Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

Authors: Deni, Ioanna, Stokes, Barbara H., Ward, Kurt E., Fairhurst, Kate J., Pasaje, Charisse Flerida A., Yeo, Tomas, Akbar, Shirin, Park, Heekuk, Muir, Ryan, Bick, Daniella S., Zhan, Wenhu, Zhang, Hao, Liu, Yi Jing, Ng, Caroline L., Kirkman, Laura A., Almaliti, Jehad, Gould, Alexandra E., Duffey, Maëlle, O'Donoghue, Anthony J., Uhlemann, Anne-Catrin, Niles, Jacquin C., da Fonseca, Paula C.A., Gerwick, William H., Lin, Gang, Bogyo, Matthew, Fidock, David A.

Source: In Cell Chemical Biology 18 May 2023 30(5):470-485

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

Authors: Yoo, Euna, Stokes, Barbara H., de Jong, Hanna, Vanaerschot, Manu, Kumar, T. R. S., Lawrence, Nina, Njoroge, Mathew, Garcia, Arnold, Van der Westhuyzen, Renier, Momper, Jeremiah D.

Source: Journal of the American Chemical Society. 140(36):11424-11437

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617346319&indx=1&recIds=ETOCRN617346319

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival

Authors: Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193204946.0x000001&indx=1&recIds=ETOCvdc_100193204946.0x000001

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.

Authors: Gnädig, Nina F.¹ (AUTHOR), Stokes, Barbara H.¹ (AUTHOR), Edwards, Rachel L.² (AUTHOR), Kalantarov, Gavreel F.³ (AUTHOR), Heimsch, Kim C.⁴ (AUTHOR), Kuderjavy, Michal⁵ (AUTHOR), Crane, Audrey¹ (AUTHOR), Lee, Marcus C. S.⁶ (AUTHOR), Straimer, Judith¹ (AUTHOR), Becker, Katja⁴ (AUTHOR), Trakht, Ilya N.³ (AUTHOR), Odom John, Audrey R.^2,7,8 (AUTHOR), Mok, Sachel¹ (AUTHOR), Fidock, David A.^1,3 (AUTHOR) df2260@cumc.columbia.edu

Source: PLoS Pathogens. 4/20/2020, Vol. 16 Issue 4, p1-35. 35p.

Subject Terms: *ARTEMISININ derivatives, *PLASMODIUM falciparum, *MITOCHONDRIAL proteins, *ENDOPLASMIC reticulum, *MONOCLONAL antibodies, *DRUG resistance, *MYOGLOBIN

Geographic Terms: SOUTHEAST Asia

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

Authors: Yoo, Euna, Schulze, Christopher J., Stokes, Barbara H., Onguka, Ouma, Yeo, Tomas, Mok, Sachel, Gnädig, Nina F., Zhou, Yani, Kurita, Kenji, Foe, Ian T., Terrell, Stephanie M., Boucher, Michael J., Cieplak, Piotr, Kumpornsin, Krittikorn, Lee, Marcus C.S., Linington, Roger G., Long, Jonathan Z., Uhlemann, Anne-Catrin, Weerapana, Eranthie, Fidock, David A., Bogyo, Matthew

Source: Cell chemical biology. 27(2):143-157.e5

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115277878.0x000001&indx=1&recIds=ETOCvdc_100115277878.0x000001

Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.

Authors: Mihreteab, Selam¹, smuqubay@gmail.com, Platon, Lucien^2,3,4, Berhane, Araia⁵, Stokes, Barbara H.⁶, Warsame, Marian⁷, Campagne, Pascal⁸, Criscuolo, Alexis⁸, Ma, Laurence⁹, Petiot, Nathalie², Doderer-Lang, Cécile¹⁰, Legrand, Eric^2,3, Ward, Kurt E.⁶, Kassahun, Assefash Zehaie¹¹, Ringwald, Pascal¹², Fidock, David A.^6,13, Ménard, Didier^2,3,10,14, dmenard@pasteur.fr

Source: New England Journal of Medicine; 9/28/2023, Vol. 389 Issue 13, p1191-1202, 12p

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.

Authors: Stokes, Barbara H.¹, Yoo, Euna², Murithi, James M.¹, Luth, Madeline R.³, Afanasyev, Pavel⁴, da Fonseca, Paula C. A.⁴, Winzeler, Elizabeth A.³, Ng, Caroline L.¹ caroline.ng@unmc.edu, Bogyo, Matthew² mbogyo@stanford.edu, Fidock, David A.^1,5 df2260@cumc.columbia.edu

Source: PLoS Pathogens. 6/6/2019, Vol. 15 Issue 6, p1-29. 29p.

Subject Terms: *PLASMODIUM falciparum, *PROTEASOMES, *ANTIMALARIALS, *MULTIDRUG resistance, *PARASITOLOGY, *ARTEMISININ

A G358S mutation in the Plasmodium falciparum Na⁺ pump PfATP4 confers clinically-relevant resistance to cipargamin.

Authors: Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M.

Source: Nature Communications; 9/30/2022, Vol. 13 Issue 1, p1-18, 18p

Subject Terms: PLASMODIUM falciparum, PLASMODIUM, ORAL drug administration, PARASITES, TOXOPLASMA gondii, ADENOSINE triphosphatase

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.

Authors: Stokes, Barbara H.¹, Dhingra, Satish K.¹, Rubiano, Kelly¹, Mok, Sachel¹, Straimer, Judith¹, Gnädig, Nina F.¹, Deni, Ioanna¹, Schindler, Kyra A.¹, Bath, Jade R.¹, Ward, Kurt E.^1,2, Striepen, Josefine¹, Yeo, Tomas¹, Ross, Leila S.¹, Legrand, Eric³, Ariey, Frédéric⁴, Cunningham, Clark H.⁵, Souleymane, Issa M.⁶, Gansané, Adama⁷, Nzoumbou-Boko, Romaric⁸, Ndayikunda, Claudette⁹

Source: eLife. 7/29/2021, p1-29. 29p.

Subject Terms: *PLASMODIUM falciparum, *ARTEMISININ, *TREATMENT failure, *MINIMAL art, *PLASMODIUM, *PARASITES, *GENOME editing

Geographic Terms: SOUTHEAST Asia, RWANDA

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13R561H mutant parasites in Rwanda

Authors: Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, Menard, Didier

Source: Nature Medicine; October 2020, Vol. 26 Issue: 10 p1602-1608, 7p

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Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13R561H mutant parasites in Rwanda

Authors: Uwimana, Aline, Legrand, Eric, Stokes, Barbara H., Ndikumana, Jean-Louis Mangala, Warsame, Marian, Umulisa, Noella, Ngamije, Daniel, Munyaneza, Tharcisse, Mazarati, Jean-Baptiste, Munguti, Kaendi, Campagne, Pascal, Criscuolo, Alexis, Ariey, Frédéric, Murindahabi, Monique, Ringwald, Pascal, Fidock, David A., Mbituyumuremyi, Aimable, Menard, Didier

Source: Nature Medicine; 20210101, Issue: Preprints p1-3, 3p

Defining the Determinants of Specificity of PlasmodiumProteasome Inhibitors

Authors: Yoo, Euna, Stokes, Barbara H., de Jong, Hanna, Vanaerschot, Manu, Kumar, TRS, Lawrence, Nina, Njoroge, Mathew, Garcia, Arnold, Van der Westhuyzen, Renier, Momper, Jeremiah D., Ng, Caroline L., Fidock, David A., Bogyo, Matthew

Source: Journal of the American Chemical Society; September 2018, Vol. 140 Issue: 36 p11424-11437, 14p

Evidence of Artemisinin-Resistant Malaria in Africa.

Authors: Stokes, Barbara H.¹, Ward, Kurt E.¹, Fidock, David A.¹ df2260@columbia.edu

Source: New England Journal of Medicine. 4/7/2022, Vol. 386 Issue 14, p1385-1386. 2p.

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Plasmodium bergheiK13 Mutations Mediate In VivoArtemisinin Resistance That Is Reversed by Proteasome Inhibition

Authors: Simwela, Nelson V., Stokes, Barbara H., Aghabi, Dana, Bogyo, Matt, Fidock, David A., Waters, Andrew P.

Source: mBio; December 2020, Vol. 11 Issue: 6

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