Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans

Authors: Ewa Karwatowska-Prokopczuk, Anastasia Lesogor, Jing-He Yan, Angelika Hoenlinger, Alison Margolskee, Lu Li, Sotirios Tsimikas

Source: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024)

Subject Terms: Triglycerides, ApoC-III, Ethnicity, Antisense oligonucleotide, Pancreatitis, Cardiovascular disease, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1476-511X

Access URL: https://doaj.org/article/2e72f091741646ae9beffefe9a32d9df

Associations between lipoprotein(a), oxidized phospholipids, and extracoronary vascular disease

Authors: Tiffany R. Bellomo, Yuxi Liu, Thomas C. Gilliland, Hannah Miksenas, Sara Haidermota, Megan Wong, Xingdi Hu, Joaquim Rosado Cristino, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, James L. Januzzi, Jr., Pradeep Natarajan

Source: Journal of Lipid Research, Vol 65, Iss 7, Pp 100585- (2024)

Subject Terms: peripheral artery disease, lipoprotein(a), lipid, peripheral angiography, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227524000907; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/656f0ededc1c4728a7450433adac033e

Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study

Authors: James L. Januzzi, Roland R. J. van Kimmenade, Yuxi Liu, Xingdi Hu, Auris Browne, Jorge Plutzky, Sotirios Tsimikas, Ron Blankstein, Pradeep Natarajan

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)

Subject Terms: heart failure, lipoprotein(a), outcomes, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/c929cc04d11a40d19183551f02d71323

Aspirin use for primary prevention among US adults with and without elevated Lipoprotein(a)

Authors: Alexander C. Razavi, LaTonia C. Richardson, Fátima Coronado, Omar Dzaye, Harpreet S. Bhatia, Anurag Mehta, Arshed A. Quyyumi, Viola Vaccarino, Matthew J. Budoff, Khurram Nasir, Sotirios Tsimikas, Seamus P. Whelton, Michael J. Blaha, Roger S. Blumenthal, Laurence S. Sperling

Source: American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100674- (2024)

Subject Terms: Lipoprotein(a), Aspirin, Cardiovascular disease, NHANES, Diseases of the circulatory (Cardiovascular) system, RC666-701, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666667724000424; https://doaj.org/toc/2666-6677

Access URL: https://doaj.org/article/397d51a3f8954de6bb2d5475f7fe1bf8

Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi‐Ethnic Study of Atherosclerosis

Authors: Harpreet S. Bhatia, Patrick Trainor, Samantha Carlisle, Michael Y. Tsai, Michael H. Criqui, Andrew DeFilippis, Sotirios Tsimikas

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)

Subject Terms: aspirin, cardiovascular disease, Lipoprotein(a), primary prevention, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/8b67db2d64384b8dbb914396862b4cb7

Halofuginone for non-hospitalized adult patients with COVID-19 a multicenter, randomized placebo-controlled phase 2 trial. The HALOS trial.

Authors: Bruno Martins Tomazini, Lucas Tramujas, Fernando Azevedo Medrado, Samara Pinheiro do Carmo Gomes, Karina Leal Negrelli, Gabriela Souza Murinize, Renato Hideo Nakagawa Santos, Bruna Martins Pereira Vianna, Bruna Fornazieri Piotto, Thabata Silva Veiga, Bianca Rodrigues do Santos, Ana Clara Peneluppi Horak, Olivia Mora Cavalcante Lemos, Marcela de Almeida Lopes, Beatriz Baptista Olicheski, Diego Lurentt Campones, Luiz Angelo Alencar Peixoto, Aline Dos Anjos Chaves Basilio, Otavio Celso Eluf Gebara, Ana Tarina Alvarez Lopes, Humberto Saconato, Nanci Valeis, Tamiris Abait Miranda, Ligia Nasi Laranjeira, Eliana Vieira Santucci, Aaron Foster Carlin, Jeffrey David Esko, Phillip Leo Stephan Marie Gordts, Sotirios Tsimikas, Alexandre Biasi Cavalcanti

Source: PLoS ONE, Vol 19, Iss 2, p e0299197 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8f9063cdddcc407b8037ccf8dcd06051

Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation

Authors: Sundeep Ruder, Brett Mansfield, Andrew Ronald Immelman, Nissi Varki, Phuong Miu, Frederick Raal, Sotirios Tsimikas

Source: Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-8 (2022)

Subject Terms: Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1476-511X

Access URL: https://doaj.org/article/a4ccf65eedb543e2919bd23cae8248fa

High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction

Authors: Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenböck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 64, Iss 6, Pp 100391- (2023)

Subject Terms: oxidation, immunoglobulin, myocardial infarction, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227523000640; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/7e13b8f6a4a1409992df716051956c85

Lipoprotein(a) levels in a global population with established atherosclerotic cardiovascular disease

Authors: Ulf Landmesser, Børge G Nordestgaard, Leslie Cho, Niels Eske Bruun, Sotirios Tsimikas, Stephen J Nicholls, A Michael Lincoff, Steven E Nissen, Eran Leitersdorf, Kathy Wolski, John Kastelein, Michael Blaha, Ryuichi Morishita, Junhao Liu, Brian Manning, Plamen Kozlovski, Anastasia Lesogor, Tom Thuren, Taro Shibasaki, Florin Matei, Fábio Serra Silveira, Andreas Meunch, Aysha Bada, Vinod Vijan

Source: Open Heart, Vol 9, Iss 2 (2022)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://openheart.bmj.com/content/9/2/e002060.full; https://doaj.org/toc/2053-3624

Access URL: https://doaj.org/article/69a4df2faa554bac9af4585ef3cef707

Development and validation of an isoform-independent monoclonal antibody–based ELISA for measurement of lipoprotein(a)

Authors: Santica M. Marcovina, Nazanin Navabi, Serena Allen, Ayelet Gonen, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 63, Iss 8, Pp 100239- (2022)

Subject Terms: lipoprotein(a), monoclonal antibody, isoform, kringle, cardiovascular disease, aortic stenosis, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227522000724; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/6f168a3e03d846e9bed1e4e54bf094ec

Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering

Authors: Bastian Ramms, Sohan Patel, Xiaoli Sun, Ariane R. Pessentheiner, G. Michelle Ducasa, Adam E. Mullick, Richard G. Lee, Rosanne M. Crooke, Sotirios Tsimikas, Joseph L. Witztum, Philip L.S.M. Gordts

Source: JCI Insight, Vol 7, Iss 13 (2022)

Subject Terms: Metabolism, Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/d3c85ea05ac64087a50365d3f59dcc54

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

Authors: Nicholas J. Viney, Shuling Guo, Li‐Jung Tai, Brenda F. Baker, Mariam Aghajan, Shiangtung W. Jung, Rosie Z. Yu, Sheri Booten, Heather Murray, Todd Machemer, Sebastien Burel, Sue Murray, Gustavo Buchele, Sotirios Tsimikas, Eugene Schneider, Richard S. Geary, Merrill D. Benson, Brett P. Monia

Source: ESC Heart Failure, Vol 8, Iss 1, Pp 652-661 (2021)

Subject Terms: Transthyretin, Amyloidosis, Cardiomyopathy, Polyneuropathy, Antisense, Ligand‐conjugated, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5822

Access URL: https://doaj.org/article/3297462a8e6e4c1081fbb6040b37c72e

Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a)

Authors: Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L. Witztum, Michael Boffa, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 61, Iss 9, Pp 1263-1270 (2020)

Subject Terms: lipoprotein (a), monoclonal antibody, isoform, kringle, cardiovascular disease, aortic stenosis, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520436910; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/d3ae9551f9854ddb99fa732ebadefc2a

Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis

Authors: Michael B. Boffa, Tanya T. Marar, Calvin Yeang, Nicholas J. Viney, Shuting Xia, Joseph L. Witztum, Marlys L. Koschinsky, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)

Subject Terms: apolipoprotein(a), thrombosis, atherosclerotic cardiovascular disease, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520310464; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/28dfa1e214734075affad1972af7235c

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

Authors: Matthew T. Mefford, Santica M. Marcovina, Vera Bittner, Mary Cushman, Todd M. Brown, Michael E. Farkouh, Sotirios Tsimikas, Keri L. Monda, J. Antonio G. López, Paul Muntner, Robert S. Rosenson

Source: Journal of Lipid Research, Vol 60, Iss 11, Pp 1946-1952 (2019)

Subject Terms: proprotein convertase subtilisin-kexin type 9, lipoprotein (a), apolipoprotein, oxidized phospholipids, epidemiology, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322926; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/d3387648d2aa41bda30df7af0a6912b8

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

Authors: Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts

Source: Journal of Lipid Research, Vol 60, Iss 8, Pp 1379-1395 (2019)

Subject Terms: lipid metabolism, apolipoprotein C-III, apolipoprotein E, triglyceride-rich lipoprotein clearance, fatty acids, lipase, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520322331; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/79b2fc472cb54420abab601c33268491

Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography

Authors: Audrey-Anne Després, BSc, Nicolas Perrot, MSc, Anthony Poulin, MD, Lionel Tastet, MSc, Mylène Shen, MSc, Hao Yu Chen, MSc, Raphaëlle Bourgeois, MSc, Mikaël Trottier, MD, Michel Tessier, MD, Jean Guimond, MD, Maxime Nadeau, TIM, James C. Engert, PhD, Sébastien Thériault, MD, MSc, Yohan Bossé, PhD, Joseph L. Witztum, MD, Patrick Couture, MD, Patrick Mathieu, MD, MSc, Marc R. Dweck, MD, Sotirios Tsimikas, MD, George Thanassoulis, MD, Philippe Pibarot, PhD, DVM, Marie-Annick Clavel, PhD, DVM, Benoit J. Arsenault, PhD

Source: CJC Open, Vol 1, Iss 3, Pp 131-140 (2019)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589790X19300216; https://doaj.org/toc/2589-790X

Access URL: https://doaj.org/article/3ecc4f1cde6447aa92f6bf6f6a3e3623

Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements

Authors: Calvin Yeang, Joseph L. Witztum, Sotirios Tsimikas

Source: Journal of Lipid Research, Vol 62, Iss , Pp 100053- (2021)

Subject Terms: lipoprotein(a), low density lipoprotein, cholesterol, biomarker, cardiovascular disease risk, therapy, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227521000341; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/615be8f28e424120957595e6d6cd41ff

microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production

Authors: Jianjie Dong, Ming He, Jie Li, Ariane Pessentheiner, Chen Wang, Jin Zhang, Yameng Sun, Wei-Ting Wang, Yuqing Zhang, Junhui Liu, Shen-Chih Wang, Po-Hsun Huang, Philip L.S.M. Gordts, Zu-Yi Yuan, Sotirios Tsimikas, John Y.J. Shyy

Source: JCI Insight, Vol 5, Iss 23 (2020)

Subject Terms: Metabolism, Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/31e89a04738947da9cfa9208e4ef921c

Low‐Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events

Authors: Peter Willeit, Calvin Yeang, Patrick M. Moriarty, Lena Tschiderer, Stephen A. Varvel, Joseph P. McConnell, Sotirios Tsimikas

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 23 (2020)

Subject Terms: cholesterol, guidelines, lipoprotein(a), low‐density lipoprotein, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/10f5a0e97b7a4d4aa331bbfb7923a631