Development of a virulent O'nyong'nyong challenge model to determine heterologous protection mediated by a hydrogen peroxide-inactivated chikungunya virus vaccine.

Authors: Weber, Whitney C., Streblow, Zachary J., Andoh, Takeshi F., Denton, Michael, Raué, Hans-Peter, Amanna, Ian J., Slifka, Dawn K., Kreklywich, Craig N., Arduino, Irene, Sulgey, Gauthami, Streblow, Magdalene M., Heise, Mark T., Slifka, Mark K., Streblow, Daniel N.

Source: PLoS Neglected Tropical Diseases; 3/17/2025, Vol. 19 Issue 3, p1-22, 22p

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection.

Authors: Weber, Whitney C., Andoh, Takeshi F., Kreklywich, Craig N., Streblow, Zachary J., Denton, Michael, Streblow, Magdalene M., Powers, John M., Sulgey, Gauthami, Medica, Samuel, Dmitriev, Igor, Curiel, David T., Haese, Nicole N., Streblow, Daniel N.

Source: Vaccines; Sep2024, Vol. 12 Issue 9, p970, 24p

Subject Terms: COMBINED vaccines, CHIKUNGUNYA virus, VIRUS diseases, ALPHAVIRUSES, VACCINES

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection.

Authors: Weber, Whitney C., Streblow, Zachary J., Kreklywich, Craig N., Denton, Michael, Sulgey, Gauthami, Streblow, Magdalene M., Marcano, Dorca, Flores, Paola N., Rodriguez-Santiago, Rachel M., Alvarado, Luisa I., Rivera-Amill, Vanessa, Messer, William B., Hochreiter, Romana, Kosulin, Karin, Dubischar, Katrin, Buerger, Vera, Streblow, Daniel N.

Source: Vaccines; Aug2024, Vol. 12 Issue 8, p893, 19p

Subject Terms: CHIKUNGUNYA virus, ALPHAVIRUSES, VIRAL vaccines, GENETIC distance, SEROCONVERSION

Mayaro virus pathogenesis and immunity in rhesus macaques.

Authors: Weber, Whitney C., Labriola, Caralyn S., Kreklywich, Craig N., Ray, Karina, Haese, Nicole N., Andoh, Takeshi F., Denton, Michael, Medica, Samuel, Streblow, Magdalene M., Smith, Patricia P., Mizuno, Nobuyo, Frias, Nina, Fisher, Miranda B., Barber-Axthelm, Aaron M., Chun, Kimberly, Uttke, Samantha, Whitcomb, Danika, DeFilippis, Victor, Rakshe, Shauna, Fei, Suzanne S.

Source: PLoS Neglected Tropical Diseases; 11/20/2023, Vol. 17 Issue 11, p1-40, 40p

Subject Terms: RHESUS monkeys, ALPHAVIRUS diseases, LABORATORY infections, PERIPHERAL nervous system, ALPHAVIRUSES, CHIKUNGUNYA virus, LYMPHOID tissue

Company/Entity: UNITED States. Food & Drug Administration

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein.

Authors: Powers, John M., Lyski, Zoe L., Weber, Whitney C., Denton, Michael, Streblow, Magdalene M., Mayo, Adam T., Haese, Nicole N., Nix, Chad D., Rodríguez-Santiago, Rachel, Alvarado, Luisa I., Rivera-Amill, Vanessa, Messer, William B., Streblow, Daniel N.

Source: PLoS Neglected Tropical Diseases; 3/13/2023, Vol. 16 Issue 3, p1-22, 22p

Subject Terms: CHIKUNGUNYA virus, ALPHAVIRUSES, VIRUS diseases, VENEZUELAN equine encephalomyelitis, IMMUNOLOGIC memory

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