Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization

Authors: Stark, Michal, Raz, Shachar, Assaraf, Yehuda G.

Source: In Journal of Proteomics 15 May 2021 239

Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion.

Authors: Stark, Michal¹ (AUTHOR), Levin, May^1,2 (AUTHOR), Ulitsky, Igor³ (AUTHOR), Assaraf, Yehuda G.¹ (AUTHOR) assaraf@technion.ac.il

Source: BMC Biology. 2/1/2023, Vol. 21 Issue 1, p1-23. 23p.

Subject Terms: *QUADRUPLEX nucleic acids, *CANCER invasiveness, *CANCER cells, *MESSENGER RNA, *FOLIC acid, *PHENOTYPES, *GLUTAMINE synthetase, *TRANSFER RNA

Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine

Authors: Levin, May, Stark, Michal, Berman, Bluma, Assaraf, Yehuda

Source: Cell death and disease. 10(6):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140055694.0x000001&indx=1&recIds=ETOCvdc_100140055694.0x000001

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

Authors: Zhitomirsky, Benny, Yunaev, Anna, Kreiserman, Roman, Kaplan, Ariel, Stark, Michal, Assaraf, Yehuda

Source: Cell death and disease. 9(12):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099952508.0x000001&indx=1&recIds=ETOCvdc_100099952508.0x000001

Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

Authors: Raz, Shachar, Stark, Michal, Assaraf, Yehuda G.

Source: In Drug Resistance Updates September 2016 28:43-64

Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance

Authors: Levin, May, Stark, Michal, Ofran, Yishai, Assaraf, Yehuda G.

Source: Cancer cell international. 21(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194145942.0x000001&indx=1&recIds=ETOCvdc_100194145942.0x000001

Heterogeneous Nuclear Ribonucleoprotein H1/H2-dependent Unsplicing of Thymidine Phosphorylase Results in Anticancer Drug Resistance

Authors: Stark, Michal, Bram, Eran E., Akerman, Martin, Mandel-Gutfreund, Yael, Assaraf, Yehuda G.

Source: In Journal of Biological Chemistry 4 February 2011 286(5):3741-3754

Chemotherapeutic Drug-Induced ABCG2 Promoter Demethylation as a Novel Mechanism of Acquired Multidrug Resistance

Authors: Bram, Eran E., Stark, Michal, Raz, Shachar, Assaraf, Yehuda G.

Source: In Neoplasia December 2009 11(12):1359

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

Authors: Stark, Michal, Wichman, Chen, Avivi, Irit, Assaraf, Yehuda G. ^*

Source: In Blood 30 April 2009 113(18):4362-4369

METHOD FOR PREDICTING A PATIENT'S RESPONSIVENESS TO ANTI-FOLATE THERAPY

Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier

Authors: Stark, Michal, Assaraf, Yehuda G. ^*

Source: In Blood 15 January 2006 107(2):708-715

The Reduced Folate Carrier Gene Is a Novel Selectable Marker for Recombinant Protein Overexpression

Authors: Rothem, Lilah, Berman, Bluma, Stark, Michal, Jansen, Gerrit, Assaraf, Yehuda G ^*

Source: In Molecular Pharmacology September 2005 68(3):616-624

Doubly Stimulated Corrole for Organelle-Selective Antitumor Cytotoxicity.

Authors: Sharma, Vinay K., Stark, Michal, Fridman, Natalia, Assaraf, Yehuda G., Gross, Zeev

Source: Journal of Medicinal Chemistry; 4/28/2022, Vol. 65 Issue 8, p6100-6115, 16p

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy

Authors: Fotoohi, Kambiz, Jansen, Gerrit, Assaraf, Yehuda G., Rothem, Lilah, Stark, Michal, Kathmann, Ietje, Gregorczyk, Jacek, Peters, Godefridus J., Albertioni, Freidoun

Source: In Blood 15 December 2004 104(13):4194-4201

Impaired CREB-1 Phosphorylation in Antifolate-Resistant Cell Lines with Down-Regulation of the Reduced Folate Carrier Gene

Authors: Rothem, Lilah ¹, Stark, Michal ¹, Assaraf, Yehuda G ^*

Source: In Molecular Pharmacology December 2004 66(6):1536-1543

Reduced Folate Carrier Gene Silencing in Multiple Antifolate-resistant Tumor Cell Lines Is Due to a Simultaneous Loss of Function of Multiple Transcription Factors but Not Promoter Methylation

Authors: Rothem, Lilah ^‡, Stark, Michal ^‡, Kaufman, Yotam, Mayo, Lior, Assaraf, Yehuda G. ^§

Source: In Journal of Biological Chemistry 2 January 2004 279(1):374-384

Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells

Authors: Assaraf, Yehuda G. ^{‡, §}, Rothem, Lilah ^‡, Hooijberg, Jan Hendrik ^¶, Stark, Michal ^‡, Ifergan, Ilan ^‡, Kathmann, Ietje ^¶, Dijkmans, Ben A.C. ^‖, Peters, Godefridus J. ^¶, Jansen, Gerrit ^‖

Source: In Journal of Biological Chemistry 28 February 2003 278(9):6680-6686

Multiple MAPK Cascades Regulate the Transcription of IME1, the Master Transcriptional Activator of Meiosis in Saccharomyces cerevisiae.

Authors: Kahana-Edwin, Smadar¹, Stark, Michal¹, Kassir, Yona¹ ykassir@tx.technion.ac.il

Source: PLoS ONE. Nov2013, Vol. 8 Issue 11, p1-12. 12p.

Subject Terms: *MITOGEN-activated protein kinases, *GENETIC transcription, *MEIOSIS, *SACCHAROMYCES cerevisiae, *YEAST, *GAMETOGENESIS, *CELLULAR signal transduction, *REPRODUCTION

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The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane.

Authors: Stark, Michal¹ (AUTHOR) bimichal@technion.ac.il, Silva, Tomás F. D.² (AUTHOR) tfsilva@ciencias.ulisboa.pt, Levin, Guy¹ (AUTHOR) guylevin@campus.technion.ac.il, Machuqueiro, Miguel² (AUTHOR) machuque@ciencias.ulisboa.pt, Assaraf, Yehuda G.¹ (AUTHOR) assaraf@technion.ac.il

Source: Cells (2073-4409). May2020, Vol. 9 Issue 5, p1082. 1p.

Subject Terms: *LYSOSOMES, *DRUG design, *DOSAGE forms of drugs, *ANTINEOPLASTIC agents, *MOLECULAR dynamics, *CONFOCAL microscopy