Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity

Authors: Nuša Krivec, Edouard Couvreu de Deckersberg, Yingnan Lei, Diana Al Delbany, Marius Regin, Stefaan Verhulst, Leo A. van Grunsven, Karen Sermon, Claudia Spits

Source: Cell Death and Disease, Vol 15, Iss 11, Pp 1-14 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/60a272474826499d95706714b1b9604e

When forecasting and foresight meet data and innovation: toward a taxonomy of anticipatory methods for migration policy

Authors: Sara Marcucci, Stefaan Verhulst, María Esther Cervantes

Source: Data & Policy, Vol 7 (2025)

Subject Terms: anticipatory methods, migration, nontraditional data, policy making, taxonomy, Information technology, T58.5-58.64, Political institutions and public administration (General), JF20-2112

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2632324924000567/type/journal_article; https://doaj.org/toc/2632-3249

Access URL: https://doaj.org/article/0ede78c6d9dd4689b7fdad5a80f4be4f

Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies

Authors: Vincent Merens, Elisabeth Knetemann, Elif Gürbüz, Vincent De Smet, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Leo A. van Grunsven

Source: JHEP Reports, Vol 7, Iss 1, Pp 101223- (2025)

Subject Terms: Chronic liver disease, single-cell RNA-Sequencing, parathyroid hormone, COLEC10, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924002271; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/5e811f0d21c84c269030fde61dbc2c68

Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

Authors: Harrison T. Muturi, Hilda E. Ghadieh, Suman Asalla, Sumona G. Lester, Getachew D. Belew, Sobia Zaidi, Raziyeh Abdolahipour, Abhishek P. Shrestha, Agnes O. Portuphy, Hannah L. Stankus, Raghd Abu Helal, Stefaan Verhulst, Sergio Duarte, Ali Zarrinpar, Leo A. van Grunsven, Scott L. Friedman, Robert F. Schwabe, Terry D. Hinds, Jr., Sivarajan Kumarasamy, Sonia M. Najjar

Source: Molecular Metabolism, Vol 88, Iss , Pp 102010- (2024)

Subject Terms: Hepatic fibrosis, Inflammation, Hepatic steatosis, Stellate cell proliferation, Retinoic acid, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824001418; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/e69d9f2f8521498ea5cb94a3c6b0d26c

Orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role in chronic liver disease

Authors: Vincent De Smet, Elif Gürbüz, Nathalie Eysackers, Liza Dewyse, Ayla Smout, Mina Kazemzadeh Dastjerd, Pierre Lefesvre, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven

Source: JHEP Reports, Vol 6, Iss 5, Pp 101036- (2024)

Subject Terms: Fibrosis, G-protein-coupled receptors, GPR176, Liver cirrhosis, Myofibroblasts, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555924000375; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/a220db56f1c24cd99ae3f6a1a5825e81

Spatially Self‐Organized Three‐Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development

Authors: Yoke Chin Chai, San Kit To, Susan Simorgh, Samantha Zaunz, YingLi Zhu, Karan Ahuja, Alix Lemaitre, Roya Ramezankhani, Bernard K. van derVeer, Keimpe Wierda, Stefaan Verhulst, Leo A. vanGrunsven, Vincent Pasque, Catherine Verfaillie

Source: Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)

Subject Terms: blood‐brain barrier, brain organoids, neurovascular, vascularization, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/f6b63bd6e2cc4bd79c96613892f3db5a

Unleashing collective intelligence for public decision-making: the Data for Policy community

Authors: Zeynep Engin, Emily Gardner, Andrew Hyde, Stefaan Verhulst, Jon Crowcroft

Source: Data & Policy, Vol 6 (2024)

Subject Terms: data for policy, collective intelligence, decision-making, digital transformation, governance, government, Information technology, T58.5-58.64, Political institutions and public administration (General), JF20-2112

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2632324924000026/type/journal_article; https://doaj.org/toc/2632-3249

Access URL: https://doaj.org/article/adac7648c42c4e88bdbed96fd94bd4f3

Initiation of hepatic stellate cell activation extends into chronic liver disease

Authors: Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven

Source: Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/8ea65b2a9036464990e291a1c81feff9

Identifying and addressing data asymmetries so as to enable (better) science

Authors: Stefaan Verhulst, Andrew Young

Source: Frontiers in Big Data, Vol 5 (2022)

Subject Terms: data asymmetry, data stewardship, data collaboration, Findable, Accessible, Interoperable, Information technology, T58.5-58.64

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fdata.2022.888384/full; https://doaj.org/toc/2624-909X

Access URL: https://doaj.org/article/42d583406c3f4b44a4148b32c3171523

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Authors: Jonathan De Smedt, Elise Anne van Os, Irene Talon, Sreya Ghosh, Burak Toprakhisar, Rodrigo Furtado Madeiro Da Costa, Samantha Zaunz, Marta Aguirre Vazquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie

Source: Cell Death and Disease, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/a72ccbfa4b2f428e822457e0c7616dda

Gender gaps in urban mobility

Authors: Laetitia Gauvin, Michele Tizzoni, Simone Piaggesi, Andrew Young, Natalia Adler, Stefaan Verhulst, Leo Ferres, Ciro Cattuto

Source: Humanities & Social Sciences Communications, Vol 7, Iss 1, Pp 1-13 (2020)

Subject Terms: History of scholarship and learning. The humanities, AZ20-999, Social Sciences

File Description: electronic resource

Relation: https://doaj.org/toc/2662-9992

Access URL: https://doaj.org/article/6f7ef40b858f4fd483d9e4bb618c5ab0

Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach

Authors: Philip Vlummens, Stefaan Verhulst, Kim De Veirman, Anke Maes, Eline Menu, Jérome Moreaux, Hugues De Boussac, Nicolas Robert, Elke De Bruyne, Dirk Hose, Fritz Offner, Karin Vanderkerken, Ken Maes

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: myeloma, PRMT5, DNA repair, RNA splicing, epigenetics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.879057/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/8c0741c3569949d7a42027200e618caa

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering

Authors: Mariella Obermeier, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: gene editing, CRISPR/Cas, germline stem cells, ribonucleoproteins (RNPs), germline genome editing, gene knockout, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.891173/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2329d7cb0e4346a8987ead86227e6629

Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma

Authors: Lien De Beck, Robin Maximilian Awad, Veronica Basso, Noelia Casares, Kirsten De Ridder, Yannick De Vlaeminck, Alessandra Gnata, Cleo Goyvaerts, Quentin Lecocq, Edurne San José-Enériz, Stefaan Verhulst, Ken Maes, Karin Vanderkerken, Xabier Agirre, Felipe Prosper, Juan José Lasarte, Anna Mondino, Karine Breckpot

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: melanoma, cancer vaccination, dendritic cell vaccination, adoptive T cell therapies, epigenetic targeted therapy, histone and DNA methylation/demethylation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.799636/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f6044c9296d648419688c29e75e4e1a4

TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy

Authors: Kirsten De Ridder, Hanne Locy, Elisa Piccioni, Miren Ibarra Zuazo, Robin Maximilian Awad, Stefaan Verhulst, Mathias Van Bulck, Yannick De Vlaeminck, Quentin Lecocq, Eva Reijmen, Wout De Mey, Lien De Beck, Thomas Ertveldt, Isabel Pintelon, Jean-Pierre Timmermans, David Escors, Marleen Keyaerts, Karine Breckpot, Cleo Goyvaerts

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: anti-PD-L1 immunotherapy, non small cell lung cancer (NSCLC), tumor-infiltrating myeloid cells, TNF-α, immunotherapy resistance, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.811867/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8cb0f64de304414d9efd07fa0701e7a3

Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis

Authors: Liza Dewyse, Vincent De Smet, Stefaan Verhulst, Nathalie Eysackers, Rastislav Kunda, Nouredin Messaoudi, Hendrik Reynaert, Leo A. van Grunsven

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: PCLS, DILI, hepatic stellate, VPA, human, mouse, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.862185/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/d757cdc4244b46a892963deb6304dec1

Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring

Authors: Hanne Locy, Stefaan Verhulst, Wilfried Cools, Wim Waelput, Stefanie Brock, Louise Cras, Ann Schiettecatte, Jan Jonckheere, Leo A. van Grunsven, Marian Vanhoeij, Kris Thielemans, Karine Breckpot

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: breast cancer, immunohistochemistry, gene expression profiling, tumor-infiltrating lymphocyte, immunotherapy targets, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.794175/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cbe7f728bd8a400ab71b04bfde52aa70

Mobile Big Data in the fight against COVID-19

Authors: Richard Benjamins, Jeanine Vos, Stefaan Verhulst

Source: Data & Policy, Vol 4 (2022)

Subject Terms: Information technology, T58.5-58.64, Political institutions and public administration (General), JF20-2112

File Description: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2632324921000390/type/journal_article; https://doaj.org/toc/2632-3249

Access URL: https://doaj.org/article/53ea7aa70074457c876579aa4b5865c4

Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases

Authors: Stefaan Verhulst, Elise Anne van Os, Vincent De Smet, Nathalie Eysackers, Inge Mannaerts, Leo A. van Grunsven

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: LSEC, acute liver injury, single cell RNA sequencing (scRNAseq), primary cells, NAFLD (non-alcoholic fatty liver disease), non-alcoholic steatohepatitis (NASH), Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.750044/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/f46cb7bc70ac436c9cf53041418e0672

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver diseaseResearch in context

Authors: Joeri Lambrecht, Stefaan Verhulst, Inge Mannaerts, Jan-Peter Sowa, Jan Best, Ali Canbay, Hendrik Reynaert, Leo A. van Grunsven

Source: EBioMedicine, Vol 43, Iss , Pp 501-512 (2019)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396419302750; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/5f85e40af5a64303a768e25e13006a94