Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity

Authors: Herrmann, Alexandra, Gege, Christian, Wangen, Christina, Wagner, Sabrina, Kögler, Melanie, Cordsmeier, Arne, Irrgang, Pascal, Ip, Wing-Hang, Weil, Tatjana, Hunszinger, Victoria, Groß, Rüdiger, Heinen, Natalie, Pfaender, Stephanie, Reuter, Sebastian, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Grunwald, Thomas, Hietel, Benjamin, Cynis, Holger, Münch, Jan, Sparrer, Konstantin M.J., Ensser, Armin, Tenbusch, Matthias, Dobner, Thomas, Vitt, Daniel, Kohlhof, Hella, Hahn, Friedrich

Source: In Antiviral Research November 2024 231

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques

Authors: Laliberté, Alexandre ^{1, 6}, Prelli Bozzo, Caterina ^{1, 6}, Stahl-Hennig, Christiane ^{2, 6}, Hunszinger, Victoria ^{1, 6}, Joas, Simone ¹, Sauermann, Ulrike ², Roshani, Berit ², Klippert, Antonina ², Daskalaki, Maria ², Mätz-Rensing, Kerstin ², Stolte-Leeb, Nicole ², Tharp, Gregory K. ³, Fuchs, Dietmar ², Gupta, Prachi Mehrotra ³, Silvestri, Guido ³, Nelson, Sydney A. ³, Parodi, Laura ⁴, Giavedoni, Luis ^{4, 5}, Bosinger, Steven E. ³, Sparrer, Konstantin M.J. ¹, Kirchhoff, Frank ^{1, 7, ∗}

Source: In iScience 15 December 2023 26(12)

Regulation of STING activity in DNA sensing by ISG15 modification

Authors: Lin, Chaohui, Kuffour, Edmund Osei, Fuchs, Nina V., Gertzen, Christoph G.W., Kaiser, Jesko, Hirschenberger, Maximilian, Tang, Xiao, Xu, Haifeng C., Michel, Oliver, Tao, Ronny, Haase, Alexandra, Martin, Ulrich, Kurz, Thomas, Drexler, Ingo, Görg, Boris, Lang, Philipp A., Luedde, Tom, Sparrer, Konstantin M.J., Gohlke, Holger, König, Renate, Münk, Carsten

Source: In Cell Reports 28 November 2023 42(11)

Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization

Authors: Pastorio, Chiara, Noettger, Sabrina, Nchioua, Rayhane, Zech, Fabian, Sparrer, Konstantin M.J., Kirchhoff, Frank

Source: In iScience 17 November 2023 26(11)

Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication

Authors: Serman, Taryn, Chiang, Cindy, Liu, GuanQun, Sayyad, Zuberwasim, Pandey, Shanti, Volcic, Meta, Lee, Haejeong, Muppala, Santoshi, Acharya, Dhiraj, Goins, Christopher, Stauffer, Shaun R., Sparrer, Konstantin M.J., Gack, Michaela U.

Source: In Cell Host & Microbe 9 August 2023 31(8):1317-1330

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2

Authors: Xie, Qinya ^{1, 5}, Bozzo, Caterina Prelli ^{1, 5}, Eiben, Laura ², Noettger, Sabrina ¹, Kmiec, Dorota ¹, Nchioua, Rayhane ¹, Niemeyer, Daniela ², Volcic, Meta ¹, Lee, Jung-Hyun ^{1, 4}, Zech, Fabian ¹, Sparrer, Konstantin M.J. ¹, Drosten, Christian ^{2, 3}, Kirchhoff, Frank ^{1, 6, ∗}

Source: In iScience 21 April 2023 26(4)

Actin cytoskeleton remodeling primes RIG-I-like receptor activation

Authors: Acharya, Dhiraj, Reis, Rebecca, Volcic, Meta, Liu, GuanQun, Wang, May K., Chia, Bing Shao, Nchioua, Rayhane, Groß, Rüdiger, Münch, Jan, Kirchhoff, Frank, Sparrer, Konstantin M.J., Gack, Michaela U.

Source: In Cell 15 September 2022 185(19):3588-3602

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

Authors: Pastorio, Chiara, Zech, Fabian, Noettger, Sabrina, Jung, Christoph, Jacob, Timo, Sanderson, Theo, Sparrer, Konstantin M.J., Kirchhoff, Frank

Source: In Cell Host & Microbe 14 September 2022 30(9):1255-1268

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

Authors: Bosso, Matteo, Stürzel, Christina M., Kmiec, Dorota, Badarinarayan, Smitha Srinivasachar, Braun, Elisabeth, Ito, Jumpei, Sato, Kei, Hahn, Beatrice H., Sparrer, Konstantin M.J., Sauter, Daniel, Kirchhoff, Frank

Source: In Cell Reports 21 September 2021 36(12)

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids

Authors: Krüger, Jana, Groß, Rüdiger, Conzelmann, Carina, Müller, Janis A., Koepke, Lennart, Sparrer, Konstantin M.J., Weil, Tatjana, Schütz, Desiree, Seufferlein, Thomas, Barth, Thomas F.E., Stenger, Steffen, Heller, Sandra, Münch, Jan, Kleger, Alexander

Source: In Cellular and Molecular Gastroenterology and Hepatology 2021 11(4):935-948

An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection

Authors: Conzelmann, Carina, Gilg, Andrea, Groß, Rüdiger, Schütz, Desiree, Preising, Nico, Ständker, Ludger, Jahrsdörfer, Bernd, Schrezenmeier, Hubert, Sparrer, Konstantin M.J., Stamminger, Thomas, Stenger, Steffen, Münch, Jan, Müller, Janis A.

Source: In Antiviral Research September 2020 181

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Authors: Braun, Elisabeth, Hotter, Dominik, Koepke, Lennart, Zech, Fabian, Groß, Rüdiger, Sparrer, Konstantin M.J., Müller, Janis A., Pfaller, Christian K., Heusinger, Elena, Wombacher, Rebecka, Sutter, Kathrin, Dittmer, Ulf, Winkler, Michael, Simmons, Graham, Jakobsen, Martin R., Conzelmann, Karl-Klaus, Pöhlmann, Stefan, Münch, Jan, Fackler, Oliver T., Kirchhoff, Frank, Sauter, Daniel

Source: In Cell Reports 14 May 2019 27(7):2092-2104

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

Authors: Sanchez, Jacint G., Sparrer, Konstantin M.J., Chiang, Cindy, Reis, Rebecca A., Chiang, Jessica J., Zurenski, Matthew A., Wan, Yueping, Gack, Michaela U., Pornillos, Owen

Source: In Journal of Molecular Biology 7 December 2018 430(24):5280-5293

CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins.

Authors: Hoenigsperger, Helene, Koepke, Lennart, Acharya, Dhiraj, Hunszinger, Victoria, Freisem, Dennis, Grenzner, Alexander, Wiese, Sebastian, Kirchhoff, Frank, Gack, Michaela U., Sparrer, Konstantin M.J.

Source: Autophagy; May2024, Vol. 20 Issue 5, p994-1014, 21p

Subject Terms: TRIM proteins, PROTEIN kinase CK2, AUTOPHAGY, TUBULINS, HIV, MEASLES virus, NEURAMINIDASE

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

Authors: Sanchez, Jacint G., Chiang, Jessica J., Sparrer, Konstantin M.J., Alam, Steven L., Chi, Michael, Roganowicz, Marcin D., Sankaran, Banumathi, Gack, Michaela U., Pornillos, Owen

Source: In Cell Reports 2 August 2016 16(5):1315-1325

TRIM Proteins and Their Roles in Antiviral Host Defenses.

Authors: van Gent, Michiel, Sparrer, Konstantin M.J., Gack, Michaela U.

Source: Annual Review of Virology; 2018, Vol. 5, p385-405, 18p

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity

Authors: Chiang, Jessica, Sparrer, Konstantin M.J., van Gent, Michiel, Lässig, Charlotte, Huang, Teng, Osterrieder, Nikolaus, Hopfner, Karl-Peter, Gack, Michaela U.

Source: Chiang, Jessica J., Konstantin M.J. Sparrer, Michiel van Gent, Charlotte Lässig, Teng Huang, Nikolaus Osterrieder, Karl-Peter Hopfner, and Michaela U. Gack. 2017. “Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity.” Nature immunology 19 (1): 53-62. doi:10.1038/s41590-017-0005-y. http://dx.doi.org/10.1038/s41590-017-0005-y.

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Relation: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815369/pdf/; Nature immunology

Access URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:37160159