Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis

Authors: Tuffs, Christopher ^{∗, †}, Dupovac, Mareen ^∗, Richter, Katrin ^{†, ‡}, Holten, Sophia ^∗, Schaschinger, Thomas ^∗, Marg, Oliver ^†, Poljo, Adisa ^§, Tasdemir, Ayse nur ^∗, Harnoss, Jonathan M. ^{∗, †}, Billeter, Adrian ^§, Schneider, Martin ^{∗, †}, Strowitzki, Moritz J. ^{∗, †, ∗}

Source: In The American Journal of Pathology March 2025 195(3):480-493

Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery

Authors: Dehne, Sarah, Kirschner, Lina, Strowitzki, Moritz J., Kilian, Samuel, Kummer, Laura Christine, Schneider, Martin A., Michalski, Christoph W., Büchler, Markus W., Weigand, Markus A., Larmann, Jan

Source: In Journal of Clinical Anesthesia September 2024 96

Inhibition of the Renin-Angiotensin System Improves Response to Neoadjuvant Therapy in Patients With Liver Metastasis of Colorectal Cancers

Authors: Wirsik, Naita M., Appel, Pia C., Braun, Alexander, Strowitzki, Moritz J., Schleussner, Nikolai, Nienhüser, Henrik, Schneider, Martin, Schmidt, Thomas

Source: In Journal of Surgical Research June 2024 298:176-184

Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes

Authors: Phelan, David E, Mota, Catarina, Strowitzki, Moritz J, Shigemura, Masahiko, Sznajder, Jacob I, Crowe, Louise, Masterson, Joanne C, Hayes, Sophie E, Reddan, Ben, Yin, Xiaofei, Brennan, Lorraine, Crean, Daniel, Cummins, Eoin P

Source: Immunology and cell biology. 101(6):556-577

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Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

Authors: Fitzsimons, Stephen, Muñoz-San Martín, María, Nally, Frances, Dillon, Eugene, Fashina, Ifeolutembi A., Strowitzki, Moritz J., Ramió-Torrentà, Lluís, Dowling, Jennifer K., De Santi, Chiara, McCoy, Claire E.

Source: In Molecular Therapy - Nucleic Acids 12 September 2023 33:941-959

Prolyl Hydroxylase Inhibition Mitigates Allograft Injury During Liver Transplantation

Authors: Harnoss, Jonathan M., Cai, Jun, Hinterkopf, Sascha, Radhakrishnan, Praveen, Schmitt, Annabelle, Dupovac, Mareen, Nees, Lisa K., Strowitzki, Moritz J., Taylor, Cormac T., Schneider, Martin

Source: Transplantation. 106(10):e430-e440

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179324713.0x000001&indx=1&recIds=ETOCvdc_100179324713.0x000001

Carbon Dioxide Sensing by Immune Cells Occurs through Carbonic Anhydrase 2—Dependent Changes in Intracellular pH

Authors: Strowitzki, Moritz J., Nelson, Ross, Garcia, Mario P., Tuffs, Christopher, Bleul, Marc B., Fitzsimons, Stephen, Navas, Javier, Uzieliene, Ilona, Ritter, Alina S., Phelan, David

Source: Journal of immunology. 208(10):2363-2375

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IRE1 is a promising therapeutic target in pancreatic cancer.

Authors: Lucas, Denise, Sarkar, Tamal, Niemeyer, Clara Y., Harnoss, Julian C., Schneider, Martin, Strowitzki, Moritz J., Harnoss, Jonathan M.

Source: American Journal of Physiology: Cell Physiology; Mar2025, Vol. 328 Issue 3, pC806-C824, 19p

Temporal variation in nutritional status and preoperative anemia among patients with retroperitoneal soft tissue sarcoma: a retrospective longitudinal cohort study.

Authors: Willis, Franziska, Trunk, Anna-Marlen, Musa, Julian, Harnoss, Jonathan M., Strowitzki, Moritz J., Engerer, Cosima, Harnoss, Julian-C., Al-Saeedi, Mohammed, Büchler, Markus W., Schneider, Martin

Source: Langenbeck's Archives of Surgery; 1/22/2025, Vol. 410 Issue 1, p1-11, 11p

Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?

Authors: Strowitzki, Moritz J., Ritter, Alina S., Kimmer, Gwendolyn, Schneider, Martin

Source: In Pharmacological Research September 2019 147

Mucosal inflammation downregulates PHD1 expression promoting a barrier‐protective HIF‐1α response in ulcerative colitis patients

Authors: Brown, Eric, Rowan, Catherine, Strowitzki, Moritz J., Fagundes, Raphael R., Faber, Klaas Nico, Güntsch, Annemarie, Halligan, Doug N., Kugler, Julia, Jones, Fiona, Lee, Chee T., Doherty, Glen, Taylor, Cormac T.

Source: FASEB journal. 34(3):3732-3742

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Prognostic relevance of programmed death-ligand 1 expression and microsatellite status in small bowel adenocarcinoma

Authors: Klose, Johannes, Lasitschka, Felix, Horsch, Cornelia, Strowitzki, Moritz J., Bruckner, Thomas, Volz, Claudia, Schmidt, Thomas, Schneider, Martin

Source: Scandinavian journal of gastroenterology. 55(3):321-329

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Prolyl Hydroxylase Inhibition Mitigates Pouchitis

Authors: Harnoss, Jonathan M, Gebhardt, Jasper M, Radhakrishnan, Praveen, Leowardi, Christine, Burmeister, Julius, Halligan, Doug N, Yuan, Shuai, Kennel, Kilian B, Strowitzki, Moritz J, Schaible, Anja, Lasitschka, Felix, Taylor, Cormac T, Schneider, Martin

Source: Inflammatory bowel diseases. 26(2):192-205

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Response to letter to the editor regarding “low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery”

Authors: Dehne, Sarah, Kirschner, Lina, Strowitzki, Moritz J., Kilian, Samuel, Kummer, Laura C., Schneider, Martin A., Michalski, Christoph W., Büchler, Markus W., Weigand, Markus A., Larmann, Jan

Source: In Journal of Clinical Anesthesia December 2024 99

Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells

Authors: Strowitzki, Moritz J., Kirchberg, Johanna, Tuffs, Christopher, Schiedeck, Maximilian, Ritter, Alina S., Biller, Marvin, Harnoss, Jonathan M., Lasitschka, Felix, Schmidt, Thomas, Radhakrishnan, Praveen, Ulrich, Alexis, Schneider, Martin

Source: In The American Journal of Pathology December 2018 188(12):2826-2838

Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis

Authors: Manresa, Mario C., Smith, Leila, Casals‐Diaz, Laura, Fagundes, Raphael R., Brown, Eric, Radhakrishnan, Praveen, Murphy, Stephen J., Crifo, Bianca, Strowitzki, Moritz J., Halligan, Doug N., van den Bogaard, Ellen H., Niehues, Hanna, Schneider, Martin, Taylor, Cormac T., Steinhoff, Martin

Source: Allergy. 74(4):753-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083051922.0x000001&indx=1&recIds=ETOCvdc_100083051922.0x000001

High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases

Authors: Strowitzki, Moritz, Radhakrishnan, Praveen, Pavicevic, Sandra, Scheer, Jana, Kimmer, Gwendolyn, Ritter, Alina, Tuffs, Christopher, Volz, Claudia, Vondran, Florian, Harnoss, Jonathan, Klose, Johannes, Schmidt, Thomas, Schneider, Martin

Source: British journal of cancer. 120(7):675-688

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129207134.0x000001&indx=1&recIds=ETOCvdc_100129207134.0x000001

The differences in drug disposition gene induction by rifampicin and rifabutin are unlikely due to different effects on important pregnane X receptor (NR1I2) splice variants.

Authors: Nilles, Julie, Weiss, Johanna, Masin, Martin, Tuffs, Christopher, Strowitzki, Moritz J., Haefeli, Walter E., Ruez, Stephanie, Theile, Dirk

Source: Naunyn-Schmiedeberg's Archives of Pharmacology; Apr2024, Vol. 397 Issue 4, p2485-2496, 12p

Subject Terms: PREGNANE X receptor, RIFAMPIN, GENE expression, DRUG metabolism, REPORTER genes, POLYMERASE chain reaction

Prognostic indicators lose their value with repeated resection of colorectal liver metastases

Authors: Schmidt, Thomas, Nienhüser, Henrik, Kuna, Constantin, Klose, Johannes, Strowitzki, Moritz J., Büchler, Markus W., Ulrich, Alexis, Schneider, Martin

Source: European journal of surgical oncology. 44(10):1610-1618

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100073148871.0x000001&indx=1&recIds=ETOCvdc_100073148871.0x000001

Surgical strategies in true adenocarcinoma of the esophagogastric junction (AEG II): thoracoabdominal or abdominal approach?

Authors: Blank, Susanne, Schmidt, Thomas, Heger, Patrick, Strowitzki, Moritz J., Sisic, Leila, Heger, Ulrike, Nienhueser, Henrik, Haag, Georg Martin, Bruckner, Thomas, Mihaljevic, André L., Ott, Katja, Büchler, Markus W., Ulrich, Alexis

Source: Gastric cancer. 21(2):303-314

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168179923.0x000001&indx=1&recIds=ETOCvdc_100168179923.0x000001