MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.

Authors: McInerney, Mitchell P., Awad, Wael, Souter, Michael N. T., Yang Kang, Wang, Carl J. H., Kean Chan Yew Poa, Abdelaal, Mohamed R., Le, Ngoc H., Shepherd, Chloe M., McNeice, Conor, Meehan, Lucy J., Nelson, Adam G., Raynes, Jeremy M., Mak, Jeffrey Y. W., McCluskey, James, Zhenjun Chen, Ching-Seng Ang, Fairlie, David P., Le Nours, Jérôme, Illing, Patricia T.

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/3/2024, Vol. 121 Issue 49, p1-12, 18p

Subject Terms: T cell receptors, VITAMIN B6, T cells, MAJOR histocompatibility complex, VITAMIN B2

MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection.

Authors: Wang, Huimeng, Souter, Michael N. T., de Lima Moreira, Marcela, Li, Shihan, Zhou, Yuchen, Nelson, Adam G., Yu, Jinhan, Meehan, Lucy J., Meehan, Bronwyn S., Eckle, Sidonia B. G., Lee, Hyun Jae, Schröder, Jan, Haque, Ashraful, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Wang, Zhongfang, Chen, Zhenjun, Corbett, Alexandra J.

Source: Science Immunology; 2024, Vol. 9 Issue 102, p1-19, 19p

Subject Terms: TRANSCRIPTION factors, MUCOUS membranes, BACTERIAL diseases, IMMUNE response, TRANSCRIPTOMES

A class of γ δ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Authors: Le Nours, Jérôme, Gherardin, Nicholas A., Ramarathinam, Sri H., Awad, Wael, Wiede, Florian, Gully, Benjamin S., Khandokar, Yogesh, Praveena, T., Wubben, Jacinta M., Sandow, Jarrod J., Webb, Andrew I., von Borstel, Anouk, Rice, Michael T., Redmond, Samuel J., Seneviratna, Rebecca, Sandoval-Romero, Maria L., Li, Shihan, Souter, Michael N. T., Eckle, Sidonia B. G., Corbett, Alexandra J., Reid, Hugh H., Liu, Ligong, Fairlie, David P., Giles, Edward M., Westall, Glen P., Tothill, Richard W., Davey, Martin S., Berry, Richard, Tiganis, Tony, McCluskey, James, Pellicci, Daniel G., Purcell, Anthony W., Uldrich, Adam P., Godfrey, Dale I., Rossjohn, Jamie

Source: Science, 2019 Dec . 366(6472), 1522-1527.

Access URL: https://www.jstor.org/stable/26871402

Hypersensitivities following allergen antigen recognition by unconventional T cells

Authors: Lima Moreira, Marcela, Souter, Michael N. T., Chen, Zhenjun, Loh, Liyen, McCluskey, James, Pellicci, Daniel G., Eckle, Sidonia B. G.

Source: Allergy. 75(10):2477-2490

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132301995.0x000001&indx=1&recIds=ETOCvdc_100132301995.0x000001

CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells

Authors: Reinink, Peter, Souter, Michael N. T., Cheng, Tan‐Yun, Gorkom, Tamara, Lenz, Stefanie, Kubler‐Kielb, Joanna, Strle, Klemen, Kremer, Kristin, Thijsen, Steven F.T., Steere, Allen C., Godfrey, Dale I., Pellicci, Daniel G., Moody, D. Branch, Rhijn, Ildiko

Source: European journal of immunology. 49(5):737-746

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093613354.0x000001&indx=1&recIds=ETOCvdc_100093613354.0x000001

Synthetic 5-amino-6-Dribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo.

Authors: Nelson, Adam G., Huimeng Wang, Dewar, Phoebe M., Eddy, Eleanor M., Songyi Li, Xin Yi Lim, Patton, Timothy, Yuchen Zhou, Pediongco, Troi J., Meehan, Lucy J., Meehan, Bronwyn S., Mak, Jeffrey Y. W., Fairlie, David P., Stent, Andrew W., Kjer-Nielsen, Lars, McCluskey, James, Eckle, Sidonia B. G., Corbett, Alexandra J., Souter, Michael N. T., Zhenjun Chen

Source: Frontiers in Immunology; 2023, p1-15, 15p

Subject Terms: MICROBIOLOGICAL synthesis, LABORATORY mice, T cells, CELL populations, ANIMAL disease models

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Authors: Souter, Michael N. T., Awad, Wael, Li, Shihan, Pediongco, Troi J., Meehan, Bronwyn S., Meehan, Lucy J., Tian, Zehua, Zhao, Zhe, Wang, Huimeng, Nelson, Adam

Source: Journal of experimental medicine. 219(9):e20210828-e20210828

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630161495&indx=1&recIds=ETOCRN630161495

RIPK3 controls MAIT cell accumulation during development but not during infection.

Authors: Patton, Timothy, Zhao, Zhe, Lim, Xin Yi, Eddy, Eleanor, Wang, Huimeng, Nelson, Adam G., Ennis, Bronte, Eckle, Sidonia B. G., Souter, Michael N. T., Pediongco, Troi J., Koay, Hui-Fern, Zhang, Jian-Guo, Djajawi, Tirta M., Louis, Cynthia, Lalaoui, Najoua, Jacquelot, Nicolas, Lew, Andrew M., Pellicci, Daniel G., McCluskey, James, Zhan, Yifan

Source: Cell Death & Disease; Feb2023, Vol. 14 Issue 2, p1-11, 11p

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

Authors: Souter, Michael N. T., Eckle, Sidonia B. G.

Source: Frontiers in Immunology; 8/18/2020, Vol. 11, pN.PAG-N.PAG, 13p

Subject Terms: MAJOR histocompatibility complex, ANTIGENS, T cells

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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Authors: Le Nours, Jérôme^1,2, Gherardin, Nicholas A.^3,4, Ramarathinam, Sri H.¹, Awad, Wael¹, Wiede, Florian^1,5, Gully, Benjamin S.^1,2, Khandokar, Yogesh¹, Praveena, T.¹, Wubben, Jacinta M.¹, Sandow, Jarrod J.^6,7, Webb, Andrew I.^6,7, von Borstel, Anouk^1,2, Rice, Michael T.^1,2, Redmond, Samuel J.³, Seneviratna, Rebecca³, Sandoval-Romero, Maria L.¹, Shihan Li^3,4, Souter, Michael N. T.³, Eckle, Sidonia B. G.³, Corbett, Alexandra J.³

Source: Science; 12/20/2019, Vol. 366 Issue 6472, p1522-1527, 6p, 3 Color Photographs, 1 Diagram