Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3

Authors: Zou, Ling, Matsson, Pär, Stecula, Adrian, Ngo, Huy X., Zur, Arik A., Giacomini, Kathleen M.

Source: In Journal of Pharmaceutical Sciences January 2021 110(1):347-353

Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies

Authors: Yee, Sook Wah, Buitrago, Dina, Stecula, Adrian, Ngo, Huy X., Chien, Huan‐Chieh, Zou, Ling, Koleske, Megan L., Giacomini, Kathleen M.

Source: FASEB journal. 34(12):15734-15752

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163874192.0x000001&indx=1&recIds=ETOCvdc_100163874192.0x000001

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Authors: Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D., Stahl, Simone H., Fenner, Katherine S., Giacomini, Kathleen M. ^*

Source: In Molecular Pharmacology July 2018 94(1):689-699

Accurate structure prediction of biomolecular interactions with AlphaFold 3

Authors: Abramson, Josh, Adler, Jonas, Dunger, Jack, Evans, Richard, Green, Tim, Pritzel, Alexander, Ronneberger, Olaf, Willmore, Lindsay, Ballard, Andrew J., Bambrick, Joshua, Bodenstein, Sebastian W., Evans, David A., Hung, Chia-Chun, O’Neill, Michael, Reiman, David, Tunyasuvunakool, Kathryn, Wu, Zachary, Žemgulytė, Akvilė, Arvaniti, Eirini, Beattie, Charles, Bertolli, Ottavia, Bridgland, Alex, Cherepanov, Alexey, Congreve, Miles, Cowen-Rivers, Alexander I., Cowie, Andrew, Figurnov, Michael, Fuchs, Fabian B., Gladman, Hannah, Jain, Rishub, Khan, Yousuf A., Low, Caroline M. R., Perlin, Kuba, Potapenko, Anna, Savy, Pascal, Singh, Sukhdeep, Stecula, Adrian, Thillaisundaram, Ashok, Tong, Catherine, Yakneen, Sergei, Zhong, Ellen D., Zielinski, Michal, Žídek, Augustin, Bapst, Victor, Kohli, Pushmeet, Jaderberg, Max, Hassabis, Demis, Jumper, John M.

Source: Nature; June 2024, Vol. 630 Issue: 8016 p493-500, 8p

Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer

Authors: Stecula, Adrian, Schlessinger, Avner, Giacomini, Kathleen M., Sali, Andrej

Source: Biochemistry. 56(27):3475-3483

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612240782&indx=1&recIds=ETOCRN612240782

Quantitative Correlation of the Effect of Process Conditions on the Capping Tendencies of Tablet Formulations

Authors: Akseli, Ilgaz ^*, Stecuła, Adrian, He, Xiaorong, Ladyzhynsky, Nadia

Source: In Journal of Pharmaceutical Sciences June 2014 103(6):1652-1663

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

Authors: Yee, Sook Wah¹, Stecula, Adrian¹, Chien, Huan-Chieh¹, Zou, Ling¹, Feofanova, Elena V.², van Borselen, Marjolein¹, Cheung, Kit Wun Kathy¹ kathy.giacomini@ucsf.edu, Yousri, Noha A.^3,4, Suhre, Karsten⁵, Kinchen, Jason M.⁶, Boerwinkle, Eric^2,7, Irannejad, Roshanak⁸, Yu, Bing², Giacomini, Kathleen M.^1,9

Source: PLoS Genetics. 9/25/2019, Vol. 15 Issue 9, p1-38. 38p.

Subject Terms: *STEROIDS, *STEROID hormones, *BILE acids, *COMPUTATIONAL biology, *NUCLEAR receptors (Biochemistry)

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study.

Authors: Wallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O'Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung

Source: Scientific Reports; 9/16/2024, Vol. 14 Issue 1, p1-2, 2p

Subject Terms: HIGH throughput screening (Drug development), CHILDREN'S hospitals, CHEMICAL structure, MEDICAL centers, INTERNET publishing

Addendum: Accurate structure prediction of biomolecular interactions with AlphaFold 3

Authors: Abramson, Josh, Adler, Jonas, Dunger, Jack, Evans, Richard, Green, Tim, Pritzel, Alexander, Ronneberger, Olaf, Willmore, Lindsay, Ballard, Andrew J., Bambrick, Joshua, Bodenstein, Sebastian W., Evans, David A., Hung, Chia-Chun, O’Neill, Michael, Reiman, David, Tunyasuvunakool, Kathryn, Wu, Zachary, Žemgulytė, Akvilė, Arvaniti, Eirini, Beattie, Charles, Bertolli, Ottavia, Bridgland, Alex, Cherepanov, Alexey, Congreve, Miles, Cowen-Rivers, Alexander I., Cowie, Andrew, Figurnov, Michael, Fuchs, Fabian B., Gladman, Hannah, Jain, Rishub, Khan, Yousuf A., Low, Caroline M. R., Perlin, Kuba, Potapenko, Anna, Savy, Pascal, Singh, Sukhdeep, Stecula, Adrian, Thillaisundaram, Ashok, Tong, Catherine, Yakneen, Sergei, Zhong, Ellen D., Zielinski, Michal, Žídek, Augustin, Bapst, Victor, Kohli, Pushmeet, Jaderberg, Max, Hassabis, Demis, Jumper, John M.

Source: Nature; December 2024, Vol. 636 Issue: 8042 pE4-E4, 1p

Discovery of Novel Inhibitors of a Critical Brain Enzyme Using a Homology Model and a Deep Convolutional Neural Network.

Authors: Stecula, Adrian, Hussain, Muhammad S., Viola, Ronald E.

Source: Journal of Medicinal Chemistry; 8/27/2020, Vol. 63 Issue 16, p8867-8875, 9p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.