Advancing the chemotherapy of tuberculous meningitis: a consensus view

Authors: Wasserman, Sean ^{a, d, †}, Donovan, Joseph ^{e, †}, Kestelyn, Evelyne ^{f, †}, Watson, James A ^{f, †}, Aarnoutse, Robert E ^g, Barnacle, James R ^{a, h, i}, Boulware, David R ^j, Chow, Felicia C ^k, Cresswell, Fiona V ^{l, n, o}, Davis, Angharad G ^{a, h}, Dooley, Kelly E ^p, Figaji, Anthony A ^c, Gibb, Diana M ^q, Huynh, Julie ^{f, r}, Imran, Darma ^s, Marais, Suzaan ^b, Meya, David B ^{l, m}, Misra, Usha K ^t, Modi, Manish ^u, Raberahona, Mihaja ^v, Ganiem, Ahmad Rizal ^w, Rohlwink, Ursula K ^{a, c}, Ruslami, Rovina ^x, Seddon, James A ^{i, y}, Skolimowska, Keira H ^{a, d}, Solomons, Regan S ^y, Stek, Cari J ^a, Thuong, Nguyen Thuy Thuong ^f, van Crevel, Reinout ^g, Whitaker, Claire ^a, Thwaites, Guy E ^{f, r, †}, Wilkinson, Robert J ^{a, h, i, †, *}

Source: In The Lancet Infectious Diseases January 2025 25(1):e47-e58

Exploring Health-Related Quality of Life (HRQOL) among patients with HIV-associated TB in Khayelitsha, South Africa.

Authors: Hickman, John-Henry, Swartz, Alison, Sicwebu, Namhla, Stek, Cari, Masimini, Nobom, Nöstlinger, Christiana

Source: PLoS ONE; 11/4/2024, Vol. 19 Issue 11, p1-17, 17p

Subject Terms: QUALITY of life, PHENOMENOLOGY, THEMATIC analysis, SOCIAL stigma, WELL-being

Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the Second International Post-Tuberculosis Symposium.

Authors: Auld, Sara C., Barczak, Amy K., Bishai, William, Coussens, Anna K., Dewi, Intan M. W., Mitini-Nkhoma, Steven C., Muefong, Caleb, Naidoo, Threnesan, Pooran, Anil, Stek, Cari, Steyn, Adrie J. C., Tezera, Liku, Walker, Naomi F.

Source: American Journal of Respiratory & Critical Care Medicine; 10/15/2024, Vol. 210 Issue 8, p979-993, 15p

Subject Terms: LUNG diseases, MATRIX metalloproteinases, EVIDENCE gaps, TUBERCULOSIS

Linezolid Population Pharmacokinetic Model in Plasma and Cerebrospinal Fluid Among Patients With Tuberculosis Meningitis.

Authors: Abdelgawad, Noha, Wasserman, Sean, Abdelwahab, Mahmoud Tareq, Davis, Angharad, Stek, Cari, Wiesner, Lubbe, Black, John, Meintjes, Graeme, Wilkinson, Robert J, Denti, Paolo

Source: Journal of Infectious Diseases; 4/15/2024, Vol. 229 Issue 4, p1200-1208, 9p

Subject Terms: LINEZOLID, CEREBROSPINAL fluid, CLINICAL trial registries, TUBERCULOSIS patients, TUBERCULOUS meningitis

Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.

Authors: Stek, Cari^1,2,3 (AUTHOR) cari.stek@uct.ac.za, Shey, Muki^1,3 (AUTHOR), Mnika, Khuthala⁴ (AUTHOR), Schutz, Charlotte^1,3 (AUTHOR), Thienemann, Friedrich^1,3 (AUTHOR), Wilkinson, Robert J^1,3,5,6 (AUTHOR), Lynen, Lutgarde² (AUTHOR), Meintjes, Graeme^1,3 (AUTHOR)

Source: Open Forum Infectious Diseases. Jul2023, Vol. 10 Issue 7, p1-4. 4p.

Subject Terms: *IMMUNE reconstitution inflammatory syndrome, *PREDNISONE

A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus–Associated Tuberculous Meningitis: The LASER-TBM Trial.

Authors: Davis, Angharad G, Wasserman, Sean, Stek, Cari, Maxebengula, Mpumi, Liang, C Jason, Stegmann, Stephani, Koekemoer, Sonya, Jackson, Amanda, Kadernani, Yakub, Bremer, Marise, Daroowala, Remy, Aziz, Saalikha, Goliath, Rene, Sai, Louise Lai, Sihoyiya, Thandi, Denti, Paolo, Lai, Rachel P J, Crede, Thomas, Naude, Jonathan, Szymanski, Patryk

Source: Clinical Infectious Diseases; 4/15/2023, Vol. 76 Issue 8, p1412-1422, 11p

Subject Terms: HIV infection complications, DRUG efficacy, COMBINATION drug therapy, HETEROCYCLIC compounds, DISEASES, LINEZOLID, TREATMENT effectiveness, RANDOMIZED controlled trials, ASPIRIN, KAPLAN-Meier estimator, RESEARCH funding, STATISTICAL sampling, DRUG side effects, PATIENT safety

Two donor-related infections in a heart transplant recipient: One common, the other a tropical surprise

Authors: Brügemann, Johan, Kampinga, Greetje A., Riezebos-Brilman, Annelies, Stek, Cari J., Edel, Jan Pieter, van der Bij, Wim, Sprenger, Herman G., Zijlstra, Felix

Source: In Journal of Heart and Lung Transplantation 2010 29(12):1433-1437

Cognitive Impairment in Tuberculous Meningitis.

Authors: Davis, Angharad G, Dreyer, Anna J, Albertyn, Christine, Maxebengula, Mpumi, Stek, Cari, Wasserman, Sean, Marais, Suzaan, Bateman, Kathleen, Solms, Mark, Joska, John, Wilkinson, Robert J, Nightingale, Sam

Source: Clinical Infectious Diseases; Mar2023, Vol. 76 Issue 5, p842-849, 8p

Subject Terms: COGNITION disorders diagnosis, HIV infection complications, CLINICAL drug trials, COGNITION disorders, FUNCTIONAL assessment, COMPARATIVE studies, RESEARCH funding, DESCRIPTIVE statistics, COGNITIVE testing, PATIENT compliance, PSYCHOLOGY of HIV-positive persons

Geographic Terms: SOUTH Africa

Prednisone for the prevention of tuberculosis-associated IRIS (randomized controlled trial): Impact on the health-related quality of life.

Authors: Wouters, Edwin, Stek, Cari, Swartz, Alison, Buyze, Jozefien, Schutz, Charlotte, Thienemann, Friedrich, Wilkinson, Robert J., Meintjes, Graeme, Lynen, Lutgarde, Nöstlinger, Christiana

Source: Frontiers in Psychology; 10/6/2022, Vol. 13, p01-13, 13p

Subject Terms: IMMUNE reconstitution inflammatory syndrome, DIRECTLY observed therapy, QUALITY of life, PREDNISONE, ANTIRETROVIRAL agents

Geographic Terms: SUB-Saharan Africa, SOUTH Africa

T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Authors: Keeton, Roanne, Tincho, Marius B., Ngomti, Amkele, Baguma, Richard, Benede, Ntombi, Suzuki, Akiko, Khan, Khadija, Cele, Sandile, Bernstein, Mallory, Karim, Farina, Madzorera, Sharon V., Moyo-Gwete, Thandeka, Mennen, Mathilda, Skelem, Sango, Adriaanse, Marguerite, Mutithu, Daniel, Aremu, Olukayode, Stek, Cari, du Bruyn, Elsa, Van Der Mescht, Mieke A.

Source: Nature; Mar2022, Vol. 603 Issue 7901, p488-492, 5p

Diagnostic Accuracy of the INSHI Consensus Case De?nition for theDiagnosis of Paradoxical Tuberculosis-IRIS.

Authors: Stek, Cari^1,2,3 cari_stek@hotmail.com, Buyze, Jozefien¹, Menten, Joris¹, Schutz, Charlotte^2,3, Thienemann, Friedrich², Blumenthal, Lisette², Maartens, Gary^2,3, Boyles, Tom³, Wilkinson, Robert J.^2,3,4,5, Meintjes, Graeme^2,3, Lynen, Lutgarde¹

Source: JAIDS: Journal of Acquired Immune Deficiency Syndromes. 4/15/2021, Vol. 86 Issue 5, p587-592. 6p.

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Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.

Authors: Meintjes, G.^1,2, graemein@mweb.co.za, Stek, C.^1,2,3, Blumenthal, L.¹, Thienemann, F.^1,2, Schutz, C.^1,2, Buyze, J.³, Ravinetto, R.³, van Loen, H.³, Nair, A.¹, Jackson, A.¹, Colebunders, R.³, Maartens, G.⁴, Wilkinson, R. J.^1,2,5, Lynen, L.³, Meintjes, Graeme⁶, Stek, Cari⁶, Blumenthal, Lisette⁶, Thienemann, Friedrich⁶, Schutz, Charlotte⁶, Buyze, Jozefien⁶

Source: New England Journal of Medicine; 11/15/2018, Vol. 379 Issue 20, p1915-1925, 11p

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Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Authors: Keeton, Roanne, Tincho, Marius B., Ngomti, Amkele, Baguma, Richard, Benede, Ntombi, Suzuki, Akiko, Khan, Khadija, Cele, Sandile, Bernstein, Mallory, Karim, Farina, Madzorera, Sharon V., Moyo-Gwete, Thandeka, Mennen, Mathilda, Skelem, Sango, Adriaanse, Marguerite, Mutithu, Daniel, Aremu, Olukayode, Stek, Cari, du Bruyn, Elsa, Van Der Mescht, Mieke A.

Source: Nature; 4/28/2022, Vol. 604 Issue 7907, pE25-E25, 1p

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Pegylated Interferon-a Monotherapy Leads to Low Response Rates in HIV-Infected Patients with Acute Hepatitis C

Authors: Arends, Joop E, van Assen, Sander, Stek, Cari J, Wensing, Annemarie MJ, Fransen, Justin H, Schellens, Ingrid M, Spijkers, Sanne NM, Mudrikova, Tania, van Baarle, Debbie, Sprenger, Herman G, Hoepelman, Andy IM

Source: Antiviral Therapy; October 2011, Vol. 16 Issue: 7 p979-988, 10p

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

Authors: Riou, Catherine, Keeton, Roanne, Moyo-Gwete, Thandeka, Hermanus, Tandile, Kgagudi, Prudence, Baguma, Richard, Valley-Omar, Ziyaad, Smith, Mikhail, Tegally, Houriiyah, Doolabh, Deelan, Iranzadeh, Arash, Tyers, Lynn, Mutavhatsindi, Hygon, Tincho, Marius B., Benede, Ntombi, Marais, Gert, Chinhoyi, Lionel R., Mennen, Mathilda, Skelem, Sango, du Bruyn, Elsa, Stek, Cari, de Oliveira, Tulio, Williamson, Carolyn, Moore, Penny L., Wilkinson, Robert J., Ntusi, Ntobeko A. B., Burgers, Wendy A.

Source: Science Translational Medicine; December 2021, Vol. 14 Issue: 631