Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

Authors: Hamer, Melinda J, Houser, Katherine V, Hofstetter, Amelia R, Ortega-Villa, Ana M, Lee, Christine, Preston, Anne, Augustine, Brooke, Andrews, Charla, Yamshchikov, Galina V, Hickman, Somia, Schech, Steven, Hutter, Jack N, Scott, Paul T, Waterman, Paige E, Amare, Mihret F, Kioko, Victoria, Storme, Casey, Modjarrad, Kayvon, McCauley, Melanie D, Robb, Merlin L, Gaudinski, Martin R, Gordon, Ingelise J, Holman, LaSonji A, Widge, Alicia T, Strom, Larisa, Happe, Myra, Cox, Josephine H, Vazquez, Sandra, Stanley, Daphne A, Murray, Tamar, Dulan, Caitlyn N M, Hunegnaw, Ruth, Narpala, Sandeep R, Swanson, Phillip A, Basappa, Manjula, Thillainathan, Jagada, Padilla, Marcelino, Flach, Britta, O'Connell, Sarah, Trofymenko, Olga, Morgan, Patricia, Coates, Emily E, Gall, Jason G, McDermott, Adrian B, Koup, Richard A, Mascola, John R, Ploquin, Aurélie, Sullivan, Nancy J, Ake, Julie A, Ledgerwood, Julie E

Source: Lancet. 401(10373):294-302

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188796962.0x000001&indx=1&recIds=ETOCvdc_100188796962.0x000001

Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

Authors: Lampley, Rebecca, Larkin, Brenda, Costner, Pamela, Wilson, Hope, Read, Mike, Hamer, Melinda J, Houser, Katherine V ^*, Hofstetter, Amelia R, Ortega-Villa, Ana M, Lee, Christine, Preston, Anne, Augustine, Brooke, Andrews, Charla, Yamshchikov, Galina V, Hickman, Somia, Schech, Steven, Hutter, Jack N, Scott, Paul T, Waterman, Paige E, Amare, Mihret F, Kioko, Victoria, Storme, Casey, Modjarrad, Kayvon, McCauley, Melanie D, Robb, Merlin L, Gaudinski, Martin R, Gordon, Ingelise J, Holman, LaSonji A, Widge, Alicia T, Strom, Larisa, Happe, Myra, Cox, Josephine H, Vazquez, Sandra, Stanley, Daphne A, Murray, Tamar, Dulan, Caitlyn N M, Hunegnaw, Ruth, Narpala, Sandeep R, Swanson, Phillip A, II, Basappa, Manjula, Thillainathan, Jagada, Padilla, Marcelino, Flach, Britta, O’Connell, Sarah, Trofymenko, Olga, Morgan, Patricia, Coates, Emily E, Gall, Jason G, McDermott, Adrian B, Koup, Richard A, Mascola, John R, Ploquin, Aurélie, Sullivan, Nancy J, Ake, Julie A, Ledgerwood, Julie E

Source: In The Lancet 28 January 2023 401(10373):294-302

Vaccine Generation of Protective Ebola Antibodies and Identification of Conserved B-Cell Signatures

Authors: Cagigi, Alberto, Misasi, John, Ploquin, Aurélie, Stanley, Daphne A., Ambrozak, David, Tsybovsky, Yaroslav, Mason, Rosemarie D., Roederer, Mario, Sullivan, Nancy J.

Source: The Journal of Infectious Diseases, 2018 Dec . 218, S528-S536.

Access URL: https://www.jstor.org/stable/26576223

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

Authors: Tapia, Milagritos D, Sow, Samba O, Lyke, Kirsten E, Haidara, Fadima Cheick, Diallo, Fatoumata, Doumbia, Moussa, Traore, Awa, Coulibaly, Flanon, Kodio, Mamoudou, Onwuchekwa, Uma, Sztein, Marcelo B, Wahid, Rezwanul, Campbell, James D, Kieny, Marie-Paule, Moorthy, Vasee, Imoukhuede, Egeruan B, Rampling, Tommy, Roman, Francois, De Ryck, Iris, Bellamy, Abbie R, Dally, Len, Mbaya, Olivier Tshiani, Ploquin, Aurélie, Zhou, Yan, Stanley, Daphne A, Bailer, Robert, Koup, Richard A, Roederer, Mario, Ledgerwood, Julie, Hill, Adrian V S, Ballou, W Ripley, Sullivan, Nancy, Graham, Barney, Levine, Myron M

Source: In The Lancet Infectious Diseases January 2016 16(1):31-42

Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials.

Authors: Happe, Myra, Hofstetter, Amelia R., Wang, Jing, Yamshchikov, Galina V., Holman, LaSonji A., Novik, Laura, Strom, Larisa, Kiweewa, Francis, Wakabi, Salim, Millard, Monica, Kelley, Colleen F., Kabbani, Sarah, Edupuganti, Srilatha, Beck, Allison, Kaltovich, Florence, Murray, Tamar, Tsukerman, Susanna, Carr, Derick, Ashman, Carl, Stanley, Daphne A.

Source: NPJ Vaccines; 3/29/2024, Vol. 9 Issue 1, p1-11, 11p

Subject Terms: EBOLA virus, EBOLA virus disease, VACCINIA, VACCINES, VIRUS diseases, ANTIBODY formation

Geographic Terms: UGANDA

Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques

Authors: Liang, Frank, Ploquin, Aurélie, Hernández, José DelaO, Fausther-Bovendo, Hugues, Lindgren, Gustaf, Stanley, Daphne, Martinez, Aiala Salvador, Brenchley, Jason M., Koup, Richard A., Loré, Karin, Sullivan, Nancy J.

Source: In Journal of Immunological Methods October 2015 425:69-78

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial

Authors: Kibuuka, Hannah, Berkowitz, Nina M, Millard, Monica, Enama, Mary E, Tindikahwa, Allan, Sekiziyivu, Arthur B, Costner, Pamela, Sitar, Sandra, Glover, Deline, Hu, Zonghui, Joshi, Gyan, Stanley, Daphne, Kunchai, Meghan, Eller, Leigh Anne, Bailer, Robert T, Koup, Richard A, Nabel, Gary J, Mascola, John R, Sullivan, Nancy J, Graham, Barney S, Roederer, Mario, Michael, Nelson L, Robb, Merlin L, Ledgerwood, Julie E

Source: In The Lancet 18-24 April 2015 385(9977):1545-1554

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

Authors: Corti, Davide, Misasi, John, Mulangu, Sabue, Stanley, Daphne A., Kanekiyo, Masaru, Wollen, Suzanne, Ploquin, Aurélie, Doria-Rose, Nicole A., Staupe, Ryan P., Bailey, Michael, Shi, Wei, Choe, Misook, Marcus, Hadar, Thompson, Emily A., Cagigi, Alberto, Silacci, Chiara, Fernandez-Rodriguez, Blanca, Perez, Laurent, Sallusto, Federica, Vanzetta, Fabrizia, Agatic, Gloria, Cameroni, Elisabetta, Kisalu, Neville, Gordon, Ingelise, Ledgerwood, Julie E., Mascola, John R., Graham, Barney S., Muyembe-Tamfun, Jean-Jacques, Trefry, John C., Lanzavecchia, Antonio, Sullivan, Nancy J.

Source: Science, 2016 Mar . 351(6279), 1339-1342.

Access URL: http://www.jstor.org/stable/24742403

A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates.

Authors: Hunegnaw, Ruth, Honko, Anna N., Wang, Lingshu, Carr, Derick, Murray, Tamar, Shi, Wei, Nguyen, Lam, Storm, Nadia, Dulan, Caitlyn N. M., Foulds, Kathryn E., Agans, Krystle N., Cross, Robert W., Geisbert, Joan B., Cheng, Cheng, Ploquin, Aurélie, Stanley, Daphne A., Geisbert, Thomas W., Nabel, Gary J., Sullivan, Nancy J.

Source: Science Translational Medicine; 12/14/2022, Vol. 14 Issue 675, p1-12, 12p

Subject Terms: EBOLA virus, MARBURG virus, HEMORRHAGIC fever, VACCINE effectiveness, PRIMATES, PRIMATE diseases

Geographic Terms: WEST Africa

Company/Entity: CENTERS for Disease Control & Prevention (U.S.), NATIONAL Institute of Allergy & Infectious Diseases (U.S.)

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge.

Authors: Stanley, Daphne A¹, Honko, Anna N², Asiedu, Clement³, Trefry, John C⁴, Lau-Kilby, Annie W¹, Johnson, Joshua C², Hensley, Lisa², Ammendola, Virginia⁵, Abbate, Adele⁵, Grazioli, Fabiana⁵, Foulds, Kathryn E¹, Cheng, Cheng¹, Wang, Lingshu¹, Donaldson, Mitzi M¹, Colloca, Stefano⁵, Folgori, Antonella⁵, Roederer, Mario¹, Nabel, Gary J⁶, Mascola, John¹, Nicosia, Alfredo⁷

Source: Nature Medicine. Oct2014, Vol. 20 Issue 10, p1126-1129. 4p. 1 Chart, 2 Graphs.

Subject Terms: *EBOLA virus disease, *HUMAN adenoviruses, *GLYCOPROTEINS, *VACCINE effectiveness, *VIRAL replication, *MACAQUES

Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates.

Authors: Marcus, Hadar, Thompson, Emily, Zhou, Yan, Bailey, Michael, Donaldson, Mitzi M., Stanley, Daphne A., Asiedu, Clement, Foulds, Kathryn E., Roederer, Mario, Moliva, Juan I., Sullivan, Nancy J.

Source: Frontiers in Immunology; 3/9/2021, Vol. 11, pN.PAG-N.PAG, 11p

Subject Terms: DNA, IMMUNE response, PRIMATES, EBOLA virus, HEMORRHAGIC diseases, HUMORAL immunity

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CD8⁺ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates.

Authors: Sullivan, Nancy J, Hensley, Lisa, Asiedu, Clement, Geisbert, Thomas W, Stanley, Daphne, Johnson, Joshua, Honko, Anna, Olinger, Gene, Bailey, Michael, Geisbert, Joan B, Reimann, Keith A, Bao, Saran, Rao, Srinivas, Roederer, Mario, Jahrling, Peter B, Koup, Richard A, Nabel, Gary J

Source: Nature Medicine; Sep2011, Vol. 17 Issue 9, p1128-1131, 4p, 1 Chart, 3 Graphs

Subject Terms: CELLULAR immunity, EBOLA virus disease, VIRAL vaccines, ADENOVIRUS diseases, GLYCOPROTEINS, MACAQUES, T cells

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