Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis.

Authors: Ramirez-Malule, Howard¹, Junne, Stefan², Nicolás Cruz-Bournazou, Mariano², Neubauer, Peter², Ríos-Estepa, Rigoberto³ rigoberto.rios@udea.edu.co

Source: Applied Microbiology & Biotechnology. May2018, Vol. 102 Issue 9, p4009-4023. 15p.

Subject Terms: *STREPTOMYCES clavuligerus, *CLAVULANIC acid, *KREBS cycle, *MICROBIOLOGICAL synthesis, *BACTERIAL metabolism

Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus

Authors: Dongxu Zhang, Wenyu Du, Xingming Pan, Xiaoxu Lin, Fang-Ru Li, Qingling Wang, Qian Yang, Hui-Min Xu, Liao-Bin Dong

Source: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 815-822 (2024)

Subject Terms: bacterial terpenoid, cytochrome p450s, drimane-type sesquiterpenoid, streptomyces clavuligerus, terpenoid biosynthesis, Science, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/b3b62f2db2c2461b938c840da06a8a8e

Improvement of clavulanic acid production in Streptomyces clavuligerus F613-1 by using a claR-neo reporter strategy.

Authors: Ronghuo Qin^1,2, Chuanqing Zhong³, Gongli Zong^1,2, Jiafang Fu^1,2, Xiuhua Pang⁴ pangxiuhua@sdu.edu.cn, Guangxiang Cao^1,2 caozhong0402@163.com

Source: Electronic Journal of Biotechnology. 2017, Vol. 28, p41-46. 6p.

Subject Terms: *CLAVULANIC acid, *STREPTOMYCES clavuligerus, *BIOSYNTHESIS, *KANAMYCIN, *MUTAGENS

Genetic engineering of an industrial strain of Streptomyces clavuligerus for further enhancement of clavulanic acid production.

Authors: KIZILDOĞAN, Aslıhan KURT^1,2 aslihan.kizildogan@omu.edu.tr, JACCARD, Güliz VANLI^1,3, MUTLU, Alper^1,4, SERTDEMİR, İbrahim^1,5, ÖZCENGİZ, Gülay¹

Source: Turkish Journal of Biology. 2017, Vol. 41 Issue 2, p242-253. 15p.

Subject Terms: *GENETIC engineering, *STREPTOMYCES clavuligerus, *CLAVULANIC acid, *HIGH performance liquid chromatography, *GENE expression

Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus.

Authors: Ferguson, Nicole¹, Peña-Castillo, Lourdes, Moore, Marcus¹, Bignell, Dawn¹, Tahlan, Kapil¹ ktahlan@mun.ca

Source: Journal of Industrial Microbiology & Biotechnology. Apr2016, Vol. 43 Issue 4, p537-555. 19p. 1 Diagram, 3 Charts, 3 Graphs.

Subject Terms: *STREPTOMYCES clavuligerus, *PROTEOMICS, *CLAVULANIC acid, *BACTERIA morphology, *BACTERIAL development, *BACTERIAL metabolites

Clavulanic Acid Overproduction: A Review of Environmental Conditions, Metabolic Fluxes, and Strain Engineering in Streptomyces clavuligerus

Authors: David Gómez-Ríos, Luisa María Gómez-Gaona, Howard Ramírez-Malule

Source: Fermentation, Vol 10, Iss 10, p 526 (2024)

Subject Terms: clavulanic acid, Streptomyces clavuligerus, strain engineering, metabolic flux, Fermentation industries. Beverages. Alcohol, TP500-660

File Description: electronic resource

Relation: https://www.mdpi.com/2311-5637/10/10/526; https://doaj.org/toc/2311-5637

Access URL: https://doaj.org/article/2bc875bc295b4a30b76c8743d29e1747

Increase of Clavulanic acid production by using recombinant Streptomyces clavuligerus strain including claR gene.

Authors: Kay, Maryam¹ maryam_kay2001@yahoo.com, Hojati, Zohreh² z.hojati@sci.ui.ac.ir, Motovali-Bashi, Majid³ mbashi@sci.ui.ac.ir

Source: Biological Journal of Microorganism. Summer2014, Vol. 3 Issue 10, preceding p4-4. 9p.

Subject Terms: *CLAVULANIC acid, *STREPTOMYCES clavuligerus, *BIOSYNTHESIS, *BIOLOGICAL assay, *ANTIBIOTICS

Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.

Authors: Álvarez-Álvarez, R.^1,2, Rodríguez-García, A.^1,2, Santamarta, I.², Pérez-Redondo, R.², Prieto-Domínguez, A.¹, Martínez-Burgo, Y.¹, Liras, P.^1,2 paloma.liras@unileon.es

Source: Microbial Biotechnology. May2014, Vol. 7 Issue 3, p221-231. 11p.

Subject Terms: *STREPTOMYCES clavuligerus, *CEPHAMYCINS, *CLAVULANIC acid, *ASPARAGINE, *CARBON, *NITROGEN, *AMINO acids

A 1.8-Mb-reduced Streptomyces clavuligerus genome: relevance for secondary metabolism and differentiation.

Authors: Álvarez-Álvarez, R., Rodríguez-García, A., Martínez-Burgo, Y.¹, Robles-Reglero, V., Santamarta, I.², Pérez-Redondo, R.², Martín, J.¹, Liras, P. paloma.liras@unileon.es

Source: Applied Microbiology & Biotechnology. Mar2014, Vol. 98 Issue 5, p2183-2195. 13p.

Subject Terms: *GENOMES, *STREPTOMYCES clavuligerus, *CLAVULANIC acid, *MICROBIAL metabolism, *MICROBIAL differentiation, *POLYMERASE chain reaction

Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.

Authors: Liras, Paloma¹ paloma.liras@unileon.es

Source: Applied Microbiology & Biotechnology. Feb2014, Vol. 98 Issue 3, p1023-1030. 8p.

Subject Terms: *STREPTOMYCES clavuligerus, *BACTERIAL metabolites, *LIGASES, *FLAVOPROTEINS, *CLAVULANIC acid, *RNA synthesis

Enhancing effect of lysine combined with other compounds on cephamycin C production in Streptomyces clavuligerus.

Authors: Leite, Carla A.¹ carlaandrealeite@iq.unesp.br, Cavallieri, André P.¹ cavallieri@iq.unesp.br, Araujo, Maria L. G. C.¹ mlaraujo@iq.unesp.br

Source: BMC Microbiology. 2013, Vol. 13 Issue 1, p1-22. 22p. 3 Charts, 6 Graphs.

Subject Terms: *STREPTOMYCES clavuligerus, *CEPHAMYCINS, *LYSINE, *DIAMINES, *METABOLISM

New strategy of site-directed mutagenesis identifies new sites to improve Streptomyces clavuligerus deacetoxycephalosporin C synthase activity toward penicillin G.

Authors: Ji, Junjie¹, Tian, Xiuyun¹, Fan, Keqiang¹ fankq@im.ac.cn, Yang, Keqian¹ yangkq@im.ac.cn

Source: Applied Microbiology & Biotechnology. Mar2012, Vol. 93 Issue 6, p2395-2401. 7p.

Subject Terms: *MUTAGENESIS, *STREPTOMYCES clavuligerus, *CEPHALOSPORINS, *PENICILLIN, *GENETIC mutation

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus.

Authors: Medema, Marnix H.^1,2, Alam, Mohammad T.^2,3, Heijne, Wilbert H. M.⁴, van den Berg, Marco A.⁴, Müller, Ulrike⁴, Trefzer, Axel⁴, Bovenberg, Roel A. L.^4,5, Breitling, Rainer^2,3, Takano, Eriko¹

Source: Microbial Biotechnology. Mar2011, Vol. 4 Issue 2, p300-305. 6p.

Subject Terms: *CLAVULANIC acid, *STREPTOMYCES clavuligerus, *BIOSYNTHESIS, *BIOTECHNOLOGY, *GENE expression, *MUTAGENESIS, *CARBOXYLIC acids

A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.

Authors: Nárdiz, Nuria^1,2, Santamarta, Irene^1,2, Lorenzana, Luis M.², Martín, Juan F.^1,2, Liras, Paloma^1,2

Source: Microbial Biotechnology. Mar2011, Vol. 4 Issue 2, p216-225. 10p.

Subject Terms: *STREPTOMYCES clavuligerus, *CYSTEINE proteinases, *OXIDATIVE stress, *THIOSULFATES, *CEPHAMYCINS, *ANTIBIOTICS, *SULFUR, *PROTEINASES

Advances in Microbial Fermentation Processes

Contributors: Tufariello, Maria, Grieco, Francesco

Subject Terms: simultaneous saccharification and cultivation (SSC), intensive multiple sequential batch cultivation, thermotolerant yeast, Kluyveromyces marxianus, ethanol production, smoking with open fire, PAH, industrial smoking, clavulanic acid, Streptomyces clavuligerus, cell morphology, shear stress, high cell density cultivation (HCDC), intensive multiple sequential batch (IMSB), cell cultivation, fed-batch at cell level (FBC), S. cerevisiae, dextrin, bioreactor, chain elongation, carboxylate platform, medium-chain fatty acids, carboxylic acids, mixed culture fermentation, biocontrol, Bacillus velezensis, volatile organic compounds, vascular wilt pathogens, GABA, Indonesian fermented foods, glutamate decarboxylase, lactic acid bacteria, L. plantarum, feast/famine conditions, industrial-scale bioreactor, metabolomics, metabolic response, penicillin, Penicillium chrysogenum, scale-down, children, double fortification, fermented milk, iron and zinc, stunting, synbiotic, wine, HS-SPME-GC/MS, multivariate statistical analysis, calibration, whole-plant corn silage, bacterial community, fungal community, metabolites, fermentation quality, aerobic stability, succession pattern, fermentation process, Technology: general issues, Biotechnology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/84524
https://mdpi.com/books/pdfview/book/5508

A Study on the Production of Clavulanic Acid by Streptomyces clavuligerus using Carbon Resources such as Glucose, Glycerol, and Wheat Bran

Authors: Parisa Akhavan modares, Fatemeh Ashrafi, Taher Nejadsattari

Source: Biological Journal of Microorganism, Vol 11, Iss 41, Pp 9-20 (2022)

Subject Terms: clavulanic acid, beta-lactamase, biomass, streptomyces clavuligerus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://bjm.ui.ac.ir/article_25103_425e76016c1c73905a3cbd6456a26cfd.pdf; https://doaj.org/toc/2322-5173; https://doaj.org/toc/2322-5181

Access URL: https://doaj.org/article/1bcb62a86a8542dea56b60946fbcc13e

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

Authors: Xiaofan Niu, Jian Zhang, Xianli Xue, Depei Wang, Lin Wang, Qiang Gao

Source: Synthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 396-401 (2021)

Subject Terms: Deacetyloxycephalosporin C synthase, Expandase, Streptomyces clavuligerus, Acremonium chrysogenum, Progress, Application, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405805X21000697; https://doaj.org/toc/2405-805X

Access URL: https://doaj.org/article/3804745428b74c0d84876ec567571e1a

A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications.

Authors: Ayala‐Ruano, Sebastián¹, Santander‐Gordón, Daniela², Tejera, Eduardo^2,3, Perez‐Castillo, Yunierkis^3,4, Armijos-Jaramillo, Vinicio^2,3 vinicio.armijos@udla.edu.ec

Source: Ecology & Evolution (20457758). Mar2019, Vol. 9 Issue 5, p2602-2614. 13p.

Subject Terms: Antimicrobial peptides, Hymenoptera, Streptomyces clavuligerus, Genetic transformation, Clavulanic acid

Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.

Authors: Álvarez-Álvarez, R.¹, Rodríguez-García, A.², Martínez-Burgo, Y.¹, Martín, J. F.¹, Liras, P.¹ paloma.liras@unileon.es

Source: Applied & Environmental Microbiology. Nov2018, Vol. 84 Issue 22, p1-17. 17p.

Subject Terms: *STREPTOMYCES clavuligerus, *CLAVULANIC acid, *CARRIER proteins, *BIOSYNTHESIS, *CEPHAMYCINS

Streptomyces clavuligerus strain selection for clavulanic acid biosynthesis: a study based on culture composition effects and statistical analysis.

Alternate Title: Selección de una cepa de Streptomyces clavuligerus para la biosíntesis de ácido clavulánico: un estudio basado en los efectos de la composición del medio de cultivo y análisis estadístico.

Authors: Pinilla, Laura¹ laura.pinilla@udea.edu.co, Toro, León F.¹ lfelipe.toro@udea.edu.co, Avignone-Rossa, Claudio² c.avignone-rossa@surrey.ac.uk, Peñuela, Mariana³ mariana.penuela@udea.edu.co, Ríos-Estepa, Rigoberto³ rigoberto.rios@udea.edu.co

Source: Dyna. Jun2018, Vol. 85 Issue 205, p111-118. 8p.

Subject Terms: *STREPTOMYCES clavuligerus, *STREPTOMYCES, *STREPTOMYCETACEAE, *CLAVULANIC acid, *CULTURE media (Biology)