Antibodies and complement are key drivers of thrombosis

Authors: Stark, Konstantin, Kilani, Badr, Stockhausen, Sven, Busse, Johanna, Schubert, Irene, Tran, Thuy-Duong, Gaertner, Florian, Leunig, Alexander, Pekayvaz, Kami, Nicolai, Leo, Fumagalli, Valeria, Stermann, Julia, Stephan, Felix, David, Christian, Müller, Martin B., Heyman, Birgitta, Lux, Anja, da Palma Guerreiro, Alexandra, Frenzel, Lukas P., Schmidt, Christoph Q., Dopler, Arthur, Moser, Markus, Chandraratne, Sue, von Brühl, Marie-Luise, Lorenz, Michael, Korff, Thomas, Rudelius, Martina, Popp, Oliver, Kirchner, Marieluise, Mertins, Philipp, Nimmerjahn, Falk, Iannacone, Matteo, Sperandio, Markus, Engelmann, Bernd, Verschoor, Admar, Massberg, Steffen

Source: In Immunity 10 September 2024 57(9):2140-2156

Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis

Authors: Yang, Won Ho ^{1, 2, ∗}, Aziz, Peter V. ¹, Heithoff, Douglas M. ³, Kim, Yeolhoe ², Ko, Jeong Yeon ², Cho, Jin Won ², Mahan, Michael J. ³, Sperandio, Markus ⁴, Marth, Jamey D. ^{1, 5, ∗∗}

Source: In iScience 20 October 2023 26(10)

Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever

Authors: Jorch, Selina K., McNally, Annika, Berger, Philipp, Wolf, Jonas, Kaiser, Kim, Chetrusca Covash, Andrian, Robeck, Stefanie, Pastau, Isabell, Fehler, Olesja, Jauch-Speer, Saskia-L., Hermann, Sven, Schäfers, Michael, Van Gorp, Hanne, Kanneganti, Apurva, Dehoorne, Joke, Haerynck, Filomeen, Penco, Federica, Gattorno, Marco, Chae, Jae Jin, Kubes, Paul, Lamkanfi, Mohamed, Wullaert, Andy, Sperandio, Markus, Vogl, Thomas, Roth, Johannes, Austermann, Judith

Source: In The Journal of Allergy and Clinical Immunology July 2023 152(1):230-243

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Authors: Gatsiou, Aikaterini, Tual-Chalot, Simon, Napoli, Matteo, Ortega-Gomez, Almudena, Regen, Tommy, Badolia, Rachit, Cesarini, Valeriana, Garcia-Gonzalez, Claudia, Chevre, Raphael, Ciliberti, Giorgia, Silvestre-Roig, Carlos, Martini, Maurizio, Hoffmann, Jedrzej, Hamouche, Rana, Visker, Joseph R., Diakos, Nikolaos, Wietelmann, Astrid, Silvestris, Domenico Alessandro, Georgiopoulos, Georgios, Moshfegh, Ali, Schneider, Andre, Chen, Wei, Guenther, Stefan, Backs, Johannes, Kwak, Shin, Selzman, Craig H., Stamatelopoulos, Kimon, Rose-John, Stefan, Trautwein, Christian, Spyridopoulos, Ioakim, Braun, Thomas, Waisman, Ari, Gallo, Angela, Drakos, Stavros G., Dimmeler, Stefanie, Sperandio, Markus, Soehnlein, Oliver, Stellos, Konstantinos

Source: In Immunity 9 May 2023 56(5):979-997

Soluble uric acid inhibits β2 integrin–mediated neutrophil recruitment in innate immunity

Authors: Ma, Qiuyue ^*, Immler, Roland ^*, Pruenster, Monika, Sellmayr, Markus, Li, Chenyu, von Brunn, Albrecht, von Brunn, Brigitte, Ehmann, Rosina, Wölfel, Roman, Napoli, Matteo, Li, Qiubo, Romagnani, Paola, Böttcher, Ralph Thomas, Sperandio, Markus, Anders, Hans-Joachim, Steiger, Stefanie ^*

Source: In Blood 9 June 2022 139(23):3402-3417

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning

Authors: Yang, Won Ho, Westman, Julia S., Heithoff, Douglas M., Sperandio, Markus, Cho, Jin Won, Mahan, Michael J., Marth, Jamey D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jul . 118(29), 1-8.

Access URL: https://www.jstor.org/stable/27052548

Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation

Authors: Dudeck, Jan, Kotrba, Johanna, Immler, Roland, Hoffmann, Aaron, Voss, Martin, Alexaki, Vasileia Ismini, Morton, Lorena, Jahn, Stephan René, Katsoulis-Dimitriou, Konstantinos, Winzer, Simon, Kollias, Georg, Fischer, Thomas, Nedospasov, Sergei A., Dunay, Ildiko Rita, Chavakis, Triantafyllos, Müller, Andreas J., Schraven, Burkhart, Sperandio, Markus, Dudeck, Anne

Source: In Immunity 9 March 2021 54(3):468-483

Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation.

Authors: Wackerbarth, Lou Martha, Seifert, Sonja Birke, Napoli, Matteo, Rohwedder, Ina, Vogl, Thomas, Scheiermann, Christoph, Kolben, Thomas, Nussbaum, Claudia, Pruenster, Monika, Immler, Roland, Sperandio, Markus

Source: Journal of Leukocyte Biology; Feb2025, Vol. 117 Issue 2, p1-6, 6p

Subject Terms: NATURAL immunity, NLRP3 protein, INFLAMMASOMES, NEUTROPHILS, IMMUNE response

Cytosolic S100A8/A9 promotes Ca²⁺ supply at LFA-1 adhesion clusters during neutrophil recruitment.

Authors: Napoli, Matteo, Immler, Roland, Rohwedder, Ina, Lupperger, Valerio, Pfabe, Johannes, Pisfil, Mariano Gonzalez, Yevtushenko, Anna, Vogl, Thomas, Roth, Johannes, Salvermoser, Melanie, Dietzel, Steffen, Rupnik, Marjan Slak, Marr, Carsten, Walzog, Barbara, Sperandio, Markus, Pruenster, Monika

Source: eLife; 12/19/2024, p1-25, 25p

The eATP/P2×7R Axis Drives Quantum Dot‐Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation.

Authors: Li, Chenxi, Liu, Qiongliang, Han, Lianyong, Zhang, Haiyun, Immler, Roland, Rathkolb, Birgit, Secklehner, Judith, de Angelis, Martin Hrabe, Yildirim, Ali Önder, Zeuschner, Dagmar, Nicke, Annette, Carlin, Leo M., Sperandio, Markus, Stoeger, Tobias, Rehberg, Markus

Source: Advanced Science; 12/4/2024, Vol. 11 Issue 45, p1-16, 16p

Subject Terms: CLINICAL medicine, IMMUNE response, MICROCIRCULATION, LEUKOCYTES, PARTICLE interactions, PURINERGIC receptors

The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus

Authors: Sitte, Selina, Doehler, Daniela, Sperandio, Markus, Marth, Jamey D., Voehringer, David

Source: In Blood Advances 12 May 2020 4(9):1930-1941

Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice

Authors: Lasch, Manuel, Kleinert, Eike Christian, Meister, Sarah, Kumaraswami, Konda, Buchheim, Judith-Irina, Grantzow, Tobias, Lautz, Thomas, Salpisti, Sofia, Fischer, Silvia, Troidl, Kerstin, Fleming, Ingrid, Randi, Anna M., Sperandio, Markus, Preissner, Klaus T., Deindl, Elisabeth

Source: In Blood 24 October 2019 134(17):1469-1479

Ontogeny of platelet function

Authors: Margraf, Andreas, Nussbaum, Claudia, Sperandio, Markus ^*

Source: In Blood Advances 26 February 2019 3(4):692-703

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

Authors: Bromberger, Thomas, Klapproth, Sarah, Rohwedder, Ina, Zhu, Liang, Mittmann, Laura, Reichel, Christoph A., Sperandio, Markus, Qin, Jun, Moser, Markus ^*

Source: In Blood 27 December 2018 132(26):2754-2762

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

Authors: He, Wenyan, Holtkamp, Stephan, Hergenhan, Sophia Martina, Kraus, Kerstin, de Juan, Alba, Weber, Jasmin, Bradfield, Paul, Grenier, Julien Martin Pierre, Pelletier, Jeoffrey, Druzd, David, Chen, Chien-Sin, Ince, Louise Madeleine, Bierschenk, Susanne, Pick, Robert, Sperandio, Markus, Aurrand-Lions, Michel, Scheiermann, Christoph

Source: In Immunity 18 December 2018 49(6):1175-1190

Noncanonical Hippo Signalling in the Regulation of Leukocyte Function

Authors: Kurz, Angela R.M., Catz, Sergio D., Sperandio, Markus

Source: In Trends in Immunology August 2018 39(8):656-669

Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation

Authors: Salvermoser, Melanie, Pick, Robert, Weckbach, Ludwig T., Zehrer, Annette, Löhr, Phillip, Drechsler, Maik, Sperandio, Markus, Soehnlein, Oliver, Walzog, Barbara

Source: In Blood 26 April 2018 131(17):1887-1898

Recurrent infection progressively disables host protection against intestinal inflammation

Authors: Yang, Won Ho, Heithoff, Douglas M., Aziz, Peter V., Sperandio, Markus, Nizet, Victor, Mahan, Michael J., Marth, Jamey D.

Source: Science, 2017 Dec . 358(6370), 1588-1588.

Access URL: https://www.jstor.org/stable/26401157

Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity

Authors: Pick, Robert ^*, Begandt, Daniela ^*, Stocker, Thomas J., Salvermoser, Melanie, Thome, Sarah, Böttcher, Ralph T., Montanez, Eloi, Harrison, Ute, Forné, Ignasi, Khandoga, Alexander G., Coletti, Raffaele, Weckbach, Ludwig T., Brechtefeld, Doris, Haas, Rainer, Imhof, Axel, Massberg, Steffen, Sperandio, Markus, Walzog, Barbara

Source: In Blood 17 August 2017 130(7):847-858

Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation.

Authors: Wang, Meiyue, Flaswinkel, Heinrich, Joshi, Abhinav, Napoli, Matteo, Masgrau-Alsina, Sergi, Kamper, Julia M., Henne, Antonia, Heinz, Alexander, Berouti, Marleen, Schmacke, Niklas A., Hiller, Karsten, Kremmer, Elisabeth, Wefers, Benedikt, Wurst, Wolfgang, Sperandio, Markus, Ruland, Jürgen, Fröhlich, Thomas, Hornung, Veit

Source: Nature Communications; 7/31/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: PATTERN perception receptors, PHOSPHOFRUCTOKINASE 1, METABOLIC reprogramming, ANIMAL populations, CELL populations