ALSUntangled #70: caffeine

Authors: Hatch, Jessica, Barkhaus, Paul, Barnes, Benjamin, Beauchamp, Morgan, Benatar, Michael, Bertorini, Tulio, Bowser, Robert, Bromberg, Mark, Brown, Andrew, Mascias Cadavid, Javier, Carter, Gregory T., Cole, Nicholas, Crayle, Jesse, Dimachkie, Mazen, Ennist, David, Feldman, Eva, Fullam, Timothy, Heiman-Patterson, Terry, Jhooty, Sartaj, Levine, Todd, Li, Xiaoyan, Lund, Isaac, Mallon, Elise, Maragakis, Nicholas, McDermott, Christopher, Pattee, Gary, Pierce, Kaitlyn, Ratner, Dylan, Staats, Kim, Wicks, Paul, Wiedau, Martina, Bedlack, Richard

Source: Amyotrophic lateral sclerosis and frontotemporal degeneration. 24(7-8):766-770

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196181055.0x000001&indx=1&recIds=ETOCvdc_100196181055.0x000001

The C9ORF72 repeat expansion alters neurodevelopment

Authors: Hendricks, Eric, Quihuis, Alicia M., Hung, Shu-Ting, Chang, Jonathan, Dorjsuren, Nomongo, Der, Balint, Staats, Kim A., Shi, Yingxiao, Sta Maria, Naomi S., Jacobs, Russell E., Ichida, Justin K.

Source: Cell reports. 42(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196442822.0x000001&indx=1&recIds=ETOCvdc_100196442822.0x000001

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

Authors: Moore, Stephen, Alsop, Eric, Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Reiman, Rebecca, Chew, Jeannie, Belzil, Veronique V., W. Dickson, Dennis, Robertson, Janice, Staats, Kim A., Ichida, Justin K., Petrucelli, Leonard, Van Keuren-Jensen, Kendall, Sattler, Rita

Source: Acta neuropathologica. 138(1):49-65

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141525862.0x000001&indx=1&recIds=ETOCvdc_100141525862.0x000001

Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis.

Authors: Staats, Kim A.¹ (AUTHOR), Borchelt, David R.² (AUTHOR), Tansey, Malú Gámez³ (AUTHOR), Wymer, James⁴ (AUTHOR) James.Wymer@neurology.ufl.edu

Source: Molecular Neurodegeneration. 1/24/2022, Vol. 17 Issue 1, p1-19. 19p.

Subject Terms: *CENTRAL nervous system diseases, *AMYOTROPHIC lateral sclerosis, *BIOMARKERS, *NEURODEGENERATION, *INFLAMMATION

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Authors: Bento-Abreu, Andre, Jager, Gunilla, Swinnen, Bart, Rué, Laura, Hendrickx, Stijn, Jones, Ashley, Staats, Kim A, Taes, Ines, Eykens, Caroline, Nonneman, Annelies, Nuyts, Rik, Timmers, Mieke, Silva, Lara, Chariot, Alain, Nguyen, Laurent, Ravits, John, Lemmens, Robin, Cabooter, Deirdre, Van Den Bosch, Ludo, Van Damme, Philip, Al-Chalabi, Ammar, Bystrom, Anders, Robberecht, Wim

Source: Human molecular genetics. 27(7):1276-1289

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078408251.0x000001&indx=1&recIds=ETOCvdc_100078408251.0x000001

Dupuytren’s disease susceptibility gene, EPDR1, is involved in myofibroblast contractility

Authors: Staats, Kim A., Wu, Timothy, Gan, Bing S., O’Gorman, David B., Ophoff, Roel A.

Source: In Journal of Dermatological Science August 2016 83(2):131-137

ALSUntangled #71: Nuedexta.

Authors: Sun, Yuyao, Benatar, Michael, Mascías Cadavid, Javier, Ennist, Dave, Wicks, Paul, Staats, Kim, Beauchamp, Morgan, Jhooty, Sartaj, Pattee, Gary, Brown, Andrew, Bertorini, Tulio, Barkhaus, Paul, Bromberg, Mark, Carter, Greg, Bedlack, Richard, Li, Xiaoyan

Source: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration; Feb2024, Vol. 25 Issue 1/2, p218-222, 5p

Subject Terms: MOTOR neurons, BRAIN stem, OFF-label use (Drugs), SIGMA-1 receptor, QUINIDINE

Company/Entity: UNITED States. Food & Drug Administration

Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice

Authors: Staats, Kim A., Pombal, Diana, Schönefeldt, Susann, Van Helleputte, Lawrence, Maurin, Hervé, Dresselaers, Tom, Govaerts, Kristof, Himmelreich, Uwe, Van Leuven, Fred, Van Den Bosch, Ludo, Dooley, James, Humblet-Baron, Stephanie, Liston, Adrian

Source: In Brain Research 5 May 2015 1606:125-132

Genetic ablation of phospholipase C delta 1 increases survival in SOD1G93A mice

Authors: Staats, Kim A., Van Helleputte, Lawrence, Jones, Ashley R., Bento-Abreu, André, Van Hoecke, Annelies, Shatunov, Aleksey, Simpson, Claire L., Lemmens, Robin, Jaspers, Tom, Fukami, Kiyoko, Nakamura, Yoshikazu, Brown, Robert H., Jr., Van Damme, Philip, Liston, Adrian, Robberecht, Wim, Al-Chalabi, Ammar, Van Den Bosch, Ludo

Source: In Neurobiology of Disease December 2013 60:11-17

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice

Authors: Tian, Lei, De Hertogh, Gert, Fedeli, Maya, Staats, Kim A., Schonefeldt, Susann, Humblet-Baron, Stephanie, Van Den Bosch, Ludo, Dellabona, Paolo, Dooley, James, Liston, Adrian

Source: In Journal of Autoimmunity February 2012 38(1):39-48

A roadmap to ALS prevention: strategies and priorities.

Authors: Benatar, Michael, Goutman, Stephen A., Staats, Kim A., Feldman, Eva L., Weisskopf, Marc, Talbott, Evelyn, Dave, Kuldip D., Thakur, Neil M., Al-Chalabi, Ammar

Source: Journal of Neurology, Neurosurgery & Psychiatry; May2023, Vol. 94 Issue 5, p399-402, 4p

Subject Terms: AMYOTROPHIC lateral sclerosis, MOTOR neuron diseases, CHEMOKINE receptors, NOSOLOGY, SINGLE nucleotide polymorphisms

Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

Authors: Moore, Stephen, Alsop, Eric, Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Reiman, Rebecca, Chew, Jeannie, Belzil, Veronique V., Dickson, Dennis, Robertson, Janice, Staats, Kim A., Ichida, Justin K., Petrucelli, Leonard, Van Keuren-Jensen, Kendall, Sattler, Rita

Source: Acta neuropathologica. 138(5):883-884

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141525769.0x000001&indx=1&recIds=ETOCvdc_100141525769.0x000001

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

Authors: Staats, Kim A.^1,2,3,4, Hernandez, Sara^1,2, Schönefeldt, Susann^3,4, Bento-Abreu, André^1,2, Dooley, James^3,4, Van Damme, Philip^1,2,5, Liston, Adrian^3,4, Robberecht, Wim^1,2,5, Van Den Bosch, Ludo^1,2 Ludo.VandenBosch@vib-kuleuven.be

Source: Molecular Neurodegeneration. 2013, Vol. 8 Issue 1, p1-5. 5p.

Subject Terms: *RAPAMYCIN, *AMYOTROPHIC lateral sclerosis, *LEUKOCYTES, *LABORATORY mice, *IMMUNOREGULATION

The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications.

Authors: Guo, Wenting^1,2,3, Vandoorne, Tijs^1,2, Steyaert, Jolien^1,2, Staats, Kim A⁴, staatsk@usc.edu, Bosch, Ludo Van Den^1,2, ludo.vandenbosch@kuleuven.vib.be, Van Den Bosch, Ludo^5,6

Source: Brain: A Journal of Neurology; Jun2020, Vol. 143 Issue 6, p1651-1673, 23p

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ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD.

Authors: Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Sattler, Rita, Moore, Stephen, Alsop, Eric, Reiman, Rebecca, Van Keuren-Jensen, Kendall, Chew, Jeannie, Belzil, Veronique V., W. Dickson, Dennis, Petrucelli, Leonard, Robertson, Janice, Staats, Kim A., Ichida, Justin K.

Source: Acta Neuropathologica; Jul2019, Vol. 138 Issue 1, p49-65, 17p

Subject Terms: RNA editing, AMYOTROPHIC lateral sclerosis, RNA-binding proteins, DOUBLE-stranded RNA, CATALYTIC RNA, ADENOSINE deaminase

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Neuronal overexpression of IP3 receptor 2 is detrimental in mutant SOD1 mice

Authors: Staats, Kim A., Bogaert, Elke, Hersmus, Nicole, Jaspers, Tom, Luyten, Tomas, Bultynck, Geert, Parys, Jan B., Hisatsune, Chihiro, Mikoshiba, Katsuhiko, Van Damme, Philip, Robberecht, Wim, Van Den Bosch, Ludo

Source: In Biochemical and Biophysical Research Communications 14 December 2012 429(3-4):210-213