Synthetic nanobodies as angiotensin receptor blockers

Authors: McMahon, Conor, Staus, Dean P., Wingler, Laura M., Wang, Jialu, Skiba, Meredith A., Elgeti, Matthias, Hubbell, Wayne L., Rockman, Howard A., Kruse, Andrew C., Lefkowitz, Robert J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug . 117(33), 20284-20291.

Access URL: https://www.jstor.org/stable/26968626

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

Authors: Pani, Biswaranjan, Ahn, Seungkirl ¹, Rambarat, Paula K. ¹, Vege, Shashank, Kahsai, Alem W., Liu, Andrew, Valan, Bruno N., Staus, Dean P., Costa, Tommaso, Lefkowitz, Robert J. ^*

Source: In Molecular Pharmacology November 2021 100(5):513-525

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

Authors: Pakharukova, Natalia, Masoudi, Ali, Pani, Biswaranjan, Staus, Dean P., Lefkowitz, Robert J. ^*

Source: In Journal of Biological Chemistry 4 December 2020 295(49):16773-16784

Mechanism of β₂AR regulation by an intracellular positive allosteric modulator

Authors: Liu, Xiangyu, Masoudi, Ali, Kahsai, Alem W., Huang, Li-Yin, Pani, Biswaranjan, Staus, Dean P., Shim, Paul J., Hirata, Kunio, Simhal, Rishabh K., Schwalb, Allison M., Rambarat, Paula K., Ahn, Seungkirl, Lefkowitz, Robert J., Kobilka, Brian

Source: Science, 2019 Jun . 364(6447), 1283-1287.

Access URL: https://www.jstor.org/stable/26745285

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein–coupled receptors

Alternate Title: ACCELERATED COMMUNICATION: GPCR activity: detergent vs lipid (English)

Authors: Staus, Dean P., Wingler, Laura M., Pichugin, Dmitry, Prosser, Robert Scott, Lefkowitz, Robert J.

Source: In Journal of Biological Chemistry 6 September 2019 294(36):13218-13223

Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways.

Authors: Gareri, Clarice, Pfeiffer, Conrad T., Jiang, Xue, Paulo, Joao A., Gygi, Steven P., Pham, Uyen, Chundi, Anand, Wingler, Laura M., Staus, Dean P., Stepniewski, Tomasz Maciej, Selent, Jana, Lucero, Emilio Y., Grogan, Alyssa, Rajagopal, Sudarshan, Rockman, Howard A.

Source: Science Signaling; 8/13/2024, Vol. 17 Issue 849, p1-16, 16p

Subject Terms: G proteins, ANGIOTENSIN II, MOLECULAR dynamics, LIGANDS (Biochemistry), G protein coupled receptors, PHOSPHORYLATION

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

Authors: Wingler, Laura M., Elgeti, Matthias, Hilger, Daniel, Latorraca, Naomi R., Lerch, Michael T., Staus, Dean P., Dror, Ron O., Kobilka, Brian K., Hubbell, Wayne L., Lefkowitz, Robert J.

Source: In Cell 24 January 2019 176(3):468-478

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

Authors: Wingler, Laura M., McMahon, Conor, Staus, Dean P., Lefkowitz, Robert J., Kruse, Andrew C.

Source: In Cell 24 January 2019 176(3):479-490

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

Authors: Staus, Dean P., Wingler, Laura M., Choi, Minjung, Pani, Biswaranjan, Manglik, Aashish, Kruse, Andrew C., Lefkowitz, Robert J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Apr 01. 115(15), 3834-3839.

Access URL: https://www.jstor.org/stable/26508471

Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries

Authors: Ahn, Seungkirl ¹, Pani, Biswaranjan ¹, Kahsai, Alem W. ¹, Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T. ², Sun, Lillian D. ³, Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J. ^*

Source: In Molecular Pharmacology August 2018 94(2):850-861

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Authors: Paek, Jaeho, Kalocsay, Marian, Staus, Dean P., Wingler, Laura, Pascolutti, Roberta, Paulo, Joao A., Gygi, Steven P., Kruse, Andrew C.

Source: In Cell 6 April 2017 169(2):338-349

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Authors: Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Feb . 114(7), 1708-1713.

Access URL: https://www.jstor.org/stable/26479405

Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies

Authors: Staus, Dean P., Wingler, Laura M., Strachan, Ryan T., Rasmussen, Soren G.F., Pardon, Els, Ahn, Seungkirl, Steyaert, Jan, Kobilka, Brian K., Lefkowitz, Robert J. ^*

Source: In Molecular Pharmacology March 2014 85(3):472-481

Antibodies expand the scope of angiotensin receptor pharmacology

Authors: Skiba, Meredith A., Sterling, Sarah M., Rawson, Shaun, Zhang, Shuhao, Xu, Huixin, Jiang, Haoran, Nemeth, Genevieve R., Gilman, Morgan S. A., Hurley, Joseph D., Shen, Pengxiang, Staus, Dean P., Kim, Jihee, McMahon, Conor, Lehtinen, Maria K., Rockman, Howard A., Barth, Patrick, Wingler, Laura M., Kruse, Andrew C.

Source: Nature Chemical Biology; 20240101, Issue: Preprints p1-9, 9p

Molecular Mechanism of Biased Signaling in a Prototypical G-protein-coupled Receptor

Authors: Suomivuori, Carl-Mikael, Latorraca, Naomi R., Wingler, Laura M., Eismann, Stephan, King, Matthew C., Kleinhenz, Alissa L.W., Skiba, Meredith A., Staus, Dean P., Kruse, Andrew C., Lefkowitz, Robert J., Dror, Ron O.

Source: Biophysical journal. 118(S1):162a-162a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097805740.0x000001&indx=1&recIds=ETOCvdc_100097805740.0x000001

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc.

Authors: Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios

Source: Nature; 3/12/2020, Vol. 579 Issue 7798, p297-302, 6p, 3 Diagrams, 2 Graphs

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.

Authors: Wingler, Laura M.^1,2, Skiba, Meredith A.³, McMahon, Conor³, Staus, Dean P.^1,2, Kleinhenz, Alissa L. W.^1,2,4, Suomivuori, Carl-Mikael^5,6,7, Latorraca, Naomi R.^5,6,7,8, Dror, Ron O.^5,6,7,8, Lefkowitz, Robert J.^1,2,9, lefko001@receptor-biol.duke.edu, Kruse, Andrew C.^3,10, andrew_kruse@hms.harvard.edu

Source: Science; 2/21/2020, Vol. 367 Issue 6480, p888-892, 5p, 1 Color Photograph, 2 Diagrams, 1 Graph

This result is not displayed to guests.
Login for full access.