In silico analyses of molecular force sensors for mechanical characterization of biological systems

Authors: Lopez, Diana M. ^{1, 2, 3}, Castro, Carlos E. ^{2, 3}, Sotomayor, Marcos ^{1, 3, ∗}

Source: In Biophysical Journal 4 March 2025 124(5):829-843

CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain

Authors: Tamilselvan, Elakkiya, Sotomayor, Marcos

Source: In Structure 4 April 2024 32(4):476-491

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels

Authors: Zheng, Wang, Rawson, Shaun, Shen, Zhangfei, Tamilselvan, Elakkiya, Smith, Harper E., Halford, Julia, Shen, Chen, Murthy, Swetha E., Ulbrich, Maximilian H., Sotomayor, Marcos, Fu, Tian-Min, Holt, Jeffrey R.

Source: In Neuron 18 October 2023 111(20):3195-3210

Elastic versus brittle mechanical responses predicted for dimeric cadherin complexes

Authors: Neel, Brandon L., Nisler, Collin R., Walujkar, Sanket, Araya-Secchi, Raul, Sotomayor, Marcos

Source: Biophysical journal. 121(6):1013-1028

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163569498.0x000001&indx=1&recIds=ETOCvdc_100163569498.0x000001

Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations

Authors: Neel, Brandon L., Nisler, Collin R., Walujkar, Sanket, Araya-Secchi, Raul, Sotomayor, Marcos

Source: Biophysical journal. 121(6):991-1012

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163569511.0x000001&indx=1&recIds=ETOCvdc_100163569511.0x000001

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.

Authors: Giese, Arnaud P. J., Wei-Hsiang Weng, Kindt, Katie S., Hui Ho Vanessa Chang, Montgomery, Jonathan S., Ratzan, Evan M., Beirl, Alisha J., Rivera, Roberto Aponte, Lotthammer, Jeffrey M., Walujkar, Sanket, Foster, Mark P., Zobeiri, Omid A., Holt, Jeffrey R., Riazuddin, Saima, Cullen, Kathleen E., Sotomayor, Marcos, Ahmed, Zubair M.

Source: eLife; 1/8/2025, p1-35, 35p

A hydrophilic microenvironment in the substrate-translocating groove of the YidC membrane insertase is essential for enzyme function

Authors: Chen, Yuanyuan, Sotomayor, Marcos, Capponi, Sara, Hariharan, Balasubramani, Sahu, Indra D., Haase, Maximilian, Lorigan, Gary A., Kuhn, Andreas, White, Stephen H., Dalbey, Ross E.

Source: In Journal of Biological Chemistry March 2022 298(3)

Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

Authors: Ahmed, Tofayel, Nisler, Collin R., Fluck, Edwin C., III, Walujkar, Sanket, Sotomayor, Marcos, Moiseenkova-Bell, Vera Y.

Source: In Structure 6 January 2022 30(1):139-155

Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception

Authors: Choudhary, Deepanshu, Narui, Yoshie, Neel, Brandon L., Wimalasena, Lahiru N., Klanseck, Carissa F., De-la-Torre, Pedro, Chen, Conghui, Araya-Secchi, Raul, Tamilselvan, Elakkiya, Sotomayor, Marcos

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Oct 01. 117(40), 24837-24848.

Access URL: https://www.jstor.org/stable/26969453

A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites

Authors: Hudson, Jonathan D., Tamilselvan, Elakkiya, Sotomayor, Marcos, Cooper, Sharon R.

Source: In Structure 7 October 2021 29(10):1128-1143

Crystal structure of the nonclassical cadherin‐17 N‐terminus and implications for its adhesive binding mechanism

Authors: Gray, Michelle E., Sotomayor, Marcos

Source: Acta crystallographica.Section F.Structural biology communications. 77(3):85-94

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116433240.0x000001&indx=1&recIds=ETOCvdc_100116433240.0x000001

Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis

Authors: Nicoludis, John M., Green, Anna G., Walujkar, Sanket, May, Elizabeth J., Sotomayor, Marcos, Marks, Debora S., Gaudet, Rachelle

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep 01. 116(36), 17825-17830.

Access URL: https://www.jstor.org/stable/26851218

Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters

Authors: Park, Mi Seul, Araya-Secchi, Raul, Brackbill, James A., Phan, Hong-Duc, Kehling, Audrey C., Abd El-Wahab, Ekram W., Dayeh, Daniel M., Sotomayor, Marcos, Nakanishi, Kotaro

Source: In Molecular Cell 22 August 2019 75(4):725-740

Characterization of the Melting Transition in Two Dimensions at Vanishing External Pressure Using Molecular Dynamics Simulations

Authors: Asenjo, Daniel, Lund, Fernando, Poblete, Simón, Soto, Rodrigo, Sotomayor, Marcos

Subject Terms: Condensed Matter - Statistical Mechanics, Condensed Matter - Materials Science

Access URL: http://arxiv.org/abs/1101.4337

A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

Authors: De-la-Torre, Pedro, Choudhary, Deepanshu, Araya-Secchi, Raul, Narui, Yoshie, Sotomayor, Marcos

Source: In Biophysical Journal 18 December 2018 115(12):2368-2385

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness

Authors: Jaiganesh, Avinash, De-la-Torre, Pedro, Patel, Aniket A., Termine, Domenic J., Velez-Cortes, Florencia, Chen, Conghui, Sotomayor, Marcos

Source: In Structure 4 September 2018 26(9):1210-1225

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

Authors: Pan, Bifeng, Akyuz, Nurunisa, Liu, Xiao-Ping, Asai, Yukako, Nist-Lund, Carl, Kurima, Kiyoto, Derfler, Bruce H., György, Bence, Limapichat, Walrati, Walujkar, Sanket, Wimalasena, Lahiru N., Sotomayor, Marcos, Corey, David P., Holt, Jeffrey R.

Source: In Neuron 22 August 2018 99(4):736-753

Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase

Authors: Fecker, Tobias, Galaz-Davison, Pablo, Engelberger, Felipe, Narui, Yoshie, Sotomayor, Marcos, Parra, Loreto P., Ramírez-Sarmiento, César A.

Source: In Biophysical Journal 27 March 2018 114(6):1302-1312

A curated AlphaFold 2/AlphaFill cadherinosome

Authors: Wen, Haosheng, Weng, Wei-Hsiang, Sotomayor, Marcos

Source: Biophysical journal. 122(S1):474a-475a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188787550.0x000001&indx=1&recIds=ETOCvdc_100188787550.0x000001

Biochemical Studies Provide Insights into the Necessity for Multiple Arabidopsis thaliana Protein-Only RNase P Isoenzymes

Authors: Chen, Tien-Hao, Sotomayor, Marcos, Gopalan, Venkat

Source: Journal of molecular biology. 431(3):615-624

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081271015.0x000001&indx=1&recIds=ETOCvdc_100081271015.0x000001