High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniaeResearch in context

Authors: Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock

Source: EBioMedicine, Vol 102, Iss , Pp 105073- (2024)

Subject Terms: Multidrug-resistance, Acinetobacter baumannii, Klebsiella pneumoniae, Antibacterial drug discovery, High-throughput screening, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424001087; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/eaf98873ad5c42ceacfa2d3e86721587

Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro

Authors: Santiago M. Ruatta, Denis N. Prada Gori, Martín Fló Díaz, Franca Lorenzelli, Karen Perelmuter, Lucas N. Alberca, Carolina L. Bellera, Andrea Medeiros, Gloria V. López, Mariana Ingold, Williams Porcal, Estefanía Dibello, Irina Ihnatenko, Conrad Kunick, Marcelo Incerti, Martín Luzardo, Maximiliano Colobbio, Juan Carlos Ramos, Eduardo Manta, Lucía Minini, María Laura Lavaggi, Paola Hernández, Jonas Šarlauskas, César Sebastian Huerta García, Rafael Castillo, Alicia Hernández-Campos, Giovanni Ribaudo, Giuseppe Zagotto, Renzo Carlucci, Noelia S. Medrán, Guillermo R. Labadie, Maitena Martinez-Amezaga, Carina M. L. Delpiccolo, Ernesto G. Mata, Laura Scarone, Laura Posada, Gloria Serra, Theodora Calogeropoulou, Kyriakos Prousis, Anastasia Detsi, Mauricio Cabrera, Guzmán Alvarez, Adrián Aicardo, Verena Araújo, Cecilia Chavarría, Lucija Peterlin Mašič, Melisa E. Gantner, Manuel A. Llanos, Santiago Rodríguez, Luciana Gavernet, Soonju Park, Jinyeong Heo, Honggun Lee, Kyu-Ho Paul Park, Mariela Bollati-Fogolín, Otto Pritsch, David Shum, Alan Talevi, Marcelo A. Comini

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: in silico screening, coronavirus, COVID-19, protease, target-based, drug discovery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1193282/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/37a7aaacc38c4e40801eaddd5b8743ba

Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease

Authors: Denis N. Prada Gori, Santiago Ruatta, Martín Fló, Lucas N. Alberca, Carolina L. Bellera, Soonju Park, Jinyeong Heo, Honggun Lee, Kyu-Ho Paul Park, Otto Pritsch, David Shum, Marcelo A. Comini, Alan Talevi

Source: Frontiers in Drug Discovery, Vol 2 (2023)

Subject Terms: atpenin, tinostamustine, in silico screening, cysteine proteases, COVID-19, drug repositioning, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fddsv.2022.1082065/full; https://doaj.org/toc/2674-0338

Access URL: https://doaj.org/article/f1d823b52d2e4559a8677f810ef54512

Breakthrough infections and waning immune responses with ChAdOx1 nCoV‐19 or mRNA vaccine in healthcare workers

Authors: So Yun Lim, Jiwon Jung, Ji Yeun Kim, Soonju Park, Ji‐Soo Kwon, So Yeon Park, Sun‐Kyung Kim, Young‐Ju Lim, Eun Ok Kim, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sang‐Oh Lee, Sang‐Ho Choi, Yang Soo Kim, Nakyung Lee, Kideok Kim, David Shum, Youngmee Jee, Sung‐Han Kim

Source: Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/c7312596983e40a89ef5c59bfc64b626

Immunogenicity and Durability of Antibody Responses to Homologous and Heterologous Vaccinations with BNT162b2 and ChAdOx1 Vaccines for COVID-19

Authors: Dong-In Kim, Seo Jin Lee, Soonju Park, Paul Kim, Sun Min Lee, Nakyung Lee, David Shum, Dong Ho Kim, Eui Ho Kim

Source: Vaccines, Vol 10, Iss 11, p 1864 (2022)

Subject Terms: COVID-19, SARS-CoV-2, vaccine, BNT162b2, ChAdOx1, antibody, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/10/11/1864; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/58806b7ba4ed48db8ed367be6161dbf4

A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals

Authors: Jaewon Yang, Alexander König, Soonju Park, Eunji Jo, Pil Soo Sung, Seung Kew Yoon, Eva Zusinaite, Denis Kainov, David Shum, Marc Peter Windisch

Source: JHEP Reports, Vol 3, Iss 4, Pp 100296- (2021)

Subject Terms: HBV, HepG2-NTCP, Entry, Replication, Virion secretion, High-throughput screening, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555921000720; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/1e0390c1447c43c2833a8a97f1de481f

Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19

Authors: Frauke Assmus, Jean-Sélim Driouich, Rana Abdelnabi, Laura Vangeel, Franck Touret, Ayorinde Adehin, Palang Chotsiri, Maxime Cochin, Caroline S. Foo, Dirk Jochmans, Seungtaek Kim, Léa Luciani, Grégory Moureau, Soonju Park, Paul-Rémi Pétit, David Shum, Thanaporn Wattanakul, Birgit Weynand, Laurent Fraisse, Jean-Robert Ioset, Charles E. Mowbray, Andrew Owen, Richard M. Hoglund, Joel Tarning, Xavier de Lamballerie, Antoine Nougairède, Johan Neyts, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain

Source: Microorganisms, Vol 10, Iss 8, p 1639 (2022)

Subject Terms: COVID-19, drug repurposing, translational medicine, pandemics, clinical trials, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/10/8/1639; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/a9ef2617e75845fa98746d7ddae47ef7

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