koustoulidou, Sofia, Handula, Maryana, Beekman, Savanne, de Ridder, Corrina, Stuurman, Debra, de Blois, Erik, Buchatskaya, Yulia, van der Schilden, Karlijn, de Jong, Marion, Konijnenberg, Mark W., Seimbille, Yann

Source: Pharmaceuticals (14248247); Jul2023, Vol. 16 Issue 7, p985, 19p

Subject Terms: NEUROENDOCRINE tumors, COMPUTED tomography, ABSORBED dose, PEPTIDE receptors, SINGLE-photon emission computed tomography, DOSE-response relationship (Radiation)

First preclinical evaluation of [²²⁵Ac]Ac-DOTA-JR11 and comparison with [¹⁷⁷Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs.

Authors: Handula, Maryana, Beekman, Savanne, Konijnenberg, Mark, Stuurman, Debra, de Ridder, Corrina, Bruchertseifer, Frank, Morgenstern, Alfred, Denkova, Antonia, de Blois, Erik, Seimbille, Yann

Source: EJNMMI Radiopharmacy & Chemistry; 6/30/2023, Vol. 8 Issue 1, p1-16, 16p

Subject Terms: ALPHA rays, BINDING site assay, RADIOCHEMICAL purification, RADIOACTIVE tracers, RADIOISOTOPES, BETA rays, PEPTIDE receptors, SOMATOSTATIN receptors

Radiochemical and Biological Evaluation of 3p- C -NETA-ePSMA-16, a Promising PSMA-Targeting Agent for Radiotheranostics.

Authors: Murce, Erika, Ahenkorah, Stephen, Beekman, Savanne, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Cleeren, Frederik, Seimbille, Yann

Source: Pharmaceuticals (14248247); Jun2023, Vol. 16 Issue 6, p882, 18p

Subject Terms: SINGLE-photon emission computed tomography, COMPUTED tomography, POSITRON emission tomography, RADIOISOTOPES, PROSTATE cancer, RADIOPHARMACEUTICALS, LUTEINIZING hormone releasing hormone

Viability Analysis and High-Content Live-Cell Imaging for Drug Testing in Prostate Cancer Xenograft-Derived Organoids.

Authors: Van Hemelryk, Annelies, Erkens-Schulze, Sigrun, Lim, Lifani, de Ridder, Corrina M. A., Stuurman, Debra C., Jenster, Guido W., van Royen, Martin E., van Weerden, Wytske M.

Source: Cells (2073-4409); May2023, Vol. 12 Issue 10, p1377, 16p

Subject Terms: DRUG use testing, PROSTATE cancer, ORGANOIDS, ENDORECTAL ultrasonography, CELL nuclei, PROPIDIUM iodide

Preclinical Evaluation of a PSMA-Targeting Homodimer with an Optimized Linker for Imaging of Prostate Cancer.

Authors: Murce, Erika, Beekman, Savanne, Spaan, Evelien, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Seimbille, Yann

Source: Molecules; May2023, Vol. 28 Issue 10, p4022, 20p

Subject Terms: PROSTATE cancer, CANCER diagnosis, KIDNEY tumors, SINGLE-photon emission computed tomography

DNA-PKcs inhibitors sensitize neuroendocrine tumor cells to peptide receptor radionuclide therapy in vitro and in vivo.

Authors: Reuvers, Thom G. A., Verkaik, Nicole S., Stuurman, Debra, de Ridder, Corrina, Clahsen-van Groningen, Marian C., de Blois, Erik, Nonnekens, Julie

Source: Theranostics; 2023, Vol. 13 Issue 10, p3117-3130, 14p

Pre- and Intraoperative Visualization of GRPR-Expressing Solid Tumors: Preclinical Profiling of Novel Dual-Modality Probes for Nuclear and Fluorescence Imaging.

Authors: Verhoeven, Marjolein, Handula, Maryana, van den Brink, Lilian, de Ridder, Corrina M. A., Stuurman, Debra C., Seimbille, Yann, Dalm, Simone U.

Source: Cancers; Apr2023, Vol. 15 Issue 7, p2161, 17p

Subject Terms: TUMOR surgery, COMPUTER-assisted surgery, IN vivo studies, INDIUM, INTRAOPERATIVE care, ANIMAL experimentation, CELL receptors, FLUORESCENCE spectroscopy, GASTROINTESTINAL tumors, GENE expression profiling, RESEARCH funding, VISUALIZATION, PEPTIDE hormones, CELL lines, MOLECULAR structure, MICE, PROSTATE tumors, BREAST tumors

In Vivo Efficacy Testing of Peptide Receptor Radionuclide Therapy Radiosensitization Using Olaparib.

Authors: Feijtel, Danny, Reuvers, Thom G. A., van Tuyll-van Serooskerken, Christine, de Ridder, Corrina M. A., Stuurman, Debra C., de Blois, Erik, Verkaik, Nicole S., de Bruijn, Peter, Koolen, Stijn L. W., de Jong, Marion, Nonnekens, Julie

Source: Cancers; Feb2023, Vol. 15 Issue 3, p915, 11p

Subject Terms: DRUG efficacy, COMBINATION drug therapy, ANIMAL experimentation, CELL receptors, RADIOISOTOPES, RADIATION-sensitizing agents, NEUROENDOCRINE tumors, MICE

Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling.

Authors: Van Hemelryk, Annelies, Tomljanovic, Ingrid, de Ridder, Corrina M. A., Stuurman, Debra C., Teubel, Wilma J., Erkens-Schulze, Sigrun, Verhoef, Esther I., Remmers, Sebastiaan, Mahes, Amrish J., van Leenders, Geert J. L. H., van Royen, Martin E., van de Werken, Harmen J. G., Grudniewska, Magda, Jenster, Guido W., van Weerden, Wytske M.

Source: Cells (2073-4409); Nov2022, Vol. 11 Issue 22, p3632, 21p

Subject Terms: CASTRATION-resistant prostate cancer, ANDROGEN receptors, XENOGRAFTS, ORGANOIDS, DNA repair