PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

Authors: Hope, Jennifer L., Otero, Dennis C., Bae, Eun-Ah, Stairiker, Christopher J., Palete, Ashley B., Faso, Hannah A., Lin, Michelle, Henriquez, Monique L., Roy, Sreeja, Seo, Hyungseok, Lei, Xue, Wang, Eric S., Chow, Savio, Tinoco, Roberto, Daniels, Gregory A., Yip, Kevin, Campos, Alexandre Rosa, Yin, Jun, Adams, Peter D., Rao, Anjana, Bradley, Linda M.

Source: In Cell Reports 30 May 2023 42(5)

MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8^+ T Cell Responses

Authors: Hope, Jennifer L., Zhao, Manzhi, Stairiker, Christopher J., Kiernan, Caoimhe H., Carey, Alison J., Mueller, Yvonne M., van Meurs, Marjan, Brouwers-Haspels, Inge, Otero, Dennis C., Bae, Eun-Ah

Source: Journal of immunology. 208(3):603-617

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628547517&indx=1&recIds=ETOCRN628547517

Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells.

Authors: Stairiker, Christopher J.^1,2 (AUTHOR), van Meurs, Marjan¹ (AUTHOR), Leon, Leticia G.¹ (AUTHOR), Brouwers-Haspels, A. A.¹ (AUTHOR), Rijsbergen, Laurine³ (AUTHOR), Mueller, Yvonne M.¹ (AUTHOR), Katsikis, Peter D.¹ (AUTHOR) p.katsikis@erasmusmc.nl

Source: PLoS ONE. 7/17/2020, Vol. 15 Issue 7, p1-16. 16p.

Subject Terms: *EPITHELIAL cells, *VIRUS diseases, *GENE expression, *VIRAL genes, *RNA sequencing, *HOST-virus relationships

Acute exposure to ZnO nanoparticles induces autophagic immune cell death

Authors: Johnson, Brandon M., Fraietta, Joseph A., Gracias, Donald T., Hope, Jennifer L., Stairiker, Christopher J., Patel, Prachi R., Mueller, Yvonne M., McHugh, Michael D., Jablonowski, Lauren J., Wheatley, Margaret A., Katsikis, Peter D.

Source: Nanotoxicology. 9(6):737-748

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105935205.0x000001&indx=1&recIds=ETOCvdc_100105935205.0x000001

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.

Authors: Zhao, Manzhi¹, Kiernan, Caoimhe H.¹, Stairiker, Christopher J.¹, Hope, Jennifer L.², Leon, Leticia G.¹, van Meurs, Marjan¹, Brouwers-Haspels, Inge¹, Boers, Ruben^3,4, Boers, Joachim^3,4, Gribnau, Joost^3,4, van IJcken, Wilfred F. J.⁵, Bindels, Eric M.⁶, Hoogenboezem, Remco M.⁶, Erkeland, Stefan J.¹, Mueller, Yvonne M.¹, Katsikis, Peter D.¹, p.katsikis@erasmusmc.nl

Source: PLoS Pathogens; 6/24/2020, Vol. 16 Issue 6, p1-27, 27p

EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8⁺ T Cells.

Authors: Stairiker, Christopher J., Pfister, Sophia, Hendrickson, Eleanore, Yang, Wenjing, Xie, Tao, Lee, Catherine, Zhang, Haikuo, Dillon, Christopher, Thomas, Graham D., Salek-Ardakani, Shahram

Source: Frontiers in Immunology; 11/24/2021, Vol. 12, p1-10, 10p

Subject Terms: T cells, IMMUNE checkpoint proteins, PROTEIN models

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.

Authors: Tinoco, Roberto, Neubert, Emily N., Stairiker, Christopher J., Henriquez, Monique L., Bradley, Linda M.

Source: Frontiers in Immunology; 7/13/2021, Vol. 12, p1-13, 13p

Subject Terms: T cells, VIRUS diseases, T cell differentiation, IMMUNE checkpoint proteins, PSYCHONEUROIMMUNOLOGY, CELL death, T cell receptors

EZH2 as a Regulator of CD8+ T Cell Fate and Function.

Authors: Stairiker, Christopher J., Thomas, Graham D., Salek-Ardakani, Shahram

Source: Frontiers in Immunology; 10/6/2020, Vol. 11, pN.PAG-N.PAG, 11p

Subject Terms: T cells, CELL physiology, GENE enhancers, IMMUNE recognition

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Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model.

Authors: Hope, Jennifer L., Spantidea, Panagiota I., Kiernan, Caoimhe H., Stairiker, Christopher J., Rijsbergen, Laurine C., van Meurs, Marjan, Brouwers-Haspels, Inge, Mueller, Yvonne M., Nelson, Delia J., Bradley, Linda M., Aerts, Joachim G. J. V., Katsikis, Peter D.

Source: Frontiers in Immunology; 1/10/2020, Vol. 10, p1-14, 14p

Subject Terms: CYTOTOXIC T cells, T cells, MESOTHELIOMA, CANCER cells

Striking a Balance—Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation.

Authors: Hope, Jennifer L., Stairiker, Christopher J., Bae, Eun-Ah, Otero, Dennis C., Bradley, Linda M.

Source: Frontiers in Immunology; 7/17/2019, p1-22, 22p

Subject Terms: T cells, T cell differentiation, MEMORY, B cells, PERSISTENCE, CELL populations

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The Transcription Factor T-Bet is Regulated by MicroRNA-155 in Murine Anti-Viral CD8⁺ T Cells via SHIP-1.

Authors: Hope, Jennifer L., Stairiker, Christopher J., Spantidea, Panagiota I., Gracias, Donald T., Carey, Alison J., Fike, Adam J., van Meurs, Marjan, Brouwers-Haspels, Inge, Rijsbergen, Laurine C., Fraietta, Joseph A., Mueller, Yvonne M., Klop, Rosemarieke C., Stelekati, Erietta, Wherry, E. John, Erkeland, Stefan J., Katsikis, Peter D.

Source: Frontiers in Immunology; 12/6/2017, p1-14, 14p

Subject Terms: ANTIVIRAL agents, TRANSCRIPTION factors, MICRORNA

PSGL-1 attenuates early TCR signaling to suppress CD8+T cell progenitor differentiation and elicit terminal CD8+T cell exhaustion

Authors: Hope, Jennifer L., Otero, Dennis C., Bae, Eun-Ah, Stairiker, Christopher J., Palete, Ashley B., Faso, Hannah A., Lin, Michelle, Henriquez, Monique L., Roy, Sreeja, Seo, Hyungseok, Lei, Xue, Wang, Eric S., Chow, Savio, Tinoco, Roberto, Daniels, Gregory A., Yip, Kevin, Campos, Alexandre Rosa, Yin, Jun, Adams, Peter D., Rao, Anjana, Bradley, Linda M.

Source: Cell Reports; May 2023, Vol. 42 Issue: 5