Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function

Authors: Augusto Faria Andrade, Alva Annett, Elham Karimi, Danai Georgia Topouza, Morteza Rezanejad, Yitong Liu, Michael McNicholas, Eduardo G. Gonzalez Santiago, Dhana Llivichuzhca-Loja, Arne Gehlhaar, Selin Jessa, Antonella De Cola, Bhavyaa Chandarana, Caterina Russo, Damien Faury, Geoffroy Danieau, Evan Puligandla, Yuhong Wei, Michele Zeinieh, Qing Wu, Steven Hebert, Nikoleta Juretic, Emily M. Nakada, Brian Krug, Valerie Larouche, Alexander G. Weil, Roy W. R. Dudley, Jason Karamchandani, Sameer Agnihotri, Daniela F. Quail, Benjamin Ellezam, Liza Konnikova, Logan A. Walsh, Manav Pathania, Claudia L. Kleinman, Nada Jabado

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/69253d46aa2e495fb76b6cda5b46af80

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

Authors: William R Brothers, Steven Hebert, Claudia L Kleinman, Marc R Fabian

Source: eLife, Vol 9 (2020)

Subject Terms: mRNA decay, RNA binding protein, mRNA decapping, endonuclease, gene expression, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/54995; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2a9d8c4dbd154405bd634fc367851e06

Clinical Characteristics of the End-of-Life Phase in Children with Life-Limiting Diseases: Retrospective Study from a Single Center for Pediatric Palliative Care

Authors: Fanni Baumann, Steven Hebert, Wolfgang Rascher, Joachim Woelfle, Chara Gravou-Apostolatou

Source: Children, Vol 8, Iss 6, p 523 (2021)

Subject Terms: pediatric, palliative care, end-of-life, symptom management, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/8/6/523; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/da2ff6d2e1be437ab2aa65646df3c4e6

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress

Authors: Kyle Lewis, Rachel La Selva, Elias Maldonado, Matthew G. Annis, Ouafa Najyb, Eduardo Cepeda Cañedo, Stephanie Totten, Steven Hébert, Valérie Sabourin, Caitlynn Mirabelli, Emma Ciccolini, Camille Lehuédé, Luc Choinière, Mariana Russo, Daina Avizonis, Morag Park, Julie St-Pierre, Claudia L. Kleinman, Peter M. Siegel, Josie Ursini-Siegel

Source: Redox Biology, Vol 70, Iss , Pp 103028- (2024)

Subject Terms: p66ShcA, Breast cancer, Oxidative stress, Metabolic plasticity, Glutathione, Anoikis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724000041; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/8bcb1cc7a7684f09b3d926e68c5a0e4c

Diagnostic Utility of Interleukin-6 in Early-Onset Sepsis among Term Newborns: Impact of Maternal Risk Factors and CRP Evaluation

Authors: Maria Schleier, Julia Lubig, Sven Kehl, Steven Hébert, Joachim Woelfle, Adriana van der Donk, Alisa Bär, Heiko Reutter, Tobias Hepp, Patrick Morhart

Source: Children, Vol 11, Iss 1, p 53 (2023)

Subject Terms: sepsis, neonatal, early-onset sepsis, EOS, Interleukin-6, C-reactive protein, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/11/1/53; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/5cb8a98a562b41ce81134702ba74bb7b

'Multisystem Inflammatory Syndrome in Children'-Like Disease after COVID-19 Vaccination (MIS-V) with Potential Significance of Functional Active Autoantibodies Targeting G-Protein-Coupled Receptors (GPCR-fAAb) for Pathophysiology and Therapy

Authors: Marius Schmidt, Steven Hébert, Gerd Wallukat, Rolf Ponader, Tobias Krickau, Matthias Galiano, Heiko Reutter, Joachim Woelfle, Abbas Agaimy, Christian Mardin, André Hoerning, Bettina Hohberger

Source: Children, Vol 10, Iss 12, p 1836 (2023)

Subject Terms: COVID-19, SARS-CoV-2, MIS-V, GPCR-fAAb, MIS-C, PIMS, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/10/12/1836; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/7fc131e2481744609c8740d610214e9d

'Multisystem Inflammatory Syndrome in Children' (MIS-C) after COVID-19 Infection in the Metropolitan Area of Nuremberg-Erlangen, Germany—Expectations and Results of a Two-Year Period

Authors: Steven Hébert, Marius Schmidt, Georg Topf, Daniel Rieger, Jens Klinge, Jan Vermehren, Christoph Fusch, Christian Grillhösl, Michael Schroth, Irmgard Toni, Heiko Reutter, Patrick Morhart, Gregor Hanslik, Linda Mulzer, Joachim Woelfle, Bettina Hohberger, André Hoerning

Source: Children, Vol 10, Iss 8, p 1363 (2023)

Subject Terms: IVIG, intravenous immunoglobulins, MIS-C, Multisystem Inflammatory Syndrome in children, mAbs, monoclonal antibodies, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/10/8/1363; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/a906d8a5f2c74ee98746e35cc42525dd

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Authors: Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel

Source: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e78e979f7f9a43d280222791ea6273df

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Authors: Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8

Copy number and transcriptome alterations associated with metastatic lesion response to treatment in colorectal cancer

Authors: Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Zuanel Diaz, Cyrla Hoffert, Archana Srivastava, Steven Hébert, Benoit Samson, Bernard Lespérance, Yoo‐Joung Ko, Richard Dalfen, Eve St‐Hilaire, Lucas Sideris, Felix Couture, Ronald Burkes, Mohammed Harb, Errol Camlioglu, Adrian Gologan, Vincent Pelsser, André Constantin, Celia M.T. Greenwood, Sabine Tejpar, Petr Kavan, Claudia L. Kleinman, Gerald Batist

Source: Clinical and Translational Medicine, Vol 11, Iss 4, Pp n/a-n/a (2021)

Subject Terms: colorectal cancer, copy number aberrations, metastasis, treatment response, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/2db15e511b2048da941740287e8636c1

PRMT5 is essential for B cell development and germinal center dynamics

Authors: Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia

Source: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/33da862d42ce48bf82823c6742c63b37

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Authors: Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt, Steven Hébert, Stephanie Totten, Nicolas De Jay, Maria Carolina Festa, Yoon Kow Young, Young Kyuen Im, Tony Pawson, Antonis E. Koromilas, William J. Muller, Koren K. Mann, Claudia L. Kleinman, Josie Ursini-Siegel

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa