LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes

Authors: Jennifer Keller, Judit Danis, Isabella Krehl, Eleftheria Girousi, Takashi K. Satoh, Barbara Meier-Schiesser, Lajos Kemény, Márta Széll, W. Wei-Lynn Wong, Steve Pascolo, Lars E. French, Thomas M. Kündig, Mark Mellett

Source: Cell Death and Disease, Vol 16, Iss 1, Pp 1-14 (2025)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/d142fcc2d5814670911f4d5fb7c497f1

TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis

Authors: Benjamin Loos, Adrian Salas-Bastos, Anna Nordin, Julien Debbache, Salome Stierli, Phil F. Cheng, Stefanie Rufli, Conrad Wyss, Mitchell P. Levesque, Reinhard Dummer, Wendy Wei-Lynn Wong, Steve Pascolo, Claudio Cantù, Lukas Sommer

Source: Cell Death and Disease, Vol 15, Iss 12, Pp 1-18 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/ffa3a422e75549078e48baa042793f68

Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

Authors: Paulo Pereira, Joshua Panier, Marc Nater, Michael Herbst, Anna Laura Calvanese, Hakan Köksal, Héctor Castañón, Virginia Cecconi, Paulino Tallón de Lara, Steve Pascolo, Maries van den Broek

Source: Cell Reports, Vol 44, Iss 3, Pp 115388- (2025)

Subject Terms: CP: Cancer, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124725001597; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/7773c231f5ef4b7e887f9b76049918b3

MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides

Authors: Yun-Tsan Chang, Pacôme Prompsy, Susanne Kimeswenger, Yi-Chien Tsai, Desislava Ignatova, Olesya Pavlova, Christoph Iselin, Lars E. French, Mitchell P. Levesque, François Kuonen, Malgorzata Bobrowicz, Patrick M. Brunner, Steve Pascolo, Wolfram Hoetzenecker, Emmanuella Guenova

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1a3bf0a991644740869501ab71bb08ef

Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

Authors: Chiara F. Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Laura Volta, Francesco Manfredi, Christian Pellegrino, Steve Pascolo, Csaba Miskey, Zoltán Ivics, Judith A. Shizuru, Dario Neri, Markus G. Manz

Source: Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 56-71 (2023)

Subject Terms: Chimeric antigen receptor, CAR, non-viral gene transfer, acute myeloid leukemia, cancer immunotherapy, hematopoietic stem cell, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770523000499; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/fb577a1a841d43ec95f8517deb5c459e

Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo

Authors: Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli, Steve Pascolo

Source: Cells, Vol 13, Iss 15, p 1242 (2024)

Subject Terms: mRNA, in vitro transcription, untranslated regions, ivt mRNA, UTR, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/15/1242; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5431fc445dd74b9097329e29d690d397

The A to I editing landscape in melanoma and its relation to clinical outcome

Authors: Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett, Steve Pascolo

Source: RNA Biology, Vol 19, Iss 1, Pp 996-1006 (2022)

Subject Terms: adar, a-to-i editing, alu sequences, editing, melanoma, immune checkpoint inhibitors, immunotherapy, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1547-6286; https://doaj.org/toc/1555-8584

Access URL: https://doaj.org/article/d73ba5df73fb42d888ad2fe4592ab9ac

RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drug

Authors: Natalia Teresa Jarzebska, Marina Tusup, Julia Frei, Tobias Weiss, Tim Holzinger, Mark Mellett, Mustafa Diken, Simon Bredl, Michael Weller, Roberto F. Speck, Thomas M. Kündig, Ugur Sahin, Steve Pascolo

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: Chemotherapy, immunotherapy, RNA, toll like receptor, type I interferon, 5FU, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/636d2ae4aff3428891160e5ede030946

Increased Chlormethine-Induced DNA Double-Stranded Breaks in Malignant T Cells from Mycosis Fungoides Skin Lesions

Authors: Yun-Tsan Chang, Desislava Ignatova, Wolfram Hoetzenecker, Steve Pascolo, Christina Fassnacht, Emmanuella Guenova

Source: JID Innovations, Vol 2, Iss 1, Pp 100069- (2022)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667026721000709; https://doaj.org/toc/2667-0267

Access URL: https://doaj.org/article/ba6db92400c0419cb01a87244cd68145

mRNA Vaccines Against Infectious Diseases and Cancer

Authors: Alexander Meisel, Steve Pascolo

Source: healthbook TIMES. Oncology Hematology, Vol 9, Iss 3 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2673-2106

Access URL: https://doaj.org/article/940065234dc5496e996857810ab60577

Functional differences between protamine preparations for the transfection of mRNA

Authors: Natalia Teresa Jarzebska, Severin Lauchli, Christoph Iselin, Lars E French, Pal Johansen, Emmanuella Guenova, Thomas M Kündig, Steve Pascolo

Source: Drug Delivery, Vol 27, Iss 1, Pp 1231-1235 (2020)

Subject Terms: protamine, nanoparticles, rna, proticle, transfection, toll-like receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464

Access URL: https://doaj.org/article/b443ee8aff8746f7aab3b115e8c81a38

Correction: Tusup et al. Evaluation of the Interplay between the ADAR Editome and Immunotherapy in Melanoma. Non-Coding RNA 2021, 7, 5

Authors: Marina Tusup, Phil F. Cheng, Ernesto Picardi, Austeja Raziunaite, Reinhard Dummer, Mitchell P. Levesque, Lars E. French, Emmanuella Guenova, Thomas M. Kundig, Steve Pascolo

Source: Non-Coding RNA, Vol 8, Iss 6, p 79 (2022)

Subject Terms: n/a, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.mdpi.com/2311-553X/8/6/79; https://doaj.org/toc/2311-553X

Access URL: https://doaj.org/article/0c49cd3eed2442fb8d71cdf9530c9619

Implications of mRNA-based SARS-CoV-2 vaccination for cancer patients

Authors: Emanuela Romano, Patrick Ott, Steve Pascolo

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/6/e002932.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/8b6d974d24a64609a432866255690ad6

Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome

Authors: Christoph Iselin, Yun-Tsan Chang, Tanja Schlaepfer, Christina Fassnacht, Florentia Dimitriou, Mirjam Nägeli, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz, Emmanuella Guenova

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: cutaneous t cell lymphoma, sézary syndrome, mycosis fungoides, dermatology, extracorporeal photophoresis, cellular cytotoxicity, biomarker, treatment response, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/79be4c7424ec40aabeb2285e0800e27d

Vaccines against COVID-19: Priority to mRNA-Based Formulations

Authors: Steve Pascolo

Source: Cells, Vol 10, Iss 10, p 2716 (2021)

Subject Terms: mRNA, protein, adenovirus, SARS-CoV-2, vaccine, spike, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/10/2716; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/10eff5abdcc74d698041026d3d34494f

Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation

Authors: Ieva Saulite, Desislava Ignatova, Yun-Tsan Chang, Christina Fassnacht, Florentia Dimitriou, Eleni Varypataki, Florian Anzengruber, Mirjam Nägeli, Antonio Cozzio, Reinhard Dummer, Julia Scarisbrick, Steve Pascolo, Wolfram Hoetzenecker, Malgorzata Bobrowicz, Emmanuella Guenova

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: monoclonal antibody, immunotherapy, pd-1, pd-l1, pd-l2, leukemic cutaneous t-cell lymphoma, sézary syndrome, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/39901325e57947a4b3306900403a79ac

Design of in vitro Transcribed mRNA Vectors for Research and Therapy

Authors: Marina Tusup, Lars E. French, Mara De Matos, David Gatfield, Thomas Kundig, Steve Pascolo

Source: CHIMIA, Vol 73, Iss 5 (2019)

Subject Terms: Cap, Gene therapy, Globin utr, In vitro transcribed mrna, Ivt rna, Vaccination, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.chimia.ch/chimia/article/view/1249; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424

Access URL: https://doaj.org/article/a09f881ec4c8407db4012e9113d7d935

mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

Authors: Marina Tusup, Severin Läuchli, Natalia Teresa Jarzebska, Lars E. French, Yun-Tsan Chang, Maya Vonow-Eisenring, Andreas Su, Thomas M. Kündig, Emmanuella Guenova, Steve Pascolo

Source: Pharmaceutics, Vol 13, Iss 7, p 1040 (2021)

Subject Terms: in vitro transcribed mRNA, ivt mRNA, vaccine, T-cell lymphoma, CTCL, TCR, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/7/1040; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/740ac46bbfb44586b93eb42bb91c79c1

Protamine-Based Strategies for RNA Transfection

Authors: Natalia Teresa Jarzebska, Mark Mellett, Julia Frei, Thomas M. Kündig, Steve Pascolo

Source: Pharmaceutics, Vol 13, Iss 6, p 877 (2021)

Subject Terms: RNA, protamine, transfection, cancer therapy, vaccines, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/6/877; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/925b8efb3b5e4c179122823142014bf2

Lipofection with Synthetic mRNA as a Simple Method for T-Cell Immunomonitoring

Authors: Natalia Teresa Jarzebska, Julia Frei, Severin Lauchli, Lars E. French, Emmanuella Guenova, Cécile Gouttefangeas, Thomas M. Kündig, Mark Mellett, Steve Pascolo

Source: Viruses, Vol 13, Iss 7, p 1232 (2021)

Subject Terms: transfection, ivt mRNA, immunomonitoring, lipofection, TLR7/8, T-cells, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/7/1232; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/4f0dfa9a3a9a436ab2deb29c70b51895