Hydroxyurea therapy for neurological and cognitive protection in pediatric sickle cell anemia in Uganda (BRAIN SAFE II): Protocol for a single-arm open label trial

Authors: Mboizi, Vincent ^a, Nabaggala, Catherine ^b, Munube, Deogratias ^b, Ssenkusu, John M. ^c, Kasirye, Phillip ^b, Kamya, Samson ^d, Kawooya, Michael G. ^d, Boehme, Amelia ^e, Minja, Frank ^f, Mupere, Ezekiel ^b, Opoka, Robert ^{a, b}, Rosano, Caterina ^g, Idro, Richard ^{b, ⁎}, Green, Nancy S. ^h

Source: In Contemporary Clinical Trials Communications December 2024 42

Angiopoietin-2 is associated with sickle cell complications, including stroke risk, and decreases with hydroxyurea therapy

Authors: Siegert, Thomas F., Opoka, Robert O., Nakafeero, Maria, Carman, Aubri, Mellencamp, Kagan A., Latham, Teresa, Hume, Heather, Lane, Adam, Ware, Russell E., Ssenkusu, John M., John, Chandy C., Conroy, Andrea L.

Source: In Blood Vessels, Thrombosis & Hemostasis March 2024 1(1)

Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women

Authors: Weckman, Andrea M. ^{1, 2}, Elphinstone, Robyn E. ², Ssenkusu, John M. ³, Tran, Vanessa ^{1, 2}, Zhong, Kathleen ², Madanitsa, Mwayiwawo ⁴, Khairallah, Carole ⁵, Kalilani-Phiri, Linda ⁴, Mwapasa, Victor ⁴, Conroy, Andrea L. ⁶, Ter Kuile, Feiko O. ⁵, McDonald, Chloe R. ², Kain, Kevin C. ^{1, 2, 7, 8, 9, ∗}

Source: In iScience 16 June 2023 26(6)

Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality

Authors: Batte, Anthony, Menon, Sahit, Ssenkusu, John M., Kiguli, Sarah, Kalyesubula, Robert, Lubega, Joseph, Berrens, Zachary, Mutebi, Edrisa Ibrahim, Ogwang, Rodney, Opoka, Robert O., John, Chandy C., Conroy, Andrea L.

Source: In Kidney International October 2022 102(4):885-893

Falling through the net: An adaptive assessment of the 'Three Delays' encountered by patients seeking emergency maternal and neonatal care within a remote health system on Lake Victoria, Kenya

Authors: Salmen, Charles Reinisch, Ndunyu, Louisa, Ssenkusu, John M., Marshall, David, DesLauriers, Nicholas, Anebarassou, Ananda Vigneswari, Ogola, Evance, Benard Ouma, Gor, Mattah, Brian, Okeyo, Robinson, Otieno, Scholarstica, Friberg, Nyika, Muldoon, Lily, Hines, Kelsi, Salmen, Marcus, Prasad, Shailendra

Source: Global public health. 17(9):2156-2175

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159009474.0x000001&indx=1&recIds=ETOCvdc_100159009474.0x000001

Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study

Authors: Namazzi, Ruth, Batte, Anthony, Opoka, Robert O., Bangirana, Paul, Schwaderer, Andrew L., Berrens, Zachary, Datta, Dibyadyuti, Goings, Michael, Ssenkusu, John M., Goldstein, Stuart L., John, Chandy C., Conroy, Andrea L.

Source: In eClinicalMedicine February 2022 44

Impact of early continuous positive airway pressure in the delivery room (DR-CPAP) on neonates < 1500 g in a low-resource setting: a protocol for a pilot feasibility and acceptability randomized controlled trial.

Authors: Burgoine, Kathy¹ (AUTHOR) kathy.burgoine@gmail.com, Ssenkusu, John M.² (AUTHOR), Nakiyemba, Alice³ (AUTHOR), Okello, Francis⁴ (AUTHOR), Napyo, Agnes⁴ (AUTHOR), Hagmann, Cornelia^5,6 (AUTHOR), Namuyonga, Judith^7,8 (AUTHOR), Hewitt-Smith, Adam⁴ (AUTHOR), Martha, Muduwa¹ (AUTHOR), Loe, Kate⁹ (AUTHOR), Grace, Abongo¹ (AUTHOR), Denis, Amorut¹ (AUTHOR), Wandabwa, Julius⁴ (AUTHOR), Olupot-Olupot, Peter^1,4 (AUTHOR)

Source: Pilot & Feasibility Studies. 10/4/2024, Vol. 10 Issue 1, p1-15. 15p.

Subject Terms: *CONTINUOUS positive airway pressure, *RESPIRATORY distress syndrome, *RESOURCE-limited settings, *MEDICAL personnel, *ARTIFICIAL respiration, *PREMATURE labor, *MECONIUM aspiration syndrome

The MOMENTUM study: Putting the 'Three Delays' to work to evaluate access to emergency obstetric and neonatal care in a remote island community in Western Kenya

Authors: DesLauriers, Nicholas R., Ogola, Evance, Ouma, Gor, Salmen, Marcus, Muldoon, Lily, Pederson, Ben L., Hines, Kelsi, Ssenkusu, John M., Mattah, Brian, Okeyo, Robinson, Okinyi, Peres, Magerenge, Richard, Friberg, Nyika, McCoy, Molly, Prasad, Shailendra, Ndunyu, Louisa, Salmen, Charles R.

Source: Global public health. 15(7):1016-1029

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111043486.0x000001&indx=1&recIds=ETOCvdc_100111043486.0x000001

How interventions to maintain services during the COVID-19 pandemic strengthened systems for delivery of maternal and child health services: a case-study of Wakiso District, Uganda.

Authors: Kabwama, Steven Ndugwa, Wanyenze, Rhoda K., Razaz, Neda, Ssenkusu, John M., Alfvén, Tobias, Lindgren, Helena

Source: Global Health Action; 2024, Vol. 17 Issue 1, p1-10, 10p

Subject Terms: EVALUATION of medical care, NURSES, MATERNAL health services, FOCUS groups, INFECTION control, RESEARCH funding, CHILD health services, MOTHERS, DESCRIPTIVE statistics, RESEARCH methodology, CONCEPTUAL structures, QUALITY assurance, CASE studies, COVID-19 pandemic, EMPLOYEES' workload, SOCIAL stigma, INDUSTRIAL safety

Geographic Terms: UGANDA

Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria

Authors: Ouma, Benson J., Bangirana, Paul, Ssenkusu, John M., Datta, Dibyadyuti, Opoka, Robert O., Idro, Richard, Kain, Kevin C., John, Chandy C., Conroy, Andrea L.

Source: Malaria journal. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192949143.0x000001&indx=1&recIds=ETOCvdc_100192949143.0x000001

Severe Malaria and Academic Achievement

Authors: Nakitende, Ann Jacquelline, Bangirana, Paul, Nakasujja, Noeline, Ssenkusu, John M., Bond, Caitlin, Idro, Richard, Zhao, Yi, Semrud-Clikeman, Margaret, John, Chandy C.

Source: Pediatrics. 151(4):51-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631733620&indx=1&recIds=ETOCRN631733620

Complete sources of cluster variation on the risk of under-five malaria in Uganda: a multilevel-weighted mixed effects logistic regression model approach.

Authors: Natuhamya, Charles, Makumbi, Fredrick, Mukose, Aggrey David, Ssenkusu, John M.

Source: Malaria Journal; 10/19/2023, Vol. 22 Issue 1, p1-8, 8p

Subject Terms: LOGISTIC regression analysis, MALARIA, REGRESSION analysis, MULTILEVEL models, HYPERLINKS

Geographic Terms: UGANDA

Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study

Authors: Batte, Anthony, Starr, Michelle C., Schwaderer, Andrew L., Opoka, Robert O., Namazzi, Ruth, Phelps Nishiguchi, Erika S., Ssenkusu, John M., John, Chandy C., Conroy, Andrea L.

Source: BMC nephrology. 21(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171680395.0x000001&indx=1&recIds=ETOCvdc_100171680395.0x000001

Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria.

Authors: Vasquez, Marilyn, Sica, Margaux, Namazzi, Ruth, Opoka, Robert O., Sherman, Julian, Datta, Dibyadyuti, Duran-Frigola, Miquel, Ssenkusu, John M., John, Chandy C., Conroy, Andrea L., Rodriguez, Ana

Source: Scientific Reports; 9/7/2023, Vol. 13 Issue 1, p1-9, 9p

Subject Terms: XANTHINE oxidase, MALARIA, PLASMODIUM falciparum, ANEMIA, IMMUNE complexes, ERYTHROCYTES

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Authors: Conroy, Andrea L., Opoka, Robert O., Bangirana, Paul, Idro, Richard, Ssenkusu, John M., Datta, Dibyadyuti, Hodges, James S., Morgan, Catherine, John, Chandy C.

Source: BMC medicine. 17(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127216754.0x000001&indx=1&recIds=ETOCvdc_100127216754.0x000001

Risk factors for unplanned sex among university students in Kampala, Uganda: a qualitative study

Authors: Aluzimbi, George, Barker, Joseph, King, Rachel, Rutherford, George, Ssenkusu, John M., Lubwama, George W., Muyonga, Michael, Hladik, Wolfgang

Source: International journal of adolescence and youth. 18(3):191-203

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037710852.0x000001&indx=1&recIds=ETOCvdc_100037710852.0x000001

Plasma Amino Acid Concentrations in Children With Severe Malaria Are Associated With Mortality and Worse Long-term Kidney and Cognitive Outcomes.

Authors: Conroy, Andrea L, Tran, Tuan M, Bond, Caitlin, Opoka, Robert O, Datta, Dibyadyuti, Liechty, Edward A, Bangirana, Paul, Namazzi, Ruth, Idro, Richard, Cusick, Sarah, Ssenkusu, John M, John, Chandy C

Source: Journal of Infectious Diseases; 12/15/2022, Vol. 226 Issue 12, p2215-2225, 11p

Subject Terms: HIGH performance liquid chromatography, MALARIA, ACUTE kidney failure, CHRONIC kidney failure, ASPARAGINE, AMINO acids

Effect of four or more antenatal care visits on facility delivery and early postnatal care services utilization in Uganda: a propensity score matched analysis.

Authors: Mwebesa, Edson, Kagaayi, Joseph, Ssebagereka, Anthony, Nakafeero, Mary, Ssenkusu, John M., Guwatudde, David, Tumwesigye, Nazarius Mbona

Source: BMC Pregnancy & Childbirth; 1/3/2022, Vol. 22 Issue 1, p1-9, 9p

Subject Terms: PATIENTS' attitudes, DELIVERY (Obstetrics), POSTNATAL care, PRENATAL care, DEMOGRAPHY, PROBABILITY theory

Geographic Terms: UGANDA

Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study.

Authors: Batte, Anthony, Murphy, Kristin J., Namazzi, Ruth, Co, Katrina, Opoka, Robert O., Ssenkusu, John M., John, Chandy C., Conroy, Andrea L.

Source: BMC Nephrology; 11/6/2021, Vol. 22 Issue 1, p1-9, 9p

Subject Terms: ACUTE kidney failure, KIDNEY physiology, POINT-of-care testing, MALARIA, COHORT analysis

Geographic Terms: SUB-Saharan Africa

Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria.

Authors: Conroy, Andrea L., Opoka, Robert O., Bangirana, Paul, Namazzi, Ruth, Okullo, Allen E., Georgieff, Michael K., Cusick, Sarah, Idro, Richard, Ssenkusu, John M., John, Chandy C.

Source: BMC Medicine; 7/28/2021, Vol. 19 Issue 1, p1-12, 12p

Subject Terms: ARTEMISININ derivatives, CEREBRAL malaria, MALARIA, PATIENT readmissions, HOSPITAL mortality, STUDENT adjustment

Company/Entity: WORLD Health Organization