HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells

Authors: Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11534; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/2ba793734fde41f4aa47b970e723784c

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Authors: Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: T-cell development, Wiskott Aldrich syndrome, T-cell repertoire, ATO, CRISPR/Cas9, INDEL, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188099/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8e328ea3407848819b605b95f452cf7f

Intracellular Delivery of mRNA in Adherent and Suspension Cells by Vapor Nanobubble Photoporation

Authors: Laurens Raes, Stephan Stremersch, Juan C. Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, Xavier Saelens, Bart Vandekerckhove, Stefaan De Smedt, Koen Raemdonck, Kevin Braeckmans

Source: Nano-Micro Letters, Vol 12, Iss 1, Pp 1-17 (2020)

Subject Terms: Transfection, mRNA, Photoporation, Optoporation, Gold nanoparticles, Vapor nanobubbles, Technology

File Description: electronic resource

Relation: http://link.springer.com/article/10.1007/s40820-020-00523-0; https://doaj.org/toc/2311-6706; https://doaj.org/toc/2150-5551

Access URL: https://doaj.org/article/543a96ad06524b4f9271212ffb59401e

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Authors: Sigrid Wahlen, Filip Matthijssens, Wouter Van Loocke, Sylvie Taveirne, Laura Kiekens, Eva Persyn, Els Van Ammel, Zenzi De Vos, Stijn De Munter, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq

Source: eLife, Vol 11 (2022)

Subject Terms: NK cell development, tissue residency, RUNX2, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/80320; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/11397126237f4caebcb161863a688e20

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies

Authors: Leander Huyghe, Alexander Van Parys, Anje Cauwels, Sandra Van Lint, Stijn De Munter, Jennyfer Bultinck, Lennart Zabeau, Jeroen Hostens, An Goethals, Nele Vanderroost, Annick Verhee, Gilles Uzé, Niko Kley, Frank Peelman, Bart Vandekerckhove, Peter Brouckaert, Jan Tavernier

Source: EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-15 (2020)

Subject Terms: cancer, interferons, neovasculature, targeted therapy, tumor necrosis factor, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/0c182dbd4d474d4e99086c5f110eebd3

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Authors: Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: acute myeloid leukemia (aml), t cell immunotherapy, common gamma chain cytokines, hematopoietic stem cells, op9-dl1, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Authors: Barbara Depreter, Karin E. Weening, Karl Vandepoele, Magnus Essand, Barbara De Moerloose, Maria Themeli, Jacqueline Cloos, Diana Hanekamp, Ine Moors, Inge D’hont, Barbara Denys, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Sylvia Snauwaert, Glenn Goetgeluk, Stijn De Munter, Tessa Kerre, Bart Vandekerckhove, Tim Lammens, Jan Philippé

Source: Haematologica, Vol 105, Iss 5 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9386; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/fd108e28e0bd4466a0913f7a7117a0d5

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: acute myeloid leukemia (aml), t-cell immunotherapy, hematopoietic stem cells, op9-dl1, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Authors: Yasmine Van Caeneghem, Stijn De Munter, Paola Tieppo, Glenn Goetgeluk, Karin Weening, Greet Verstichel, Sarah Bonte, Tom Taghon, Georges Leclercq, Tessa Kerre, Reno Debets, David Vermijlen, Hinrich Abken, Bart Vandekerckhove

Source: OncoImmunology, Vol 6, Iss 3 (2017)

Subject Terms: chimeric antigen receptor, cord blood, hematopoietic precursor cell, hematopoietic stem cell, immunotherapy, t cell, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/20e75ad2cb564c7c8a949cd5e8b92798