Immune disease variants modulate gene expression in regulatory CD4+ T cells

Authors: Bossini-Castillo, Lara, Glinos, Dafni A., Kunowska, Natalia, Golda, Gosia, Lamikanra, Abigail A., Spitzer, Michaela, Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Cattermole, Claire, Alasoo, Kaur, Mann, Alice, Kundu, Kousik, Lorenc, Anna, Soranzo, Nicole, Dunham, Ian, Roberts, David J., Trynka, Gosia

Source: In Cell Genomics 13 April 2022 2(4)

Applications of machine learning in drug discovery and development

Authors: Vamathevan, Jessica, Clark, Dominic, Czodrowski, Paul, Dunham, Ian, Ferran, Edgardo, Lee, George, Li, Bin, Madabhushi, Anant, Shah, Parantu, Spitzer, Michaela, Zhao, Shanrong

Source: Nature reviews.Drug discovery. 18(6):463-477

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153477552.0x000001&indx=1&recIds=ETOCvdc_100153477552.0x000001

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

Authors: Wildenhain, Jan, Spitzer, Michaela, Dolma, Sonam, Jarvik, Nick, White, Rachel, Roy, Marcia, Griffiths, Emma, Bellows, David S., Wright, Gerard D., Tyers, Mike

Source: In Cell Systems 23 December 2015 1(6):383-395

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

Authors: Robbins, Nicole, Spitzer, Michaela, Yu, Tennison, Cerone, Robert P., Averette, Anna K., Bahn, Yong-Sun, Heitman, Joseph, Sheppard, Donald C., Tyers, Mike, Wright, Gerard D.

Source: In Cell Reports 17 November 2015 13(7):1481-1492

Combinatorial strategies for combating invasive fungal infections

Authors: Spitzer, Michaela, Robbins, Nicole, Wright, Gerard D.

Source: Virulence. 8(2):169-185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050518206.0x000001&indx=1&recIds=ETOCvdc_100050518206.0x000001

Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function

Authors: Robbins, Nicole, Spitzer, Michaela, Wang, Wenliang, Waglechner, Nicholas, Patel, Dhruv J., O'Brien, Jonathan S., Ejim, Linda, Ejim, Obi, Tyers, Mike, Wright, Gerard D.

Source: Cell chemical biology. 23(11):1383-1394

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064790631.0x000001&indx=1&recIds=ETOCvdc_100064790631.0x000001

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

Authors: Peil, Lauri, Starosta, Agata L., Lassak, Jürgen, Atkinson, Gemma, Virumäe, Kai, Spitzer, Michaela, Tenson, Tanel, Jung, Kirsten, Remme, Jaanus, Wilson, Daniel N.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Sep . 110(38), 15265-15270.

Access URL: https://www.jstor.org/stable/42713311

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

Authors: Zhou, Linna, Ishizaki, Hironori, Spitzer, Michaela, Taylor, Kerrie L., Temperley, Nicholas D., Johnson, Stephen L., Brear, Paul, Gautier, Philippe, Zeng, Zhiqiang, Mitchell, Amy, Narayan, Vikram, McNeil, Ewan M., Melton, David W., Smith, Terry K., Tyers, Mike, Westwood, Nicholas J., Patton, E. Elizabeth

Source: In Chemistry & Biology 27 July 2012 19(7):883-892

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

Authors: Zhou, Linna, Ishizaki, Hironori, Spitzer, Michaela, Taylor, Kerrie L., Temperley, Nicholas D., Johnson, Stephen L., Brear, Paul, Gautier, Philippe, Zeng, Zhiqiang, Mitchell, Amy, Narayan, Vikram, McNeil, Ewan M., Melton, David W., Smith, Terry K., Tyers, Mike, Westwood, Nicholas J., Patton, E. Elizabeth

Source: Cell chemical biology. 27(11):1452-1452

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111290327.0x000001&indx=1&recIds=ETOCvdc_100111290327.0x000001

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole.

Authors: Spitzer, Michaela¹ (AUTHOR), Griffiths, Emma^2,3 (AUTHOR), Blakely, Kim M² (AUTHOR), Wildenhain, Jan¹ (AUTHOR), Ejim, Linda² (AUTHOR), Rossi, Laura² (AUTHOR), De Pascale, Gianfranco² (AUTHOR), Curak, Jasna² (AUTHOR), Brown, Eric² (AUTHOR), Tyers, Mike¹ (AUTHOR), Wright, Gerard D² (AUTHOR)

Source: Molecular Systems Biology. 2011, Vol. 7 Issue 1, p1-N.PAG. 14p. 1 Diagram, 1 Chart, 5 Graphs.

A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase

Authors: Wong, Lai Hong, Unciti-Broceta, Asier, Spitzer, Michaela, White, Rachel, Tyers, Mike, Harrington, Lea

Source: In Chemistry & Biology 21 March 2013 20(3):333-340

Open Targets Platform: new developments and updates two years on.

Authors: Carvalho-Silva, Denise, Pierleoni, Andrea, Pignatelli, Miguel, Ong, ChuangKee, Fumis, Luca, Karamanis, Nikiforos, Carmona, Miguel, Faulconbridge, Adam, Hercules, Andrew, McAuley, Elaine, Miranda, Alfredo, Peat, Gareth, Spitzer, Michaela, Barrett, Jeffrey, Hulcoop, David G, Papa, Eliseo, Koscielny, Gautier, Dunham, Ian

Source: Nucleic Acids Research; 1/8/2019, Vol. 47 Issue D1, pD1056-D1065, 10p

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BoxPlotR: a web tool for generation of box plots.

Authors: Spitzer, Michaela¹, Wildenhain, Jan², Rappsilber, Juri³, Tyers, Mike⁴

Source: Nature Methods. Feb2014, Vol. 11 Issue 2, p121-122. 2p. 1 Graph.

Subject Terms: *TRANSCRIPTION factors, *SACCHAROMYCES cerevisiae, *DROSOPHILA melanogaster, *GENOMES, *GENOMICS