Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy.

Authors: Zhang, Ze, Sehgal, Kartik, Shirai, Keisuke, Butler, Rondi A., Wiencke, John K., Koestler, Devin C., Ramush, Geat, Lee, Min Kyung, Molinaro, Annette M., Stolrow, Hannah G., Birnbaum, Ariel, Salas, Lucas A., Haddad, Robert I., Kelsey, Karl T., Christensen, Brock C.

Source: NPJ Precision Oncology; 11/18/2024, Vol. 8 Issue 1, p1-10, 10p

Subject Terms: MONOCYTE lymphocyte ratio, NEUTROPHIL lymphocyte ratio, IMMUNE checkpoint inhibitors, OVERALL survival, SQUAMOUS cell carcinoma, HEAD & neck cancer

Prenatal exposure to genocide and subsequent adverse childhood events are associated with DNA methylation of SLC6A4, BDNF, and PRDM8 in early adulthood in Rwanda.

Authors: Rivera, Luisa Maria, Uwizeye, Glorieuse, Stolrow, Hannah, Christensen, Brock, Rutherford, Julienne, Thayer, Zaneta

Source: Scientific Reports; 11/14/2024, Vol. 12 Issue 1, p1-7, 7p

Subject Terms: DNA methylation, ADVERSE childhood experiences, PRENATAL exposure, YOUNG adults, MATERNAL exposure

Down Syndrome Altered Cell Composition in Blood, Brain, and Buccal Swab Samples Profiled by DNA-Methylation-Based Cell-Type Deconvolution.

Authors: Zhang, Ze¹ (AUTHOR) ze.zhang.gr@dartmouth.edu, Stolrow, Hannah G.¹ (AUTHOR) hannah.stolrow@dartmouth.edu, Christensen, Brock C.^1,2 (AUTHOR) brock.c.christensen@dartmouth.edu, Salas, Lucas A.^1,2 (AUTHOR) lucas.a.salas@dartmouth.edu

Source: Cells (2073-4409). Apr2023, Vol. 12 Issue 8, p1168. 13p.

Subject Terms: *DOWN syndrome, *BLOOD cells, *CYTOLOGY, *FATE mapping (Genetics), *DNA methylation, *EPIGENOMICS, *FRAGILE X syndrome

Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.

Authors: Lee, Min Kyung, Zhang, Ze, Sehgal, Kartik, Butler, Rondi, Stolrow, Hannah, Ramush, Geat, Shirai, Keisuke, Koestler, Devin C, Salas, Lucas A, Wiencke, John K, Haddad, Robert, Kelsey, Karl T, Christensen, Brock C

Source: Epigenomics; Jun2024, Vol. 16 Issue 11/12, p799-807, 9p

Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell‐type deconvolution applied to human blood epigenetic clocks.

Authors: Zhang, Ze, Reynolds, Samuel R., Stolrow, Hannah G., Chen, Ji‐Qing, Christensen, Brock C., Salas, Lucas A.

Source: Aging Cell; Mar2024, Vol. 23 Issue 3, p1-16, 16p

Subject Terms: EPIGENETICS, DNA methylation, RHEUMATOID arthritis, INDIVIDUALIZED medicine, CONFORMANCE testing, EPIGENOMICS