Use of Oncogene Overlap by Tissue-Based Next-Generation Sequencing to Explore the Mutational Landscape and Survival Impact of HER2, KRAS and MET Copy-Number Gain in Nonsmall Cell Lung Cancer

Authors: Watson, Alexander S., Krause, Harris B., Elliott, Andrew, Farrell, Alex, Liu, Stephen V., Ma, Patrick C., VanderWalde, Ari, Sledge, George W., Spetzler, David, Schenk, Erin L., Camidge, D. Ross

Source: In Clinical Lung Cancer December 2024 25(8):712-722

Somatic 9p24.1 alterations in HPV⁻ head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity

Authors: Zhao, Xin, Cohen, Ezra E. W., William, William N., Bianchi, Joy J., Abraham, Jim P., Magee, Daniel, Spetzler, David B., Gutkind, J. Silvio, Alexandrov, Ludmil B., Cavenee, Webster K., Lippman, Scott M., Davoli, Teresa

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Nov . 119(47), 1-10.

Access URL: https://www.jstor.org/stable/27208555

Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study

Authors: Wang, Jingyuan, Xiu, Joanne, Farrell, Alex, Baca, Yasmine, Arai, Hiroyuki, Battaglin, Francesca, Kawanishi, Natsuko, Soni, Shivani, Zhang, Wu, Millstein, Joshua, Shields, Anthony F, Grothey, Axel, Weinberg, Benjamin A, Marshall, John L, Lou, Emil, Khushman, Moh'd, Sohal, Davendra P S, Hall, Michael J, Liu, Tianshu, Oberley, Matthew, Spetzler, David, Korn, W Michael, Shen, Lin, Lenz, Heinz-Josef

Source: Lancet oncology. 24(2):151-161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180683570.0x000001&indx=1&recIds=ETOCvdc_100180683570.0x000001

Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset

Authors: Nagasaka, Misako, Brazel, Danielle, Baca, Yasmine, Xiu, Joanne, Al-Hallak, Mohammed Najeeb, Kim, Chul, Nieva, Jorge, Swensen, Jeffrey J., Spetzler, David, Korn, Wolfgang Michael, Socinski, Mark A., Raez, Luis E., Halmos, Balazs, Ou, Sai-Hong Ignatius

Source: In Translational Oncology October 2023 36

Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti–PD-L1 Immune Checkpoint Therapy

Authors: You, Sungyong, Kim, Minhyung, Hoi, Xen Ping, Lee, Yu Cheng, Wang, Li, Spetzler, David, Abraham, Jim, Magee, Dan, Jain, Prerna, Galsky, Matthew D, Chan, Keith Syson, Theodorescu, Dan

Source: Journal of the National Cancer Institute. 114(10):1380-1391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165288363.0x000001&indx=1&recIds=ETOCvdc_100165288363.0x000001

FOLFOXIRI and bevacizumab in patients with early-onset metastatic colorectal cancer. A pooled analysis of TRIBE and TRIBE2 studies

Authors: Antoniotti, Carlotta, Germani, Marco M., Rossini, Daniele, Lonardi, Sara, Pietrantonio, Filippo, Santini, Daniele, Marmorino, Federica, Allegrini, Giacomo, Daniel, Francesca, Raimondi, Alessandra, Borelli, Beatrice, Zaniboni, Alberto, Conca, Veronica, Abraham, Jim, Spetzler, David, Maiello, Evaristo, Boccaccino, Alessandra, Passardi, Alessandro, Giordano, Mirella, Tamburini, Emiliano, Korn, Michael W., Masi, Gianluca, Cremolini, Chiara

Source: European journal of cancer. 167:23-31

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161514732.0x000001&indx=1&recIds=ETOCvdc_100161514732.0x000001

Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications

Authors: Moretto, Roberto, Elliott, Andrew, Zhang, Jian, Arai, Hiroyuki, Germani, Marco Maria, Conca, Veronica, Xiu, Joanne, Stafford, Phillip, Oberley, Matthew, Abraham, Jim, Spetzler, David, Rossini, Daniele, Antoniotti, Carlotta, Marshall, John, Shields, Anthony, Lopes, Gilberto, Lonardi, Sara, Pietrantonio, Filippo, Tomasello, Gianluca, Passardi, Alessandro, Tamburini, Emiliano, Santini, Daniele, Aprile, Giuseppe, Masi, Gianluca, Falcone, Alfredo, Lenz, Heinz-Josef, Korn, Michael, Cremolini, Chiara

Source: Journal of the National Cancer Institute. 114(2):271-279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140766322.0x000001&indx=1&recIds=ETOCvdc_100140766322.0x000001

Immune evasion in HPV⁻ head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

Authors: William, William N., Zhao, Xin, Bianchi, Joy J., Lin, Heather Y., Cheng, Pan, Lee, J. Jack, Carter, Hannah, Alexandrov, Ludmil B., Abraham, Jim P., Spetzler, David B., Dubinett, Steven M., Cleveland, Don W., Cavenee, Webster, Davoli, Teresa, Lippman, Scott M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 May 01. 118(19), 1-12.

Access URL: https://www.jstor.org/stable/27040510

Predicted Immunogenicity of CDK12 Biallelic Loss-of-Function Tumors Varies across Cancer Types

Authors: Elliott, Andrew, Zhang, Jian, Zhang, Qing, Swensen, Jeffrey, Martin, Daniel, Xiu, Joanne, Geynisman, Daniel M., Vaena, Daniel, Herzog, Thomas J., Holloway, Robert W., El-Deiry, Wafik S., Spetzler, David, Heath, Elisabeth, Stafford, Phillip, Korn, W. Michael

Source: In The Journal of Molecular Diagnostics December 2021 23(12):1761-1773

Tumour mutational burden, microsatellite instability, and actionable alterations in metastatic colorectal cancer: Next-generation sequencing results of TRIBE2 study

Authors: Antoniotti, Carlotta, Korn, W. Michael, Marmorino, Federica, Rossini, Daniele, Lonardi, Sara, Masi, Gianluca, Randon, Giovanni, Conca, Veronica, Boccaccino, Alessandra, Tomasello, Gianluca, Passardi, Alessandro, Swensen, Jeff, Ugolini, Clara, Oberley, Matthew, Tamburini, Emiliano, Casagrande, Mariaelena, Domenyuk, Valeriy, Fontanini, Gabriella, Giordano, Mirella, Abraham, Jim, Spetzler, David, Falcone, Alfredo, Lenz, Heinz-Josef, Cremolini, Chiara

Source: In European Journal of Cancer September 2021 155:73-84

Machine learning analysis using 77,044 genomic and transcriptomic profiles to accurately predict tumor type

Authors: Abraham, Jim, Heimberger, Amy B., Marshall, John, Heath, Elisabeth, Drabick, Joseph, Helmstetter, Anthony, Xiu, Joanne, Magee, Daniel, Stafford, Phillip, Nabhan, Chadi, Antani, Sourabh, Johnston, Curtis, Oberley, Matthew, Korn, Wolfgang Michael, Spetzler, David

Source: In Translational Oncology March 2021 14(3)

Consensus molecular subtyping of metastatic colorectal cancer expands biomarker-directed therapeutic benefit for patients with CMS1 and CMS2 tumors.

Authors: Chowdhury, Saikat, Xiu, Joanne, Ribeiro, Jennifer R., Nicolaides, Theodore, Zhang, Jian, Korn, W. Michael, Poorman, Kelsey A., Lenz, Heinz-Josef, Marshall, John L., Oberley, Matthew J., Sledge Jr., George W., Spetzler, David, Kopetz, Scott, Shen, John Paul

Source: British Journal of Cancer; Nov2024, Vol. 131 Issue 8, p1328-1339, 12p

Molecular Profiling of the Metaplastic Spindle Cell Carcinoma of the Breast Reveals Potentially Targetable Biomarkers

Authors: Vranic, Semir, Stafford, Phillip, Palazzo, Juan, Skenderi, Faruk, Swensen, Jeffrey, Xiu, Joanne, Spetzler, David, Gatalica, Zoran

Source: In Clinical Breast Cancer August 2020 20(4):326-331

Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer

Authors: Malla, Midhun, Deshmukh, Sachin Kumar, Wu, Sharon, Samec, Timothy, Olevian, Dane C., El Naili, Reima, El-Rayes, Bassel, Xiu, Joanne, Farrell, Alex, Lenz, Heinz-Josef, Lou, Emil, Goel, Sanjay, Spetzler, David, Goldberg, Richard M., Hazlehurst, Lori

Source: Cancer Gene Therapy; October 2024, Vol. 31 Issue: 10 p1547-1558, 12p

Population bias in somatic measurement of microsatellite instability status

Authors: Saul, Michelle, Poorman, Kelsey, Tae, Hongseok, Vanderwalde, Ari, Stafford, Phillip, Spetzler, David, Korn, Wolfgang M., Gatalica, Zoran, Swensen, Jeff

Source: Cancer medicine. 9(17):6452-6460

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108400487.0x000001&indx=1&recIds=ETOCvdc_100108400487.0x000001

Elastic coupling power stroke mechanism of the F₁-ATPase molecular motor

Authors: Martin, James L., Ishmukhametov, Robert, Spetzler, David, Hornung, Tassilo, Frasch, Wayne D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 May . 115(22), 5750-5755.

Access URL: https://www.jstor.org/stable/26509926

Mutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation

Authors: Hsiehchen, David ^{1, 2, ∗}, Elliott, Andrew ³, Xiu, Joanne ³, Seeber, Andreas ⁴, El-Deiry, Wafik ⁵, Antonarakis, Emmanuel S. ⁶, Graff, Stephanie L. ⁷, Hall, Michael J. ⁸, Borghaei, Hossein ⁹, Hoon, Dave S.B. ¹⁰, Liu, Stephen V. ¹¹, Ma, Patrick C. ¹², McKay, Rana R. ¹³, Wise-Draper, Trisha ¹⁴, Marshall, John ¹⁵, Sledge, George W. ³, Spetzler, David ³, Zhu, Hao ^{1, 2}

Source: In Cancer Cell 9 December 2024 42(12):1985-1987

Immunohistochemistry-Enabled Precision Medicine

Authors: Gatalica, Zoran, Feldman, Rebecca, Vranić, Semir, Spetzler, David

Source: Cancer treatment and research. 178:111-136

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620732057&indx=1&recIds=ETOCRN620732057

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Authors: Le, Dung T., Durham, Jennifer N., Smith, Kellie N., Wang, Hao, Bartlett, Bjarne R., Aulakh, Laveet K., Lu, Steve, Kemberling, Holly, Wilt, Cara, Luber, Brandon S., Wong, Fay, Azad, Nilofer S., Rucki, Agnieszka A., Laheru, Dan, Donehower, Ross, Zaheer, Atif, Fisher, George A., Crocenzi, Todd S., Lee, James J., Greten, Tim F., Duffy, Austin G., Ciombor, Kristen K., Eyring, Aleksandra D., Lam, Bao H., Joe, Andrew, Kang, S. Peter, Holdhoff, Matthias, Danilova, Ludmila, Cope, Leslie, Meyer, Christian, Zhou, Shibin, Goldberg, Richard M., Armstrong, Deborah K., Bever, Katherine M., Fader, Amanda N., Taube, Janis, Housseau, Franck, Spetzler, David, Xiao, Nianqing, Pardoll, Drew M., Papadopoulos, Nickolas, Kinzler, Kenneth W., Eshleman, James R., Vogelstein, Bert, Anders, Robert A., Diaz, Luis A.

Source: Science, 2017 Jul . 357(6349), 409-413.

Access URL: https://www.jstor.org/stable/26399525

Rethinking medulloblastoma from a targeted therapeutics perspective

Authors: Hashimoto, Yuuri, Penas-Prado, Marta, Zhou, Shouhao, Wei, Jun, Khatua, Soumen, Hodges, Tiffany R., Sanai, Nader, Xiu, Joanne, Gatalica, Zoran, Kim, Lyndon, Kesari, Santosh, Rao, Ganesh, Spetzler, David, Heimberger, Amy

Source: Journal of neuro-oncology. 139(3):713-720

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118723098.0x000001&indx=1&recIds=ETOCvdc_100118723098.0x000001