Epidermal growth factor receptor mediates the basolateral uptake of phosphorothioate-modified antisense oligonucleotides in the kidney

Authors: Caetano-Pinto, Pedro, Haughan, Katie, Kragl, Angelique, Tzvetkov, Mladen V., Fenner, Katherine S., Stahl, Simone H.

Source: In Organs-on-a-Chip December 2022 4

Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters

Authors: Krishnan, Srinivasan, Ramsden, Diane, Ferguson, Douglas, Stahl, Simone H., Wang, Joanne, McGinnity, Dermot F., Hariparsad, Niresh

Source: Clinical pharmacology & therapeutics. 112(3):562-572

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163862038.0x000001&indx=1&recIds=ETOCvdc_100163862038.0x000001

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

Authors: Brouwer, Kim L.R., Evers, Raymond, Hayden, Elizabeth, Hu, Shuiying, Li, Cindy Yanfei, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle, Oswald, Stefan, Piquette‐Miller, Micheline, Saran, Chitra, Sjöstedt, Noora, Sprowl, Jason A., Stahl, Simone H., Yue, Wei

Source: Clinical pharmacology & therapeutics. 112(3):461-484

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381727.0x000001&indx=1&recIds=ETOCvdc_100158381727.0x000001

Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten.

Authors: Caetano-Pinto, Pedro¹ (AUTHOR) pintop@uni-greifswald.de, Stahl, Simone H.² (AUTHOR) simone.stahl@astrazeneca.com

Source: International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 20, p15419. 15p.

Subject Terms: *ORGANIC anion transporters, *PROXIMAL kidney tubules, *KIDNEY tubules, *SMALL molecules, *ESSENTIAL drugs, *KIDNEY physiology

The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS

Authors: Dargue, Rebecca, Grant, Isobelle, Nye, Leanne C, Nicholls, Andy, Dare, Theo, Stahl, Simone H, Plumb, Robert S, Lee, Karla, Jalan, Rajiv, Coen, Muireann, Wilson, Ian D

Source: Bioanalysis. 12(7):485-500

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186564850.0x000001&indx=1&recIds=ETOCvdc_100186564850.0x000001

Perspective on the Application of Microphysiological Systems to Drug Transporter Studies

Authors: Caetano-Pinto, Pedro, Stahl, Simone H. ^*

Source: In Drug Metabolism and Disposition November 2018 46(11):1647-1657

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Authors: Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D., Stahl, Simone H., Fenner, Katherine S., Giacomini, Kathleen M. ^*

Source: In Molecular Pharmacology July 2018 94(1):689-699

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Authors: Sjögren, Anna-Karin, Breitholtz, Katarina, Ahlberg, Ernst, Milton, Lucas, Forsgard, Malin, Persson, Mikael, Stahl, Simone H., Wilmer, Martijn J., Hornberg, Jorrit J.

Source: Archives of toxicology. 92(10):3175-3190

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125385916.0x000001&indx=1&recIds=ETOCvdc_100125385916.0x000001

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism

Authors: Stahl, Simone H., Yates, James W., Nicholls, Andrew W., Kenna, J. Gerry, Coen, Muireann, Ortega, Fernando, Nicholson, Jeremy K., Wilson, Ian D.

Source: In Drug Discovery Today: Technologies August 2015 15:9-14

Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists

Authors: Kenna, J. Gerry, Stahl, Simone H., Eakins, Julie A., Foster, Alison J., Andersson, Linda C., Bergare, Jonas, Billger, Martin, Elebring, Marie, Elmore, Charles S., Thompson, Richard A. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2015 352(2):281-290

Utilization of OATP1B Biomarker Coproporphyrin‐I to Guide Drug–Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry.

Authors: Kikuchi, Ryota, Chothe, Paresh P., Chu, Xiaoyan, Huth, Felix, Ishida, Kazuya, Ishiguro, Naoki, Jiang, Rongrong, Shen, Hong, Stahl, Simone H., Varma, Manthena V.S., Willemin, Marie‐Emilie, Morse, Bridget L.

Source: Clinical Pharmacology & Therapeutics; Dec2023, Vol. 114 Issue 6, p1170-1183, 14p

Subject Terms: DRUG interactions, RISK assessment, PHARMACEUTICAL industry, DECISION trees, CONSORTIA

Amplifying the Impact of Kidney Micro-physiological Systems: Predicting Renal Clearance Using Mechanistic Modelling Based on Reconstructed Drug Secretion.

Authors: Caetano-Pinto, Pedro, Nordell, Pär, Nieskens, Tom, Haughan, Katie, Fenner, Katherine S., Stahl, Simone H.

Source: Altex; 2023, Vol. 40 Issue 3, p408-424, 29p

Leveraging Microphysiological Systems to Address Challenges Encountered During Development of Oligonucleotide Therapeutics.

Authors: Ramsden, Diane, Belair, David G., Agarwal, Saket, Andersson, Patrik, Humphreys, Sara, Dalmas, Deidre A., Stahl, Simone H., Maclauchlin, Chris, Cichocki, Joseph A.

Source: Altex; 2022, Vol. 39 Issue 2, p273-296, 24p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Mechanistic Representation of NAG Release in Renal Proximal Tubular Cellular Injury

Authors: Hamzavi, Nader, Bhargava, Pallavi, Stahl, Simone H., Woodhead, Jeffrey

Source: Journal of the American Society of Nephrology; November 2023, Vol. 34 Issue: 11, Number 11 Supplement 11 p123-123, 1p

Strategies for Minimisation of the Cholestatic Liver Injury Liability Posed by Drug-Induced Bile Salt Export Pump (BSEP) Inhibition.

Authors: Kenna, J. Gerry, Stahl, Simone H., Noeske, Tobias

Source: Tactics in Contemporary Drug Design; 2015, p191-223, 33p

This result is not displayed to guests.
Login for full access.